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  1. Voltage-gated sodium channels (VGSCs) initiate action potentials in electrically excitable cells and tissues. Surprisingly, some VGSC genes are aberrantly expressed in a variety of cancers, derived from “non-e...

    Authors: Hengrui Liu, Jieling Weng, Christopher L.-H. Huang and Antony P. Jackson
    Citation: Biomarker Research 2024 12:70
    Content type: Review Published on:

  3. Insulin-like growth factor (IGF)-1 and its binding proteins are important in cancer growth, especially in prostate cancer. Observational studies suggest that protein restriction can lower IGF-1 levels. However...

    Authors: Maria L. Cagigas, Giovanni Fiorito, Beatrice Bertozzi, Andrius Masedunskas, Edda Cava, Francesco Spelta, Nicola Veronese, Valeria Tosti, Gayathiri Rajakumar, Tiana Pelaia, Arnold D. Bullock, Robert S. Figenshau, Gerald L. Andriole and Luigi Fontana
    Citation: Biomarker Research 2024 12:68
    Content type: Correspondence Published on:

  4. Uveal melanoma is the most common non-cutaneous melanoma and is an intraocular malignancy affecting nearly 7,000 individuals per year worldwide. Of these, approximately 50% will progress to metastatic disease ...

    Authors: Ashley N. Anderson, Patrick Conley, Christopher D. Klocke, Sidharth K. Sengupta, Amara Pang, Hannah C. Farley, Abigail R. Gillingham, Aubrey D. Dawson, Yichen Fan, Jocelyn A. Jones, Summer L. Gibbs, Alison H. Skalet, Guanming Wu and Melissa H. Wong
    Citation: Biomarker Research 2024 12:67
    Content type: Research Published on:

  5. Non-Hodgkin lymphomas (NHLs) are heterogeneous and are among the most common hematological malignancies worldwide. Despite the advances in the treatment of patients with NHLs, relapse or resistance to treatmen...

    Authors: Mehdi Bakhtiyaridovvombaygi, Somayeh Yazdanparast, Setare Kheyrandish, Seyed Mehrab Safdari, Fateme Amiri Samani, Mahsa Sohani, Akram Sadat Jaafarian, Fateme Damirchiloo, Amirhossein Izadpanah, Sahar Parkhideh, Fatemeh Mikanik, Elham Roshandel, Abbas Hajifathali and Ahmad Gharehbaghian
    Citation: Biomarker Research 2024 12:66
    Content type: Review Published on:

  6. Megakaryocytic differentiation is a complicated process regulated by a series of transcription factors in a context- and stage-dependent manner. Recent studies have suggested that krüppel-like transcription fa...

    Authors: Zhen Wang, Zhongwen Liu, Pan Zhou, Xiaona Niu, Zhengdao Sun, Huan He and Zunmin Zhu
    Citation: Biomarker Research 2024 12:65
    Content type: Research Published on:

  8. Ischemic stroke (IS), a devastating cerebrovascular accident, presents with high mortality and morbidity. Following IS onset, a cascade of pathological changes, including excitotoxicity, inflammatory damage, a...

    Authors: Liangzhe Wei, Siqi Chen, Xinpeng Deng, Yuchun Liu, Haifeng Wang, Xiang Gao and Yi Huang
    Citation: Biomarker Research 2024 12:63
    Content type: Review Published on:

  9. Inhibitors of Bruton’s tyrosine kinase (BTKi) and chimeric antigen receptor T-cell (CAR-T) therapy targeting CD19 are paradigm-shifting advances in treating patients with aggressive mantle cell lymphoma (MCL)....

    Authors: Vivian Jiang, William Lee, Tianci Zhang, Alexa Jordan, Fangfang Yan, Qingsong Cai, Joseph McIntosh, Jovanny Vargas, Yang Liu and Michael Wang
    Citation: Biomarker Research 2024 12:62
    Content type: Correspondence Published on:

  10. Individuals with acute / early HIV-1 infection are often unaware that they are infected with HIV-1 and may be involved in high-risk behavior leading to transmission of HIV-1. Identifying individuals with acute...

    Authors: Santanu Biswas, Namrata Nagarajan, Indira Hewlett and Krishnakumar Devadas
    Citation: Biomarker Research 2024 12:61
    Content type: Research Published on:

  11. Acute myeloid leukemia (AML) is the most frequent leukemia in adults with a high mortality rate. Current diagnostic criteria and selections of therapeutic strategies are generally based on gene mutations and c...

    Authors: Zhiyu Zhang, Jiayi Huang, Zhibo Zhang, Hongjie Shen, Xiaowen Tang, Depei Wu, Xiebing Bao, Guoqiang Xu and Suning Chen
    Citation: Biomarker Research 2024 12:60
    Content type: Review Published on:

  12. Pyroptosis belongs to a unique type of programmed cell death among which GSDME is reported to exert anti-tumor immunity. However, the underlying mechanisms of how to boost tumor-infiltrating lymphocytes and wh...

    Authors: Bixian Luo, Shun Zhang, Xinbo Yu, Dan Tan, Ying Wang and Mingliang Wang
    Citation: Biomarker Research 2024 12:59
    Content type: Research Published on:

    The Correction to this article has been published in Biomarker Research 2024 12:64

  13. Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous malignancy characterized by varied responses to treatment and prognoses. Understanding the metabolic characteristics driving DLBCL progression is crucia...

    Authors: Liyuan Dai, Guangyu Fan, Tongji Xie, Lin Li, Le Tang, Haizhu Chen, Yuankai Shi and Xiaohong Han
    Citation: Biomarker Research 2024 12:58
    Content type: Research Published on:

  14. Cerebral cavernous malformations (CCMs) are vascular abnormalities associated with deregulated angiogenesis. Their pathogenesis and optimal treatment remain unclear. This study aims to investigate the molecula...

    Authors: Chengwei Chen, Yuting Bao, Sihan Ju, Conglin Jiang, Xiang Zou, Xin Zhang and Liang Chen
    Citation: Biomarker Research 2024 12:57
    Content type: Research Published on:

  15. Accumulating evidence suggests that the gut microbiota and metabolites can modulate tumor responses to immunotherapy; however, limited data has been reported on biliary tract cancer (BTC). This study used meta...

    Authors: Chengpei Zhu, Yunchao Wang, Ruijuan Zhu, Shanshan Wang, Jingnan Xue, Dongya Zhang, Zhou Lan, Chenchen Zhang, Yajun Liang, Nan Zhang, Ziyu Xun, Longhao Zhang, Cong Ning, Xu Yang, Jiashuo Chao, Junyu Long…
    Citation: Biomarker Research 2024 12:56
    Content type: Research Published on:

  16. Placenta accreta spectrum disorders (PAS) are a severe complication characterized by abnormal trophoblast invasion into the myometrium. The underlying mechanisms of PAS involve a complex interplay of various c...

    Authors: Kaiyuan Ji, Yunshan Chen, Xiuyu Pan, Lina Chen, Xiaodi Wang, Bolun Wen, Junjie Bao, Junmin Zhong, Zi Lv, Zheng Zheng and Huishu Liu
    Citation: Biomarker Research 2024 12:55
    Content type: Research Published on:

  17. Chimeric antigen receptor T cell (CAR-T) therapy has revolutionized the treatment approach for cancer, autoimmune disease, and heart disease. The integration of CAR into T cells is typically facilitated by ret...

    Authors: Ping Song, Qiqi Zhang, Zhiyong Xu, Yueli Shi, Ruirui Jing and Dingcun Luo
    Citation: Biomarker Research 2024 12:54
    Content type: Review Published on:

    The Correction to this article has been published in Biomarker Research 2024 12:69

  19. Protein tyrosine kinase 2 (PTK2), epidermal growth factor receptor (EGFR), and toll-like receptor (TLRs) are amplified in non-small cell lung cancer (NSCLC). However, the functional and clinical associations b...

    Authors: Ji Young Kim, Ji Hye Shin, Mi-Jeong Kim, Bongkum Choi, Yeeun Kang, Jimin Choi, Seo Hyun Kim, Dohee Kwan, Duk-Hwan Kim, Eunyoung Chun and Ki-Young Lee
    Citation: Biomarker Research 2024 12:52
    Content type: Correspondence Published on:

  20. Nowadays, immunotherapy is one of the most promising anti-tumor therapeutic strategy. Specifically, immune-related targets can be used to predict the efficacy and side effects of immunotherapy and monitor the ...

    Authors: Kai Yang, Rongrong Lu, Jie Mei, Kai Cao, Tianyu Zeng, Yijia Hua, Xiang Huang, Wei Li and Yongmei Yin
    Citation: Biomarker Research 2024 12:51
    Content type: Review Published on:

  21. Cell- and antibody-based CD19-directed therapies have demonstrated great potential for treating B-cell non-Hodgkin lymphoma (B-NHL). However, all these approaches suffer from limited response rates and conside...

    Authors: Dominik Sonanini, Johannes Schwenck, Simone Blaess, Julia Schmitt, Andreas Maurer, Walter Ehrlichmann, Malte Ritter, Julia Skokowa, Manfred Kneilling, Gundram Jung, Falko Fend, Simon Krost, Christian M. Seitz, Peter Lang, Gerald Reischl, Rupert Handgretinger…
    Citation: Biomarker Research 2024 12:50
    Content type: Correspondence Published on:

  22. Long non-coding RNAs (lncRNAs) are closely implicated in biological processes and diseases with high inflammatory components. These molecules exhibit significant temporal and tissue specificity. However, the e...

    Authors: Lorena Pérez-Carrillo, Isaac Giménez-Escamilla, Irene González-Torrent, Marta Delgado-Arija, Ignacio Sánchez-Lázaro, María García-Manzanares, Luis Martínez-Dolz, Manuel Portolés, Estefanía Tarazón and Esther Roselló-Lletí
    Citation: Biomarker Research 2024 12:49
    Content type: Correspondence Published on:

  23. Tumors exhibit metabolic heterogeneity, influencing cancer progression. However, understanding metabolic diversity in retinoblastoma (RB), the primary intraocular malignancy in children, remains limited.

    Authors: Junjie Tang, Yaoming Liu, Yinghao Wang, Zhihui Zhang, Jiahe Nie, Xinyue Wang, Siming Ai, Jinmiao Li, Yang Gao, Cheng Li, Chao Cheng, Shicai Su, Shuxia Chen, Ping Zhang and Rong Lu
    Citation: Biomarker Research 2024 12:48
    Content type: Research Published on:

  24. Despite advancements in chronic myeloid leukemia (CML) therapy with tyrosine kinase inhibitors (TKIs), resistance and intolerance remain significant challenges. Leukemia stem cells (LSCs) and TKI-resistant cel...

    Authors: Barbora Orlikova-Boyer, Anne Lorant, Sruthi Reddy Gajulapalli, Claudia Cerella, Michael Schnekenburger, Jin-Young Lee, Ji Yeon Paik, Yejin Lee, David Siegel, David Ross, Byung Woo Han, Thi Kim Yen Nguyen, Christo Christov, Hyoung Jin Kang, Mario Dicato and Marc Diederich
    Citation: Biomarker Research 2024 12:47
    Content type: Research Published on:

  25. The human leukocyte antigen (HLA) genes, exhibiting significant genetic diversity, are associated with susceptibility to various clinical diseases and diverse in drug responses. High costs of HLA sequencing an...

    Authors: Wan-Hsuan Chou, Lu-Chun Chen, Henry Sung-Ching Wong, Ching-Hsuan Chao, Hou-Wei Chu and Wei-Chiao Chang
    Citation: Biomarker Research 2024 12:46
    Content type: Research Published on:

  26. Cell death is an important part of the life cycle, serving as a foundation for both the orderly development and the maintenance of physiological equilibrium within organisms. This process is fundamental, as it...

    Authors: Jinyu Chen, Boyuan Ma, Yubiao Yang, Bitao Wang, Jian Hao and Xianhu Zhou
    Citation: Biomarker Research 2024 12:45
    Content type: Review Published on:

  27. Metabolic dysfunction-associated steatotic liver disease (MASLD) is estimated to affect 30% of the world’s population, and its prevalence is increasing in line with obesity. Liver fibrosis is closely related t...

    Authors: David Pérez Compte, Lucas Etourneau, Anne-Marie Hesse, Alexandra Kraut, Justine Barthelon, Nathalie Sturm, Hélène Borges, Salomé Biennier, Marie Courçon, Marc de Saint Loup, Victoria Mignot, Charlotte Costentin, Thomas Burger, Yohann Couté, Christophe Bruley, Thomas Decaens…
    Citation: Biomarker Research 2024 12:44
    Content type: Research Published on:

  28. Activation of CD28 on multiple myeloma (MM) plasma cells, by binding to CD80 and CD86 on dendritic cells, decreases proteasome subunit expression in the tumor cells and thereby helps them evade being killed by...

    Authors: Patrizia Leone, Eleonora Malerba, Marcella Prete, Antonio Giovanni Solimando, Giorgio Alberto Croci, Paolo Ditonno, Marco Tucci, Nicola Susca, Afshin Derakhshani, Antoine Dufour, Valli De Re, Nicola Silvestris and Vito Racanelli
    Citation: Biomarker Research 2024 12:43
    Content type: Research Published on:

  29. Autologous hematopoietic stem cell transplantation (AHSCT) remains the most prevalent type of stem cell transplantation. In our study, we investigated the changes in circulating miRNAs in AHSCT recipients and ...

    Authors: Damian Mikulski, Mateusz Nowicki, Izabela Dróżdż, Ewelina Perdas, Piotr Strzałka, Kacper Kościelny, Małgorzata Misiewicz, Konrad Stawiski, Agnieszka Wierzbowska and Wojciech Fendler
    Citation: Biomarker Research 2024 12:42
    Content type: Correspondence Published on:

  30. Regulatory T cells (Tregs) are essential to the negative regulation of the immune system, as they avoid excessive inflammation and mediate tumor development. The abundance of Tregs in tumor tissues suggests th...

    Authors: Yukai Shan, Tianao Xie, Yuchao Sun, Ziyi Lu, Win Topatana, Sarun Juengpanich, Tianen Chen, Yina Han, Jiasheng Cao, Jiahao Hu, Shijie Li, Xiujun Cai and Mingyu Chen
    Citation: Biomarker Research 2024 12:41
    Content type: Review Published on:

  31. IL-15 plays a vital role in enhancing NK cell- and T-cell-mediated antitumor immune responses; however, the direct effect of IL-15 on tumor cells has not been fully elucidated. Herein, we investigated the effe...

    Authors: Shaojie Hu, Kelin Meng, Tianlai Wang, Rirong Qu, Boyu Wang, Yu Xi, Taiyan Yu, Zhiwei Yuan, Zihao Cai, Yitao Tian, Chenxi Zeng, Xue Wang, Wenbin Zou, Xiangning Fu and Lequn Li
    Citation: Biomarker Research 2024 12:40
    Content type: Research Published on:

  32. Liquid-liquid phase separation (LLPS) is a complex and subtle phenomenon whose formation and regulation take essential roles in cancer initiation, growth, progression, invasion, and metastasis. This domain hol...

    Authors: Song-Bin Guo, Xue-Zhao Feng, Wei-Juan Huang, Zhen-Zhong Zhou and Xiao-Peng Tian
    Citation: Biomarker Research 2024 12:39
    Content type: Correspondence Published on:

  33. Metallothionein-3 (hMT3) is a structurally unique member of the metallothioneins family of low-mass cysteine-rich proteins. hMT3 has poorly characterized functions, and its importance for hepatocellular carcin...

    Authors: Miguel Angel Merlos Rodrigo, Hana Michalkova, Ana Maria Jimenez Jimenez, Frantisek Petrlak, Tomas Do, Ladislav Sivak, Yazan Haddad, Petra Kubickova, Vivian de los Rios, J. Ignacio Casal, Marina Serrano-Macia, Teresa C. Delgado, Loreto Boix, Jordi Bruix, Maria L. Martinez Chantar, Vojtech Adam…
    Citation: Biomarker Research 2024 12:38
    Content type: Research Published on:

  34. Authors: Federica Ganci, Matteo Allegretti, Carlotta Frascolla, Francesca Spinella, Francesca Rollo, Andrea Sacconi, Valentina De Pascale, Alina Catalina Palcau, Valentina Manciocco, Mariavittoria Vescovo, Ettore Cotroneo, Francesca Blandino, Maria Benevolo, Renato Covello, Paola Muti, Sabrina Strano…
    Citation: Biomarker Research 2024 12:37
    Content type: Correction Published on:

    The original article was published in Biomarker Research 2024 12:32

  36. Mesenchymal stromal/stem cells (MSCs) are used in many studies due to their therapeutic potential, including their differentiative ability and immunomodulatory properties. These cells perform their therapeutic...

    Authors: Ali Hazrati, Kosar Malekpour, Hossein Khorramdelazad, Samira Rajaei and Seyed Mahmoud Hashemi
    Citation: Biomarker Research 2024 12:35
    Content type: Review Published on:

  38. Helicobacter pylori (H pylori) infection is the primary cause of gastric cancer (GC). The role of Disabled-2 (DAB2) in GC remains largely unclear. This study aimed to investigate the role of DAB2 in H pylori-med...

    Authors: Yantao Duan, Pengfei Kong, Mingzhu Huang, Yonghao Yan, Yi Dou, Binhao Huang, Jing Guo, Wei Kang, Caixia Zhu, Yuyan Wang, Donglei Zhou, Qiliang Cai and Dazhi Xu
    Citation: Biomarker Research 2024 12:33
    Content type: Research Published on:

  39. Locoregional recurrences represent a frequently unexpected problem in head and neck squamous cell carcinoma (HNSCC). Relapse often (10–30%) occurs in patients with histologically negative resection margins (RM...

    Authors: Federica Ganci, Matteo Allegretti, Carlotta Frascolla, Francesca Spinella, Francesca Rollo, Andrea Sacconi, Pascale De Valentina, Alina Catalina Palcau, Valentina Manciocco, Mariavittoria Vescovo, Ettore Cotroneo, Francesca Blandino, Maria Benevolo, Renato Covello, Paola Muti, Sabrina Strano…
    Citation: Biomarker Research 2024 12:32
    Content type: Correspondence Published on:

    The Correction to this article has been published in Biomarker Research 2024 12:37

  40. Changes in serum metabolites in individuals with altered cardiac function and morphology may exhibit information about cardiovascular disease (CVD) pathway dysregulations and potential CVD risk factors. We aim...

    Authors: Juliane Maushagen, Nuha Shugaa Addin, Christopher Schuppert, Cavin K. Ward-Caviness, Johanna Nattenmüller, Jerzy Adamski, Annette Peters, Fabian Bamberg, Christopher L. Schlett, Rui Wang-Sattler and Susanne Rospleszcz
    Citation: Biomarker Research 2024 12:31
    Content type: Research Published on:

  42. Colorectal cancer (CRC) is a common malignancy worldwide. Angiogenesis and metastasis are the critical hallmarks of malignant tumor. Runt-related transcription factor 1 (RUNX1), an efficient transcription fact...

    Authors: Xuxue Guo, Haonan Zhang, Chengcheng He, Kaiwen Qin, Qiuhua Lai, Yuxin Fang, Qianhui Chen, Weize Li, Yiqing Wang, Xinke Wang, Aimin Li, Side Liu and Qingyuan Li
    Citation: Biomarker Research 2024 12:29
    Content type: Research Published on:

  45. Systemic therapies using programmed death-1 (PD-1) and programmed death ligand 1 (PD-L1) inhibitors have demonstrated commendable efficacy in some patients with advanced hepatocellular carcinoma (HCC); however...

    Authors: Nan Zhang, Xu Yang, Mingjian Piao, Ziyu Xun, Yunchao Wang, Cong Ning, Xinmu Zhang, Longhao Zhang, Yanyu Wang, Shanshan Wang, Jiashuo Chao, Zhenhui Lu, Xiaobo Yang, Hanping Wang and Haitao Zhao
    Citation: Biomarker Research 2024 12:26
    Content type: Review Published on:

  46. In recent decades, preterm birth (PTB) has become a significant research focus in the healthcare field, as it is a leading cause of neonatal mortality worldwide. Using five independent study cohorts including ...

    Authors: Oshma Chakoory, Vincent Barra, Emmanuelle Rochette, Loïc Blanchon, Vincent Sapin, Etienne Merlin, Maguelonne Pons, Denis Gallot, Sophie Comtet-Marre and Pierre Peyret
    Citation: Biomarker Research 2024 12:25
    Content type: Correspondence Published on:

  47. Lung cancer ranks among the most common cancers world-wide and is the first cancer-related cause of death. The classification of lung cancer has evolved tremendously over the past two decades. Today, non-small...

    Authors: Alex Friedlaender, Maurice Perol, Giuseppe Luigi Banna, Kaushal Parikh and Alfredo Addeo
    Citation: Biomarker Research 2024 12:24
    Content type: Review Published on:

  48. Immunoglobulin A nephropathy (IgAN) is an autoimmune disease characterized by abnormal IgA deposition in glomerulus. Current diagnosis of IgAN still depends on renal biopsy, an invasive method that might incre...

    Authors: Szu-Ying Ho, Chih-Chin Kao, Che-Mai Chang, Yi-Chien Chou, Wei-Tzu Luo, Wan-Hsuan Chou, I-Lin Tsai, Mai-Szu Wu and Wei-Chiao Chang
    Citation: Biomarker Research 2024 12:23
    Content type: Correspondence Published on:

  49. Hemodialysis patients are susceptible to cardiovascular remodeling, which increases the risk of cardiovascular morbidity and mortality. Circulating extracellular matrix (ECM)-associated molecules increase duri...

    Authors: Hyeon Seok Hwang, Jihyun Baek, So-Young Lee, Hye Yun Jeong, Jin Sug Kim, Yang Gyun Kim, ShinYoung Ahn, Kipyo Kim, Seok Hui Kang, Min-Jeong Lee, Dong-Young Lee and Yu Ho Lee
    Citation: Biomarker Research 2024 12:22
    Content type: Correspondence Published on:

  50. Transcription factor BTB domain and CNC homology 1 (BACH1) belongs to the Cap ‘n’ Collar and basic region Leucine Zipper (CNC-bZIP) family. BACH1 is widely expressed in mammalian tissues, where it regulates ep...

    Authors: Dian Hu, Zerui Zhang, Xiangyuan Luo, Siwen Li, Junqing Jiang, Jiaqian Zhang, Zhangfan Wu, Yijun Wang, Mengyu Sun, Xiaoping Chen, Bixiang Zhang, Xiao Xu, Shuai Wang, Shengjun Xu, Yufei Wang, Wenjie Huang…
    Citation: Biomarker Research 2024 12:21
    Content type: Review Published on:
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