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  1. Autologous hematopoietic stem cell transplantation (AHSCT) remains the most prevalent type of stem cell transplantation. In our study, we investigated the changes in circulating miRNAs in AHSCT recipients and ...

    Authors: Damian Mikulski, Mateusz Nowicki, Izabela Dróżdż, Ewelina Perdas, Piotr Strzałka, Kacper Kościelny, Małgorzata Misiewicz, Konrad Stawiski, Agnieszka Wierzbowska and Wojciech Fendler
    Citation: Biomarker Research 2024 12:42
  2. Regulatory T cells (Tregs) are essential to the negative regulation of the immune system, as they avoid excessive inflammation and mediate tumor development. The abundance of Tregs in tumor tissues suggests th...

    Authors: Yukai Shan, Tianao Xie, Yuchao Sun, Ziyi Lu, Win Topatana, Sarun Juengpanich, Tianen Chen, Yina Han, Jiasheng Cao, Jiahao Hu, Shijie Li, Xiujun Cai and Mingyu Chen
    Citation: Biomarker Research 2024 12:41
  3. IL-15 plays a vital role in enhancing NK cell- and T-cell-mediated antitumor immune responses; however, the direct effect of IL-15 on tumor cells has not been fully elucidated. Herein, we investigated the effe...

    Authors: Shaojie Hu, Kelin Meng, Tianlai Wang, Rirong Qu, Boyu Wang, Yu Xi, Taiyan Yu, Zhiwei Yuan, Zihao Cai, Yitao Tian, Chenxi Zeng, Xue Wang, Wenbin Zou, Xiangning Fu and Lequn Li
    Citation: Biomarker Research 2024 12:40
  4. Liquid-liquid phase separation (LLPS) is a complex and subtle phenomenon whose formation and regulation take essential roles in cancer initiation, growth, progression, invasion, and metastasis. This domain hol...

    Authors: Song-Bin Guo, Xue-Zhao Feng, Wei-Juan Huang, Zhen-Zhong Zhou and Xiao-Peng Tian
    Citation: Biomarker Research 2024 12:39
  5. Metallothionein-3 (hMT3) is a structurally unique member of the metallothioneins family of low-mass cysteine-rich proteins. hMT3 has poorly characterized functions, and its importance for hepatocellular carcin...

    Authors: Miguel Angel Merlos Rodrigo, Hana Michalkova, Ana Maria Jimenez Jimenez, Frantisek Petrlak, Tomas Do, Ladislav Sivak, Yazan Haddad, Petra Kubickova, Vivian de los Rios, J. Ignacio Casal, Marina Serrano-Macia, Teresa C. Delgado, Loreto Boix, Jordi Bruix, Maria L. Martinez Chantar, Vojtech Adam…
    Citation: Biomarker Research 2024 12:38
  6. Authors: Federica Ganci, Matteo Allegretti, Carlotta Frascolla, Francesca Spinella, Francesca Rollo, Andrea Sacconi, Valentina De Pascale, Alina Catalina Palcau, Valentina Manciocco, Mariavittoria Vescovo, Ettore Cotroneo, Francesca Blandino, Maria Benevolo, Renato Covello, Paola Muti, Sabrina Strano…
    Citation: Biomarker Research 2024 12:37

    The original article was published in Biomarker Research 2024 12:32

  7. Mesenchymal stromal/stem cells (MSCs) are used in many studies due to their therapeutic potential, including their differentiative ability and immunomodulatory properties. These cells perform their therapeutic...

    Authors: Ali Hazrati, Kosar Malekpour, Hossein Khorramdelazad, Samira Rajaei and Seyed Mahmoud Hashemi
    Citation: Biomarker Research 2024 12:35
  8. Helicobacter pylori (H pylori) infection is the primary cause of gastric cancer (GC). The role of Disabled-2 (DAB2) in GC remains largely unclear. This study aimed to investigate the role of DAB2 in H pylori-med...

    Authors: Yantao Duan, Pengfei Kong, Mingzhu Huang, Yonghao Yan, Yi Dou, Binhao Huang, Jing Guo, Wei Kang, Caixia Zhu, Yuyan Wang, Donglei Zhou, Qiliang Cai and Dazhi Xu
    Citation: Biomarker Research 2024 12:33
  9. Locoregional recurrences represent a frequently unexpected problem in head and neck squamous cell carcinoma (HNSCC). Relapse often (10–30%) occurs in patients with histologically negative resection margins (RM...

    Authors: Federica Ganci, Matteo Allegretti, Carlotta Frascolla, Francesca Spinella, Francesca Rollo, Andrea Sacconi, Pascale De Valentina, Alina Catalina Palcau, Valentina Manciocco, Mariavittoria Vescovo, Ettore Cotroneo, Francesca Blandino, Maria Benevolo, Renato Covello, Paola Muti, Sabrina Strano…
    Citation: Biomarker Research 2024 12:32

    The Correction to this article has been published in Biomarker Research 2024 12:37

  10. Changes in serum metabolites in individuals with altered cardiac function and morphology may exhibit information about cardiovascular disease (CVD) pathway dysregulations and potential CVD risk factors. We aim...

    Authors: Juliane Maushagen, Nuha Shugaa Addin, Christopher Schuppert, Cavin K. Ward-Caviness, Johanna Nattenmüller, Jerzy Adamski, Annette Peters, Fabian Bamberg, Christopher L. Schlett, Rui Wang-Sattler and Susanne Rospleszcz
    Citation: Biomarker Research 2024 12:31
  11. Colorectal cancer (CRC) is a common malignancy worldwide. Angiogenesis and metastasis are the critical hallmarks of malignant tumor. Runt-related transcription factor 1 (RUNX1), an efficient transcription fact...

    Authors: Xuxue Guo, Haonan Zhang, Chengcheng He, Kaiwen Qin, Qiuhua Lai, Yuxin Fang, Qianhui Chen, Weize Li, Yiqing Wang, Xinke Wang, Aimin Li, Side Liu and Qingyuan Li
    Citation: Biomarker Research 2024 12:29
  12. Systemic therapies using programmed death-1 (PD-1) and programmed death ligand 1 (PD-L1) inhibitors have demonstrated commendable efficacy in some patients with advanced hepatocellular carcinoma (HCC); however...

    Authors: Nan Zhang, Xu Yang, Mingjian Piao, Ziyu Xun, Yunchao Wang, Cong Ning, Xinmu Zhang, Longhao Zhang, Yanyu Wang, Shanshan Wang, Jiashuo Chao, Zhenhui Lu, Xiaobo Yang, Hanping Wang and Haitao Zhao
    Citation: Biomarker Research 2024 12:26
  13. In recent decades, preterm birth (PTB) has become a significant research focus in the healthcare field, as it is a leading cause of neonatal mortality worldwide. Using five independent study cohorts including ...

    Authors: Oshma Chakoory, Vincent Barra, Emmanuelle Rochette, Loïc Blanchon, Vincent Sapin, Etienne Merlin, Maguelonne Pons, Denis Gallot, Sophie Comtet-Marre and Pierre Peyret
    Citation: Biomarker Research 2024 12:25
  14. Lung cancer ranks among the most common cancers world-wide and is the first cancer-related cause of death. The classification of lung cancer has evolved tremendously over the past two decades. Today, non-small...

    Authors: Alex Friedlaender, Maurice Perol, Giuseppe Luigi Banna, Kaushal Parikh and Alfredo Addeo
    Citation: Biomarker Research 2024 12:24
  15. Immunoglobulin A nephropathy (IgAN) is an autoimmune disease characterized by abnormal IgA deposition in glomerulus. Current diagnosis of IgAN still depends on renal biopsy, an invasive method that might incre...

    Authors: Szu-Ying Ho, Chih-Chin Kao, Che-Mai Chang, Yi-Chien Chou, Wei-Tzu Luo, Wan-Hsuan Chou, I-Lin Tsai, Mai-Szu Wu and Wei-Chiao Chang
    Citation: Biomarker Research 2024 12:23
  16. Hemodialysis patients are susceptible to cardiovascular remodeling, which increases the risk of cardiovascular morbidity and mortality. Circulating extracellular matrix (ECM)-associated molecules increase duri...

    Authors: Hyeon Seok Hwang, Jihyun Baek, So-Young Lee, Hye Yun Jeong, Jin Sug Kim, Yang Gyun Kim, ShinYoung Ahn, Kipyo Kim, Seok Hui Kang, Min-Jeong Lee, Dong-Young Lee and Yu Ho Lee
    Citation: Biomarker Research 2024 12:22
  17. Transcription factor BTB domain and CNC homology 1 (BACH1) belongs to the Cap ‘n’ Collar and basic region Leucine Zipper (CNC-bZIP) family. BACH1 is widely expressed in mammalian tissues, where it regulates ep...

    Authors: Dian Hu, Zerui Zhang, Xiangyuan Luo, Siwen Li, Junqing Jiang, Jiaqian Zhang, Zhangfan Wu, Yijun Wang, Mengyu Sun, Xiaoping Chen, Bixiang Zhang, Xiao Xu, Shuai Wang, Shengjun Xu, Yufei Wang, Wenjie Huang…
    Citation: Biomarker Research 2024 12:21
  18. Multiple primary malignant neoplasms are a rare disease with tumors of different histology or morphology arising in various sites. Next-generation sequencing is essential in the etiology, diagnosis, treatment,...

    Authors: Mingyang Ma, Kun Shang, Jiewei Wang, Xiaojing Teng, Peng Li and Jing Wang
    Citation: Biomarker Research 2024 12:20
  19. Distant metastasis is the major cause of lung adenocarcinoma (LUAD)-associated mortality. However, molecular mechanisms involved in LUAD metastasis remain to be fully understood. While the role of long non-cod...

    Authors: Hao Feng, Dengfei Xu, Chenyang Jiang, Yuming Chen, Junru Wang, Zirui Ren, Xiang Li, Xu Dong Zhang and Shundong Cang
    Citation: Biomarker Research 2024 12:19
  20. Abnormal alterations in human epidermal growth factor receptor 2 (HER2, neu, and erbB2) are associated with the development of many tumors. It is currently a crucial treatment for multiple cancers. Advanced in...

    Authors: Kunrui Zhu, Xinyi Yang, Hebei Tai, Xiaorong Zhong, Ting Luo and Hong Zheng
    Citation: Biomarker Research 2024 12:16
  21. Small noncoding RNAs play an important role in various disease states, including cancer. PIWI proteins, a subfamily of Argonaute proteins, and PIWI-interacting RNAs (piRNAs) were originally described as germli...

    Authors: Elena Garcia-Borja, Frantisek Siegl, Rosana Mateu, Ondrej Slaby, Aleksi Sedo, Petr Busek and Jiri Sana
    Citation: Biomarker Research 2024 12:15
  22. The tumor immune microenvironment can influence the prognosis and treatment response to immunotherapy. We aimed to develop a non-invasive radiomic signature in high-grade glioma (HGG) to predict the absolute d...

    Authors: Di Chen, Rui Zhang, Xiaoming Huang, Chunxia Ji, Wei Xia, Ying Qi, Xinyu Yang, Lishuang Lin, Jing Wang, Haixia Cheng, Weijun Tang, Jinhua Yu, Dave S. B. Hoon, Jun Zhang, Xin Gao and Yu Yao
    Citation: Biomarker Research 2024 12:14
  23. Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype lacking effective targeted therapies, necessitating innovative treatment approaches. While targeting ROS proto-oncogene 1 (ROS1) with...

    Authors: Ximin Tan, Deguang Kong, Zhuoli Tao, Fangling Cheng, Baoyuan Zhang, Zaiqi Wang, Qi Mei, Chuang Chen and Kongming Wu
    Citation: Biomarker Research 2024 12:13
  24. Accurate prediction of tumor molecular alterations is vital for optimizing cancer treatment. Traditional tissue-based approaches encounter limitations due to invasiveness, heterogeneity, and molecular dynamic ...

    Authors: Xingping Zhang, Guijuan Zhang, Xingting Qiu, Jiao Yin, Wenjun Tan, Xiaoxia Yin, Hong Yang, Hua Wang and Yanchun Zhang
    Citation: Biomarker Research 2024 12:12
  25. Neoplastic cells need to adapt their gene expression pattern to survive in an ever-changing or unfavorable tumor microenvironment. Protein synthesis (or mRNA translation), an essential part of gene expression,...

    Authors: Dan Su, Chen Ding, Jiangdong Qiu, Gang Yang, Ruobing Wang, Yueze Liu, Jinxin Tao, Wenhao Luo, Guihu Weng and Taiping Zhang
    Citation: Biomarker Research 2024 12:11
  26. Disease relapse remains a major barrier to success after allogeneic hematopoietic cell transplantation (allo-HCT) in myelodysplastic neoplasms (MDS). While certain high risk genomic alterations are associated ...

    Authors: Guru Subramanian Guru Murthy, Tao Zhang, Yung-Tsi Bolon, Stephen Spellman, Jing Dong, Paul Auer and Wael Saber
    Citation: Biomarker Research 2024 12:10
  27. Uncontrolled productive infection of BK polyomaviruses (BKV) in immunocompromised patients was reported to result in serious diseases, especially renourinary malignancies. However, the mechanism of BKV as a ro...

    Authors: Cuidi Xu, Siyue Chen, Juntao Chen, Jina Wang, Xinhao Niu, Ruiming Rong, Tongyu Zhu and Yigang Zeng
    Citation: Biomarker Research 2024 12:9
  28. As a newly identified checkpoint, T cell immunoreceptor with immunoglobulin and tyrosine-based inhibitory motif (ITIM) domain (TIGIT) is highly expressed on CD4+ T cells, CD8+ T cells, natural killer (NK) cells, ...

    Authors: Peng Zhang, Xinyuan Liu, Zhuoyu Gu, Zhongxing Jiang, Song Zhao, Yongping Song and Jifeng Yu
    Citation: Biomarker Research 2024 12:7
  29. Metabolic associated steatohepatitis (MASH) is metabolic disease that may progress to cirrhosis and hepatocellular carcinoma. Mouse models of diet-induced MASH, which is characterized by the high levels of fat...

    Authors: Cian-Ru Yang, Wen-Jen Lin, Pei-Chun Shen, Pei-Yin Liao, Yuan-Chang Dai, Yao-Ching Hung, Hsueh‐Chou Lai, Shiraz Mehmood, Wei-Chung Cheng and Wen-Lung Ma
    Citation: Biomarker Research 2024 12:6
  30. The liver ranks as the sixth most prevalent site of primary cancer in humans, and it frequently experiences metastases from cancers originating in other organs. To facilitate the development of effective treat...

    Authors: Zhiao Chen, Qili Shi, Yiming Zhao, Midie Xu, Yizhe Liu, Xinrong Li, Li Liu, Menghong Sun, Xiaohua Wu, Zhimin Shao, Ye Xu, Lu Wang and Xianghuo He
    Citation: Biomarker Research 2024 12:4
  31. Metabolic elevation in soft-tissue sarcomas (STS), as documented with 18F-Fluorodeoxyglucose positron emission tomography (18F-FDG-PET/CT) has been linked with cell proliferation, higher grade, and lower survival...

    Authors: Amandine Crombé, Frédéric Bertolo, Lucile Vanhersecke, Jean-Philippe Guegan, Alban Bessede, Raul Perret, François Le Loarer, Vanessa Chaire, Jean-Michel Coindre, Carlo Lucchesi and Antoine Italiano
    Citation: Biomarker Research 2024 12:3
  32. The cGAS-STING signaling pathway has emerged as a critical mediator of innate immune responses, playing a crucial role in improving antitumor immunity through immune effector responses. Targeting the cGAS-STIN...

    Authors: Xi Chen, Zhijie Xu, Tongfei Li, Abhimanyu Thakur, Yu Wen, Kui Zhang, Yuanhong Liu, Qiuju Liang, Wangrui Liu, Jiang-Jiang Qin and Yuanliang Yan
    Citation: Biomarker Research 2024 12:2
  33. Tumor-associated macrophages (TAMs) are a heterogeneous population that play diverse functions in tumors. Their identity is determined not only by intrinsic factors, such as origins and transcription factors, ...

    Authors: Yujing Qian, Yujia Yin, Xiaocui Zheng, Zhaoyuan Liu and Xipeng Wang
    Citation: Biomarker Research 2024 12:1
  34. S100A8 and S100A9 are members of Ca2+-binding EF-hand superfamily, mainly expressed by macrophages and neutrophils. Limited by the poor stability of homodimers, they commonly exist as heterodimers. Beyond acting ...

    Authors: Xiaojun Zhang, Mengke Niu, Tianye Li, Yuze Wu, Jinnan Gao, Ming Yi and Kongming Wu
    Citation: Biomarker Research 2023 11:106
  35. KMT2A-rearranged acute myeloid leukemia (KMT2Ar-AML) is an aggressive subtype of AML with poor response and prognosis. KMT2Ar-AML has been demonstrated to be sensitive to BCL2 inhibitor venetoclax (VEN), but thes...

    Authors: Qing Ling, Yutong Zhou, Yu Qian, Jiejing Qian, Yi Zhang, Jinghan Wang, Yanan Zhu, Yile Zhou, Juying Wei, Chunmei Yang, Jie Sun, Wenjuan Yu, Jie Jin and Xiang Zhang
    Citation: Biomarker Research 2023 11:105
  36. Adoptive cell therapy using T cell receptor-engineered T cells (TCR-T) is a promising approach for cancer therapy with an expectation of no significant side effects. In the human body, mature T cells are armed...

    Authors: Zhi Pang, Man-man Lu, Yu Zhang, Yuan Gao, Jin-jin Bai, Jian-ying Gu, Lu Xie and Wei-zhong Wu
    Citation: Biomarker Research 2023 11:104
  37. Today, adoptive cell therapy has many successes in cancer therapy, and this subject is brilliant in using chimeric antigen receptor T cells. The CAR T cell therapy, with its FDA-approved drugs, could treat sev...

    Authors: Kaveh Hadiloo, Siavash Taremi, Mahmood Heidari and Abdolreza Esmaeilzadeh
    Citation: Biomarker Research 2023 11:103
  38. Reliable pre-surgical prediction of spreading through air spaces (STAS) in primary lung cancer is essential for precision treatment and surgical decision-making. We aimed to develop and validate a dual-delta d...

    Authors: Weiqiu Jin, Leilei Shen, Yu Tian, Hongda Zhu, Ningyuan Zou, Mengwei Zhang, Qian Chen, Changzi Dong, Qisheng Yang, Long Jiang, Jia Huang, Zheng Yuan, Xiaodan Ye and Qingquan Luo
    Citation: Biomarker Research 2023 11:102
  39. Authors: Scott R. Ceresnak, Yaqi Zhang, Xuefeng B. Ling, Kuo Jung Su, Qiming Tang, Bo Jin, James Schilling, C. James Chou, Zhi Han, Brendan J. Floyd, John C. Whitin, Kuo Yuan Hwa, Karl G. Sylvester, Henry Chubb, Ruben Y. Luo, Lu Tian…
    Citation: Biomarker Research 2023 11:101

    The original article was published in Biomarker Research 2023 11:97

  40. Tumor-associated macrophages (TAMs), one of the most abundant immune cell types in the tumor microenvironment (TME), account for approximately 50% of the local hematopoietic cells. TAMs play an important role ...

    Authors: Manli Zhou, Xiaoyun He, Cheng Mei and Chunlin Ou
    Citation: Biomarker Research 2023 11:100
  41. While the field of precision oncology is rapidly expanding and more targeted options are revolutionizing cancer treatment paradigms, therapeutic resistance particularly to immunotherapy remains a pressing chal...

    Authors: Karama Asleh, Valerie Dery, Catherine Taylor, Michelle Davey, Marie-Ange Djeungoue-Petga and Rodney J. Ouellette
    Citation: Biomarker Research 2023 11:99

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