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  1. Content type: Research

    Well-differentiated neuroendocrine tumors (NET) most frequently arise from the gastrointestinal tract (GI), pancreas, and lung. Patients often present as metastasis with an unknown primary, and the clinical ma...

    Authors: Michelle X. Yang, Ryan F. Coates, Abiy Ambaye, Valerie Cortright, Jeannette M. Mitchell, Alexa M. Buskey, Richard Zubarik, James G. Liu, Steven Ades and Maura M. Barry

    Citation: Biomarker Research 2018 6:15

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  2. Content type: Research

    Inhaled allergen challenges are often used to evaluate novel asthma treatments in early phase clinical trials. Current novel therapeutic targets in asthma include phosphoinositide 3-kinases (PI3K) delta and ga...

    Authors: Thomas Southworth, Sarah Mason, Alan Bell, Isabel Ramis, Marta Calbet, Anna Domenech, Neus Prats, Montserrat Miralpeix and Dave Singh

    Citation: Biomarker Research 2018 6:14

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  3. Content type: Case report

    GATA2 deficiency presents with a spectrum of phenotypes including increased susceptibility to viral and bacterial infections, multi-lineage cytopenias, aplastic anemia, leukemic transformation and lymphedema. ...

    Authors: Allen Sanyi, David L. Jaye, Cecilia B. Rosand, Amanda Box, Chandrakasan Shanmuganathan and Edmund K. Waller

    Citation: Biomarker Research 2018 6:13

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  4. Content type: Short report

    Biomarkers promise biomolecular explanations as well as reliable diagnostics, stratification, and treatment strategies that have the potential to help mitigate the effects of disorders. While no reliable bioma...

    Authors: Daniel P. Howsmon, James B. Adams, Uwe Kruger, Elizabeth Geis, Eva Gehn and Juergen Hahn

    Citation: Biomarker Research 2018 6:12

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  5. Content type: Research

    Yin Yang 1 (YY1) is a transcription factor that plays an important role during all stages of B cell differentiation. Several studies reported upregulation of YY1 in B cell derived lymphoma, indicating that it ...

    Authors: Jéssica Arribas Arranz, Dalia Nilufar Winter, Hans Günter Drexler and Sonja Eberth

    Citation: Biomarker Research 2018 6:11

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  6. Content type: Review

    Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase and a catalytic component of PRC2, catalyzes tri-methylation of histone H3 at Lys 27 (H3K27me3) to regulate gene expression through epigenetic ma...

    Authors: Lu Gan, Yanan Yang, Qian Li, Yi Feng, Tianshu Liu and Weijian Guo

    Citation: Biomarker Research 2018 6:10

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  7. Content type: Correction

    The original article [1] contains an error in Fig. 3 whereby the trend lines denoting Low & High E-cadherin were mistakenly labelled the opposite way around.

    Authors: W. Goto, S. Kashiwagi, Y. Asano, K. Takada, K. Takahashi, T. Hatano, T. Takashima, S. Tomita, H. Motomura, M. Ohsawa, K. Hirakawa and M. Ohira

    Citation: Biomarker Research 2018 6:9

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    The original article was published in Biomarker Research 2017 5:19

  8. Content type: Research

    Sphingosine kinase (SphK) 2 has been implicated in the development of a range of cancers and inhibitors of this enzyme are currently in clinical trial. We have previously demonstrated a role for SphK2 in the d...

    Authors: Vicki Xie, Daochen Tong, Craig T. Wallington-Beddoe, Ken F. Bradstock and Linda J. Bendall

    Citation: Biomarker Research 2018 6:6

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  9. Content type: Research

    Alzheimer’s disease (AD) is a most common dementia in elderly people. Since AD symptoms resemble those of other neurodegenerative diseases, including idiopathic normal pressure hydrocephalus (iNPH), it is diff...

    Authors: Yuki Nagata, Akiyoshi Hirayama, Satsuki Ikeda, Aoi Shirahata, Futaba Shoji, Midori Maruyama, Mitsunori Kayano, Masahiko Bundo, Kotaro Hattori, Sumiko Yoshida, Yu-ichi Goto, Katsuya Urakami, Tomoyoshi Soga, Kouichi Ozaki and Shumpei Niida

    Citation: Biomarker Research 2018 6:5

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  10. Content type: Research

    Acute kidney injury (AKI) is a frequent complication of cardiac surgery. We sought prognostic combinations of postoperative biomarkers measured within 6 h of surgery, potentially in combination with cardiopulm...

    Authors: Allison Meisner, Kathleen F. Kerr, Heather Thiessen-Philbrook, Francis Perry Wilson, Amit X. Garg, Michael G. Shlipak, Peter Kavsak, Richard P. Whitlock, Steven G. Coca and Chirag R. Parikh

    Citation: Biomarker Research 2018 6:3

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  11. Content type: Research

    Platelets support cancer growth and spread making platelet proteins candidates in the search for biomarkers.

    Authors: Marta Lomnytska, Rui Pinto, Susanne Becker, Ulla Engström, Sonja Gustafsson, Christina Björklund, Markus Templin, Jan Bergstrand, Lei Xu, Jerker Widengren, Elisabeth Epstein, Bo Franzén and Gert Auer

    Citation: Biomarker Research 2018 6:2

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  12. Content type: Research

    Diagnosis of malaria in pregnancy is problematic due to the low sensitivity of conventional diagnostic tests (rapid diagnostic test and microscopy), which is exacerbated due to low peripheral parasite densitie...

    Authors: E. Ruizendaal, H. D. F. H. Schallig, J. Bradley, M. Traore-Coulibaly, P. Lompo, U. d’Alessandro, S. Scott, F. Njie, S. H. Zango, O. Sawadogo, M. D. de Jong, H. Tinto and P. F. Mens

    Citation: Biomarker Research 2017 5:34

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  13. Content type: Research

    Selective kinase and immune checkpoint inhibitors, and their combinations, have significantly improved the survival of patients with advanced metastatic melanoma. Not all patients will respond to treatment how...

    Authors: Su Yin Lim, Jenny H. Lee, Sarah J. Welsh, Seong Beom Ahn, Edmond Breen, Alamgir Khan, Matteo S. Carlino, Alexander M. Menzies, Richard F. Kefford, Richard A. Scolyer, Georgina V. Long and Helen Rizos

    Citation: Biomarker Research 2017 5:32

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  14. Content type: Research

    Quantitative proteomics allows for the discovery and functional investigation of blood-based pre-diagnostic biomarkers for early cancer detection. However, a major limitation of proteomic investigations in bio...

    Authors: Christine Y. Yeh, Ravali Adusumilli, Majlinda Kullolli, Parag Mallick, Esther M. John and Sharon J. Pitteri

    Citation: Biomarker Research 2017 5:30

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  15. Content type: Research

    Monomeric laminin-γ2 in urine is a potential biomarker for bladder cancer. However, the current detection system uses an antibody that cannot discriminate between monomeric laminin-γ2 and the heterotrimeric γ2...

    Authors: Masatoshi Nakagawa, Takashi Karashima, Masayuki Kamada, Eisaku Yoshida, Toru Yoshimura, Masanori Nojima, Keiji Inoue, Taro Shuin, Motoharu Seiki and Naohiko Koshikawa

    Citation: Biomarker Research 2017 5:29

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  16. Content type: Methodology

    The pattern of serotonin transporter clustering on the plasma membrane of lymphocytes extracted from human whole blood samples has been identified as a putative biomarker of therapeutic efficacy in major depre...

    Authors: Raquel Romay-Tallon, Tania Rivera-Baltanas, Josh Allen, Jose M. Olivares, Lisa E. Kalynchuk and Hector J. Caruncho

    Citation: Biomarker Research 2017 5:27

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  17. Content type: Research

    Because soluble (or secreted) amyloid precursor protein-β (sAPPβ) and -α (sAPPα) possibly reflect pathological features of Alzheimer’s disease (AD), they are potential biomarker candidates for dementia disorde...

    Authors: Wataru Araki, Kotaro Hattori, Kazutomi Kanemaru, Yuma Yokoi, Yoshie Omachi, Harumasa Takano, Masuhiro Sakata, Sumiko Yoshida, Tadashi Tsukamoto, Miho Murata, Yuko Saito, Hiroshi Kunugi, Yu-ichi Goto, Utako Nagaoka, Masahiro Nagao, Takashi Komori…

    Citation: Biomarker Research 2017 5:28

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