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  1. Novel neoadjuvant immunotherapy combined with chemotherapy (neoICT) has improved outcomes for patients with esophageal squamous-cell carcinoma (ESCC), but challenges persist in low response rates and therapy r...

    Authors: Jun Jiang, Chao Xu, Donghui Han, Yuan Lu, Fa Yang, Jiawei Wang, Xiaolong Yan, Xiaorong Mu, Jipeng Zhang, Chenghui Jia, Xinyao Xu, Kui Liu, Zhenhua Liu, Li Gong, Yi Wan and Qiang Lu
    Citation: Biomarker Research 2024 12:113
    Content type: Research Published on:

  2. Resistance to immunotherapy in bladder cancer has greatly limited its clinical application. Through single-cell sequencing, we determined that ACSM6, an oncogene that is highly expressed in bladder cancer, pro...

    Authors: Zhenyu Nie, Bolong Liu, Jinhui Liu, Xiongbing Zu, Juanhua Wang, Jinbo Chen, Benyi Fan and Dingshan Deng
    Citation: Biomarker Research 2024 12:112
    Content type: Correspondence Published on:

  3. DNA damage response (DDR) deficiency has been one of the emerging targets in treating breast cancer in recent years. On the one hand, DDR coordinates cell cycle and signal transduction, whose dysfunction may l...

    Authors: Jiayi Li, Ziqi Jia, Lin Dong, Heng Cao, Yansong Huang, Hengyi Xu, Zhixuan Xie, Yiwen Jiang, Xiang Wang and Jiaqi Liu
    Citation: Biomarker Research 2024 12:111
    Content type: Review Published on:

  4. Cells, as the fundamental units of life, contain multidimensional spatiotemporal information. Single-cell RNA sequencing (scRNA-seq) is revolutionizing biomedical science by analyzing cellular state and interc...

    Authors: Xiangyu Wu, Xin Yang, Yunhan Dai, Zihan Zhao, Junmeng Zhu, Hongqian Guo and Rong Yang
    Citation: Biomarker Research 2024 12:110
    Content type: Review Published on:

  7. As one of the most common tumors in women, the pathogenesis and tumor heterogeneity of breast cancer have long been the focal point of research, with the emergence of tumor metastasis and drug resistance posin...

    Authors: Xin Xiong, Xin Wang, Cui-Cui Liu, Zhi-Ming Shao and Ke-Da Yu
    Citation: Biomarker Research 2024 12:107
    Content type: Review Published on:

  8. Podocalyxin-like protein (PODXL) is known to originate from tumor cells in several cancers; however, which cell type it is expressed in, whether and how it may contribute to tumor progression after radiotherap...

    Authors: Rui Huang, Fuhao Wang, Wenxue Zou, Xiaohui Li, Tianyu Lei, Peihang Li, Yajun Song, Chao Liu and Jinbo Yue
    Citation: Biomarker Research 2024 12:106
    Content type: Correspondence Published on:

  9. Methyltransferase-like protein is a ubiquitous enzyme-like protein in the human body, with binding domains for nucleic acids, proteins and other small molecules, and plays an important role in a variety of bio...

    Authors: Huhu Zhang, Fulin Sun, Shuyao Jiang, Fanghao Yang, Xiaolei Dong, Guoxiang Liu, Mengjun Wang, Ya Li, Mohan Su, Ziyuan Wen, Chunjuan Yu, Chenkai Fan, Xiaoxia Li, Zhe Zhang, Lina Yang and Bing Li
    Citation: Biomarker Research 2024 12:105
    Content type: Review Published on:

  10. Chimeric antigen receptor T (CAR-T) cell therapy has greatly improved the prognosis of relapsed and refractory patients with large B-cell lymphoma (LBCL). Early identification and intervention of patients who ...

    Authors: Ling-Shuang Sheng, Rong Shen, Zi-Xun Yan, Chao Wang, Xin Zheng, Yi-Lun Zhang, Hao-Xu Yang, Wen Wu, Peng-Peng Xu, Shu Cheng, Emmanuel Bachy, Pierre Sesques, Nicolas Jacquet-Francillon, Xu-Feng Jiang, Wei-Li Zhao and Li Wang
    Citation: Biomarker Research 2024 12:104
    Content type: Correspondence Published on:

  11. Temporal lobe epilepsy (TLE) is among the most common types of epilepsy and often leads to cognitive, emotional, and psychiatric issues due to the frequent seizures. A notable pathological change related to TL...

    Authors: Quanlei Liu, Chunhao Shen, Yang Dai, Ting Tang, Changkai Hou, Hongyi Yang, Yihe Wang, Jinkun Xu, Yongchang Lu, Yunming Wang, Yongzhi Shan, Penghu Wei and Guoguang Zhao
    Citation: Biomarker Research 2024 12:103
    Content type: Research Published on:

  12. Multiple myeloma (MM) is a hematological cancer characterized by the abnormal proliferation of plasma cells. Initial treatments often include immunomodulatory drugs (IMiDs), proteasome inhibitors (PIs), and mo...

    Authors: Fatemeh Nasiri, Yasaman Asaadi, Farzaneh Mirzadeh, Shahrokh Abdolahi, Sedigheh Molaei, Somayeh Piri Gavgani and Fatemeh Rahbarizadeh
    Citation: Biomarker Research 2024 12:102
    Content type: Review Published on:

  13. Acute myeloid leukemia (AML), as the most common subtype of leukemia in adults, is characterised by rapid progression and poor prognosis. In the context of the rapid development of medical technology and the c...

    Authors: Yeming Zhou, Guiqin Huang, Xiaoya Cai, Ying Liu, Bingxin Qian and Dengju Li
    Citation: Biomarker Research 2024 12:101
    Content type: Research Published on:

  14. Multiple studies have shown that tumor-associated macrophages (TAMs) promote cancer initiation and progression. However, the reprogramming of macrophages in the tumor microenvironment (TME) and the cross-talk ...

    Authors: Zhao-Ru Dong, Meng-Ya Zhang, Ling-Xin Qu, Jie Zou, Yong-Heng Yang, Yun-Long Ma, Chun-Cheng Yang, Xue-Lei Cao, Li-Yuan Wang, Xiao-Lu Zhang and Tao Li
    Citation: Biomarker Research 2024 12:100
    Content type: Research Published on:

  15. Gene therapy utilizes nucleic acid drugs to treat diseases, encompassing gene supplementation, gene replacement, gene silencing, and gene editing. It represents a distinct therapeutic approach from traditional...

    Authors: Tingting Wu, Yu Hu and Liang V. Tang
    Citation: Biomarker Research 2024 12:99
    Content type: Review Published on:

  17. Immunotherapy has shown promising anti-tumor effects across various tumors, yet it encounters challenges from the inhibitory tumor immune microenvironment (TIME). Infiltrating regulatory T cells (Tregs) are im...

    Authors: Zhaokai Zhou, Jiaxin Xu, Shutong Liu, Yingying Lv, Ruiqi Zhang, Xing Zhou, Yuyuan Zhang, Siyuan Weng, Hui Xu, Yuhao Ba, Anning Zuo, Xinwei Han and Zaoqu Liu
    Citation: Biomarker Research 2024 12:97
    Content type: Review Published on:

  18. Tumor cells possess complex immune evasion mechanisms to evade immune system attacks, primarily through metabolic reprogramming, which significantly alters the tumor microenvironment (TME) to modulate immune c...

    Authors: Haixia Zhang, Shizhen Li, Dan Wang, Siyang Liu, Tengfei Xiao, Wangning Gu, Hongmin Yang, Hui Wang, Minghua Yang and Pan Chen
    Citation: Biomarker Research 2024 12:96
    Content type: Review Published on:

  19. Immunotherapy has emerged as a pivotal modality in cancer treatment, with immune checkpoint inhibitors effectively combating malignancies by impeding crucial pathways within the immune system and stimulating p...

    Authors: Lin Chen, Yuqing Chao, Wenjing Li, Zhixia Wu and Qinchuan Wang
    Citation: Biomarker Research 2024 12:95
    Content type: Review Published on:

  22. Fibrosis is an excessive wound-healing response induced by repeated or chronic external stimuli to tissues, significantly impacting quality of life and primarily contributing to organ failure. Organ fibrosis i...

    Authors: Qun Wei, Cailing Gan, Meng Sun, Yuting Xie, Hongyao Liu, Taixiong Xue, Conghui Deng, Chunheng Mo and Tinghong Ye
    Citation: Biomarker Research 2024 12:92
    Content type: Review Published on:

  23. Serial CA125 and second line transvaginal ultrasound (TVS) screening in the UKCTOCS indicated a shift towards detection of earlier stage ovarian cancer (OvCa), but did not yield a significant mortality reducti...

    Authors: Johannes F. Fahrmann, Seyyed Mahmood Ghasemi, Chae Y. Han, Ranran Wu, Jennifer B. Dennison, Jody Vykoukal, Joseph Celestino, Karen Lu, Zhen Lu, Charles Drescher, Kim-Anh Do, Samir Hanash, Robert C. Bast and Ehsan Irajizad
    Citation: Biomarker Research 2024 12:91
    Content type: Correspondence Published on:

  24. The use of proton therapy (PT) in early-stage non-small cell lung cancer (ES-NSCLC) remains controversial, with insufficient evidence to determine its superiority over photon therapy (XRT). We conducted a syst...

    Authors: Junyi He, Yingxin Liu, Xiaojing Zhang, Butuo Li, Linlin Yang, Haohua Wang, Shijiang Wang, Jinming Yu and Linlin Wang
    Citation: Biomarker Research 2024 12:90
    Content type: Correspondence Published on:

  25. Colorectal cancer (CRC) ranks as the third most prevalent cancer globally. It’s recognized that the molecular subtype of CRC, characterized by mismatch repair deficiency (dMMR) or microsatellite instability-hi...

    Authors: Wen-Xuan Fan, Fei Su, Yan Zhang, Xiao-Ling Zhang, Yun-Yi Du, Yang-Jun Gao, Wei-Ling Li, Wen-Qing Hu and Jun Zhao
    Citation: Biomarker Research 2024 12:89
    Content type: Review Published on:

  26. Platelets are a significant component of the cell population in the tumour microenvironment (TME). Platelets influence other immune cells and perform cross-talk with tumour cells, playing an important role in ...

    Authors: Tongtao Zhuang, Shenrong Wang, Xiaoqian Yu, Xiaoyun He, Hongbin Guo and Chunlin Ou
    Citation: Biomarker Research 2024 12:88
    Content type: Review Published on:

  27. Breast cancer is a leading cause of morbidity and mortality among women worldwide. This study aimed to assess the global burden of breast cancer and identify attributable risk factors across 204 countries and ...

    Authors: Rui Sha, Xiang-meng Kong, Xin-yu Li and Ya-bing Wang
    Citation: Biomarker Research 2024 12:87
    Content type: Research Published on:

  31. MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional regulation of gene expression. Mounting evidence underscores the dysregulation of miRNAs to be associated with cancer development a...

    Authors: Yu Shuai, Xiaofang Zhang, Birgit D. A. Lavrijssen, M. Arfan Ikram, Rikje Ruiter, Bruno Stricker and Mohsen Ghanbari
    Citation: Biomarker Research 2024 12:83
    Content type: Correspondence Published on:

  32. Human trophoblastic cell surface antigen 2 (Trop2) is a glycoprotein, a cellular marker of trophoblastic and stem cells, and a calcium signaling transducer involved in several signaling pathways, leading to th...

    Authors: Yixuan Hu, Yinxing Zhu, Dan Qi, Cuiju Tang and Wenwen Zhang
    Citation: Biomarker Research 2024 12:82
    Content type: Review Published on:

  33. Tissue-resident macrophages and recruited macrophages play pivotal roles in innate immunity and the maintenance of brain homeostasis. Investigating the involvement of these macrophage populations in eliciting ...

    Authors: Hongyue Ma, Mingxia Zhu, Mengjie Chen, Xiuli Li and Xinhong Feng
    Citation: Biomarker Research 2024 12:81
    Content type: Review Published on:

  34. High-grade serous ovarian cancer (HGSOC), which is known for its heterogeneity, high recurrence rate, and metastasis, is often diagnosed after being dispersed in several sites, with about 80% of patients exper...

    Authors: Hye-Yeon Ju, Seo Yeon Youn, Jun Kang, Min Yeop Whang, Youn Jin Choi and Mi-Ryung Han
    Citation: Biomarker Research 2024 12:80
    Content type: Research Published on:

  35. Understanding the biological mechanisms underlying racial differences in diseases is crucial to developing targeted prevention and treatment. There is, however, limited knowledge of the impact of race on lipid...

    Authors: Ghazaleh Pourali, Liang Li, Kayla R. Getz, Myung Sik Jeon, Jingqin Luo, Chongliang Luo and Adetunji T. Toriola
    Citation: Biomarker Research 2024 12:79
    Content type: Correspondence Published on:

  36. The incidence of esophageal adenocarcinoma (EAC) has surged by 600% in recent decades, with a dismal 5-year survival rate of just 15%. Barrett’s esophagus (BE), affecting about 2% of the population, raises the...

    Authors: Yusi Fu, Swati Agrawal, Daniel R. Snyder, Shiwei Yin, Na Zhong, James A. Grunkemeyer, Nicholas Dietz, Ryan Corlett, Laura A. Hansen, Al-Refaie Waddah, Kalyana C. Nandipati and Jun Xia
    Citation: Biomarker Research 2024 12:78
    Content type: Correspondence Published on:

  37. Cancer immunotherapy has sparked a wave of cancer research, driven by recent successful proof-of-concept clinical trials. However, barriers are emerging during its rapid development, including broad adverse ef...

    Authors: Chao Sui, Heqing Wu, Xinxin Li, Yuhang Wang, Jiaqi Wei, Jianhua Yu and Xiaojin Wu
    Citation: Biomarker Research 2024 12:77
    Content type: Review Published on:

  39. Accurate prostate cancer (PCa) patient diagnosis and risk assessment are key to ensure the best outcome. Currently, low- and favorable intermediate-risk PCa patients may be offered AS due to the indolent natur...

    Authors: Ângela Albuquerque-Castro, Catarina Macedo-Silva, Rúben Oliveira-Sousa, Vera Constâncio, João Lobo, Isa Carneiro, Rui Henrique and Carmen Jerónimo
    Citation: Biomarker Research 2024 12:75
    Content type: Correspondence Published on:

  40. Lysine methylation is a crucial post-translational modification (PTM) that significantly impacts gene expression regulation. This modification not only influences cancer development directly but also has signi...

    Authors: Yiming Luo, Junli Lu, Zhen Lei, He Zhu, Dean Rao, Tiantian Wang, Chenan Fu, Zhiwei Zhang, Limin Xia and Wenjie Huang
    Citation: Biomarker Research 2024 12:74
    Content type: Review Published on:

  41. Cancer-associated fibroblasts (CAFs) are the major components of the tumor microenvironment and are related to tumor proliferation, metastasis, relapse, and drug resistance. With the development of sequencing ...

    Authors: Pin Lyu, Xiaoming Gu, Fuqi Wang, Haifeng Sun, Quanbo Zhou, Shuaixi Yang and Weitang Yuan
    Citation: Biomarker Research 2024 12:73
    Content type: Review Published on:

  44. Voltage-gated sodium channels (VGSCs) initiate action potentials in electrically excitable cells and tissues. Surprisingly, some VGSC genes are aberrantly expressed in a variety of cancers, derived from “non-e...

    Authors: Hengrui Liu, Jieling Weng, Christopher L.-H. Huang and Antony P. Jackson
    Citation: Biomarker Research 2024 12:70
    Content type: Review Published on:

  46. Insulin-like growth factor (IGF)-1 and its binding proteins are important in cancer growth, especially in prostate cancer. Observational studies suggest that protein restriction can lower IGF-1 levels. However...

    Authors: Maria L. Cagigas, Giovanni Fiorito, Beatrice Bertozzi, Andrius Masedunskas, Edda Cava, Francesco Spelta, Nicola Veronese, Valeria Tosti, Gayathiri Rajakumar, Tiana Pelaia, Arnold D. Bullock, Robert S. Figenshau, Gerald L. Andriole and Luigi Fontana
    Citation: Biomarker Research 2024 12:68
    Content type: Correspondence Published on:

  47. Uveal melanoma is the most common non-cutaneous melanoma and is an intraocular malignancy affecting nearly 7,000 individuals per year worldwide. Of these, approximately 50% will progress to metastatic disease ...

    Authors: Ashley N. Anderson, Patrick Conley, Christopher D. Klocke, Sidharth K. Sengupta, Amara Pang, Hannah C. Farley, Abigail R. Gillingham, Aubrey D. Dawson, Yichen Fan, Jocelyn A. Jones, Summer L. Gibbs, Alison H. Skalet, Guanming Wu and Melissa H. Wong
    Citation: Biomarker Research 2024 12:67
    Content type: Research Published on:

  48. Non-Hodgkin lymphomas (NHLs) are heterogeneous and are among the most common hematological malignancies worldwide. Despite the advances in the treatment of patients with NHLs, relapse or resistance to treatmen...

    Authors: Mehdi Bakhtiyaridovvombaygi, Somayeh Yazdanparast, Setare Kheyrandish, Seyed Mehrab Safdari, Fateme Amiri Samani, Mahsa Sohani, Akram Sadat Jaafarian, Fateme Damirchiloo, Amirhossein Izadpanah, Sahar Parkhideh, Fatemeh Mikanik, Elham Roshandel, Abbas Hajifathali and Ahmad Gharehbaghian
    Citation: Biomarker Research 2024 12:66
    Content type: Review Published on:

  49. Megakaryocytic differentiation is a complicated process regulated by a series of transcription factors in a context- and stage-dependent manner. Recent studies have suggested that krüppel-like transcription fa...

    Authors: Zhen Wang, Zhongwen Liu, Pan Zhou, Xiaona Niu, Zhengdao Sun, Huan He and Zunmin Zhu
    Citation: Biomarker Research 2024 12:65
    Content type: Research Published on:
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