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  1. The use of blood biomarkers after mild traumatic brain injury (mTBI) has been widely studied. We have identified eight unresolved issues related to the use of five commonly investigated blood biomarkers: neuro...

    Authors: Daniel B. Hier, Tayo Obafemi-Ajayi, Matthew S. Thimgan, Gayla R. Olbricht, Sima Azizi, Blaine Allen, Bassam A. Hadi and Donald C. Wunsch II

    Citation: Biomarker Research 2021 9:70

    Content type: Review

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  2. Lack of biomarkers and in vitro models has contributed to inadequate understanding of the mechanisms underlying the inferior clinical response to immune checkpoint inhibitors (ICIs) in patients with oncogene-d...

    Authors: Weijie Ma, Jie Zeng, Shuai Chen, Yue Lyu, Kyra A. Toomey, Chinh T. Phan, Ken Y. Yoneda and Tianhong Li

    Citation: Biomarker Research 2021 9:69

    Content type: Research

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  3. Wnt signaling was initially recognized to be vital for tissue development and homeostasis maintenance. Further studies revealed that this pathway is also important for tumorigenesis and progression. Abnormal e...

    Authors: Zhuo Wang, Tingting Zhao, Shihui Zhang, Junkai Wang, Yunyun Chen, Hongzhou Zhao, Yaxin Yang, Songlin Shi, Qiang Chen and Kuancan Liu

    Citation: Biomarker Research 2021 9:68

    Content type: Review

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  4. Extracellular vesicles are membrane vesicles that are released into the extracellular environment and accumulate in the circulation in vascular disease. We aimed to quantify circulating extracellular vesicles ...

    Authors: Akram Abolbaghaei, Marc-André Langlois, Helen R Murphy, Denice S. Feig and Dylan Burger

    Citation: Biomarker Research 2021 9:67

    Content type: Research

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  5. Deubiquitinases (DUBs) are enzymes that control the stability, interactions or localization of most cellular proteins by removing their ubiquitin modification. In recent years, some DUBs, such as USP7, USP9X a...

    Authors: Hu Lei, Jiaqi Wang, Jiacheng Hu, Qian Zhu and Yingli Wu

    Citation: Biomarker Research 2021 9:66

    Content type: Review

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  6. MicroRNAs may be important regulators of risk for type 2 diabetes. The purpose of this longitudinal observational study was to assess whether circulating microRNAs predicted improvements in fasting blood gluco...

    Authors: Elena Flowers, Isabel Elaine Allen, Alka M. Kanaya and Bradley E. Aouizerat

    Citation: Biomarker Research 2021 9:65

    Content type: Research

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  7. Cell therapy has evolved rapidly in the past several years with more than 250 clinical trials ongoing around the world. While more indications of cellular therapy with chimeric antigen receptor – engineered T ...

    Authors: Hongtao Liu, Chongxian Pan, Wenru Song, Delong Liu, Zihai Li and Lei Zheng

    Citation: Biomarker Research 2021 9:62

    Content type: Review

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  8. Neoantigens, a type of tumor-specific antigens derived from non-synonymous mutations, have recently been characterized as attractive targets for cancer immunotherapy. Owing to the development of next-generatio...

    Authors: Xuan Zhao, Xiaoxin Pan, Yi Wang and Yi Zhang

    Citation: Biomarker Research 2021 9:61

    Content type: Review

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  9. Tumor angiogenesis induces local hypoxia and recruits immunosuppressive cells, whereas hypoxia subsequently promotes tumor angiogenesis. Immunotherapy efficacy depends on the accumulation and activity of tumor...

    Authors: Wuzhen Chen, Lesang Shen, Jingxin Jiang, Leyi Zhang, Zhigang Zhang, Jun Pan, Chao Ni and Zhigang Chen

    Citation: Biomarker Research 2021 9:59

    Content type: Review

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  10. In Western countries, ovarian cancer (OC) still represents the leading cause of gynecological cancer-related deaths, despite the remarkable gains in therapeutical options. Novel biomarkers of early diagnosis, ...

    Authors: E. Krasniqi, A. Sacconi, D. Marinelli, L. Pizzuti, M. Mazzotta, D. Sergi, E. Capomolla, S. Donzelli, M. Carosi, A. Bagnato, T. Gamucci, S. Tomao, C. Natoli, P. Marchetti, A. Grassadonia, N. Tinari…

    Citation: Biomarker Research 2021 9:57

    Content type: Research

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  11. Contemporary to the rapidly evolving landscape of cancer immunotherapy is the equally changing understanding of immune tumor microenvironments (TMEs) which is crucial to the success of these therapies. Their r...

    Authors: Sarabjot Pabla, R. J. Seager, Erik Van Roey, Shuang Gao, Carrie Hoefer, Mary K. Nesline, Paul DePietro, Blake Burgher, Jonathan Andreas, Vincent Giamo, Yirong Wang, Felicia L. Lenzo, Margot Schoenborn, Shengle Zhang, Roger Klein, Sean T. Glenn…

    Citation: Biomarker Research 2021 9:56

    Content type: Research

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  12. Every year around the world, more than 2 million women are diagnosed with breast cancer and genital tract cancers. However, there are rare studies comprehensively describing the global and regional trends of i...

    Authors: Ming Yi, Tianye Li, Mengke Niu, Suxia Luo, Qian Chu and Kongming Wu

    Citation: Biomarker Research 2021 9:55

    Content type: Research

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  13. Long non-coding RNAs (lncRNAs) represent a diverse class of RNAs involved in the regulation of various physiological and pathological cellular processes, including transcription, intracellular trafficking, and...

    Authors: Francesca Maria Orlandella, Giovanni Smaldone, Giuliana Salvatore, Luigi Vitagliano, Alessandra Cianflone, Rosanna Parasole, Giuliana Beneduce, Giuseppe Menna, Marco Salvatore and Peppino Mirabelli

    Citation: Biomarker Research 2021 9:54

    Content type: Research

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  14. Myelodysplastic syndrome with myelofibrosis (MDS-MF) has been associated with an inferior prognosis compared with MDS without MF. However, MDS-MF is not listed independently as a subtype of MDS, and its clinic...

    Authors: Minghua Hong, Junqing Wu, Lifeng Ma, Xiaoping Han, Ting Lu, Zhaoming Wang, Jing Zhao, Lizhen Liu, Huarui Fu, Weijia Huang, Weiyan Zheng, Jingsong He, Guoqing Wei, Huanping Wang, Zhimei Chen, He Huang…

    Citation: Biomarker Research 2021 9:53

    Content type: Letter to the Editor

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  15. After decades during which the treatment of acute myeloblastic leukemia was limited to variations around a skeleton of cytarabine/anthracycline, targeted therapies appeared. These therapies, first based on mon...

    Authors: Lamia Madaci, Julien Colle, Geoffroy Venton, Laure Farnault, Béatrice Loriod and Régis Costello

    Citation: Biomarker Research 2021 9:50

    Content type: Review

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  16. Tumor immunotherapy has attracted more and more attention nowadays, and multiple clinical trials have confirmed its effect in a variety of solid tumors. Immune checkpoint inhibitors (ICIs), cancer vaccines, ad...

    Authors: Wenyu Cao, Xinyue Ma, Jean Victoria Fischer, Chenggong Sun, Beihua Kong and Qing Zhang

    Citation: Biomarker Research 2021 9:49

    Content type: Review

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  17. SMAD1, a central mediator in TGF-β signaling, is involved in a broad range of biological activities including cell growth, apoptosis, development and immune response, and is implicated in diverse type of malig...

    Authors: Jian Wu, Min Zhang, Omar Faruq, Eldad Zacksenhaus, Wenming Chen, Aijun Liu and Hong Chang

    Citation: Biomarker Research 2021 9:48

    Content type: Research

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  18. Metastasis suggests a poor prognosis for cancer patients, and treatment strategies for metastatic cancer are still very limited. Numerous studies have shown that cancer-associated fibroblasts (CAFs), a large c...

    Authors: Zimu Wang, Jiaxin Liu, Hairong Huang, Mingxiang Ye, Xinying Li, Ranpu Wu, Hongbing Liu and Yong Song

    Citation: Biomarker Research 2021 9:47

    Content type: Review

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  19. Myelodysplastic syndrome (MDS) is an aggressive and genetically heterogeneous disease with poor prognosis. Cellular immune disorder is a common characteristic of this disease and is thought to be related to cl...

    Authors: Xin Huang, Cunte Chen, Mengjun Zhong, Suxia Geng, Yujie Zhao, Minming Li, Chenxin Deng, Lingji Zeng, Ping Wu, Zesheng Lu, Jianyu Weng, Xin Du and Yangqiu Li

    Citation: Biomarker Research 2021 9:46

    Content type: Letter to the Editor

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  20. Although some studies have demonstrated that lncRNAs are dysregulated in hematopoietic malignancies and may regulate the progression of leukemia, the detailed mechanism underlying tumorigenesis is still unclea...

    Authors: Xuanmei Huang, Libin Huang, Qing Xie, Ling Zhang, Shaohui Huang, Mingye Hong, Jiangbin Li, Zunnan Huang and Hua Zhang

    Citation: Biomarker Research 2021 9:45

    Content type: Research

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  21. The E-Cadherin gene (CDH1, Cadherin 1), located at 16q22.1 encodes for a calcium-dependent membranous glycoprotein with an important role in cellular adhesion and polarity maintenance.

    Authors: Eike Burandt, Felix Lübbersmeyer, Natalia Gorbokon, Franziska Büscheck, Andreas M. Luebke, Anne Menz, Martina Kluth, Claudia Hube-Magg, Andrea Hinsch, Doris Höflmayer, Sören Weidemann, Christoph Fraune, Katharina Möller, Frank Jacobsen, Patrick Lebok, Till Sebastian Clauditz…

    Citation: Biomarker Research 2021 9:44

    Content type: Research

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  22. Oral squamous cell carcinoma (OSCC) is a capricious cancer with poor survival rates, even for early-stage patients. There is a pressing need to develop more precise risk assessment methods to appropriately tai...

    Authors: Chi T. Viet, Gary Yu, Kesava Asam, Carissa M. Thomas, Angela J. Yoon, Yan Chen Wongworawat, Mina Haghighiabyaneh, Courtney A. Kilkuts, Caitlyn M. McGue, Marcus A. Couey, Nicholas F. Callahan, Coleen Doan, Paul C. Walker, Khanh Nguyen, Stephanie C. Kidd, Steve C. Lee…

    Citation: Biomarker Research 2021 9:42

    Content type: Research

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  23. It has been suggested that the heterogeneity of TAAs in lung cancer may affect the therapeutic response and disease progression. Up to now, several tumor-associated antigen (TAA)-based cancer vaccines have bee...

    Authors: Fang Lv, Xueying Wu, Jin Song, Pan Wang, Shucheng Ren, Wei Guo, Qi Xue, Henghui Zhang and Jun Zhao

    Citation: Biomarker Research 2021 9:41

    Content type: Letter to the Editor

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  24. N6-methyladenosine (m6A) modification is the most prevalent internal mRNA modification and is involved in many biological processes in eukaryotes. Accumulating evidence has demonstrated that m6A may play eithe...

    Authors: Fangchao Zheng, Feng Du, Jiuda Zhao, Xue Wang, Yiran Si, Peng Jin, Haili Qian, Binghe Xu and Peng Yuan

    Citation: Biomarker Research 2021 9:39

    Content type: Review

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  25. T cell-based immunotherapies have revolutionized treatment paradigms in various cancers, however, limited response rates secondary to lack of significant T-cell infiltration in the tumor site remain a major pr...

    Authors: Shujie Zhou, Mingguo Liu, Fei Ren, Xiangjiao Meng and Jinming Yu

    Citation: Biomarker Research 2021 9:38

    Content type: Review

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  26. Mechanisms driving the progression of chronic lymphocytic leukemia (CLL) from its early stages are not fully understood. The acquisition of molecular changes at the time of progression has been observed in a s...

    Authors: Isabel Jiménez, Bárbara Tazón-Vega, Pau Abrisqueta, Juan C. Nieto, Sabela Bobillo, Carles Palacio-García, Júlia Carabia, Rafael Valdés-Mas, Magdalena Munuera, Lluís Puigdefàbregas, Genís Parra, Anna Esteve-Codina, Clara Franco-Jarava, Gloria Iacoboni, María José Terol, José Antonio García-Marco…

    Citation: Biomarker Research 2021 9:37

    Content type: Research

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  27. Acute myeloid leukemia (AML) remains an incurable malignancy despite recent advances in treatment. Recently a number of new therapies have emerged for the treatment of AML which target BCL-2 or the membrane re...

    Authors: Jayna J Mistry, Charlotte Hellmich, Amelia Lambert, Jamie A Moore, Aisha Jibril, Angela Collins, Kristian M Bowles and Stuart A Rushworth

    Citation: Biomarker Research 2021 9:35

    Content type: Letter to the Editor

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  28. The myristoylated alanine-rich C-kinase substrate (MARCKS) protein has been at the crossroads of multiple signaling pathways that govern several critical operations in normal and malignant cellular physiology....

    Authors: Deepak Narayanan Iyer, Omar Faruq, Lun Zhang, Nasrin Rastgoo, Aijun Liu and Hong Chang

    Citation: Biomarker Research 2021 9:34

    Content type: Review

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  29. Reversion of tumor to a normal differentiated cell once considered a dream is now at the brink of becoming a reality. Different layers of molecules/events such as microRNAs, transcription factors, alternative ...

    Authors: Avantika Tripathi, Anjali Kashyap, Greesham Tripathi, Joni Yadav, Rakhi Bibban, Nikita Aggarwal, Kulbhushan Thakur, Arun Chhokar, Mohit Jadli, Ashok Kumar Sah, Yeshvandra Verma, Hatem Zayed, Amjad Husain, Alok Chandra Bharti and Manoj Kumar Kashyap

    Citation: Biomarker Research 2021 9:31

    Content type: Review

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  30. Venetoclax (VEN) plus azacitidine has become the first-line therapy for elderly patients with acute myeloid leukemia (AML), and has a complete remission (CR) plus CR with incomplete recovery of hemogram rate o...

    Authors: Xiang Zhang, Jiejing Qian, Huafeng Wang, Yungui Wang, Yi Zhang, Pengxu Qian, Yinjun Lou, Jie Jin and Honghu Zhu

    Citation: Biomarker Research 2021 9:30

    Content type: Letter to the Editor

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  31. Hospitalized patients with COVID-19 demonstrate a higher risk of developing thromboembolism. Anticoagulation (AC) has been proposed for high-risk patients, even without confirmed thromboembolism. However, bene...

    Authors: Bo Yu, Victor Perez Gutierrez, Alex Carlos, Gregory Hoge, Anjana Pillai, J. Daniel Kelly and Vidya Menon

    Citation: Biomarker Research 2021 9:29

    Content type: Research

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  32. N6-methyladenosine(m6A) methylation modification affects the tumorigenesis, progression, and metastasis of breast cancer (BC). However, the expression characteristics and prognostic value of m6A modification i...

    Authors: Fangchao Zheng, Feng Du, Haili Qian, Jiuda Zhao, Xue Wang, Jian Yue, Nanlin Hu, Yiran Si, Binghe Xu and Peng Yuan

    Citation: Biomarker Research 2021 9:28

    Content type: Research

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  33. N6-methyladenosine (m6A) is a prevalent internal RNA modification in higher eukaryotic cells. As the pivotal m6A regulator, RNA methyltransferase-like 3 (METTL3) is responsible for methyl group transfer in the pr...

    Authors: Yiqing Cai, Rui Feng, Tiange Lu, Xiaomin Chen, Xiangxiang Zhou and Xin Wang

    Citation: Biomarker Research 2021 9:27

    Content type: Review

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  34. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Jie Wu, Chunlei Zheng, Yizhe Wang, Zichang Yang, Ce Li, Wanxia Fang, Yue Jin, Kezuo Hou, Yang Cheng, Jianfei Qi, Xiujuan Qu, Yunpeng Liu, Xiaofang Che and Xuejun Hu

    Citation: Biomarker Research 2021 9:25

    Content type: Correction

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    The original article was published in Biomarker Research 2021 9:9

  35. Dalpiciclib (SHR6390) is a novel inhibitor of cyclin-dependent kinase 4/6 which demonstrated promising anti-tumor potency in preclinical models. This first-in-human study was conducted to evaluate the tolerabi...

    Authors: Pin Zhang, Binghe Xu, Lin Gui, Wenna Wang, Meng Xiu, Xiao Zhang, Guilan Sun, Xiaoyu Zhu and Jianjun Zou

    Citation: Biomarker Research 2021 9:24

    Content type: Research

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  36. To evaluate the predictive value of AR-V7 expression detected by immunohistochemical (IHC) in the prognosis of prostate cancer patients receiving adjuvant hormonal therapy (AHT) following radical prostatectomy...

    Authors: Wei Ouyang, Yucong Zhang, Gongwei Long, Guoliang Sun, Man Liu, Fan Li, Chunguang Yang, Xing Zeng, Jun Yang, Xiao Yu, Zhihua Wang, Zheng Liu, Wei Guan, Zhiquan Hu, Shaogang Wang, Xiaming Liu…

    Citation: Biomarker Research 2021 9:23

    Content type: Research

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  37. The phase I trial of the humanized anti-CD26 monoclonal antibody YS110 for CD26-expressing tumors was conducted recently. The present study identifies a potential prognostic biomarker for CD26-targeted therapy...

    Authors: Yutaro Kaneko, Ryo Hatano, Naoto Hirota, Nicolas Isambert, Véronique Trillet-Lenoir, Benoit You, Jérôme Alexandre, Gérard Zalcman, Fanny Valleix, Thomas Podoll, Yoshimi Umezawa, Seiichi Takao, Satoshi Iwata, Osamu Hosono, Tetsuo Taguchi, Taketo Yamada…

    Citation: Biomarker Research 2021 9:21

    Content type: Research

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