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Featured review: SALL4 as a transcriptional and epigenetic regulator in normal and leukemic hematopoiesis

This review by Dr. Jianchang Yang summarizes recent advances in the biology of SALL4 with a focus on its regulatory functions in normal and leukemic hematopoiesis. In the normal hematopoietic system, expression of SALL4 is mainly enriched in the bone marrow hematopoietic stem/progenitor cells (HSCs/HPCs), but is rapidly silenced following lineage differentiation. In hematopoietic malignancies, however, SALL4 expression is abnormally re-activated and linked with deteriorated disease status in patients. Further, SALL4 activation participates in the pathogenesis of tumor initiation and disease progression. Thus, a better understanding of SALL4’s biologic functions and mechanisms will facilitate development of advanced targeted anti-leukemia approaches in future.

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Editors-in-Chief

Chung-Tsen Hsueh, Loma Linda University, USA

Delong Liu, New York Medical College, USA​​​​​​​

Aims and scope

Biomarker Research is an open access, peer-reviewed journal that encompasses all aspects of biomarker investigation. Biomarker Research aims to publish original discoveries, novel concepts, commentaries and reviews related to biomarker investigation from all biomedical disciplines.

The study of biomarkers has evolved rapidly in the advance of personalized medicine and individual health. The identification and validation of biomarkers in drug discovery/development and in disease diagnosis, treatment, prognosis, and prevention play an essential role in the genome era. With a quick turnaround time from submission to publication and online feedback from readers, Biomarker Research strives to provide fast dissemination of novel findings and new knowledge.

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2017 Journal Metrics

  • Speed
    33 days to first decision for reviewed manuscripts only
    30 days to first decision for all manuscripts
    76 days from submission to acceptance
    12 days from acceptance to publication

    Usage 
    151,816 Downloads
    74 Altmetric mentions

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