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  1. Content type: Short report

    Metronomic therapy has been gaining importance in the neoadjuvant setting of breast cancer treatment. Its clinical benefits may involve antiangiogenic machinery. Cancer cells induce angiogenesis to support tum...

    Authors: Roberto J. Arai, Vanessa Petry, Paulo M. Hoff and Max S. Mano

    Citation: Biomarker Research 2018 6:20

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  2. Content type: Research

    For glioblastoma (GBM) treatments to be effective in vivo, understanding the effects of the tumor microenvironment is imperative. In traditional cell culture conditions, glucose concentrations do not model phy...

    Authors: Kiera Walker, Nathaniel H. Boyd, Joshua C. Anderson, Christopher D. Willey and Anita B. Hjelmeland

    Citation: Biomarker Research 2018 6:22

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  3. Content type: Letter to the Editor

    Chemerin is a recently discovered adipokine shown to be involved in both inflammatory and metabolic processes. Here, we demonstrate that chemerin serum levels are elevated in patients with multiple myeloma and...

    Authors: Marita Westhrin, Siv Helen Moen, Ida Bruun Kristensen, Glenn Buene, Anne Kærsgaard Mylin, Ingemar Turesson, Niels Abildgaard, Anders Waage and Therese Standal

    Citation: Biomarker Research 2018 6:21

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  4. Content type: Research

    Colorectal cancer has significant impact on individuals and healthcare systems. Many genes have been identified to influence its pathogenesis. However, the genetic basis of mucinous tumor histology, an aggress...

    Authors: Michelle E. Penney, Patrick S. Parfrey, Sevtap Savas and Yildiz E. Yilmaz

    Citation: Biomarker Research 2018 6:17

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  5. Content type: Short report

    Calretinin is the most widespread positive marker for the immunohistochemical identification of malignant mesothelioma (MM) and was proposed to serve as a blood-based biomarker. Functionally, evidence has accu...

    Authors: Walter Blum, Thomas Henzi, Hugues-Etienne Châtel-Soulet, Laszlo Pecze, Janine Wörthmüller Rodriguez, Bart Vrugt and Beat Schwaller

    Citation: Biomarker Research 2018 6:19

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  6. Content type: Review

    Despite tremendous research efforts focused on diagnosis and treatment, pancreatic ductal adenocarcinoma remains the third leading cause of cancer-related death in the United States, with a 5-year overall surv...

    Authors: Shixiang Guo, Andrew Fesler, Huaizhi Wang and Jingfang Ju

    Citation: Biomarker Research 2018 6:18

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  7. Content type: Case report

    Germline mutations in the RUNX1 transcription factor give rise to a rare autosomal dominant genetic condition classified under the entity: Familial Platelet Disorders with predisposition to Acute Myeloid Leukaemi...

    Authors: Isaac KS Ng, Joanne Lee, Christopher Ng, Bustamin Kosmo, Lily Chiu, Elaine Seah, Michelle Meng Huang Mok, Karen Tan, Motomi Osato, Wee-Joo Chng, Benedict Yan and Lip Kun Tan

    Citation: Biomarker Research 2018 6:16

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  8. Content type: Research

    Well-differentiated neuroendocrine tumors (NET) most frequently arise from the gastrointestinal tract (GI), pancreas, and lung. Patients often present as metastasis with an unknown primary, and the clinical ma...

    Authors: Michelle X. Yang, Ryan F. Coates, Abiy Ambaye, Valerie Cortright, Jeannette M. Mitchell, Alexa M. Buskey, Richard Zubarik, James G. Liu, Steven Ades and Maura M. Barry

    Citation: Biomarker Research 2018 6:15

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  9. Content type: Research

    Inhaled allergen challenges are often used to evaluate novel asthma treatments in early phase clinical trials. Current novel therapeutic targets in asthma include phosphoinositide 3-kinases (PI3K) delta and ga...

    Authors: Thomas Southworth, Sarah Mason, Alan Bell, Isabel Ramis, Marta Calbet, Anna Domenech, Neus Prats, Montserrat Miralpeix and Dave Singh

    Citation: Biomarker Research 2018 6:14

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  10. Content type: Case report

    GATA2 deficiency presents with a spectrum of phenotypes including increased susceptibility to viral and bacterial infections, multi-lineage cytopenias, aplastic anemia, leukemic transformation and lymphedema. ...

    Authors: Allen Sanyi, David L. Jaye, Cecilia B. Rosand, Amanda Box, Chandrakasan Shanmuganathan and Edmund K. Waller

    Citation: Biomarker Research 2018 6:13

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  11. Content type: Short report

    Biomarkers promise biomolecular explanations as well as reliable diagnostics, stratification, and treatment strategies that have the potential to help mitigate the effects of disorders. While no reliable bioma...

    Authors: Daniel P. Howsmon, James B. Adams, Uwe Kruger, Elizabeth Geis, Eva Gehn and Juergen Hahn

    Citation: Biomarker Research 2018 6:12

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  12. Content type: Research

    Yin Yang 1 (YY1) is a transcription factor that plays an important role during all stages of B cell differentiation. Several studies reported upregulation of YY1 in B cell derived lymphoma, indicating that it ...

    Authors: Jéssica Arribas Arranz, Dalia Nilufar Winter, Hans Günter Drexler and Sonja Eberth

    Citation: Biomarker Research 2018 6:11

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  13. Content type: Review

    Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase and a catalytic component of PRC2, catalyzes tri-methylation of histone H3 at Lys 27 (H3K27me3) to regulate gene expression through epigenetic ma...

    Authors: Lu Gan, Yanan Yang, Qian Li, Yi Feng, Tianshu Liu and Weijian Guo

    Citation: Biomarker Research 2018 6:10

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  14. Content type: Correction

    The original article [1] contains an error in Fig. 3 whereby the trend lines denoting Low & High E-cadherin were mistakenly labelled the opposite way around.

    Authors: W. Goto, S. Kashiwagi, Y. Asano, K. Takada, K. Takahashi, T. Hatano, T. Takashima, S. Tomita, H. Motomura, M. Ohsawa, K. Hirakawa and M. Ohira

    Citation: Biomarker Research 2018 6:9

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    The original article was published in Biomarker Research 2017 5:19

  15. Content type: Research

    Sphingosine kinase (SphK) 2 has been implicated in the development of a range of cancers and inhibitors of this enzyme are currently in clinical trial. We have previously demonstrated a role for SphK2 in the d...

    Authors: Vicki Xie, Daochen Tong, Craig T. Wallington-Beddoe, Ken F. Bradstock and Linda J. Bendall

    Citation: Biomarker Research 2018 6:6

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  16. Content type: Research

    Alzheimer’s disease (AD) is a most common dementia in elderly people. Since AD symptoms resemble those of other neurodegenerative diseases, including idiopathic normal pressure hydrocephalus (iNPH), it is diff...

    Authors: Yuki Nagata, Akiyoshi Hirayama, Satsuki Ikeda, Aoi Shirahata, Futaba Shoji, Midori Maruyama, Mitsunori Kayano, Masahiko Bundo, Kotaro Hattori, Sumiko Yoshida, Yu-ichi Goto, Katsuya Urakami, Tomoyoshi Soga, Kouichi Ozaki and Shumpei Niida

    Citation: Biomarker Research 2018 6:5

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  17. Content type: Research

    Acute kidney injury (AKI) is a frequent complication of cardiac surgery. We sought prognostic combinations of postoperative biomarkers measured within 6 h of surgery, potentially in combination with cardiopulm...

    Authors: Allison Meisner, Kathleen F. Kerr, Heather Thiessen-Philbrook, Francis Perry Wilson, Amit X. Garg, Michael G. Shlipak, Peter Kavsak, Richard P. Whitlock, Steven G. Coca and Chirag R. Parikh

    Citation: Biomarker Research 2018 6:3

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  18. Content type: Research

    Platelets support cancer growth and spread making platelet proteins candidates in the search for biomarkers.

    Authors: Marta Lomnytska, Rui Pinto, Susanne Becker, Ulla Engström, Sonja Gustafsson, Christina Björklund, Markus Templin, Jan Bergstrand, Lei Xu, Jerker Widengren, Elisabeth Epstein, Bo Franzén and Gert Auer

    Citation: Biomarker Research 2018 6:2

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  19. Content type: Research

    Diagnosis of malaria in pregnancy is problematic due to the low sensitivity of conventional diagnostic tests (rapid diagnostic test and microscopy), which is exacerbated due to low peripheral parasite densitie...

    Authors: E. Ruizendaal, H. D. F. H. Schallig, J. Bradley, M. Traore-Coulibaly, P. Lompo, U. d’Alessandro, S. Scott, F. Njie, S. H. Zango, O. Sawadogo, M. D. de Jong, H. Tinto and P. F. Mens

    Citation: Biomarker Research 2017 5:34

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  20. Content type: Research

    Selective kinase and immune checkpoint inhibitors, and their combinations, have significantly improved the survival of patients with advanced metastatic melanoma. Not all patients will respond to treatment how...

    Authors: Su Yin Lim, Jenny H. Lee, Sarah J. Welsh, Seong Beom Ahn, Edmond Breen, Alamgir Khan, Matteo S. Carlino, Alexander M. Menzies, Richard F. Kefford, Richard A. Scolyer, Georgina V. Long and Helen Rizos

    Citation: Biomarker Research 2017 5:32

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