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  1. Metastasis suggests a poor prognosis for cancer patients, and treatment strategies for metastatic cancer are still very limited. Numerous studies have shown that cancer-associated fibroblasts (CAFs), a large c...

    Authors: Zimu Wang, Jiaxin Liu, Hairong Huang, Mingxiang Ye, Xinying Li, Ranpu Wu, Hongbing Liu and Yong Song

    Citation: Biomarker Research 2021 9:47

    Content type: Review

    Published on:

  2. Myelodysplastic syndrome (MDS) is an aggressive and genetically heterogeneous disease with poor prognosis. Cellular immune disorder is a common characteristic of this disease and is thought to be related to cl...

    Authors: Xin Huang, Cunte Chen, Mengjun Zhong, Suxia Geng, Yujie Zhao, Minming Li, Chenxin Deng, Lingji Zeng, Ping Wu, Zesheng Lu, Jianyu Weng, Xin Du and Yangqiu Li

    Citation: Biomarker Research 2021 9:46

    Content type: Letter to the Editor

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  3. Although some studies have demonstrated that lncRNAs are dysregulated in hematopoietic malignancies and may regulate the progression of leukemia, the detailed mechanism underlying tumorigenesis is still unclea...

    Authors: Xuanmei Huang, Libin Huang, Qing Xie, Ling Zhang, Shaohui Huang, Mingye Hong, Jiangbin Li, Zunnan Huang and Hua Zhang

    Citation: Biomarker Research 2021 9:45

    Content type: Research

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  4. The E-Cadherin gene (CDH1, Cadherin 1), located at 16q22.1 encodes for a calcium-dependent membranous glycoprotein with an important role in cellular adhesion and polarity maintenance.

    Authors: Eike Burandt, Felix Lübbersmeyer, Natalia Gorbokon, Franziska Büscheck, Andreas M. Luebke, Anne Menz, Martina Kluth, Claudia Hube-Magg, Andrea Hinsch, Doris Höflmayer, Sören Weidemann, Christoph Fraune, Katharina Möller, Frank Jacobsen, Patrick Lebok, Till Sebastian Clauditz…

    Citation: Biomarker Research 2021 9:44

    Content type: Research

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  5. Oral squamous cell carcinoma (OSCC) is a capricious cancer with poor survival rates, even for early-stage patients. There is a pressing need to develop more precise risk assessment methods to appropriately tai...

    Authors: Chi T. Viet, Gary Yu, Kesava Asam, Carissa M. Thomas, Angela J. Yoon, Yan Chen Wongworawat, Mina Haghighiabyaneh, Courtney A. Kilkuts, Caitlyn M. McGue, Marcus A. Couey, Nicholas F. Callahan, Coleen Doan, Paul C. Walker, Khanh Nguyen, Stephanie C. Kidd, Steve C. Lee…

    Citation: Biomarker Research 2021 9:42

    Content type: Research

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  6. It has been suggested that the heterogeneity of TAAs in lung cancer may affect the therapeutic response and disease progression. Up to now, several tumor-associated antigen (TAA)-based cancer vaccines have bee...

    Authors: Fang Lv, Xueying Wu, Jin Song, Pan Wang, Shucheng Ren, Wei Guo, Qi Xue, Henghui Zhang and Jun Zhao

    Citation: Biomarker Research 2021 9:41

    Content type: Letter to the Editor

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  7. N6-methyladenosine (m6A) modification is the most prevalent internal mRNA modification and is involved in many biological processes in eukaryotes. Accumulating evidence has demonstrated that m6A may play eithe...

    Authors: Fangchao Zheng, Feng Du, Jiuda Zhao, Xue Wang, Yiran Si, Peng Jin, Haili Qian, Binghe Xu and Peng Yuan

    Citation: Biomarker Research 2021 9:39

    Content type: Review

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  8. T cell-based immunotherapies have revolutionized treatment paradigms in various cancers, however, limited response rates secondary to lack of significant T-cell infiltration in the tumor site remain a major pr...

    Authors: Shujie Zhou, Mingguo Liu, Fei Ren, Xiangjiao Meng and Jinming Yu

    Citation: Biomarker Research 2021 9:38

    Content type: Review

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  9. Mechanisms driving the progression of chronic lymphocytic leukemia (CLL) from its early stages are not fully understood. The acquisition of molecular changes at the time of progression has been observed in a s...

    Authors: Isabel Jiménez, Bárbara Tazón-Vega, Pau Abrisqueta, Juan C. Nieto, Sabela Bobillo, Carles Palacio-García, Júlia Carabia, Rafael Valdés-Mas, Magdalena Munuera, Lluís Puigdefàbregas, Genís Parra, Anna Esteve-Codina, Clara Franco-Jarava, Gloria Iacoboni, María José Terol, José Antonio García-Marco…

    Citation: Biomarker Research 2021 9:37

    Content type: Research

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  10. Acute myeloid leukemia (AML) remains an incurable malignancy despite recent advances in treatment. Recently a number of new therapies have emerged for the treatment of AML which target BCL-2 or the membrane re...

    Authors: Jayna J Mistry, Charlotte Hellmich, Amelia Lambert, Jamie A Moore, Aisha Jibril, Angela Collins, Kristian M Bowles and Stuart A Rushworth

    Citation: Biomarker Research 2021 9:35

    Content type: Letter to the Editor

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  11. The myristoylated alanine-rich C-kinase substrate (MARCKS) protein has been at the crossroads of multiple signaling pathways that govern several critical operations in normal and malignant cellular physiology....

    Authors: Deepak Narayanan Iyer, Omar Faruq, Lun Zhang, Nasrin Rastgoo, Aijun Liu and Hong Chang

    Citation: Biomarker Research 2021 9:34

    Content type: Review

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  12. Reversion of tumor to a normal differentiated cell once considered a dream is now at the brink of becoming a reality. Different layers of molecules/events such as microRNAs, transcription factors, alternative ...

    Authors: Avantika Tripathi, Anjali Kashyap, Greesham Tripathi, Joni Yadav, Rakhi Bibban, Nikita Aggarwal, Kulbhushan Thakur, Arun Chhokar, Mohit Jadli, Ashok Kumar Sah, Yeshvandra Verma, Hatem Zayed, Amjad Husain, Alok Chandra Bharti and Manoj Kumar Kashyap

    Citation: Biomarker Research 2021 9:31

    Content type: Review

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  13. Venetoclax (VEN) plus azacitidine has become the first-line therapy for elderly patients with acute myeloid leukemia (AML), and has a complete remission (CR) plus CR with incomplete recovery of hemogram rate o...

    Authors: Xiang Zhang, Jiejing Qian, Huafeng Wang, Yungui Wang, Yi Zhang, Pengxu Qian, Yinjun Lou, Jie Jin and Honghu Zhu

    Citation: Biomarker Research 2021 9:30

    Content type: Letter to the Editor

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  14. Hospitalized patients with COVID-19 demonstrate a higher risk of developing thromboembolism. Anticoagulation (AC) has been proposed for high-risk patients, even without confirmed thromboembolism. However, bene...

    Authors: Bo Yu, Victor Perez Gutierrez, Alex Carlos, Gregory Hoge, Anjana Pillai, J. Daniel Kelly and Vidya Menon

    Citation: Biomarker Research 2021 9:29

    Content type: Research

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  15. N6-methyladenosine(m6A) methylation modification affects the tumorigenesis, progression, and metastasis of breast cancer (BC). However, the expression characteristics and prognostic value of m6A modification i...

    Authors: Fangchao Zheng, Feng Du, Haili Qian, Jiuda Zhao, Xue Wang, Jian Yue, Nanlin Hu, Yiran Si, Binghe Xu and Peng Yuan

    Citation: Biomarker Research 2021 9:28

    Content type: Research

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  16. N6-methyladenosine (m6A) is a prevalent internal RNA modification in higher eukaryotic cells. As the pivotal m6A regulator, RNA methyltransferase-like 3 (METTL3) is responsible for methyl group transfer in the pr...

    Authors: Yiqing Cai, Rui Feng, Tiange Lu, Xiaomin Chen, Xiangxiang Zhou and Xin Wang

    Citation: Biomarker Research 2021 9:27

    Content type: Review

    Published on:

  17. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Jie Wu, Chunlei Zheng, Yizhe Wang, Zichang Yang, Ce Li, Wanxia Fang, Yue Jin, Kezuo Hou, Yang Cheng, Jianfei Qi, Xiujuan Qu, Yunpeng Liu, Xiaofang Che and Xuejun Hu

    Citation: Biomarker Research 2021 9:25

    Content type: Correction

    Published on:

    The original article was published in Biomarker Research 2021 9:9

  18. Dalpiciclib (SHR6390) is a novel inhibitor of cyclin-dependent kinase 4/6 which demonstrated promising anti-tumor potency in preclinical models. This first-in-human study was conducted to evaluate the tolerabi...

    Authors: Pin Zhang, Binghe Xu, Lin Gui, Wenna Wang, Meng Xiu, Xiao Zhang, Guilan Sun, Xiaoyu Zhu and Jianjun Zou

    Citation: Biomarker Research 2021 9:24

    Content type: Research

    Published on:

  19. To evaluate the predictive value of AR-V7 expression detected by immunohistochemical (IHC) in the prognosis of prostate cancer patients receiving adjuvant hormonal therapy (AHT) following radical prostatectomy...

    Authors: Wei Ouyang, Yucong Zhang, Gongwei Long, Guoliang Sun, Man Liu, Fan Li, Chunguang Yang, Xing Zeng, Jun Yang, Xiao Yu, Zhihua Wang, Zheng Liu, Wei Guan, Zhiquan Hu, Shaogang Wang, Xiaming Liu…

    Citation: Biomarker Research 2021 9:23

    Content type: Research

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  20. The phase I trial of the humanized anti-CD26 monoclonal antibody YS110 for CD26-expressing tumors was conducted recently. The present study identifies a potential prognostic biomarker for CD26-targeted therapy...

    Authors: Yutaro Kaneko, Ryo Hatano, Naoto Hirota, Nicolas Isambert, Véronique Trillet-Lenoir, Benoit You, Jérôme Alexandre, Gérard Zalcman, Fanny Valleix, Thomas Podoll, Yoshimi Umezawa, Seiichi Takao, Satoshi Iwata, Osamu Hosono, Tetsuo Taguchi, Taketo Yamada…

    Citation: Biomarker Research 2021 9:21

    Content type: Research

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  21. We evaluated organ-specific response rates (OSRRs) to first-line lenvatinib plus anti-PD-1 antibodies in patients with advanced hepatocellular carcinoma (HCC).

    Authors: Cheng Huang, Xiao-Dong Zhu, Ying-Hao Shen, Dong Wu, Yuan Ji, Ning-Ling Ge, Ling-Li Chen, Chang-Jun Tan, Jian Zhou, Jia Fan and Hui-Chuan Sun

    Citation: Biomarker Research 2021 9:19

    Content type: Research

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  22. miRNA-21 is among the most abundant and highly conserved microRNAs (miRNAs) recognized. It is expressed in essentially all cells where it performs vital regulatory roles in health and disease. It is also frequ...

    Authors: Ana E. Jenike and Marc K. Halushka

    Citation: Biomarker Research 2021 9:18

    Content type: Review

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  23. T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive subtype of leukemia with poor prognosis, and biomarkers and novel therapeutic targets are urgently needed for this disease. Our previous studies hav...

    Authors: Kehan Li, Cunte Chen, Rili Gao, Xibao Yu, Youxue Huang, Zheng Chen, Zhuandi Liu, Shaohua Chen, Gengxin Luo, Xin Huang, Grzegorz K. Przybylski, Yangqiu Li and Chengwu Zeng

    Citation: Biomarker Research 2021 9:17

    Content type: Letter to the Editor

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  24. Chromodomain helicase/ATPase DNA binding protein 1-like gene (CHD1L) is a multifunctional protein participated in diverse cellular processes, including chromosome remodeling, cell differentiation and developme...

    Authors: Xifeng Xiong, Xudong Lai, Aiguo Li, Zhihe Liu and Ningfang Ma

    Citation: Biomarker Research 2021 9:16

    Content type: Review

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  25. Knowledge of immune cell phenotypes, function, and developmental trajectory in acute myeloid leukemia (AML) microenvironment is essential for understanding mechanisms of evading immune surveillance and immunot...

    Authors: Rongqun Guo, Mengdie Lü, Fujiao Cao, Guanghua Wu, Fengcai Gao, Haili Pang, Yadan Li, Yinyin Zhang, Haizhou Xing, Chunyan Liang, Tianxin Lyu, Chunyan Du, Yingmei Li, Rong Guo, Xinsheng Xie, Wei Li…

    Citation: Biomarker Research 2021 9:15

    Content type: Research

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  26. A subset of men with metastatic prostate cancer (mPC) responds to immune checkpoint inhibitors, and there is an unmet need to predict those most likely to benefit. We characterized circulating tumor cells (CTC...

    Authors: Tian Zhang, Anika Agarwal, R. Garland Almquist, Daniella Runyambo, Sally Park, Elizabeth Bronson, Rengasamy Boominathan, Chandra Rao, Monika Anand, Taofik Oyekunle, Patrick Healy, Megan A. McNamara, Kathryn Ware, Jason A. Somarelli, Daniel J. George and Andrew J. Armstrong

    Citation: Biomarker Research 2021 9:14

    Content type: Rapid communication

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  27. We used the eXtreme Gradient Boosting algorithm, an optimized gradient boosting machine learning library, and established a model to predict events in Philadelphia chromosome-positive acute lymphoblastic leuke...

    Authors: Satoshi Nishiwaki, Isamu Sugiura, Daisuke Koyama, Yukiyasu Ozawa, Masahide Osaki, Yuichi Ishikawa and Hitoshi Kiyoi

    Citation: Biomarker Research 2021 9:13

    Content type: Letter to the Editor

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  28. Early diagnosis of esophageal squamous cell carcinoma (ESCC) remains a challenge due to the lack of specific blood biomarkers. We aimed to develop a serum multi-protein signature for the early detection of ESCC.

    Authors: Xiaorong Yang, Chen Suo, Tongchao Zhang, Xiaolin Yin, Jinyu Man, Ziyu Yuan, Jingru Yu, Li Jin, Xingdong Chen, Ming Lu and Weimin Ye

    Citation: Biomarker Research 2021 9:12

    Content type: Research

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  29. Malignant mesothelioma (MM) is a treatment-resistant tumor originating in the mesothelial lining of the pleura or the abdominal cavity with very limited treatment options. More effective therapeutic approaches...

    Authors: Laura Castelletti, Dannel Yeo, Nico van Zandwijk and John E. J. Rasko

    Citation: Biomarker Research 2021 9:11

    Content type: Review

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  30. Experimental evidence points to the role of Zinc fingers and homeoboxes protein 1 and 2 (ZHX1 and ZHX2) in the development and progression of several types of cancer, including hematological malignancies. Here...

    Authors: Natália Ioseph Gladistone Maciel, Luma Dayane Carvalho Filiú-Braga, Francisco Assis Rocha Neves, Eduardo Magalhaes Rego, Antonio Roberto Lucena-Araujo and Felipe Saldanha-Araujo

    Citation: Biomarker Research 2021 9:10

    Content type: Letter to the Editor

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  31. Epidermal growth factor receptor-tyrosinase kinase inhibitor (EGFR-TKI) resistance is the major obstacle in the treatment of lung adenocarcinoma (LUAD) patients harboring EGFR-sensitive mutations. However, the...

    Authors: Jie Wu, Chunlei Zheng, Yizhe Wang, Zichang Yang, Ce Li, Wanxia Fang, Yue Jin, Kezuo Hou, Yang Cheng, Jianfei Qi, Xiujuan Qu, Yunpeng Liu, Xiaofang Che and Xuejun Hu

    Citation: Biomarker Research 2021 9:9

    Content type: Research

    Published on:

    The Correction to this article has been published in Biomarker Research 2021 9:25

  32. Chronic myeloid leukemia (CML) and chronic neutrophilic leukemia (CNL) are two myeloproliferative neoplasms with mutually exclusive diagnostic criteria. A hallmark of CML is the Philadelphia chromosome (Ph), w...

    Authors: Sarah A. Carratt, Diana Brewer, Julia E. Maxson, Brian J. Druker and Theodore P. Braun

    Citation: Biomarker Research 2021 9:8

    Content type: Case report

    Published on:

  33. Tumor protein 63 (p63) is a transcription factor of the p53 gene family involved in differentiation of several tissues including squamous epithelium. p63 immunohistochemistry is broadly used for tumor classifi...

    Authors: Stefan Steurer, Claudia Riemann, Franziska Büscheck, Andreas M. Luebke, Martina Kluth, Claudia Hube-Magg, Andrea Hinsch, Doris Höflmayer, Sören Weidemann, Christoph Fraune, Katharina Möller, Anne Menz, Margit Fisch, Michael Rink, Christian Bernreuther, Patrick Lebok…

    Citation: Biomarker Research 2021 9:7

    Content type: Research

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  34. Infection and graft-versus-host disease (GvHD) are the major causes for mortality and morbidity of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Plasma-derived extracellular vesicles (EVs) co...

    Authors: Hooi Ching Lim, Shamit Soneji, Róbert Pálmason, Stig Lenhoff, Thomas Laurell and Stefan Scheding

    Citation: Biomarker Research 2021 9:6

    Content type: Research

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  35. Biomarkers that can objectively guide the diagnosis of sports-related concussion, and consequent return-to-play decisions, are urgently needed. In this study, we aimed to determine the temporal profile and dia...

    Authors: Stuart J. McDonald, William T. O’Brien, Georgia F. Symons, Zhibin Chen, Jesse Bain, Brendan P. Major, Daniel Costello, Glenn Yamakawa, Mujun Sun, Rhys D. Brady, Biswadev Mitra, Richelle Mychasiuk, Terence J. O’Brien and Sandy R. Shultz

    Citation: Biomarker Research 2021 9:4

    Content type: Research

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  36. Alzheimer’s disease (AD) is the most common cause of dementia and most of AD patients suffer from vascular abnormalities and neuroinflammation. There is an urgent need to develop novel blood biomarkers capable...

    Authors: Jung Eun Park, Do Sung Lim, Yeong Hee Cho, Kyu Yeong Choi, Jang Jae Lee, Byeong C. Kim, Kun Ho Lee and Jung Sup Lee

    Citation: Biomarker Research 2021 9:5

    Content type: Research

    Published on:

  37. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Antonio E. Pontiroli, Lara Loreggian, Marco P. L. Rovati, Elena De Patto, Laura Folini, Federico Raveglia, Matilde De Simone, Alessandro Baisi and Ugo Cioffi

    Citation: Biomarker Research 2021 9:3

    Content type: Correction

    Published on:

    The original article was published in Biomarker Research 2017 5:13

  38. Cancer-associated adipocytes (CAAs), as a main component of the tumor-adipose microenvironment (TAME), have various functions, including remodeling the extracellular matrix and interacting with tumor cells or ...

    Authors: Qi Wu, Bei Li, Juanjuan Li, Si Sun, Jingping Yuan and Shengrong Sun

    Citation: Biomarker Research 2021 9:2

    Content type: Review

    Published on:

  39. Macrophages are critical mediators of tissue homeostasis, with the function of tissue development and repair, but also in defense against pathogens. Tumor-associated macrophages (TAMs) are considered as the ma...

    Authors: Yang Liu, Ruyi Xu, Huiyao Gu, Enfan Zhang, Jianwei Qu, Wen Cao, Xi Huang, Haimeng Yan, Jingsong He and Zhen Cai

    Citation: Biomarker Research 2021 9:1

    Content type: Review

    Published on:

  40. Myeloproliferative neoplasms are characterized by mutations in JAK2, MPL and CALR genes. Commonly in diagnostics and previous studies mainly sequencing and common PCR techniques under conventional detection li...

    Authors: Luise Grunwald, Christina Grosse-Thie, Sina Sender, Gudrun Knuebel, Saskia Krohn, Catrin Roolf, Christian Junghanss, Larissa Henze and Hugo Murua Escobar

    Citation: Biomarker Research 2020 8:73

    Content type: Letter to the Editor

    Published on:

  41. Ibrutinib, an irreversible Bruton Tyrosine Kinase (BTK) inhibitor, has revolutionized Chronic Lymphocytic Leukemia (CLL) treatment, but resistances to ibrutinib have emerged, whether related or not to BTK muta...

    Authors: Sarah Cadot, Carine Valle, Marie Tosolini, Frederic Pont, Laetitia Largeaud, Camille Laurent, Jean Jacques Fournie, Loic Ysebaert and Anne Quillet-Mary

    Citation: Biomarker Research 2020 8:72

    Content type: Research

    Published on:

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