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  1. Content type: Research

    Sphingosine kinase (SphK) 2 has been implicated in the development of a range of cancers and inhibitors of this enzyme are currently in clinical trial. We have previously demonstrated a role for SphK2 in the d...

    Authors: Vicki Xie, Daochen Tong, Craig T. Wallington-Beddoe, Ken F. Bradstock and Linda J. Bendall

    Citation: Biomarker Research 2018 6:6

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  2. Content type: Research

    Alzheimer’s disease (AD) is a most common dementia in elderly people. Since AD symptoms resemble those of other neurodegenerative diseases, including idiopathic normal pressure hydrocephalus (iNPH), it is diff...

    Authors: Yuki Nagata, Akiyoshi Hirayama, Satsuki Ikeda, Aoi Shirahata, Futaba Shoji, Midori Maruyama, Mitsunori Kayano, Masahiko Bundo, Kotaro Hattori, Sumiko Yoshida, Yu-ichi Goto, Katsuya Urakami, Tomoyoshi Soga, Kouichi Ozaki and Shumpei Niida

    Citation: Biomarker Research 2018 6:5

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  3. Content type: Research

    Acute kidney injury (AKI) is a frequent complication of cardiac surgery. We sought prognostic combinations of postoperative biomarkers measured within 6 h of surgery, potentially in combination with cardiopulm...

    Authors: Allison Meisner, Kathleen F. Kerr, Heather Thiessen-Philbrook, Francis Perry Wilson, Amit X. Garg, Michael G. Shlipak, Peter Kavsak, Richard P. Whitlock, Steven G. Coca and Chirag R. Parikh

    Citation: Biomarker Research 2018 6:3

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  4. Content type: Research

    Platelets support cancer growth and spread making platelet proteins candidates in the search for biomarkers.

    Authors: Marta Lomnytska, Rui Pinto, Susanne Becker, Ulla Engström, Sonja Gustafsson, Christina Björklund, Markus Templin, Jan Bergstrand, Lei Xu, Jerker Widengren, Elisabeth Epstein, Bo Franzén and Gert Auer

    Citation: Biomarker Research 2018 6:2

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  5. Content type: Research

    Diagnosis of malaria in pregnancy is problematic due to the low sensitivity of conventional diagnostic tests (rapid diagnostic test and microscopy), which is exacerbated due to low peripheral parasite densitie...

    Authors: E. Ruizendaal, H. D. F. H. Schallig, J. Bradley, M. Traore-Coulibaly, P. Lompo, U. d’Alessandro, S. Scott, F. Njie, S. H. Zango, O. Sawadogo, M. D. de Jong, H. Tinto and P. F. Mens

    Citation: Biomarker Research 2017 5:34

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  6. Content type: Research

    Selective kinase and immune checkpoint inhibitors, and their combinations, have significantly improved the survival of patients with advanced metastatic melanoma. Not all patients will respond to treatment how...

    Authors: Su Yin Lim, Jenny H. Lee, Sarah J. Welsh, Seong Beom Ahn, Edmond Breen, Alamgir Khan, Matteo S. Carlino, Alexander M. Menzies, Richard F. Kefford, Richard A. Scolyer, Georgina V. Long and Helen Rizos

    Citation: Biomarker Research 2017 5:32

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  7. Content type: Research

    Quantitative proteomics allows for the discovery and functional investigation of blood-based pre-diagnostic biomarkers for early cancer detection. However, a major limitation of proteomic investigations in bio...

    Authors: Christine Y. Yeh, Ravali Adusumilli, Majlinda Kullolli, Parag Mallick, Esther M. John and Sharon J. Pitteri

    Citation: Biomarker Research 2017 5:30

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  8. Content type: Research

    Monomeric laminin-γ2 in urine is a potential biomarker for bladder cancer. However, the current detection system uses an antibody that cannot discriminate between monomeric laminin-γ2 and the heterotrimeric γ2...

    Authors: Masatoshi Nakagawa, Takashi Karashima, Masayuki Kamada, Eisaku Yoshida, Toru Yoshimura, Masanori Nojima, Keiji Inoue, Taro Shuin, Motoharu Seiki and Naohiko Koshikawa

    Citation: Biomarker Research 2017 5:29

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  9. Content type: Research

    Because soluble (or secreted) amyloid precursor protein-β (sAPPβ) and -α (sAPPα) possibly reflect pathological features of Alzheimer’s disease (AD), they are potential biomarker candidates for dementia disorde...

    Authors: Wataru Araki, Kotaro Hattori, Kazutomi Kanemaru, Yuma Yokoi, Yoshie Omachi, Harumasa Takano, Masuhiro Sakata, Sumiko Yoshida, Tadashi Tsukamoto, Miho Murata, Yuko Saito, Hiroshi Kunugi, Yu-ichi Goto, Utako Nagaoka, Masahiro Nagao, Takashi Komori…

    Citation: Biomarker Research 2017 5:28

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  10. Content type: Methodology

    The pattern of serotonin transporter clustering on the plasma membrane of lymphocytes extracted from human whole blood samples has been identified as a putative biomarker of therapeutic efficacy in major depre...

    Authors: Raquel Romay-Tallon, Tania Rivera-Baltanas, Josh Allen, Jose M. Olivares, Lisa E. Kalynchuk and Hector J. Caruncho

    Citation: Biomarker Research 2017 5:27

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  11. Content type: Research

    The purpose of this study was to investigate the potential of cerebrospinal fluid miRNAs as diagnostic biomarkers of acute ischemic stroke using three different profiling techniques in order to identify and by...

    Authors: Sofie Sølvsten Sørensen, Ann-Britt Nygaard, Anting Liu Carlsen, Niels H. H. Heegaard, Mads Bak and Thomas Christensen

    Citation: Biomarker Research 2017 5:24

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  12. Content type: Review

    Because the prevalence of antibiotic resistance markedly increases with time worldwide, anti-H. pylori treatment is continuing to be a great challenge forsphysicians in clinical practice. The Real-world Practice ...

    Authors: Chih-Chieh Huang, Kuo-Wang Tsai, Tzung-Jiun Tsai and Ping-I Hsu

    Citation: Biomarker Research 2017 5:23

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  13. Content type: Review

    Chimeric antigen receptor redirected T cells (CAR-T cells) have achieved inspiring outcomes in patients with B cell malignancies, and are now being investigated in other hematologic malignancies and solid tumo...

    Authors: Cheng Zhang, Jun Liu, Jiang F. Zhong and Xi Zhang

    Citation: Biomarker Research 2017 5:22

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  14. Content type: Research

    Breast cancer, the most commonly diagnosed cancer among women and leading cause of cancer-related deaths worldwide, exhibits aggressive behavior in indigenous African women evidenced by high histologic grade t...

    Authors: Benjamin Arko-Boham, Justice Tanihu Lomotey, Emmanuel Nomo Tetteh, Emmanuel Ayitey Tagoe, Nii Ayite Aryee, Ewurama Ampadu Owusu, Isaac Okai, Richard Michael Blay and Joe-Nat Clegg-Lamptey

    Citation: Biomarker Research 2017 5:21

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  15. Content type: Letter to the Editor

    Analysis of databases from the human genome project (HGP), the 1000 Genomes Project (1KGP), and The Cancer Genome Atlas (TCGA) revealed bacterial DNA integration into the human somatic genome, particularly in ...

    Authors: Saveen Sidhoo, Jesusa L. Rosales and Ki-Young Lee

    Citation: Biomarker Research 2017 5:20

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  16. Content type: Research

    Circulating tumor cells (CTCs) are linked to metastatic relapse and are regarded as a prognostic marker for human cancer. High expression of plakoglobin, a cell adhesion protein, within the primary tumor is po...

    Authors: Wataru Goto, Shinichiro Kashiwagi, Yuka Asano, Koji Takada, Katsuyuki Takahashi, Takaharu Hatano, Tsutomu Takashima, Shuhei Tomita, Hisashi Motomura, Masahiko Ohsawa, Kosei Hirakawa and Masaichi Ohira

    Citation: Biomarker Research 2017 5:19

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    The Correction to this article has been published in Biomarker Research 2018 6:9

  17. Content type: Short report

    Alternate BRAF splicing is the most common mechanism of acquired resistance to BRAF inhibitor treatment in melanoma. Recently, alternate BRAF exon 4–8 splicing was shown to involve an intronic mutation, locate...

    Authors: Gulietta M. Pupo, Suzanah C. Boyd, Carina Fung, Matteo S. Carlino, Alexander M. Menzies, Bernadette Pedersen, Peter Johansson, Nicholas K. Hayward, Richard F. Kefford, Richard A. Scolyer, Georgina V. Long and Helen Rizos

    Citation: Biomarker Research 2017 5:17

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  18. Content type: Case report

    Babesiosis is endemic in selected areas in North America. Babesia infection is commonly associated with anemia, thrombocytopenia, hyponatremia and elevated liver enzymes. Autoimmune hemolytic anemia (AIHA) is ...

    Authors: Roshni Narurkar, Aleksandra Mamorska-Dyga, John C. Nelson and Delong Liu

    Citation: Biomarker Research 2017 5:14

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  19. Content type: Case series

    Low albumin levels and low lymphocyte counts are intra hospital conditions that exert a negative influence on prognosis, healing and length of hospitalization. The study aimed to analyze the correlation betwee...

    Authors: Antonio E. Pontiroli, Lara Loreggian, Marco P. L. Rovati, Elena De Patto, Laura Folini, Federico Raveglia, Matilde De Simone, Alessandro Baisi and Ugo Cioffi

    Citation: Biomarker Research 2017 5:13

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  20. Content type: Research

    Cancer is a genetic disease; its development and metastasis depend on the function of many proteins. Human serum contains thousands of proteins; it is a window for the homeostasis of individual’s health. Many ...

    Authors: David L. Wang, Chuanguang Xiao, Guofeng Fu, Xing Wang and Liang Li

    Citation: Biomarker Research 2017 5:11

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  21. Content type: Research

    Urothelial bladder cancer (UBC) is a disease that often is discovered when the tumour is non-muscle invasive, i.e. in Ta or T1 stage. Some patients will progress into muscle-invasive disease, a potentially dea...

    Authors: Karolina Boman, Gustav Andersson, Christoffer Wennersten, Björn Nodin, Göran Ahlgren and Karin Jirström

    Citation: Biomarker Research 2017 5:10

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  22. Content type: Research

    Environmental Enteropathy (EE) is a subclinical condition caused by constant fecal-oral contamination and resulting in blunting of intestinal villi and intestinal inflammation. Of primary interest in the clini...

    Authors: Miao Lu, Jianhui Zhou, Caitlin Naylor, Beth D. Kirkpatrick, Rashidul Haque, William A. Petri Jr and Jennie Z. Ma

    Citation: Biomarker Research 2017 5:9

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  23. Content type: Research

    The aim of this study was to validate previously described diagnostic and prognostic microRNA expression profiles in tissue samples from patients with pancreatic cancer and other periampullary cancers.

    Authors: Dan Calatayud, Christian Dehlendorff, Mogens K. Boisen, Jane Preuss Hasselby, Nicolai Aagaard Schultz, Jens Werner, Heike Immervoll, Anders Molven, Carsten Palnæs Hansen and Julia S. Johansen

    Citation: Biomarker Research 2017 5:8

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  24. Content type: Case Report

    Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin lymphoma. Rhabdomyosarcoma, the most common soft tissue sarcoma of childhood. makes up less than 1% of solid malignancies in adults ...

    Authors: M. D. Mathias, M. V. Ortiz, H. Magnan, S. R. Ambati, E. K. Slotkin, A. J. Chou, M. F. Walsh, K. Offit, C. Moskowitz, A. Kentsis and L. H. Wexler

    Citation: Biomarker Research 2017 5:7

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  25. Content type: Review

    CD20 negative B cell non-Hodgkin lymphoma (NHL) is rare and accounts for approximately 1-2% of B cell lymphomas. CD20- negative NHL is frequently associated with extranodal involvement, atypical morphology, ag...

    Authors: Tasleem Katchi and Delong Liu

    Citation: Biomarker Research 2017 5:5

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  26. Content type: Review

    Synovial sarcoma (SS) is an aggressive soft tissue sarcoma (STS) that typically occurs in the extremities near a joint. Metastatic disease is common and usually occurs in the lungs and lymph nodes. Surgical ma...

    Authors: Rosalia de Necochea-Campion, Lee M. Zuckerman, Hamid R. Mirshahidi, Shahrzad Khosrowpour, Chien-Shing Chen and Saied Mirshahidi

    Citation: Biomarker Research 2017 5:4

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  27. Content type: Research

    Essential molecular pathways such as the MAPK pathway, NO system, or the influence of PIK3CA as an oncogene are known to regulate fundamental signalling networks. However, few knowledge about their role in the...

    Authors: Steffen Koerdt, Nadine Tanner, Niklas Rommel, Nils H. Rohleder, Gesche Frohwitter, Oliver Ristow, Klaus-Dietrich Wolff and Marco R. Kesting

    Citation: Biomarker Research 2017 5:3

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  28. Content type: Review

    DNA methylation plays an important role in gene expression, chromatin stability, and genetic imprinting. In mammals, DNA methylation patterns are written and regulated by DNA methyltransferases (DNMTs), includ...

    Authors: Wu Zhang and Jie Xu

    Citation: Biomarker Research 2017 5:1

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  29. Content type: Methodology

    Glucocorticoids (GCs) remain the first line treatment for almost all non-infectious inflammatory diseases, ranging from acute asthma to rheumatoid arthritis. However, across all conditions, patients have a var...

    Authors: Emily L. Williams, Madeleine L. Stimpson, Peter L. Collins, Doyo G. Enki, Ashish Sinha, Richard W. Lee and Ashwin D. Dhanda

    Citation: Biomarker Research 2016 4:26

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  30. Content type: Review

    There is an urgent need for new anti-malaria drugs with broad therapeutic potential and novel mode of action, for effective treatment and to overcome emerging drug resistance. Plant-derived anti-malarials rema...

    Authors: Protus Arrey Tarkang, Regina Appiah-Opong, Michael F. Ofori, Lawrence S. Ayong and Alexander K. Nyarko

    Citation: Biomarker Research 2016 4:25

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  31. Content type: Methodology

    Mild cognitive impairment (MCI) is an intermediate state between normal aging and dementia including Alzheimer’s disease. Early detection of dementia, and MCI, is a crucial issue in terms of secondary preventi...

    Authors: Mitsunori Kayano, Sayuri Higaki, Jun-ichi Satoh, Kenji Matsumoto, Etsuro Matsubara, Osamu Takikawa and Shumpei Niida

    Citation: Biomarker Research 2016 4:22

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  32. Content type: Review

    It is crucial to develop new antischistosomal drugs since there is no vaccine and the whole world is relying on only a single drug for the treatment of schistosomiasis. One of the obstacles to the development ...

    Authors: Emmanuel Mouafo Tekwu, William Kofi Anyan, Daniel Boamah, Kofi Owusu Baffour-Awuah, Stephanie Keyetat Tekwu, Veronique Penlap Beng, Alexander Kwadwo Nyarko and Kwabena Mante Bosompem

    Citation: Biomarker Research 2016 4:21

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  33. Content type: Review

    Pancreatic cancer is characterized as a disease with low survival and high mortality because of no effective diagnostic and therapeutic strategies available in clinic. Conventional clinical diagnostic methods ...

    Authors: Jing Huang, Jianzhou Liu, Kevin Chen-Xiao, Xuemei Zhang, W. N. Paul Lee, Vay Liang W. Go and Gary Guishan Xiao

    Citation: Biomarker Research 2016 4:20

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  34. Content type: Case report

    Population studies showed that patients with JAK2 V617F mutation had increased mortality, and increased risk of any cancer, hematologic cancer, and myeloproliferative disease.

    Authors: Kenneth G. Liu, Amit Verma, Olga Derman, Noah Kornblum, Murali Janakiram, Ira Braunschweig and Ramakrishna Battini

    Citation: Biomarker Research 2016 4:19

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  35. Content type: Case report

    Bone marrow sarcoidosis is extremely rare. The association between sarcoidosis and lymphoproliferative disorders has been previously speculated, although the diagnosis of sarcoidosis often precedes any hematol...

    Authors: John Gubatan, Xiaohui Wang, Abner Louissaint, Anuj Mahindra and John Vanderpool

    Citation: Biomarker Research 2016 4:18

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