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  1. Gene therapy utilizes nucleic acid drugs to treat diseases, encompassing gene supplementation, gene replacement, gene silencing, and gene editing. It represents a distinct therapeutic approach from traditional...

    Authors: Tingting Wu, Yu Hu and Liang V. Tang
    Citation: Biomarker Research 2024 12:99
    Content type: Review Published on:

  3. Immunotherapy has shown promising anti-tumor effects across various tumors, yet it encounters challenges from the inhibitory tumor immune microenvironment (TIME). Infiltrating regulatory T cells (Tregs) are im...

    Authors: Zhaokai Zhou, Jiaxin Xu, Shutong Liu, Yingying Lv, Ruiqi Zhang, Xing Zhou, Yuyuan Zhang, Siyuan Weng, Hui Xu, Yuhao Ba, Anning Zuo, Xinwei Han and Zaoqu Liu
    Citation: Biomarker Research 2024 12:97
    Content type: Review Published on:

  4. Tumor cells possess complex immune evasion mechanisms to evade immune system attacks, primarily through metabolic reprogramming, which significantly alters the tumor microenvironment (TME) to modulate immune c...

    Authors: Haixia Zhang, Shizhen Li, Dan Wang, Siyang Liu, Tengfei Xiao, Wangning Gu, Hongmin Yang, Hui Wang, Minghua Yang and Pan Chen
    Citation: Biomarker Research 2024 12:96
    Content type: Review Published on:

  5. Immunotherapy has emerged as a pivotal modality in cancer treatment, with immune checkpoint inhibitors effectively combating malignancies by impeding crucial pathways within the immune system and stimulating p...

    Authors: Lin Chen, Yuqing Chao, Wenjing Li, Zhixia Wu and Qinchuan Wang
    Citation: Biomarker Research 2024 12:95
    Content type: Review Published on:

  8. Fibrosis is an excessive wound-healing response induced by repeated or chronic external stimuli to tissues, significantly impacting quality of life and primarily contributing to organ failure. Organ fibrosis i...

    Authors: Qun Wei, Cailing Gan, Meng Sun, Yuting Xie, Hongyao Liu, Taixiong Xue, Conghui Deng, Chunheng Mo and Tinghong Ye
    Citation: Biomarker Research 2024 12:92
    Content type: Review Published on:

  9. Serial CA125 and second line transvaginal ultrasound (TVS) screening in the UKCTOCS indicated a shift towards detection of earlier stage ovarian cancer (OvCa), but did not yield a significant mortality reducti...

    Authors: Johannes F. Fahrmann, Seyyed Mahmood Ghasemi, Chae Y. Han, Ranran Wu, Jennifer B. Dennison, Jody Vykoukal, Joseph Celestino, Karen Lu, Zhen Lu, Charles Drescher, Kim-Anh Do, Samir Hanash, Robert C. Bast and Ehsan Irajizad
    Citation: Biomarker Research 2024 12:91
    Content type: Correspondence Published on:

  10. The use of proton therapy (PT) in early-stage non-small cell lung cancer (ES-NSCLC) remains controversial, with insufficient evidence to determine its superiority over photon therapy (XRT). We conducted a syst...

    Authors: Junyi He, Yingxin Liu, Xiaojing Zhang, Butuo Li, Linlin Yang, Haohua Wang, Shijiang Wang, Jinming Yu and Linlin Wang
    Citation: Biomarker Research 2024 12:90
    Content type: Correspondence Published on:

  11. Colorectal cancer (CRC) ranks as the third most prevalent cancer globally. It’s recognized that the molecular subtype of CRC, characterized by mismatch repair deficiency (dMMR) or microsatellite instability-hi...

    Authors: Wen-Xuan Fan, Fei Su, Yan Zhang, Xiao-Ling Zhang, Yun-Yi Du, Yang-Jun Gao, Wei-Ling Li, Wen-Qing Hu and Jun Zhao
    Citation: Biomarker Research 2024 12:89
    Content type: Review Published on:

  12. Platelets are a significant component of the cell population in the tumour microenvironment (TME). Platelets influence other immune cells and perform cross-talk with tumour cells, playing an important role in ...

    Authors: Tongtao Zhuang, Shenrong Wang, Xiaoqian Yu, Xiaoyun He, Hongbin Guo and Chunlin Ou
    Citation: Biomarker Research 2024 12:88
    Content type: Review Published on:

  13. Breast cancer is a leading cause of morbidity and mortality among women worldwide. This study aimed to assess the global burden of breast cancer and identify attributable risk factors across 204 countries and ...

    Authors: Rui Sha, Xiang-meng Kong, Xin-yu Li and Ya-bing Wang
    Citation: Biomarker Research 2024 12:87
    Content type: Research Published on:

  17. MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional regulation of gene expression. Mounting evidence underscores the dysregulation of miRNAs to be associated with cancer development a...

    Authors: Yu Shuai, Xiaofang Zhang, Birgit D. A. Lavrijssen, M. Arfan Ikram, Rikje Ruiter, Bruno Stricker and Mohsen Ghanbari
    Citation: Biomarker Research 2024 12:83
    Content type: Correspondence Published on:

  18. Human trophoblastic cell surface antigen 2 (Trop2) is a glycoprotein, a cellular marker of trophoblastic and stem cells, and a calcium signaling transducer involved in several signaling pathways, leading to th...

    Authors: Yixuan Hu, Yinxing Zhu, Dan Qi, Cuiju Tang and Wenwen Zhang
    Citation: Biomarker Research 2024 12:82
    Content type: Review Published on:

  19. Tissue-resident macrophages and recruited macrophages play pivotal roles in innate immunity and the maintenance of brain homeostasis. Investigating the involvement of these macrophage populations in eliciting ...

    Authors: Hongyue Ma, Mingxia Zhu, Mengjie Chen, Xiuli Li and Xinhong Feng
    Citation: Biomarker Research 2024 12:81
    Content type: Review Published on:

  20. High-grade serous ovarian cancer (HGSOC), which is known for its heterogeneity, high recurrence rate, and metastasis, is often diagnosed after being dispersed in several sites, with about 80% of patients exper...

    Authors: Hye-Yeon Ju, Seo Yeon Youn, Jun Kang, Min Yeop Whang, Youn Jin Choi and Mi-Ryung Han
    Citation: Biomarker Research 2024 12:80
    Content type: Research Published on:

  21. Understanding the biological mechanisms underlying racial differences in diseases is crucial to developing targeted prevention and treatment. There is, however, limited knowledge of the impact of race on lipid...

    Authors: Ghazaleh Pourali, Liang Li, Kayla R. Getz, Myung Sik Jeon, Jingqin Luo, Chongliang Luo and Adetunji T. Toriola
    Citation: Biomarker Research 2024 12:79
    Content type: Correspondence Published on:

  22. The incidence of esophageal adenocarcinoma (EAC) has surged by 600% in recent decades, with a dismal 5-year survival rate of just 15%. Barrett’s esophagus (BE), affecting about 2% of the population, raises the...

    Authors: Yusi Fu, Swati Agrawal, Daniel R. Snyder, Shiwei Yin, Na Zhong, James A. Grunkemeyer, Nicholas Dietz, Ryan Corlett, Laura A. Hansen, Al-Refaie Waddah, Kalyana C. Nandipati and Jun Xia
    Citation: Biomarker Research 2024 12:78
    Content type: Correspondence Published on:

  23. Cancer immunotherapy has sparked a wave of cancer research, driven by recent successful proof-of-concept clinical trials. However, barriers are emerging during its rapid development, including broad adverse ef...

    Authors: Chao Sui, Heqing Wu, Xinxin Li, Yuhang Wang, Jiaqi Wei, Jianhua Yu and Xiaojin Wu
    Citation: Biomarker Research 2024 12:77
    Content type: Review Published on:

  25. Accurate prostate cancer (PCa) patient diagnosis and risk assessment are key to ensure the best outcome. Currently, low- and favorable intermediate-risk PCa patients may be offered AS due to the indolent natur...

    Authors: Ângela Albuquerque-Castro, Catarina Macedo-Silva, Rúben Oliveira-Sousa, Vera Constâncio, João Lobo, Isa Carneiro, Rui Henrique and Carmen Jerónimo
    Citation: Biomarker Research 2024 12:75
    Content type: Correspondence Published on:

  26. Lysine methylation is a crucial post-translational modification (PTM) that significantly impacts gene expression regulation. This modification not only influences cancer development directly but also has signi...

    Authors: Yiming Luo, Junli Lu, Zhen Lei, He Zhu, Dean Rao, Tiantian Wang, Chenan Fu, Zhiwei Zhang, Limin Xia and Wenjie Huang
    Citation: Biomarker Research 2024 12:74
    Content type: Review Published on:

  27. Cancer-associated fibroblasts (CAFs) are the major components of the tumor microenvironment and are related to tumor proliferation, metastasis, relapse, and drug resistance. With the development of sequencing ...

    Authors: Pin Lyu, Xiaoming Gu, Fuqi Wang, Haifeng Sun, Quanbo Zhou, Shuaixi Yang and Weitang Yuan
    Citation: Biomarker Research 2024 12:73
    Content type: Review Published on:

  30. Voltage-gated sodium channels (VGSCs) initiate action potentials in electrically excitable cells and tissues. Surprisingly, some VGSC genes are aberrantly expressed in a variety of cancers, derived from “non-e...

    Authors: Hengrui Liu, Jieling Weng, Christopher L.-H. Huang and Antony P. Jackson
    Citation: Biomarker Research 2024 12:70
    Content type: Review Published on:

  32. Insulin-like growth factor (IGF)-1 and its binding proteins are important in cancer growth, especially in prostate cancer. Observational studies suggest that protein restriction can lower IGF-1 levels. However...

    Authors: Maria L. Cagigas, Giovanni Fiorito, Beatrice Bertozzi, Andrius Masedunskas, Edda Cava, Francesco Spelta, Nicola Veronese, Valeria Tosti, Gayathiri Rajakumar, Tiana Pelaia, Arnold D. Bullock, Robert S. Figenshau, Gerald L. Andriole and Luigi Fontana
    Citation: Biomarker Research 2024 12:68
    Content type: Correspondence Published on:

  33. Uveal melanoma is the most common non-cutaneous melanoma and is an intraocular malignancy affecting nearly 7,000 individuals per year worldwide. Of these, approximately 50% will progress to metastatic disease ...

    Authors: Ashley N. Anderson, Patrick Conley, Christopher D. Klocke, Sidharth K. Sengupta, Amara Pang, Hannah C. Farley, Abigail R. Gillingham, Aubrey D. Dawson, Yichen Fan, Jocelyn A. Jones, Summer L. Gibbs, Alison H. Skalet, Guanming Wu and Melissa H. Wong
    Citation: Biomarker Research 2024 12:67
    Content type: Research Published on:

  34. Non-Hodgkin lymphomas (NHLs) are heterogeneous and are among the most common hematological malignancies worldwide. Despite the advances in the treatment of patients with NHLs, relapse or resistance to treatmen...

    Authors: Mehdi Bakhtiyaridovvombaygi, Somayeh Yazdanparast, Setare Kheyrandish, Seyed Mehrab Safdari, Fateme Amiri Samani, Mahsa Sohani, Akram Sadat Jaafarian, Fateme Damirchiloo, Amirhossein Izadpanah, Sahar Parkhideh, Fatemeh Mikanik, Elham Roshandel, Abbas Hajifathali and Ahmad Gharehbaghian
    Citation: Biomarker Research 2024 12:66
    Content type: Review Published on:

  35. Megakaryocytic differentiation is a complicated process regulated by a series of transcription factors in a context- and stage-dependent manner. Recent studies have suggested that krüppel-like transcription fa...

    Authors: Zhen Wang, Zhongwen Liu, Pan Zhou, Xiaona Niu, Zhengdao Sun, Huan He and Zunmin Zhu
    Citation: Biomarker Research 2024 12:65
    Content type: Research Published on:

  37. Ischemic stroke (IS), a devastating cerebrovascular accident, presents with high mortality and morbidity. Following IS onset, a cascade of pathological changes, including excitotoxicity, inflammatory damage, a...

    Authors: Liangzhe Wei, Siqi Chen, Xinpeng Deng, Yuchun Liu, Haifeng Wang, Xiang Gao and Yi Huang
    Citation: Biomarker Research 2024 12:63
    Content type: Review Published on:

  38. Inhibitors of Bruton’s tyrosine kinase (BTKi) and chimeric antigen receptor T-cell (CAR-T) therapy targeting CD19 are paradigm-shifting advances in treating patients with aggressive mantle cell lymphoma (MCL)....

    Authors: Vivian Jiang, William Lee, Tianci Zhang, Alexa Jordan, Fangfang Yan, Qingsong Cai, Joseph McIntosh, Jovanny Vargas, Yang Liu and Michael Wang
    Citation: Biomarker Research 2024 12:62
    Content type: Correspondence Published on:

  39. Individuals with acute / early HIV-1 infection are often unaware that they are infected with HIV-1 and may be involved in high-risk behavior leading to transmission of HIV-1. Identifying individuals with acute...

    Authors: Santanu Biswas, Namrata Nagarajan, Indira Hewlett and Krishnakumar Devadas
    Citation: Biomarker Research 2024 12:61
    Content type: Research Published on:

  40. Acute myeloid leukemia (AML) is the most frequent leukemia in adults with a high mortality rate. Current diagnostic criteria and selections of therapeutic strategies are generally based on gene mutations and c...

    Authors: Zhiyu Zhang, Jiayi Huang, Zhibo Zhang, Hongjie Shen, Xiaowen Tang, Depei Wu, Xiebing Bao, Guoqiang Xu and Suning Chen
    Citation: Biomarker Research 2024 12:60
    Content type: Review Published on:

  41. Pyroptosis belongs to a unique type of programmed cell death among which GSDME is reported to exert anti-tumor immunity. However, the underlying mechanisms of how to boost tumor-infiltrating lymphocytes and wh...

    Authors: Bixian Luo, Shun Zhang, Xinbo Yu, Dan Tan, Ying Wang and Mingliang Wang
    Citation: Biomarker Research 2024 12:59
    Content type: Research Published on:

    The Correction to this article has been published in Biomarker Research 2024 12:64

  42. Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous malignancy characterized by varied responses to treatment and prognoses. Understanding the metabolic characteristics driving DLBCL progression is crucia...

    Authors: Liyuan Dai, Guangyu Fan, Tongji Xie, Lin Li, Le Tang, Haizhu Chen, Yuankai Shi and Xiaohong Han
    Citation: Biomarker Research 2024 12:58
    Content type: Research Published on:

  43. Cerebral cavernous malformations (CCMs) are vascular abnormalities associated with deregulated angiogenesis. Their pathogenesis and optimal treatment remain unclear. This study aims to investigate the molecula...

    Authors: Chengwei Chen, Yuting Bao, Sihan Ju, Conglin Jiang, Xiang Zou, Xin Zhang and Liang Chen
    Citation: Biomarker Research 2024 12:57
    Content type: Research Published on:

  44. Accumulating evidence suggests that the gut microbiota and metabolites can modulate tumor responses to immunotherapy; however, limited data has been reported on biliary tract cancer (BTC). This study used meta...

    Authors: Chengpei Zhu, Yunchao Wang, Ruijuan Zhu, Shanshan Wang, Jingnan Xue, Dongya Zhang, Zhou Lan, Chenchen Zhang, Yajun Liang, Nan Zhang, Ziyu Xun, Longhao Zhang, Cong Ning, Xu Yang, Jiashuo Chao, Junyu Long…
    Citation: Biomarker Research 2024 12:56
    Content type: Research Published on:

  45. Placenta accreta spectrum disorders (PAS) are a severe complication characterized by abnormal trophoblast invasion into the myometrium. The underlying mechanisms of PAS involve a complex interplay of various c...

    Authors: Kaiyuan Ji, Yunshan Chen, Xiuyu Pan, Lina Chen, Xiaodi Wang, Bolun Wen, Junjie Bao, Junmin Zhong, Zi Lv, Zheng Zheng and Huishu Liu
    Citation: Biomarker Research 2024 12:55
    Content type: Research Published on:

  46. Chimeric antigen receptor T cell (CAR-T) therapy has revolutionized the treatment approach for cancer, autoimmune disease, and heart disease. The integration of CAR into T cells is typically facilitated by ret...

    Authors: Ping Song, Qiqi Zhang, Zhiyong Xu, Yueli Shi, Ruirui Jing and Dingcun Luo
    Citation: Biomarker Research 2024 12:54
    Content type: Review Published on:

    The Correction to this article has been published in Biomarker Research 2024 12:69

  48. Protein tyrosine kinase 2 (PTK2), epidermal growth factor receptor (EGFR), and toll-like receptor (TLRs) are amplified in non-small cell lung cancer (NSCLC). However, the functional and clinical associations b...

    Authors: Ji Young Kim, Ji Hye Shin, Mi-Jeong Kim, Bongkum Choi, Yeeun Kang, Jimin Choi, Seo Hyun Kim, Dohee Kwan, Duk-Hwan Kim, Eunyoung Chun and Ki-Young Lee
    Citation: Biomarker Research 2024 12:52
    Content type: Correspondence Published on:

  49. Nowadays, immunotherapy is one of the most promising anti-tumor therapeutic strategy. Specifically, immune-related targets can be used to predict the efficacy and side effects of immunotherapy and monitor the ...

    Authors: Kai Yang, Rongrong Lu, Jie Mei, Kai Cao, Tianyu Zeng, Yijia Hua, Xiang Huang, Wei Li and Yongmei Yin
    Citation: Biomarker Research 2024 12:51
    Content type: Review Published on:

  50. Cell- and antibody-based CD19-directed therapies have demonstrated great potential for treating B-cell non-Hodgkin lymphoma (B-NHL). However, all these approaches suffer from limited response rates and conside...

    Authors: Dominik Sonanini, Johannes Schwenck, Simone Blaess, Julia Schmitt, Andreas Maurer, Walter Ehrlichmann, Malte Ritter, Julia Skokowa, Manfred Kneilling, Gundram Jung, Falko Fend, Simon Krost, Christian M. Seitz, Peter Lang, Gerald Reischl, Rupert Handgretinger…
    Citation: Biomarker Research 2024 12:50
    Content type: Correspondence Published on:
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