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  1. Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype lacking effective targeted therapies, necessitating innovative treatment approaches. While targeting ROS proto-oncogene 1 (ROS1) with...

    Authors: Ximin Tan, Deguang Kong, Zhuoli Tao, Fangling Cheng, Baoyuan Zhang, Zaiqi Wang, Qi Mei, Chuang Chen and Kongming Wu
    Citation: Biomarker Research 2024 12:13
    Content type: Research Published on:

  2. Accurate prediction of tumor molecular alterations is vital for optimizing cancer treatment. Traditional tissue-based approaches encounter limitations due to invasiveness, heterogeneity, and molecular dynamic ...

    Authors: Xingping Zhang, Guijuan Zhang, Xingting Qiu, Jiao Yin, Wenjun Tan, Xiaoxia Yin, Hong Yang, Hua Wang and Yanchun Zhang
    Citation: Biomarker Research 2024 12:12
    Content type: Research Published on:

  3. Neoplastic cells need to adapt their gene expression pattern to survive in an ever-changing or unfavorable tumor microenvironment. Protein synthesis (or mRNA translation), an essential part of gene expression,...

    Authors: Dan Su, Chen Ding, Jiangdong Qiu, Gang Yang, Ruobing Wang, Yueze Liu, Jinxin Tao, Wenhao Luo, Guihu Weng and Taiping Zhang
    Citation: Biomarker Research 2024 12:11
    Content type: Review Published on:

  4. Disease relapse remains a major barrier to success after allogeneic hematopoietic cell transplantation (allo-HCT) in myelodysplastic neoplasms (MDS). While certain high risk genomic alterations are associated ...

    Authors: Guru Subramanian Guru Murthy, Tao Zhang, Yung-Tsi Bolon, Stephen Spellman, Jing Dong, Paul Auer and Wael Saber
    Citation: Biomarker Research 2024 12:10
    Content type: Correspondence Published on:

  5. Uncontrolled productive infection of BK polyomaviruses (BKV) in immunocompromised patients was reported to result in serious diseases, especially renourinary malignancies. However, the mechanism of BKV as a ro...

    Authors: Cuidi Xu, Siyue Chen, Juntao Chen, Jina Wang, Xinhao Niu, Ruiming Rong, Tongyu Zhu and Yigang Zeng
    Citation: Biomarker Research 2024 12:9
    Content type: Correspondence Published on:

  7. As a newly identified checkpoint, T cell immunoreceptor with immunoglobulin and tyrosine-based inhibitory motif (ITIM) domain (TIGIT) is highly expressed on CD4+ T cells, CD8+ T cells, natural killer (NK) cells, ...

    Authors: Peng Zhang, Xinyuan Liu, Zhuoyu Gu, Zhongxing Jiang, Song Zhao, Yongping Song and Jifeng Yu
    Citation: Biomarker Research 2024 12:7
    Content type: Review Published on:

  8. Metabolic associated steatohepatitis (MASH) is metabolic disease that may progress to cirrhosis and hepatocellular carcinoma. Mouse models of diet-induced MASH, which is characterized by the high levels of fat...

    Authors: Cian-Ru Yang, Wen-Jen Lin, Pei-Chun Shen, Pei-Yin Liao, Yuan-Chang Dai, Yao-Ching Hung, Hsueh‐Chou Lai, Shiraz Mehmood, Wei-Chung Cheng and Wen-Lung Ma
    Citation: Biomarker Research 2024 12:6
    Content type: Research Published on:

  10. The liver ranks as the sixth most prevalent site of primary cancer in humans, and it frequently experiences metastases from cancers originating in other organs. To facilitate the development of effective treat...

    Authors: Zhiao Chen, Qili Shi, Yiming Zhao, Midie Xu, Yizhe Liu, Xinrong Li, Li Liu, Menghong Sun, Xiaohua Wu, Zhimin Shao, Ye Xu, Lu Wang and Xianghuo He
    Citation: Biomarker Research 2024 12:4
    Content type: Research Published on:

  11. Metabolic elevation in soft-tissue sarcomas (STS), as documented with 18F-Fluorodeoxyglucose positron emission tomography (18F-FDG-PET/CT) has been linked with cell proliferation, higher grade, and lower survival...

    Authors: Amandine Crombé, Frédéric Bertolo, Lucile Vanhersecke, Jean-Philippe Guegan, Alban Bessede, Raul Perret, François Le Loarer, Vanessa Chaire, Jean-Michel Coindre, Carlo Lucchesi and Antoine Italiano
    Citation: Biomarker Research 2024 12:3
    Content type: Correspondence Published on:

  12. The cGAS-STING signaling pathway has emerged as a critical mediator of innate immune responses, playing a crucial role in improving antitumor immunity through immune effector responses. Targeting the cGAS-STIN...

    Authors: Xi Chen, Zhijie Xu, Tongfei Li, Abhimanyu Thakur, Yu Wen, Kui Zhang, Yuanhong Liu, Qiuju Liang, Wangrui Liu, Jiang-Jiang Qin and Yuanliang Yan
    Citation: Biomarker Research 2024 12:2
    Content type: Review Published on:

  13. Tumor-associated macrophages (TAMs) are a heterogeneous population that play diverse functions in tumors. Their identity is determined not only by intrinsic factors, such as origins and transcription factors, ...

    Authors: Yujing Qian, Yujia Yin, Xiaocui Zheng, Zhaoyuan Liu and Xipeng Wang
    Citation: Biomarker Research 2024 12:1
    Content type: Review Published on:

  14. S100A8 and S100A9 are members of Ca2+-binding EF-hand superfamily, mainly expressed by macrophages and neutrophils. Limited by the poor stability of homodimers, they commonly exist as heterodimers. Beyond acting ...

    Authors: Xiaojun Zhang, Mengke Niu, Tianye Li, Yuze Wu, Jinnan Gao, Ming Yi and Kongming Wu
    Citation: Biomarker Research 2023 11:106
    Content type: Research Published on:

  15. KMT2A-rearranged acute myeloid leukemia (KMT2Ar-AML) is an aggressive subtype of AML with poor response and prognosis. KMT2Ar-AML has been demonstrated to be sensitive to BCL2 inhibitor venetoclax (VEN), but thes...

    Authors: Qing Ling, Yutong Zhou, Yu Qian, Jiejing Qian, Yi Zhang, Jinghan Wang, Yanan Zhu, Yile Zhou, Juying Wei, Chunmei Yang, Jie Sun, Wenjuan Yu, Jie Jin and Xiang Zhang
    Citation: Biomarker Research 2023 11:105
    Content type: Correspondence Published on:

  16. Adoptive cell therapy using T cell receptor-engineered T cells (TCR-T) is a promising approach for cancer therapy with an expectation of no significant side effects. In the human body, mature T cells are armed...

    Authors: Zhi Pang, Man-man Lu, Yu Zhang, Yuan Gao, Jin-jin Bai, Jian-ying Gu, Lu Xie and Wei-zhong Wu
    Citation: Biomarker Research 2023 11:104
    Content type: Review Published on:

  17. Today, adoptive cell therapy has many successes in cancer therapy, and this subject is brilliant in using chimeric antigen receptor T cells. The CAR T cell therapy, with its FDA-approved drugs, could treat sev...

    Authors: Kaveh Hadiloo, Siavash Taremi, Mahmood Heidari and Abdolreza Esmaeilzadeh
    Citation: Biomarker Research 2023 11:103
    Content type: Review Published on:

  18. Reliable pre-surgical prediction of spreading through air spaces (STAS) in primary lung cancer is essential for precision treatment and surgical decision-making. We aimed to develop and validate a dual-delta d...

    Authors: Weiqiu Jin, Leilei Shen, Yu Tian, Hongda Zhu, Ningyuan Zou, Mengwei Zhang, Qian Chen, Changzi Dong, Qisheng Yang, Long Jiang, Jia Huang, Zheng Yuan, Xiaodan Ye and Qingquan Luo
    Citation: Biomarker Research 2023 11:102
    Content type: Research Published on:

  19. Authors: Scott R. Ceresnak, Yaqi Zhang, Xuefeng B. Ling, Kuo Jung Su, Qiming Tang, Bo Jin, James Schilling, C. James Chou, Zhi Han, Brendan J. Floyd, John C. Whitin, Kuo Yuan Hwa, Karl G. Sylvester, Henry Chubb, Ruben Y. Luo, Lu Tian…
    Citation: Biomarker Research 2023 11:101
    Content type: Correction Published on:

    The original article was published in Biomarker Research 2023 11:97

  20. Tumor-associated macrophages (TAMs), one of the most abundant immune cell types in the tumor microenvironment (TME), account for approximately 50% of the local hematopoietic cells. TAMs play an important role ...

    Authors: Manli Zhou, Xiaoyun He, Cheng Mei and Chunlin Ou
    Citation: Biomarker Research 2023 11:100
    Content type: Review Published on:

  21. While the field of precision oncology is rapidly expanding and more targeted options are revolutionizing cancer treatment paradigms, therapeutic resistance particularly to immunotherapy remains a pressing chal...

    Authors: Karama Asleh, Valerie Dery, Catherine Taylor, Michelle Davey, Marie-Ange Djeungoue-Petga and Rodney J. Ouellette
    Citation: Biomarker Research 2023 11:99
    Content type: Review Published on:

  22. Concurrent chemoradiotherapy (cCRT) is the mainstay of treatment for patients diagnosed with locally advanced non-small cell lung cancer (NSCLC). One significant challenge in the effectiveness of this therapy ...

    Authors: Diego de Miguel-Perez, Francisco Gabriel Ortega, Rosario Guerrero Tejada, Antonio Martínez-Única, Christine B. Peterson, Alessandro Russo, Muthukumar Gunasekaran, Andres F. Cardona, Victor Amezcua, Jose Antonio Lorente, Jose Expósito Hernández, Christian Rolfo and Maria Jose Serrano
    Citation: Biomarker Research 2023 11:98
    Content type: Correspondence Published on:

  23. Congenital heart disease (CHD) represents a significant contributor to both morbidity and mortality in neonates and children. There’s currently no analogous dried blood spot (DBS) screening for CHD immediately...

    Authors: Scott R. Ceresnak, Yaqi Zhang, Xuefeng B. Ling, Kuo Jung Su, Qiming Tang, Bo Jin, James Schilling, C. James Chou, Zhi Han, Brendan J. Floyd, John C. Whitin, Kuo Yuan Hwa, Karl G Sylvester, Henry Chubb, Ruben Y. Luo, Lu Tian…
    Citation: Biomarker Research 2023 11:97
    Content type: Correspondence Published on:

    The Correction to this article has been published in Biomarker Research 2023 11:101

  24. Authors: Neeti Swarup, Jordan Cheng, Irene Choi, You Jeong Heo, Misagh Kordi, Mohammad Aziz, Akanksha Arora, Feng Li, David Chia, Fang Wei, David Elashoff, Liying Zhang, Sung Kim, Yong Kim and David T.W. Wong
    Citation: Biomarker Research 2023 11:96
    Content type: Correction Published on:

    The original article was published in Biomarker Research 2023 11:90

  26. Small extracellular vesicles (sEVs) in the blood of cancer patients contain higher amounts of tumor markers than those identified as free-circulating. miRNAs have significant biomedical relevance due to their ...

    Authors: Miranda Burdiel, Julia Jiménez, Carlos Rodríguez-Antolín, Álvaro García-Guede, Olga Pernía, Ana Sastre-Perona, Rocío Rosas-Alonso, Julián Colmenarejo, Carmen Rodríguez-Jiménez, María Dolores Diestro, Virginia Martínez-Marín, Oliver Higueras, Patricia Cruz, Itsaso Losantos-García, Héctor Peinado, Olga Vera…
    Citation: Biomarker Research 2023 11:94
    Content type: Correspondence Published on:

  27. Genomic testing is crucial for the management of ovarian cancer. DNA from biopsies at diagnostic laparoscopies or interval debulking surgery after neoadjuvant chemotherapy, has a high failure rate. At relapse,...

    Authors: Maria Kfoury, Reda El Hazzaz, Claire Sanson, Felix Blanc Durand, Judith Michels, Emeline Colomba Blameble, Roseline Tang, Audrey Le Formal, Elodie Lecerf, Sebastien Gouy, Amandine Maulard, Patricia Pautier, Etienne Rouleau and Alexandra Leary
    Citation: Biomarker Research 2023 11:93
    Content type: Correspondence Published on:

  28. T-cell lymphoblastic acute leukemia (T-ALL) is an aggressive blood cancer, characterized by restricted cellular subsets with enriched leukemia initiating cells (LICs). Recently, Ephrin receptors (Eph) were des...

    Authors: Mattia Colucci, Nadia Trivieri, Gandino Mencarelli, Elisabetta De Santis, Francesca Sansico, Francesco Tamiro, Alberto Visioli, Chiara Barile, Riccardo Pracella, Giovanni Rossi, Elena Binda and Vincenzo Giambra
    Citation: Biomarker Research 2023 11:92
    Content type: Correspondence Published on:

  29. Light chain amyloidosis (AL) is a rare disease caused by the generalized deposition of misfolded free light chains. Patients with immunoglobulin M gammopathy (IgM) and indolent B-cell lymphoma such as marginal...

    Authors: Felix Korell, Stefan Schönland, Anita Schmitt, Madelaine Jansen, Kiavasch Farid, Carsten Müller-Tidow, Peter Dreger, Michael Schmitt and Ute Hegenbart
    Citation: Biomarker Research 2023 11:91
    Content type: Correspondence Published on:

  30. Recent advances in circulating cell-free DNA (cfDNA) analysis from biofluids have opened new avenues for liquid biopsy (LB). However, current cfDNA LB assays are limited by the availability of existing informa...

    Authors: Neeti Swarup, Jordan Cheng, Irene Choi, You Jeong Heo, Misagh Kordi, Mohammad Aziz, Akanksha Arora, Feng Li, David Chia, Fang Wei, David Elashoff, Liying Zhang, Sung Kim, Yong Kim and David T.W. Wong
    Citation: Biomarker Research 2023 11:90
    Content type: Research Published on:

    The Correction to this article has been published in Biomarker Research 2023 11:96

  31. Mitochondria are energy-generated organelles and take an important part in biological metabolism. Mitochondria could be transferred between cells, which serves as a new intercellular communication. Mitochondri...

    Authors: Xiaodong Guo, Can Can, Wancheng Liu, Yihong Wei, Xinyu Yang, Jinting Liu, Hexiao Jia, Wenbo Jia, Hanyang Wu and Daoxin Ma
    Citation: Biomarker Research 2023 11:89
    Content type: Review Published on:

  32. Pancreatic cancer is one of the most challenging cancers due to its high mortality rates. Considering the late diagnosis and the limited survival benefit with current treatment options, it becomes imperative t...

    Authors: María Victoria García-Ortiz, Pablo Cano-Ramírez, Marta Toledano-Fonseca, Enrique Aranda and Antonio Rodríguez-Ariza
    Citation: Biomarker Research 2023 11:88
    Content type: Review Published on:

  33. The presence of microvascular invasion (MVI) will impair the surgical outcome of hepatocellular carcinoma (HCC). Adipose and muscle tissues have been confirmed to be associated with the prognosis of HCC. We ai...

    Authors: Xin-Cheng Mao, Shuo Shi, Lun-Jie Yan, Han-Chao Wang, Zi-Niu Ding, Hui Liu, Guo-Qiang Pan, Xiao Zhang, Cheng-Long Han, Bao-Wen Tian, Dong-Xu Wang, Si-Yu Tan, Zhao-Ru Dong, Yu-Chuan Yan and Tao Li
    Citation: Biomarker Research 2023 11:87
    Content type: Research Published on:

  34. Major histocompatibility complex class I related chain A (MICA) is an important and stress-induced ligand of the natural killer group 2 member D receptor (NKG2D) that is expressed in various tumour cells. Give...

    Authors: Jing Zhang, Qizhi Luo, Xin Li, Junshuang Guo, Quan Zhu, Xiaofang Lu, Leiyan Wei, Zhiqing Xiang, Manqing Peng, Chunlin Ou and Yizhou Zou
    Citation: Biomarker Research 2023 11:86
    Content type: Review Published on:

  35. Extracellular vesicles (EVs) have considerable potential as diagnostic, prognostic, and therapeutic agents, in large part because molecular patterns on the EV surface betray the cell of origin and may also be ...

    Authors: Md. Khirul Islam, Misba Khan, Kamlesh Gidwani, Kenneth W. Witwer, Urpo Lamminmäki and Janne Leivo
    Citation: Biomarker Research 2023 11:85
    Content type: Review Published on:

  37. Annotating cells in the analysis of single-cell RNA-seq (scRNA-seq) data is one of the most challenging tasks that researchers are actively addressing. Manual cell annotation is generally considered the gold s...

    Authors: Fan-Lin Meng, Xiao-Ling Huang, Wen-Yan Qin, Kun-Bang Liu, Yan Wang, Ming Li, Yong-Hong Ren, Yan-Ze Li and Yi-Min Sun
    Citation: Biomarker Research 2023 11:83
    Content type: Correspondence Published on:

  38. Medullary Thyroid Carcinoma (MTC) is a rare neuroendocrine tumour whose diagnosis includes evaluating calcitonin serum levels, which can present fluctuations unrelated to MTC. Here, we investigated circulating...

    Authors: Anna Citarella, Zein Mersini Besharat, Sofia Trocchianesi, Tanja Milena Autilio, Antonella Verrienti, Giuseppina Catanzaro, Elena Splendiani, Zaira Spinello, Silvia Cantara, Patrizia Zavattari, Eleonora Loi, Cristina Romei, Raffaele Ciampi, Luciano Pezzullo, Maria Grazia Castagna, Antonio Angeloni…
    Citation: Biomarker Research 2023 11:82
    Content type: Correspondence Published on:

  39. Colorectal cancer is a major cause of cancer-related deaths worldwide. A third of colorectal cancers reside in the rectum. Many patients with rectal cancer present in the locally-advanced stage which needs mul...

    Authors: Parmida Sadat Pezeshki and Reza Ghalehtaki
    Citation: Biomarker Research 2023 11:81
    Content type: Correspondence Published on:

  40. Small cell lung cancer (SCLC) has an exceptionally poor prognosis; as most of the cases are initially diagnosed as extensive disease with hematogenous metastasis. Therefore, the early diagnosis of SCLC is very...

    Authors: Dong Ha Kim, Hyojeong Park, Yun Jung Choi, Kyungtaek Im, Chae Won Lee, Da-Som Kim, Chan-Gi Pack, Hyun-Yi Kim, Chang-Min Choi, Jae Cheol Lee, Wonjun Ji and Jin Kyung Rho
    Citation: Biomarker Research 2023 11:80
    Content type: Research Published on:

  41. Growing evidence supports that extracellular vesicles (EVs) in blood plasma and other body fluids may function as biomarkers for disease. We previously found that secretory autophagosomes (SAPs), a kind of EV,...

    Authors: Xue-cheng Dong, Xin-yi Xu, Yue-ru Huang, Xing-xing Zhu, Yi Yang, Wei Huang and Ling Liu
    Citation: Biomarker Research 2023 11:79
    Content type: Correspondence Published on:

  42. S100A6 (also called calcyclin) is a Ca2+-binding protein that belongs to the S100 protein family. S100A6 has many functions related to the cytoskeleton, cell stress, proliferation, and differentiation. S100A6 als...

    Authors: Yidian Wang, Xuewen Kang, Xin Kang and Fengguang Yang
    Citation: Biomarker Research 2023 11:78
    Content type: Review Published on:

  43. Extracellular vesicles (EVs) have garnered significant interest in the field of biomedical science due to their potential applications in therapy and diagnosis. These vesicles participate in cell-to-cell commu...

    Authors: Islam M. Saadeldin, Seif Ehab and Jongki Cho
    Citation: Biomarker Research 2023 11:77
    Content type: Review Published on:

  44. RNA-binding proteins have increasingly been identified as important regulators of gene expression given their ability to bind distinct RNA sequences and regulate their fate. Mounting evidence suggests that RNA...

    Authors: Mark Sicking, Isabel Falke, Maria T. Löblein, Hans Th. Eich, Martin Götte, Burkhard Greve and Fabian M. Troschel
    Citation: Biomarker Research 2023 11:76
    Content type: Review Published on:

  45. Sarcomas are a group of diverse and complex cancers of mesenchymal origin that remains poorly understood. Recent developments in cancer immunotherapy have demonstrated a potential for better outcomes with immu...

    Authors: Chin Sern Yiong, Tzu Ping Lin, Vivian Yujing Lim, Tan Boon Toh and Valerie Shiwen Yang
    Citation: Biomarker Research 2023 11:75
    Content type: Review Published on:

  46. Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a dismal prognosis, and despite significant advances in our understanding of its genetic drivers, like KRAS, TP53, CDKN2A, and SMAD4, effec...

    Authors: Jiatong Wang, Chi Hin Wong, Yinxin Zhu, Xiaoqiang Yao, Kelvin K C Ng, Chengzhi Zhou, Ka Fai To and Yangchao Chen
    Citation: Biomarker Research 2023 11:74
    Content type: Research Published on:

  47. A subset of triple-negative breast cancers (TNBCs) have homologous recombination deficiency with upregulation of compensatory DNA repair pathways. PIKTOR, a combination of TAK-228 (TORC1/2 inhibitor) and TAK-1...

    Authors: Jessica D. Lang, Tuong Vi V. Nguyen, Maren K. Levin, Page E. Blas, Heather L. Williams, Esther San Roman Rodriguez, Natalia Briones, Claudius Mueller, William Selleck, Sarah Moore, Victoria L. Zismann, William P.D. Hendricks, Virginia Espina and Joyce O’Shaughnessy
    Citation: Biomarker Research 2023 11:73
    Content type: Research Published on:

  49. For early screening and diagnosis of non-small cell lung cancer (NSCLC), a robust model based on plasma proteomics and metabolomics is required for accurate and accessible non-invasive detection. Here we aim t...

    Authors: Runhao Xu, Jiongran Wang, Qingqing Zhu, Chen Zou, Zehao Wei, Hao Wang, Zian Ding, Minjie Meng, Huimin Wei, Shijin Xia, Dongqing Wei, Li Deng and Shulin Zhang
    Citation: Biomarker Research 2023 11:71
    Content type: Research Published on:

  50. Biomarkers are detectable molecules that can reflect specific physiological states of cells, organs, and organisms and therefore be regarded as indicators for specific diseases. And the discovery of biomarkers...

    Authors: Yongshu Li, Winnie Wailing TAM, Yuanyuan Yu, Zhenjian Zhuo, Zhichao Xue, Chiman Tsang, Xiaoting Qiao, Xiaokang Wang, Weijing Wang, Yongyi Li, Yanyang Tu and Yunhua Gao
    Citation: Biomarker Research 2023 11:70
    Content type: Review Published on:
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    Journal Impact Factor: 9.5
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