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  1. The cGAS-STING signaling pathway has emerged as a critical mediator of innate immune responses, playing a crucial role in improving antitumor immunity through immune effector responses. Targeting the cGAS-STIN...

    Authors: Xi Chen, Zhijie Xu, Tongfei Li, Abhimanyu Thakur, Yu Wen, Kui Zhang, Yuanhong Liu, Qiuju Liang, Wangrui Liu, Jiang-Jiang Qin and Yuanliang Yan
    Citation: Biomarker Research 2024 12:2
  2. S100A8 and S100A9 are members of Ca2+-binding EF-hand superfamily, mainly expressed by macrophages and neutrophils. Limited by the poor stability of homodimers, they commonly exist as heterodimers. Beyond acting ...

    Authors: Xiaojun Zhang, Mengke Niu, Tianye Li, Yuze Wu, Jinnan Gao, Ming Yi and Kongming Wu
    Citation: Biomarker Research 2023 11:106
  3. KMT2A-rearranged acute myeloid leukemia (KMT2Ar-AML) is an aggressive subtype of AML with poor response and prognosis. KMT2Ar-AML has been demonstrated to be sensitive to BCL2 inhibitor venetoclax (VEN), but thes...

    Authors: Qing Ling, Yutong Zhou, Yu Qian, Jiejing Qian, Yi Zhang, Jinghan Wang, Yanan Zhu, Yile Zhou, Juying Wei, Chunmei Yang, Jie Sun, Wenjuan Yu, Jie Jin and Xiang Zhang
    Citation: Biomarker Research 2023 11:105
  4. Adoptive cell therapy using T cell receptor-engineered T cells (TCR-T) is a promising approach for cancer therapy with an expectation of no significant side effects. In the human body, mature T cells are armed...

    Authors: Zhi Pang, Man-man Lu, Yu Zhang, Yuan Gao, Jin-jin Bai, Jian-ying Gu, Lu Xie and Wei-zhong Wu
    Citation: Biomarker Research 2023 11:104
  5. Today, adoptive cell therapy has many successes in cancer therapy, and this subject is brilliant in using chimeric antigen receptor T cells. The CAR T cell therapy, with its FDA-approved drugs, could treat sev...

    Authors: Kaveh Hadiloo, Siavash Taremi, Mahmood Heidari and Abdolreza Esmaeilzadeh
    Citation: Biomarker Research 2023 11:103
  6. Reliable pre-surgical prediction of spreading through air spaces (STAS) in primary lung cancer is essential for precision treatment and surgical decision-making. We aimed to develop and validate a dual-delta d...

    Authors: Weiqiu Jin, Leilei Shen, Yu Tian, Hongda Zhu, Ningyuan Zou, Mengwei Zhang, Qian Chen, Changzi Dong, Qisheng Yang, Long Jiang, Jia Huang, Zheng Yuan, Xiaodan Ye and Qingquan Luo
    Citation: Biomarker Research 2023 11:102
  7. Authors: Scott R. Ceresnak, Yaqi Zhang, Xuefeng B. Ling, Kuo Jung Su, Qiming Tang, Bo Jin, James Schilling, C. James Chou, Zhi Han, Brendan J. Floyd, John C. Whitin, Kuo Yuan Hwa, Karl G. Sylvester, Henry Chubb, Ruben Y. Luo, Lu Tian…
    Citation: Biomarker Research 2023 11:101

    The original article was published in Biomarker Research 2023 11:97

  8. Tumor-associated macrophages (TAMs), one of the most abundant immune cell types in the tumor microenvironment (TME), account for approximately 50% of the local hematopoietic cells. TAMs play an important role ...

    Authors: Manli Zhou, Xiaoyun He, Cheng Mei and Chunlin Ou
    Citation: Biomarker Research 2023 11:100
  9. While the field of precision oncology is rapidly expanding and more targeted options are revolutionizing cancer treatment paradigms, therapeutic resistance particularly to immunotherapy remains a pressing chal...

    Authors: Karama Asleh, Valerie Dery, Catherine Taylor, Michelle Davey, Marie-Ange Djeungoue-Petga and Rodney J. Ouellette
    Citation: Biomarker Research 2023 11:99
  10. Concurrent chemoradiotherapy (cCRT) is the mainstay of treatment for patients diagnosed with locally advanced non-small cell lung cancer (NSCLC). One significant challenge in the effectiveness of this therapy ...

    Authors: Diego de Miguel-Perez, Francisco Gabriel Ortega, Rosario Guerrero Tejada, Antonio Martínez-Única, Christine B. Peterson, Alessandro Russo, Muthukumar Gunasekaran, Andres F. Cardona, Victor Amezcua, Jose Antonio Lorente, Jose Expósito Hernández, Christian Rolfo and Maria Jose Serrano
    Citation: Biomarker Research 2023 11:98
  11. Congenital heart disease (CHD) represents a significant contributor to both morbidity and mortality in neonates and children. There’s currently no analogous dried blood spot (DBS) screening for CHD immediately...

    Authors: Scott R. Ceresnak, Yaqi Zhang, Xuefeng B. Ling, Kuo Jung Su, Qiming Tang, Bo Jin, James Schilling, C. James Chou, Zhi Han, Brendan J. Floyd, John C. Whitin, Kuo Yuan Hwa, Karl G Sylvester, Henry Chubb, Ruben Y. Luo, Lu Tian…
    Citation: Biomarker Research 2023 11:97

    The Correction to this article has been published in Biomarker Research 2023 11:101

  12. Authors: Neeti Swarup, Jordan Cheng, Irene Choi, You Jeong Heo, Misagh Kordi, Mohammad Aziz, Akanksha Arora, Feng Li, David Chia, Fang Wei, David Elashoff, Liying Zhang, Sung Kim, Yong Kim and David T.W. Wong
    Citation: Biomarker Research 2023 11:96

    The original article was published in Biomarker Research 2023 11:90

  13. Small extracellular vesicles (sEVs) in the blood of cancer patients contain higher amounts of tumor markers than those identified as free-circulating. miRNAs have significant biomedical relevance due to their ...

    Authors: Miranda Burdiel, Julia Jiménez, Carlos Rodríguez-Antolín, Álvaro García-Guede, Olga Pernía, Ana Sastre-Perona, Rocío Rosas-Alonso, Julián Colmenarejo, Carmen Rodríguez-Jiménez, María Dolores Diestro, Virginia Martínez-Marín, Oliver Higueras, Patricia Cruz, Itsaso Losantos-García, Héctor Peinado, Olga Vera…
    Citation: Biomarker Research 2023 11:94
  14. Genomic testing is crucial for the management of ovarian cancer. DNA from biopsies at diagnostic laparoscopies or interval debulking surgery after neoadjuvant chemotherapy, has a high failure rate. At relapse,...

    Authors: Maria Kfoury, Reda El Hazzaz, Claire Sanson, Felix Blanc Durand, Judith Michels, Emeline Colomba Blameble, Roseline Tang, Audrey Le Formal, Elodie Lecerf, Sebastien Gouy, Amandine Maulard, Patricia Pautier, Etienne Rouleau and Alexandra Leary
    Citation: Biomarker Research 2023 11:93
  15. T-cell lymphoblastic acute leukemia (T-ALL) is an aggressive blood cancer, characterized by restricted cellular subsets with enriched leukemia initiating cells (LICs). Recently, Ephrin receptors (Eph) were des...

    Authors: Mattia Colucci, Nadia Trivieri, Gandino Mencarelli, Elisabetta De Santis, Francesca Sansico, Francesco Tamiro, Alberto Visioli, Chiara Barile, Riccardo Pracella, Giovanni Rossi, Elena Binda and Vincenzo Giambra
    Citation: Biomarker Research 2023 11:92
  16. Light chain amyloidosis (AL) is a rare disease caused by the generalized deposition of misfolded free light chains. Patients with immunoglobulin M gammopathy (IgM) and indolent B-cell lymphoma such as marginal...

    Authors: Felix Korell, Stefan Schönland, Anita Schmitt, Madelaine Jansen, Kiavasch Farid, Carsten Müller-Tidow, Peter Dreger, Michael Schmitt and Ute Hegenbart
    Citation: Biomarker Research 2023 11:91
  17. Recent advances in circulating cell-free DNA (cfDNA) analysis from biofluids have opened new avenues for liquid biopsy (LB). However, current cfDNA LB assays are limited by the availability of existing informa...

    Authors: Neeti Swarup, Jordan Cheng, Irene Choi, You Jeong Heo, Misagh Kordi, Mohammad Aziz, Akanksha Arora, Feng Li, David Chia, Fang Wei, David Elashoff, Liying Zhang, Sung Kim, Yong Kim and David T.W. Wong
    Citation: Biomarker Research 2023 11:90

    The Correction to this article has been published in Biomarker Research 2023 11:96

  18. Mitochondria are energy-generated organelles and take an important part in biological metabolism. Mitochondria could be transferred between cells, which serves as a new intercellular communication. Mitochondri...

    Authors: Xiaodong Guo, Can Can, Wancheng Liu, Yihong Wei, Xinyu Yang, Jinting Liu, Hexiao Jia, Wenbo Jia, Hanyang Wu and Daoxin Ma
    Citation: Biomarker Research 2023 11:89
  19. Pancreatic cancer is one of the most challenging cancers due to its high mortality rates. Considering the late diagnosis and the limited survival benefit with current treatment options, it becomes imperative t...

    Authors: María Victoria García-Ortiz, Pablo Cano-Ramírez, Marta Toledano-Fonseca, Enrique Aranda and Antonio Rodríguez-Ariza
    Citation: Biomarker Research 2023 11:88
  20. The presence of microvascular invasion (MVI) will impair the surgical outcome of hepatocellular carcinoma (HCC). Adipose and muscle tissues have been confirmed to be associated with the prognosis of HCC. We ai...

    Authors: Xin-Cheng Mao, Shuo Shi, Lun-Jie Yan, Han-Chao Wang, Zi-Niu Ding, Hui Liu, Guo-Qiang Pan, Xiao Zhang, Cheng-Long Han, Bao-Wen Tian, Dong-Xu Wang, Si-Yu Tan, Zhao-Ru Dong, Yu-Chuan Yan and Tao Li
    Citation: Biomarker Research 2023 11:87
  21. Major histocompatibility complex class I related chain A (MICA) is an important and stress-induced ligand of the natural killer group 2 member D receptor (NKG2D) that is expressed in various tumour cells. Give...

    Authors: Jing Zhang, Qizhi Luo, Xin Li, Junshuang Guo, Quan Zhu, Xiaofang Lu, Leiyan Wei, Zhiqing Xiang, Manqing Peng, Chunlin Ou and Yizhou Zou
    Citation: Biomarker Research 2023 11:86
  22. Extracellular vesicles (EVs) have considerable potential as diagnostic, prognostic, and therapeutic agents, in large part because molecular patterns on the EV surface betray the cell of origin and may also be ...

    Authors: Md. Khirul Islam, Misba Khan, Kamlesh Gidwani, Kenneth W. Witwer, Urpo Lamminmäki and Janne Leivo
    Citation: Biomarker Research 2023 11:85
  23. Annotating cells in the analysis of single-cell RNA-seq (scRNA-seq) data is one of the most challenging tasks that researchers are actively addressing. Manual cell annotation is generally considered the gold s...

    Authors: Fan-Lin Meng, Xiao-Ling Huang, Wen-Yan Qin, Kun-Bang Liu, Yan Wang, Ming Li, Yong-Hong Ren, Yan-Ze Li and Yi-Min Sun
    Citation: Biomarker Research 2023 11:83
  24. Medullary Thyroid Carcinoma (MTC) is a rare neuroendocrine tumour whose diagnosis includes evaluating calcitonin serum levels, which can present fluctuations unrelated to MTC. Here, we investigated circulating...

    Authors: Anna Citarella, Zein Mersini Besharat, Sofia Trocchianesi, Tanja Milena Autilio, Antonella Verrienti, Giuseppina Catanzaro, Elena Splendiani, Zaira Spinello, Silvia Cantara, Patrizia Zavattari, Eleonora Loi, Cristina Romei, Raffaele Ciampi, Luciano Pezzullo, Maria Grazia Castagna, Antonio Angeloni…
    Citation: Biomarker Research 2023 11:82
  25. Colorectal cancer is a major cause of cancer-related deaths worldwide. A third of colorectal cancers reside in the rectum. Many patients with rectal cancer present in the locally-advanced stage which needs mul...

    Authors: Parmida Sadat Pezeshki and Reza Ghalehtaki
    Citation: Biomarker Research 2023 11:81
  26. Small cell lung cancer (SCLC) has an exceptionally poor prognosis; as most of the cases are initially diagnosed as extensive disease with hematogenous metastasis. Therefore, the early diagnosis of SCLC is very...

    Authors: Dong Ha Kim, Hyojeong Park, Yun Jung Choi, Kyungtaek Im, Chae Won Lee, Da-Som Kim, Chan-Gi Pack, Hyun-Yi Kim, Chang-Min Choi, Jae Cheol Lee, Wonjun Ji and Jin Kyung Rho
    Citation: Biomarker Research 2023 11:80
  27. Growing evidence supports that extracellular vesicles (EVs) in blood plasma and other body fluids may function as biomarkers for disease. We previously found that secretory autophagosomes (SAPs), a kind of EV,...

    Authors: Xue-cheng Dong, Xin-yi Xu, Yue-ru Huang, Xing-xing Zhu, Yi Yang, Wei Huang and Ling Liu
    Citation: Biomarker Research 2023 11:79
  28. S100A6 (also called calcyclin) is a Ca2+-binding protein that belongs to the S100 protein family. S100A6 has many functions related to the cytoskeleton, cell stress, proliferation, and differentiation. S100A6 als...

    Authors: Yidian Wang, Xuewen Kang, Xin Kang and Fengguang Yang
    Citation: Biomarker Research 2023 11:78
  29. Extracellular vesicles (EVs) have garnered significant interest in the field of biomedical science due to their potential applications in therapy and diagnosis. These vesicles participate in cell-to-cell commu...

    Authors: Islam M. Saadeldin, Seif Ehab and Jongki Cho
    Citation: Biomarker Research 2023 11:77
  30. RNA-binding proteins have increasingly been identified as important regulators of gene expression given their ability to bind distinct RNA sequences and regulate their fate. Mounting evidence suggests that RNA...

    Authors: Mark Sicking, Isabel Falke, Maria T. Löblein, Hans Th. Eich, Martin Götte, Burkhard Greve and Fabian M. Troschel
    Citation: Biomarker Research 2023 11:76
  31. Sarcomas are a group of diverse and complex cancers of mesenchymal origin that remains poorly understood. Recent developments in cancer immunotherapy have demonstrated a potential for better outcomes with immu...

    Authors: Chin Sern Yiong, Tzu Ping Lin, Vivian Yujing Lim, Tan Boon Toh and Valerie Shiwen Yang
    Citation: Biomarker Research 2023 11:75
  32. Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a dismal prognosis, and despite significant advances in our understanding of its genetic drivers, like KRAS, TP53, CDKN2A, and SMAD4, effec...

    Authors: Jiatong Wang, Chi Hin Wong, Yinxin Zhu, Xiaoqiang Yao, Kelvin K C Ng, Chengzhi Zhou, Ka Fai To and Yangchao Chen
    Citation: Biomarker Research 2023 11:74
  33. A subset of triple-negative breast cancers (TNBCs) have homologous recombination deficiency with upregulation of compensatory DNA repair pathways. PIKTOR, a combination of TAK-228 (TORC1/2 inhibitor) and TAK-1...

    Authors: Jessica D. Lang, Tuong Vi V. Nguyen, Maren K. Levin, Page E. Blas, Heather L. Williams, Esther San Roman Rodriguez, Natalia Briones, Claudius Mueller, William Selleck, Sarah Moore, Victoria L. Zismann, William P.D. Hendricks, Virginia Espina and Joyce O’Shaughnessy
    Citation: Biomarker Research 2023 11:73
  34. For early screening and diagnosis of non-small cell lung cancer (NSCLC), a robust model based on plasma proteomics and metabolomics is required for accurate and accessible non-invasive detection. Here we aim t...

    Authors: Runhao Xu, Jiongran Wang, Qingqing Zhu, Chen Zou, Zehao Wei, Hao Wang, Zian Ding, Minjie Meng, Huimin Wei, Shijin Xia, Dongqing Wei, Li Deng and Shulin Zhang
    Citation: Biomarker Research 2023 11:71
  35. Biomarkers are detectable molecules that can reflect specific physiological states of cells, organs, and organisms and therefore be regarded as indicators for specific diseases. And the discovery of biomarkers...

    Authors: Yongshu Li, Winnie Wailing TAM, Yuanyuan Yu, Zhenjian Zhuo, Zhichao Xue, Chiman Tsang, Xiaoting Qiao, Xiaokang Wang, Weijing Wang, Yongyi Li, Yanyang Tu and Yunhua Gao
    Citation: Biomarker Research 2023 11:70
  36. . At present, the prognostic prediction in advanced oral cavity squamous cell carcinoma (OCSCC) is based on the tumor-node-metastasis (TNM) staging system, and the most used imaging modality in these patients ...

    Authors: Anna Corti, Loris De Cecco, Stefano Cavalieri, Deborah Lenoci, Federico Pistore, Giuseppina Calareso, Davide Mattavelli, Pim de Graaf, C. René Leemans, Ruud H. Brakenhoff, Marco Ravanelli, Tito Poli, Lisa Licitra, Valentina Corino and Luca Mainardi
    Citation: Biomarker Research 2023 11:69
  37. Comprehensive and integrative analysis of hepatocellular carcinoma (HCC) is important. In this study, we explored Taiwanese HCCs using multi-omics analyses.

    Authors: Ya-Sian Chang, Siang-Jyun Tu, Hong-Da Chen, Chin-Chun Chung, Ming-Hon Hsu, Yu-Pao Chou, Ya-Ting Lee, Ju-Chen Yen, Long-Bin Jeng and Jan-Gowth Chang
    Citation: Biomarker Research 2023 11:68
  38. Chimeric antigen receptor (CAR) T cells and natural killer (NK) cells are genetically engineered immune cells that can detect target antigens on the surface of target cells and eliminate them following adoptiv...

    Authors: Hamed Dabiri, Pooria Safarzadeh Kozani, Mahdi Habibi Anbouhi, Mohadeseh Mirzaee Godarzee, Mohammad Hossein Haddadi, Mohsen Basiri, Vahab Ziaei, Majid Sadeghizadeh and Ensiyeh Hajizadeh Saffar
    Citation: Biomarker Research 2023 11:67
  39. Cancer exerts a multitude of effects on metabolism, including the reprogramming of cellular metabolic pathways and alterations in metabolites that facilitate inappropriate proliferation of cancer cells and ada...

    Authors: Wenxiang Wang, Zhiwei Rong, Guangxi Wang, Yan Hou, Fan Yang and Mantang Qiu
    Citation: Biomarker Research 2023 11:66
  40. The most common kind of acute leukemia in adults is acute myeloid leukemia (AML), which is often treated with induction chemotherapy regimens followed by consolidation or allogeneic hematopoietic stem cell tra...

    Authors: Ruonan Shao, Zijian Li, Honglei Xin, Suyu Jiang, Yilin Zhu, Jingan Liu, Rong Huang, Kailin Xu and Xiaofeng Shi
    Citation: Biomarker Research 2023 11:65
  41. Late diagnosis is one of the major confounders in oral squamous cell carcinoma (OSCC). Despite recent advances in molecular diagnostics, no disease-specific biomarkers are clinically available for early risk p...

    Authors: Aditi Patel, Parina Patel, Dushyant Mandlik, Kaustubh Patel, Pooja Malaviya, Kaid Johar, Krishna B.S Swamy, Shanaya Patel and Vivek Tanavde
    Citation: Biomarker Research 2023 11:64

    The Correction to this article has been published in Biomarker Research 2024 12:28

  42. The ATP-adenosine pathway has emerged as a promising target for cancer therapy, but challenges remain in achieving effective tumor control. Early research focused on blocking the adenosine generating enzyme CD...

    Authors: Yao Liu, Zhongliang Li, Xiaoguang Zhao, Jing Xiao, Jiacheng Bi, Xian-Yang Li, Guokai Chen and Ligong Lu
    Citation: Biomarker Research 2023 11:63
  43. N6-methyladenosine (m6A) is the most prevalent and well-characterized internal chemical modification in eukaryotic RNA, influencing gene expression and phenotypic changes by controlling RNA fate. Insulin-like gro...

    Authors: Tian-Yu Zhu, Lian-Lian Hong and Zhi-Qiang Ling
    Citation: Biomarker Research 2023 11:62

    The Correction to this article has been published in Biomarker Research 2023 11:72

  44. Tissue factor (TF) is a protein that plays a critical role in blood clotting, but recent research has also shown its involvement in cancer development and progression. Herein, we provide an overview of the str...

    Authors: Seyed Esmaeil Ahmadi, Ashkan Shabannezhad, Amir Kahrizi, Armin Akbar, Seyed Mehrab Safdari, Taraneh Hoseinnezhad, Mohammad Zahedi, Soroush Sadeghi, Mahsa Golizadeh Mojarrad and Majid Safa
    Citation: Biomarker Research 2023 11:60
  45. Aberrant expression of circRNAs has been proven to play a crucial role in the progression of acute myeloid leukemia (AML); however, its regulatory mechanism remains unclear. Herein, we identified a novel circR...

    Authors: Xinyu Yang, Fengjiao Han, Xiang Hu, Guosheng Li, Hanyang Wu, Can Can, Yihong Wei, Jinting Liu, Ruiqing Wang, Wenbo Jia, Chunyan ji and Daoxin Ma
    Citation: Biomarker Research 2023 11:59
  46. Chronic lymphocytic leukemia (CLL) is one of the most frequent occurring types of leukemia. It typically occurs in elderly patients and has a highly variable clinical course. At present, the molecular mechanis...

    Authors: Wenjie Zhang, Jinlan Long, Peixia Tang, Kaili Chen, Guangyao Guo, Zezhong Yu, Jie Lin, Liping Liu, Rong Zhan and Zhenshu Xu
    Citation: Biomarker Research 2023 11:58

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