Citation Impact 2023
Journal Impact Factor: 9.5
5-year Journal Impact Factor: 9.4
Source Normalized Impact per Paper (SNIP): 1.953
SCImago Journal Rank (SJR): 3.024
Speed 2023
Submission to first editorial decision (median days): 5
Submission to acceptance (median days): 72
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Articles
Page 1 of 13
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Citation: Biomarker Research 2024 12:69
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Effects of protein restriction on insulin-like growth factor (IGF)-1 in men with prostate cancer: results from a randomized clinical trial
Insulin-like growth factor (IGF)-1 and its binding proteins are important in cancer growth, especially in prostate cancer. Observational studies suggest that protein restriction can lower IGF-1 levels. However...
Citation: Biomarker Research 2024 12:68 -
Detection of neoplastic-immune hybrid cells with metastatic properties in uveal melanoma
Uveal melanoma is the most common non-cutaneous melanoma and is an intraocular malignancy affecting nearly 7,000 individuals per year worldwide. Of these, approximately 50% will progress to metastatic disease ...
Citation: Biomarker Research 2024 12:67 -
Harnessing natural killer cells for refractory/relapsed non-Hodgkin lymphoma: biological roles, clinical trials, and future prospective
Non-Hodgkin lymphomas (NHLs) are heterogeneous and are among the most common hematological malignancies worldwide. Despite the advances in the treatment of patients with NHLs, relapse or resistance to treatmen...
Citation: Biomarker Research 2024 12:66 -
The involvement of krüppel-like transcription factor 2 in megakaryocytic differentiation induction by phorbol 12-myrestrat 13-acetate
Megakaryocytic differentiation is a complicated process regulated by a series of transcription factors in a context- and stage-dependent manner. Recent studies have suggested that krüppel-like transcription fa...
Citation: Biomarker Research 2024 12:65 -
Correction: Gasdermin E benefits CD8 + T cell mediated anti-immunity through mitochondrial damage to activate cGAS-STING-interferonβ axis in colorectal cancer
Citation: Biomarker Research 2024 12:64 -
Metabolomic discoveries for early diagnosis and traditional Chinese medicine efficacy in ischemic stroke
Ischemic stroke (IS), a devastating cerebrovascular accident, presents with high mortality and morbidity. Following IS onset, a cascade of pathological changes, including excitotoxicity, inflammatory damage, a...
Citation: Biomarker Research 2024 12:63 -
The CDK9 inhibitor enitociclib overcomes resistance to BTK inhibition and CAR-T therapy in mantle cell lymphoma
Inhibitors of Bruton’s tyrosine kinase (BTKi) and chimeric antigen receptor T-cell (CAR-T) therapy targeting CD19 are paradigm-shifting advances in treating patients with aggressive mantle cell lymphoma (MCL)....
Citation: Biomarker Research 2024 12:62 -
Identification of a circulating long non-coding RNA signature panel in plasma as a novel biomarker for the detection of acute/early-stage HIV-1 infection
Individuals with acute / early HIV-1 infection are often unaware that they are infected with HIV-1 and may be involved in high-risk behavior leading to transmission of HIV-1. Identifying individuals with acute...
Citation: Biomarker Research 2024 12:61 -
Application of omics in the diagnosis, prognosis, and treatment of acute myeloid leukemia
Acute myeloid leukemia (AML) is the most frequent leukemia in adults with a high mortality rate. Current diagnostic criteria and selections of therapeutic strategies are generally based on gene mutations and c...
Citation: Biomarker Research 2024 12:60 -
Gasdermin E benefits CD8+T cell mediated anti-immunity through mitochondrial damage to activate cGAS-STING-interferonβ axis in colorectal cancer
Pyroptosis belongs to a unique type of programmed cell death among which GSDME is reported to exert anti-tumor immunity. However, the underlying mechanisms of how to boost tumor-infiltrating lymphocytes and wh...
Citation: Biomarker Research 2024 12:59 -
Single-cell and spatial transcriptomics reveal a high glycolysis B cell and tumor-associated macrophages cluster correlated with poor prognosis and exhausted immune microenvironment in diffuse large B-cell lymphoma
Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous malignancy characterized by varied responses to treatment and prognoses. Understanding the metabolic characteristics driving DLBCL progression is crucia...
Citation: Biomarker Research 2024 12:58 -
Single-cell and bulk RNA-seq unveils the immune infiltration landscape associated with cuproptosis in cerebral cavernous malformations
Cerebral cavernous malformations (CCMs) are vascular abnormalities associated with deregulated angiogenesis. Their pathogenesis and optimal treatment remain unclear. This study aims to investigate the molecula...
Citation: Biomarker Research 2024 12:57 -
Gut microbiota and metabolites signatures of clinical response in anti-PD-1/PD-L1 based immunotherapy of biliary tract cancer
Accumulating evidence suggests that the gut microbiota and metabolites can modulate tumor responses to immunotherapy; however, limited data has been reported on biliary tract cancer (BTC). This study used meta...
Citation: Biomarker Research 2024 12:56 -
Single-cell and spatial transcriptomics reveal alterations in trophoblasts at invasion sites and disturbed myometrial immune microenvironment in placenta accreta spectrum disorders
Placenta accreta spectrum disorders (PAS) are a severe complication characterized by abnormal trophoblast invasion into the myometrium. The underlying mechanisms of PAS involve a complex interplay of various c...
Citation: Biomarker Research 2024 12:55 -
CRISPR/Cas-based CAR-T cells: production and application
Chimeric antigen receptor T cell (CAR-T) therapy has revolutionized the treatment approach for cancer, autoimmune disease, and heart disease. The integration of CAR into T cells is typically facilitated by ret...
Citation: Biomarker Research 2024 12:54 -
FGL1 and FGL2: emerging regulators of liver health and disease
Liver disease is a complex group of diseases with high morbidity and mortality rates, emerging as a major global health concern. Recent studies have highlighted the involvement of fibrinogen-like proteins, spe...
Citation: Biomarker Research 2024 12:53 -
PTK2 is a potential biomarker and therapeutic target for EGFR- or TLRs-induced lung cancer progression via the regulation of the cross-talk between EGFR- and TLRs-mediated signals
Protein tyrosine kinase 2 (PTK2), epidermal growth factor receptor (EGFR), and toll-like receptor (TLRs) are amplified in non-small cell lung cancer (NSCLC). However, the functional and clinical associations b...
Citation: Biomarker Research 2024 12:52 -
The war between the immune system and the tumor - using immune biomarkers as tracers
Nowadays, immunotherapy is one of the most promising anti-tumor therapeutic strategy. Specifically, immune-related targets can be used to predict the efficacy and side effects of immunotherapy and monitor the ...
Citation: Biomarker Research 2024 12:51 -
CD19-immunoPET for noninvasive visualization of CD19 expression in B-cell lymphoma patients
Cell- and antibody-based CD19-directed therapies have demonstrated great potential for treating B-cell non-Hodgkin lymphoma (B-NHL). However, all these approaches suffer from limited response rates and conside...
Citation: Biomarker Research 2024 12:50 -
Circulating long non-coding RNAs detection after heart transplantation and its accuracy in the diagnosis of acute cardiac rejection
Long non-coding RNAs (lncRNAs) are closely implicated in biological processes and diseases with high inflammatory components. These molecules exhibit significant temporal and tissue specificity. However, the e...
Citation: Biomarker Research 2024 12:49 -
Deciphering metabolic heterogeneity in retinoblastoma unravels the role of monocarboxylate transporter 1 in tumor progression
Tumors exhibit metabolic heterogeneity, influencing cancer progression. However, understanding metabolic diversity in retinoblastoma (RB), the primary intraocular malignancy in children, remains limited.
Citation: Biomarker Research 2024 12:48 -
Antileukemic potential of methylated indolequinone MAC681 through immunogenic necroptosis and PARP1 degradation
Despite advancements in chronic myeloid leukemia (CML) therapy with tyrosine kinase inhibitors (TKIs), resistance and intolerance remain significant challenges. Leukemia stem cells (LSCs) and TKI-resistant cel...
Citation: Biomarker Research 2024 12:47 -
Phenomic landscape and pharmacogenomic implications for HLA region in a Taiwan Han Chinese population
The human leukocyte antigen (HLA) genes, exhibiting significant genetic diversity, are associated with susceptibility to various clinical diseases and diverse in drug responses. High costs of HLA sequencing an...
Citation: Biomarker Research 2024 12:46 -
Disulfidptosis decoded: a journey through cell death mysteries, regulatory networks, disease paradigms and future directions
Cell death is an important part of the life cycle, serving as a foundation for both the orderly development and the maintenance of physiological equilibrium within organisms. This process is fundamental, as it...
Citation: Biomarker Research 2024 12:45 -
Plasma ALS and Gal-3BP differentiate early from advanced liver fibrosis in MASLD patients
Metabolic dysfunction-associated steatotic liver disease (MASLD) is estimated to affect 30% of the world’s population, and its prevalence is increasing in line with obesity. Liver fibrosis is closely related t...
Citation: Biomarker Research 2024 12:44 -
Immune escape of multiple myeloma cells results from low miR29b and the ensuing epigenetic silencing of proteasome genes
Activation of CD28 on multiple myeloma (MM) plasma cells, by binding to CD80 and CD86 on dendritic cells, decreases proteasome subunit expression in the tumor cells and thereby helps them evade being killed by...
Citation: Biomarker Research 2024 12:43 -
MicroRNAs predict early complications of autologous hematopoietic stem cell transplantation
Autologous hematopoietic stem cell transplantation (AHSCT) remains the most prevalent type of stem cell transplantation. In our study, we investigated the changes in circulating miRNAs in AHSCT recipients and ...
Citation: Biomarker Research 2024 12:42 -
Lipid metabolism in tumor-infiltrating regulatory T cells: perspective to precision immunotherapy
Regulatory T cells (Tregs) are essential to the negative regulation of the immune system, as they avoid excessive inflammation and mediate tumor development. The abundance of Tregs in tumor tissues suggests th...
Citation: Biomarker Research 2024 12:41 -
Lung cancer cell-intrinsic IL-15 promotes cell migration and sensitizes murine lung tumors to anti-PD-L1 therapy
IL-15 plays a vital role in enhancing NK cell- and T-cell-mediated antitumor immune responses; however, the direct effect of IL-15 on tumor cells has not been fully elucidated. Herein, we investigated the effe...
Citation: Biomarker Research 2024 12:40 -
Global research hotspots, development trends and prospect discoveries of phase separation in cancer: a decade-long informatics investigation
Liquid-liquid phase separation (LLPS) is a complex and subtle phenomenon whose formation and regulation take essential roles in cancer initiation, growth, progression, invasion, and metastasis. This domain hol...
Citation: Biomarker Research 2024 12:39 -
Metallothionein-3 is a multifunctional driver that modulates the development of sorafenib-resistant phenotype in hepatocellular carcinoma cells
Metallothionein-3 (hMT3) is a structurally unique member of the metallothioneins family of low-mass cysteine-rich proteins. hMT3 has poorly characterized functions, and its importance for hepatocellular carcin...
Citation: Biomarker Research 2024 12:38 -
Correction: Combined TP53 status in tumor-free resection margins and circulating microRNA profiling predicts the risk of locoregional recurrence in head and neck cancer
Citation: Biomarker Research 2024 12:37 -
Harnessing adenovirus in cancer immunotherapy: evoking cellular immunity and targeting delivery in cell-specific manner
Recombinant adenovirus (rAd) regimens, including replication-competent oncolytic adenovirus (OAV) and replication-deficient adenovirus, have been identified as potential cancer therapeutics. OAV presents advan...
Citation: Biomarker Research 2024 12:36 -
Therapeutic and immunomodulatory potentials of mesenchymal stromal/stem cells and immune checkpoints related molecules
Mesenchymal stromal/stem cells (MSCs) are used in many studies due to their therapeutic potential, including their differentiative ability and immunomodulatory properties. These cells perform their therapeutic...
Citation: Biomarker Research 2024 12:35 -
p53 biology and reactivation for improved therapy in MDS and AML
Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) originate from preleukemic hematopoietic conditions, such as clonal hematopoiesis of indeterminate potential (CHIP) or clonal cytopenia of undete...
Citation: Biomarker Research 2024 12:34 -
STAT3–mediated up-regulation of DAB2 via SRC-YAP1 signaling axis promotes Helicobacter pylori-driven gastric tumorigenesis
Helicobacter pylori (H pylori) infection is the primary cause of gastric cancer (GC). The role of Disabled-2 (DAB2) in GC remains largely unclear. This study aimed to investigate the role of DAB2 in H pylori-med...
Citation: Biomarker Research 2024 12:33 -
Combined TP53 status in tumor-free resection margins and circulating microRNA profiling predicts the risk of locoregional recurrence in head and neck cancer
Locoregional recurrences represent a frequently unexpected problem in head and neck squamous cell carcinoma (HNSCC). Relapse often (10–30%) occurs in patients with histologically negative resection margins (RM...
Citation: Biomarker Research 2024 12:32 -
Serum metabolite signatures of cardiac function and morphology in individuals from a population-based cohort
Changes in serum metabolites in individuals with altered cardiac function and morphology may exhibit information about cardiovascular disease (CVD) pathway dysregulations and potential CVD risk factors. We aim...
Citation: Biomarker Research 2024 12:31 -
The role of kinesin family members in hepatobiliary carcinomas: from bench to bedside
As a major component of the digestive system malignancies, tumors originating from the hepatic and biliary ducts seriously endanger public health. The kinesins (KIFs) are molecular motors that enable the micro...
Citation: Biomarker Research 2024 12:30 -
RUNX1 promotes angiogenesis in colorectal cancer by regulating the crosstalk between tumor cells and tumor associated macrophages
Colorectal cancer (CRC) is a common malignancy worldwide. Angiogenesis and metastasis are the critical hallmarks of malignant tumor. Runt-related transcription factor 1 (RUNX1), an efficient transcription fact...
Citation: Biomarker Research 2024 12:29 -
Correction: A novel 3-miRNA network regulates tumour progression in oral squamous cell carcinoma
Citation: Biomarker Research 2024 12:28 -
Correction: HMGA1 augments palbociclib efficacy via PI3K/mTOR signaling in intrahepatic cholangiocarcinoma
Citation: Biomarker Research 2024 12:27 -
Biomarkers and prognostic factors of PD-1/PD-L1 inhibitor-based therapy in patients with advanced hepatocellular carcinoma
Systemic therapies using programmed death-1 (PD-1) and programmed death ligand 1 (PD-L1) inhibitors have demonstrated commendable efficacy in some patients with advanced hepatocellular carcinoma (HCC); however...
Citation: Biomarker Research 2024 12:26 -
DeepMPTB: a vaginal microbiome-based deep neural network as artificial intelligence strategy for efficient preterm birth prediction
In recent decades, preterm birth (PTB) has become a significant research focus in the healthcare field, as it is a leading cause of neonatal mortality worldwide. Using five independent study cohorts including ...
Citation: Biomarker Research 2024 12:25 -
Oncogenic alterations in advanced NSCLC: a molecular super-highway
Lung cancer ranks among the most common cancers world-wide and is the first cancer-related cause of death. The classification of lung cancer has evolved tremendously over the past two decades. Today, non-small...
Citation: Biomarker Research 2024 12:24 -
Characterization of T-Cell receptor repertoire in immunoglobulin a nephropathy
Immunoglobulin A nephropathy (IgAN) is an autoimmune disease characterized by abnormal IgA deposition in glomerulus. Current diagnosis of IgAN still depends on renal biopsy, an invasive method that might incre...
Citation: Biomarker Research 2024 12:23 -
Association between circulating ECM-associated molecules and cardiovascular outcomes in hemodialysis patients: a multicenter prospective cohort study
Hemodialysis patients are susceptible to cardiovascular remodeling, which increases the risk of cardiovascular morbidity and mortality. Circulating extracellular matrix (ECM)-associated molecules increase duri...
Citation: Biomarker Research 2024 12:22 -
Transcription factor BACH1 in cancer: roles, mechanisms, and prospects for targeted therapy
Transcription factor BTB domain and CNC homology 1 (BACH1) belongs to the Cap ‘n’ Collar and basic region Leucine Zipper (CNC-bZIP) family. BACH1 is widely expressed in mammalian tissues, where it regulates ep...
Citation: Biomarker Research 2024 12:21 -
A patient with multiple primary malignant neoplasms with high variant allele frequencies of RB1, TP53, and TERT
Multiple primary malignant neoplasms are a rare disease with tumors of different histology or morphology arising in various sites. Next-generation sequencing is essential in the etiology, diagnosis, treatment,...
Citation: Biomarker Research 2024 12:20
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Winners of the 2022 Cardio-Oncology Journal Prize
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