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  1. Review

    DNA methyltransferases and their roles in tumorigenesis

    DNA methylation plays an important role in gene expression, chromatin stability, and genetic imprinting. In mammals, DNA methylation patterns are written and regulated by DNA methyltransferases (DNMTs), includ...

    Wu Zhang and Jie Xu

    Biomarker Research 2017 5:1

    Published on: 20 January 2017

  2. Methodology

    Development and validation of a novel bioassay to determine glucocorticoid sensitivity

    Glucocorticoids (GCs) remain the first line treatment for almost all non-infectious inflammatory diseases, ranging from acute asthma to rheumatoid arthritis. However, across all conditions, patients have a var...

    Emily L. Williams, Madeleine L. Stimpson, Peter L. Collins, Doyo G. Enki, Ashish Sinha, Richard W. Lee and Ashwin D. Dhanda

    Biomarker Research 2016 4:26

    Published on: 15 December 2016

  3. Review

    Application of multi-target phytotherapeutic concept in malaria drug discovery: a systems biology approach in biomarker identification

    There is an urgent need for new anti-malaria drugs with broad therapeutic potential and novel mode of action, for effective treatment and to overcome emerging drug resistance. Plant-derived anti-malarials rema...

    Protus Arrey Tarkang, Regina Appiah-Opong, Michael F. Ofori, Lawrence S. Ayong and Alexander K. Nyarko

    Biomarker Research 2016 4:25

    Published on: 13 December 2016

  4. Methodology

    Plasma microRNA biomarker detection for mild cognitive impairment using differential correlation analysis

    Mild cognitive impairment (MCI) is an intermediate state between normal aging and dementia including Alzheimer’s disease. Early detection of dementia, and MCI, is a crucial issue in terms of secondary preventi...

    Mitsunori Kayano, Sayuri Higaki, Jun-ichi Satoh, Kenji Matsumoto, Etsuro Matsubara, Osamu Takikawa and Shumpei Niida

    Biomarker Research 2016 4:22

    Published on: 12 December 2016

  5. Review

    Mechanically produced schistosomula as a higher-throughput tools for phenotypic pre-screening in drug sensitivity assays: current research and future trends

    It is crucial to develop new antischistosomal drugs since there is no vaccine and the whole world is relying on only a single drug for the treatment of schistosomiasis. One of the obstacles to the development ...

    Emmanuel Mouafo Tekwu, William Kofi Anyan, Daniel Boamah, Kofi Owusu Baffour-Awuah, Stephanie Keyetat Tekwu, Veronique Penlap Beng, Alexander Kwadwo Nyarko and Kwabena Mante Bosompem

    Biomarker Research 2016 4:21

    Published on: 22 November 2016

  6. Review

    Advance in microRNA as a potential biomarker for early detection of pancreatic cancer

    Pancreatic cancer is characterized as a disease with low survival and high mortality because of no effective diagnostic and therapeutic strategies available in clinic. Conventional clinical diagnostic methods ...

    Jing Huang, Jianzhou Liu, Kevin Chen-Xiao, Xuemei Zhang, W. N. Paul Lee, Vay Liang W. Go and Gary Guishan Xiao

    Biomarker Research 2016 4:20

    Published on: 22 October 2016

  7. Case report

    Hypercalcemia associated with isolated bone marrow sarcoidosis in a patient with underlying monoclonal gammopathy of undetermined significance: case report and review of literature

    Bone marrow sarcoidosis is extremely rare. The association between sarcoidosis and lymphoproliferative disorders has been previously speculated, although the diagnosis of sarcoidosis often precedes any hematol...

    John Gubatan, Xiaohui Wang, Abner Louissaint, Anuj Mahindra and John Vanderpool

    Biomarker Research 2016 4:18

    Published on: 15 September 2016

  8. Short report

    A novel three-way rearrangement involving ETV6 (12p13) and ABL1 (9q34) with an unknown partner on 3p25 resulting in a possible ETV6-ABL1 fusion in a patient with acute myeloid leukemia: a case report and a review of the literature

    Acute myeloid leukemia (AML) is commonly characterized by several chromosomal abnormalities resulting in the formation of chimeric genes that play various roles in leukemogenesis. Translocations resulting in the

    Carlos A. Tirado, Ken Siangchin, David S. Shabsovich, Maryam Sharifian and Gary Schiller

    Biomarker Research 2016 4:16

    Published on: 25 August 2016

  9. Case report

    Pediatric chronic myeloid leukemia with inv(3)(q21q26.2) and T lymphoblastic transformation: a case report

    Chronic myeloid leukemia (CML) comprises ~3 % of pediatric leukemia. Although therapy with tyrosine kinase inhibitors (TKIs) is highly effective for CML, multiple factors have been identified as predictive of ...

    Margaret Lewen, Renee Gresh, Maria Queenan, Michele Paessler, Vinodh Pillai, Elizabeth Hexner, Dale Frank, Adam Bagg, Richard Aplenc, Emi Caywood and Gerald Wertheim

    Biomarker Research 2016 4:14

    Published on: 22 July 2016

  10. Research

    The effect of n-3 polyunsaturated fatty acids on incidence and severity of oxaliplatin induced peripheral neuropathy: a randomized controlled trial

    Oxaliplatin induced peripheral neurotoxicity (OXIPN) is the major dose-limiting and long-lasting side effect of oxaliplatin. N-3 PUFAs have neuroprotective property via their effects on voltage-gated ion chann...

    Ali Esfahani, Mohammad hossein Somi, Hormoz Ayromlou, Alireza Nikanfar, Mohammad Asghari Jafarabadi, Bina Eftekhar Sadat and Zohreh Ghoreishi

    Biomarker Research 2016 4:13

    Published on: 23 June 2016

  11. Research

    The CXCR4 antagonist plerixafor enhances the effect of rituximab in diffuse large B-cell lymphoma cell lines

    Diffuse large B-cell lymphoma (DLBCL) is an aggressive disease with variable clinical outcome, accounting for at least 25-30 % of adult non-Hodgkin lymphomas. Approximately one third of DLBCL patients are not ...

    Linn Reinholdt, Maria Bach Laursen, Alexander Schmitz, Julie Støve Bødker, Lasse Hjort Jakobsen, Martin Bøgsted, Hans Erik Johnsen and Karen Dybkær

    Biomarker Research 2016 4:12

    Published on: 14 June 2016

  12. Research

    Expression of IFITM1 as a prognostic biomarker in resected gastric and esophageal adenocarcinoma

    There is an increasing amount of reports on IFITM1 (interferon-inducible transmembrane protein 1) in various malignancies. The aim of this study was to examine the expression of IFITM1 and its prognostic signi...

    David Borg, Charlotta Hedner, Alexander Gaber, Björn Nodin, Richard Fristedt, Karin Jirström, Jakob Eberhard and Anders Johnsson

    Biomarker Research 2016 4:10

    Published on: 14 May 2016

  13. Short report

    Evaluation of Caspase-9b and PP2Acα2 as potential biomarkers for chronic lymphocytic leukemia

    Disruption of alternative splicing in apoptotic factors has been associated to chronic lymphocytic leukemia among other cancers and hematological malignancies. The proapoptotic proteins Caspase-9 and PP2Acα ar...

    Leticia Domínguez-Berrocal, Xiguang Zhang, Jean Marc Zini, Jesús Fominaya, Angelita Rebollo and Jerónimo Bravo

    Biomarker Research 2016 4:9

    Published on: 4 May 2016

  14. Research

    The combinatorial approach of laser-captured microdissection and reverse transcription quantitative polymerase chain reaction accurately determines HER2 status in breast cancer

    HER2 expression in breast cancer correlates with increased metastatic potential, higher tumor recurrence rates and improved response to targeted therapies. Fluorescence in situ hybridization (FISH) and immunohist...

    Elisabeth Hofmann, Rita Seeboeck, Nico Jacobi, Peter Obrist, Samuel Huter, Christian Klein, Kamil Oender, Christoph Wiesner, Harald Hundsberger and Andreas Eger

    Biomarker Research 2016 4:8

    Published on: 7 April 2016

  15. Case report

    Treatment with rituximab and brentuximab vedotin in a patient of common variable immune deficiency-associated classic Hodgkin lymphoma

    Patients with common variable immunodeficiency (CVID) have an increased risk of developing lymphoproliferative diseases, including non-Hodgkins lymphoma (Blood 116:1228–1234, 2010; Blood 119:1650–7, 2012). The...

    Efren Rael, Kevin Rakszawski, Kristian Koller, Michael Bayerl, Manish Butte and Hong Zheng

    Biomarker Research 2016 4:7

    Published on: 9 March 2016

  16. Review

    SOX11 is a biomarker for cyclin D1-negative mantle cell lymphoma

    Cyclin D1 (CCND1) protein overexpression and/or the t(11;14)(q13;q32) translocation are the pathognomonic hallmarks of mantle cell lymphoma (MCL). However, there have been cases that lacked both t(11;14) and c...

    Roshni Narurkar, Mohammad Alkayem and Delong Liu

    Biomarker Research 2016 4:6

    Published on: 3 March 2016

  17. Research

    c-MYB is a transcriptional regulator of ESPL1/Separase in BCR-ABL-positive chronic myeloid leukemia

    Genomic instability and clonal evolution are hallmarks of progressing chronic myeloid leukemia (CML). Recently, we have shown that clonal evolution and blast crisis correlate with altered expression and activi...

    Wiltrud Prinzhorn, Michael Stehle, Helga Kleiner, Sabrina Ruppenthal, Martin C. Müller, Wolf-Karsten Hofmann, Alice Fabarius and Wolfgang Seifarth

    Biomarker Research 2016 4:5

    Published on: 2 March 2016

  18. Research

    A robust prognostic gene expression signature for early stage lung adenocarcinoma

    Stage I lung adenocarcinoma is usually not treated with adjuvant chemotherapy; however, around half of these patients do not survive 5 years. Therefore, a reliable prognostic biomarker for early stage patients...

    Marcin Krzystanek, Judit Moldvay, David Szüts, Zoltan Szallasi and Aron Charles Eklund

    Biomarker Research 2016 4:4

    Published on: 19 February 2016

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