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  1. Extracellular vesicles (EVs) have considerable potential as diagnostic, prognostic, and therapeutic agents, in large part because molecular patterns on the EV surface betray the cell of origin and may also be ...

    Authors: Md. Khirul Islam, Misba Khan, Kamlesh Gidwani, Kenneth W. Witwer, Urpo Lamminmäki and Janne Leivo
    Citation: Biomarker Research 2023 11:85
  2. Annotating cells in the analysis of single-cell RNA-seq (scRNA-seq) data is one of the most challenging tasks that researchers are actively addressing. Manual cell annotation is generally considered the gold s...

    Authors: Fan-Lin Meng, Xiao-Ling Huang, Wen-Yan Qin, Kun-Bang Liu, Yan Wang, Ming Li, Yong-Hong Ren, Yan-Ze Li and Yi-Min Sun
    Citation: Biomarker Research 2023 11:83
  3. Medullary Thyroid Carcinoma (MTC) is a rare neuroendocrine tumour whose diagnosis includes evaluating calcitonin serum levels, which can present fluctuations unrelated to MTC. Here, we investigated circulating...

    Authors: Anna Citarella, Zein Mersini Besharat, Sofia Trocchianesi, Tanja Milena Autilio, Antonella Verrienti, Giuseppina Catanzaro, Elena Splendiani, Zaira Spinello, Silvia Cantara, Patrizia Zavattari, Eleonora Loi, Cristina Romei, Raffaele Ciampi, Luciano Pezzullo, Maria Grazia Castagna, Antonio Angeloni…
    Citation: Biomarker Research 2023 11:82
  4. Colorectal cancer is a major cause of cancer-related deaths worldwide. A third of colorectal cancers reside in the rectum. Many patients with rectal cancer present in the locally-advanced stage which needs mul...

    Authors: Parmida Sadat Pezeshki and Reza Ghalehtaki
    Citation: Biomarker Research 2023 11:81
  5. Small cell lung cancer (SCLC) has an exceptionally poor prognosis; as most of the cases are initially diagnosed as extensive disease with hematogenous metastasis. Therefore, the early diagnosis of SCLC is very...

    Authors: Dong Ha Kim, Hyojeong Park, Yun Jung Choi, Kyungtaek Im, Chae Won Lee, Da-Som Kim, Chan-Gi Pack, Hyun-Yi Kim, Chang-Min Choi, Jae Cheol Lee, Wonjun Ji and Jin Kyung Rho
    Citation: Biomarker Research 2023 11:80
  6. Growing evidence supports that extracellular vesicles (EVs) in blood plasma and other body fluids may function as biomarkers for disease. We previously found that secretory autophagosomes (SAPs), a kind of EV,...

    Authors: Xue-cheng Dong, Xin-yi Xu, Yue-ru Huang, Xing-xing Zhu, Yi Yang, Wei Huang and Ling Liu
    Citation: Biomarker Research 2023 11:79
  7. S100A6 (also called calcyclin) is a Ca2+-binding protein that belongs to the S100 protein family. S100A6 has many functions related to the cytoskeleton, cell stress, proliferation, and differentiation. S100A6 als...

    Authors: Yidian Wang, Xuewen Kang, Xin Kang and Fengguang Yang
    Citation: Biomarker Research 2023 11:78
  8. Extracellular vesicles (EVs) have garnered significant interest in the field of biomedical science due to their potential applications in therapy and diagnosis. These vesicles participate in cell-to-cell commu...

    Authors: Islam M. Saadeldin, Seif Ehab and Jongki Cho
    Citation: Biomarker Research 2023 11:77
  9. RNA-binding proteins have increasingly been identified as important regulators of gene expression given their ability to bind distinct RNA sequences and regulate their fate. Mounting evidence suggests that RNA...

    Authors: Mark Sicking, Isabel Falke, Maria T. Löblein, Hans Th. Eich, Martin Götte, Burkhard Greve and Fabian M. Troschel
    Citation: Biomarker Research 2023 11:76
  10. Sarcomas are a group of diverse and complex cancers of mesenchymal origin that remains poorly understood. Recent developments in cancer immunotherapy have demonstrated a potential for better outcomes with immu...

    Authors: Chin Sern Yiong, Tzu Ping Lin, Vivian Yujing Lim, Tan Boon Toh and Valerie Shiwen Yang
    Citation: Biomarker Research 2023 11:75
  11. Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a dismal prognosis, and despite significant advances in our understanding of its genetic drivers, like KRAS, TP53, CDKN2A, and SMAD4, effec...

    Authors: Jiatong Wang, Chi Hin Wong, Yinxin Zhu, Xiaoqiang Yao, Kelvin K C Ng, Chengzhi Zhou, Ka Fai To and Yangchao Chen
    Citation: Biomarker Research 2023 11:74
  12. A subset of triple-negative breast cancers (TNBCs) have homologous recombination deficiency with upregulation of compensatory DNA repair pathways. PIKTOR, a combination of TAK-228 (TORC1/2 inhibitor) and TAK-1...

    Authors: Jessica D. Lang, Tuong Vi V. Nguyen, Maren K. Levin, Page E. Blas, Heather L. Williams, Esther San Roman Rodriguez, Natalia Briones, Claudius Mueller, William Selleck, Sarah Moore, Victoria L. Zismann, William P.D. Hendricks, Virginia Espina and Joyce O’Shaughnessy
    Citation: Biomarker Research 2023 11:73
  13. For early screening and diagnosis of non-small cell lung cancer (NSCLC), a robust model based on plasma proteomics and metabolomics is required for accurate and accessible non-invasive detection. Here we aim t...

    Authors: Runhao Xu, Jiongran Wang, Qingqing Zhu, Chen Zou, Zehao Wei, Hao Wang, Zian Ding, Minjie Meng, Huimin Wei, Shijin Xia, Dongqing Wei, Li Deng and Shulin Zhang
    Citation: Biomarker Research 2023 11:71
  14. Biomarkers are detectable molecules that can reflect specific physiological states of cells, organs, and organisms and therefore be regarded as indicators for specific diseases. And the discovery of biomarkers...

    Authors: Yongshu Li, Winnie Wailing TAM, Yuanyuan Yu, Zhenjian Zhuo, Zhichao Xue, Chiman Tsang, Xiaoting Qiao, Xiaokang Wang, Weijing Wang, Yongyi Li, Yanyang Tu and Yunhua Gao
    Citation: Biomarker Research 2023 11:70
  15. . At present, the prognostic prediction in advanced oral cavity squamous cell carcinoma (OCSCC) is based on the tumor-node-metastasis (TNM) staging system, and the most used imaging modality in these patients ...

    Authors: Anna Corti, Loris De Cecco, Stefano Cavalieri, Deborah Lenoci, Federico Pistore, Giuseppina Calareso, Davide Mattavelli, Pim de Graaf, C. René Leemans, Ruud H. Brakenhoff, Marco Ravanelli, Tito Poli, Lisa Licitra, Valentina Corino and Luca Mainardi
    Citation: Biomarker Research 2023 11:69
  16. Comprehensive and integrative analysis of hepatocellular carcinoma (HCC) is important. In this study, we explored Taiwanese HCCs using multi-omics analyses.

    Authors: Ya-Sian Chang, Siang-Jyun Tu, Hong-Da Chen, Chin-Chun Chung, Ming-Hon Hsu, Yu-Pao Chou, Ya-Ting Lee, Ju-Chen Yen, Long-Bin Jeng and Jan-Gowth Chang
    Citation: Biomarker Research 2023 11:68
  17. Chimeric antigen receptor (CAR) T cells and natural killer (NK) cells are genetically engineered immune cells that can detect target antigens on the surface of target cells and eliminate them following adoptiv...

    Authors: Hamed Dabiri, Pooria Safarzadeh Kozani, Mahdi Habibi Anbouhi, Mohadeseh Mirzaee Godarzee, Mohammad Hossein Haddadi, Mohsen Basiri, Vahab Ziaei, Majid Sadeghizadeh and Ensiyeh Hajizadeh Saffar
    Citation: Biomarker Research 2023 11:67
  18. Cancer exerts a multitude of effects on metabolism, including the reprogramming of cellular metabolic pathways and alterations in metabolites that facilitate inappropriate proliferation of cancer cells and ada...

    Authors: Wenxiang Wang, Zhiwei Rong, Guangxi Wang, Yan Hou, Fan Yang and Mantang Qiu
    Citation: Biomarker Research 2023 11:66
  19. The most common kind of acute leukemia in adults is acute myeloid leukemia (AML), which is often treated with induction chemotherapy regimens followed by consolidation or allogeneic hematopoietic stem cell tra...

    Authors: Ruonan Shao, Zijian Li, Honglei Xin, Suyu Jiang, Yilin Zhu, Jingan Liu, Rong Huang, Kailin Xu and Xiaofeng Shi
    Citation: Biomarker Research 2023 11:65
  20. Late diagnosis is one of the major confounders in oral squamous cell carcinoma (OSCC). Despite recent advances in molecular diagnostics, no disease-specific biomarkers are clinically available for early risk p...

    Authors: Aditi Patel, Parina Patel, Dushyant Mandlik, Kaustubh Patel, Pooja Malaviya, Kaid Johar, Krishna B.S Swamy, Shanaya Patel and Vivek Tanavde
    Citation: Biomarker Research 2023 11:64
  21. The ATP-adenosine pathway has emerged as a promising target for cancer therapy, but challenges remain in achieving effective tumor control. Early research focused on blocking the adenosine generating enzyme CD...

    Authors: Yao Liu, Zhongliang Li, Xiaoguang Zhao, Jing Xiao, Jiacheng Bi, Xian-Yang Li, Guokai Chen and Ligong Lu
    Citation: Biomarker Research 2023 11:63
  22. N6-methyladenosine (m6A) is the most prevalent and well-characterized internal chemical modification in eukaryotic RNA, influencing gene expression and phenotypic changes by controlling RNA fate. Insulin-like gro...

    Authors: Tian-Yu Zhu, Lian-Lian Hong and Zhi-Qiang Ling
    Citation: Biomarker Research 2023 11:62

    The Correction to this article has been published in Biomarker Research 2023 11:72

  23. Tissue factor (TF) is a protein that plays a critical role in blood clotting, but recent research has also shown its involvement in cancer development and progression. Herein, we provide an overview of the str...

    Authors: Seyed Esmaeil Ahmadi, Ashkan Shabannezhad, Amir Kahrizi, Armin Akbar, Seyed Mehrab Safdari, Taraneh Hoseinnezhad, Mohammad Zahedi, Soroush Sadeghi, Mahsa Golizadeh Mojarrad and Majid Safa
    Citation: Biomarker Research 2023 11:60
  24. Aberrant expression of circRNAs has been proven to play a crucial role in the progression of acute myeloid leukemia (AML); however, its regulatory mechanism remains unclear. Herein, we identified a novel circR...

    Authors: Xinyu Yang, Fengjiao Han, Xiang Hu, Guosheng Li, Hanyang Wu, Can Can, Yihong Wei, Jinting Liu, Ruiqing Wang, Wenbo Jia, Chunyan ji and Daoxin Ma
    Citation: Biomarker Research 2023 11:59
  25. Chronic lymphocytic leukemia (CLL) is one of the most frequent occurring types of leukemia. It typically occurs in elderly patients and has a highly variable clinical course. At present, the molecular mechanis...

    Authors: Wenjie Zhang, Jinlan Long, Peixia Tang, Kaili Chen, Guangyao Guo, Zezhong Yu, Jie Lin, Liping Liu, Rong Zhan and Zhenshu Xu
    Citation: Biomarker Research 2023 11:58
  26. Immune checkpoint inhibitors (ICIs) have dramatically enhanced the treatment outcomes for diverse malignancies. Yet, only 15–60% of patients respond significantly. Therefore, accurate responder identification ...

    Authors: Ruixia Song, Fengsen Liu, Yu Ping, Yi Zhang and Liping Wang
    Citation: Biomarker Research 2023 11:57
  27. Inducible T cell costimulator ICOS is an emerging target in immuno-oncology. The aim of this study was to investigate the epigenetic regulation of ICOS in melanoma by DNA methylation.

    Authors: Damian J. Ralser, Emmanuelle Herr, Luka de Vos, Zsófi Kulcsár, Romina Zarbl, Niklas Klümper, Gerrit H. Gielen, Alexander Philippe Maas, Friederike Hoffmann, Jörn Dietrich, Pia Kuster, Alexander Mustea, Nicole Glodde, Glen Kristiansen, Sebastian Strieth, Jennifer Landsberg…
    Citation: Biomarker Research 2023 11:56
  28. Blood tests would be much easier to implement in the clinical diagnosis of Alzheimer’s disease (AD) as minimally invasive measurements. Multiple inspection technologies promoted AD-associated blood biomarkers’...

    Authors: Yan Wang, Ying Li, Yan Li, Tingting Li, Qi Wang, Qigeng Wang, Shuman Cao, Fangyu Li and Jianping Jia
    Citation: Biomarker Research 2023 11:53
  29. We analyzed single nucleotide polymorphisms (SNPs) in PKNOX1 (rs2839629) and in the intergenic region between PKNOX1 and CBS (rs915854) by Sanger sequencing in 88 patients with multiple myeloma treated with borte...

    Authors: Xiang Zhou, Seungbin Han, Nadine Cebulla, Larissa Haertle, Maximilian J. Steinhardt, Daniel Schirmer, Eva Runau, Leon Flamm, Calvin Terhorst, Laura Jähnel, Cornelia Vogt, Silvia Nerreter, Eva Teufel, Emilia Stanojkovska, Julia Mersi, Umair Munawar…
    Citation: Biomarker Research 2023 11:52
  30. Authors: Jie Wu, Chunlei Zheng, Yizhe Wang, Zichang Yang, Ce Li, Wanxia Fang, Yue Jin, Kezuo Hou, Yang Cheng, Jianfei Qi, Xiujuan Qu, Yunpeng Liu, Xiaofang Che and Xuejun Hu
    Citation: Biomarker Research 2023 11:51

    The original article was published in Biomarker Research 2021 9:9

  31. Chimeric antigen receptor (CAR) T cell therapy, in which a patient’s own T lymphocytes are engineered to recognize and kill cancer cells, has achieved striking success in some hematological malignancies in pre...

    Authors: Marzieh Mazinani and Fatemeh Rahbarizadeh
    Citation: Biomarker Research 2023 11:49
  32. Urinary bladder cancer (UBC) is a common malignancy of the urinary tract; however, the mechanism underlying its high recurrence and responses to immunotherapy remains unclear, making clinical outcome predictio...

    Authors: Zhen-Duo Shi, Xiao-Xiao Han, Zi-Jian Song, Yang Dong, Kun Pang, Xin-Lei Wang, Xin-Yu Liu, Hao Lu, Guang-Zhi Xu, Lin Hao, Bing-Zheng Dong, Qing Liang, Xiao-Ke Wu and Cong-Hui Han
    Citation: Biomarker Research 2023 11:47
  33. Advanced hepatic fibrosis is the main risk factor of liver-related morbidity and mortality in patients with chronic liver disease. In this study, we assessed the potential role of bone morphogenetic protein 8A...

    Authors: Patricia Marañón, Stephania C. Isaza, Carlos Ernesto Fernández-García, Esther Rey, Rocío Gallego-Durán, Rocío Montero-Vallejo, Javier Rodríguez de Cía, Javier Ampuero, Ángela M. Valverde, Manuel Romero-Gómez, Carmelo García-Monzón and Águeda González-Rodríguez
    Citation: Biomarker Research 2023 11:46
  34. Lung cancer remains the leading cause of cancer mortality worldwide. Early detection of lung cancer helps improve treatment and survival. Numerous aberrant DNA methylations have been reported in early-stage lu...

    Authors: Shuo Hu, Jinsheng Tao, Minhua Peng, Zhujia Ye, Zhiwei Chen, Haisheng Chen, Haifeng Yu, Bo Wang, Jian-Bing Fan and Bin Ni
    Citation: Biomarker Research 2023 11:45
  35. Definitive chemoradiotherapy (dCRT) is a standard treatment option for locally advanced stage inoperable esophageal squamous cell carcinoma (ESCC). Evaluating clinical outcome prior to dCRT remains challenging...

    Authors: Jinfeng Cui, Li Li, Ning Liu, Wenhong Hou, Yinjun Dong, Fengchang Yang, Shouhui Zhu, Jun Li and Shuanghu Yuan
    Citation: Biomarker Research 2023 11:44
  36. N6-methyladenosine (m6A) methylation is the most abundant chemical posttranscriptional modification of mRNA, and it is associated with the regulation of the immune response to tumors. However, the function of ...

    Authors: Lei Zhan, Jing Zhang, Jun-Hui Zhang, Xiao-Jing Liu, Bao Guo, Jia-Hua Chen, Zhen-Hai Tang, Wen-Yan Wang, Qing-Yuan Wang, Bing Wei and Yun-Xia Cao
    Citation: Biomarker Research 2023 11:43
  37. N6-methyladenosine (m6A) is considered as the most common and important internal transcript modification in several diseases like type 2 diabetes, schizophrenia and especially cancer. As a main target of m6A meth...

    Authors: Jinxin Tang, Jinhui Zhang, Yu Lu, Jieyu He, Hua Wang, Binfeng Liu, Chao Tu and Zhihong Li
    Citation: Biomarker Research 2023 11:42
  38. Neoantigens generated by non-synonymous mutations of tumor genes can induce activation of neoantigen-reactive T (NRT) cells which have the ability to resist the growth of tumors expressing specific neoantigens...

    Authors: Ruichen Huang, Bi Zhao, Shi Hu, Qian Zhang, Xiaoping Su and Wei Zhang
    Citation: Biomarker Research 2023 11:41
  39. Osteoarthritis (OA) is the most prevalent age-related disease in the world. Chondrocytes undergo an age-dependent decline in their proliferation and synthetic capacity, which is the main cause of OA developmen...

    Authors: Panyang Shen, Jun Gao, Shaohan Huang, Chenan You, Haitao Wang, Pengyu Chen, Teng Yao, Tianyou Gao, Bohao Zhou, Shuying Shen, Xing Zhao and Jianjun Ma
    Citation: Biomarker Research 2023 11:39
  40. Uveal melanoma (UM) is the most common intraocular malignancy in adults, with a poor survival prognosis. To date, limited understanding of UM’s molecular mechanisms constitutes an obstacle to developing effect...

    Authors: Jingting Luo, Haowen Li, Jingying Xiu, Jingyao Zeng, Zhaoxun Feng, Hanqing Zhao, Yang Li and Wenbin Wei
    Citation: Biomarker Research 2023 11:38
  41. Androgen receptor (AR) splice variants (AR-Vs) have been discussed as a biomarker in prostate cancer (PC). However, some reports question the predictive property of AR-Vs. From a mechanistic perspective, the c...

    Authors: Neele Wüstmann, Konstantin Seitzer, Verena Humberg, Julia Vieler, Norbert Grundmann, Julie Steinestel, Dorothee Tiedje, Stefan Duensing, Laura-Maria Krabbe, Martin Bögemann, Andres Jan Schrader, Christof Bernemann and Katrin Schlack
    Citation: Biomarker Research 2023 11:37
  42. Interleukin-25 (IL-25), also known as IL-17E, is a cytokine belonging to the IL-17 family. IL-25 is abundantly expressed by Th2 cells and various kinds of epithelial cells. IL-25 is an alarm signal generated u...

    Authors: Qingfang Yuan, Na Peng, Fan Xiao, Xiaofei Shi, Bo Zhu, Ke Rui, Jie Tian and Liwei Lu
    Citation: Biomarker Research 2023 11:36

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