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  1. Content type: Research

    Quantitative proteomics allows for the discovery and functional investigation of blood-based pre-diagnostic biomarkers for early cancer detection. However, a major limitation of proteomic investigations in bio...

    Authors: Christine Y. Yeh, Ravali Adusumilli, Majlinda Kullolli, Parag Mallick, Esther M. John and Sharon J. Pitteri

    Citation: Biomarker Research 2017 5:30

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  2. Content type: Research

    Monomeric laminin-γ2 in urine is a potential biomarker for bladder cancer. However, the current detection system uses an antibody that cannot discriminate between monomeric laminin-γ2 and the heterotrimeric γ2...

    Authors: Masatoshi Nakagawa, Takashi Karashima, Masayuki Kamada, Eisaku Yoshida, Toru Yoshimura, Masanori Nojima, Keiji Inoue, Taro Shuin, Motoharu Seiki and Naohiko Koshikawa

    Citation: Biomarker Research 2017 5:29

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  3. Content type: Research

    Because soluble (or secreted) amyloid precursor protein-β (sAPPβ) and -α (sAPPα) possibly reflect pathological features of Alzheimer’s disease (AD), they are potential biomarker candidates for dementia disorde...

    Authors: Wataru Araki, Kotaro Hattori, Kazutomi Kanemaru, Yuma Yokoi, Yoshie Omachi, Harumasa Takano, Masuhiro Sakata, Sumiko Yoshida, Tadashi Tsukamoto, Miho Murata, Yuko Saito, Hiroshi Kunugi, Yu-ichi Goto, Utako Nagaoka, Masahiro Nagao, Takashi Komori…

    Citation: Biomarker Research 2017 5:28

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  4. Content type: Methodology

    The pattern of serotonin transporter clustering on the plasma membrane of lymphocytes extracted from human whole blood samples has been identified as a putative biomarker of therapeutic efficacy in major depre...

    Authors: Raquel Romay-Tallon, Tania Rivera-Baltanas, Josh Allen, Jose M. Olivares, Lisa E. Kalynchuk and Hector J. Caruncho

    Citation: Biomarker Research 2017 5:27

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  5. Content type: Research

    The purpose of this study was to investigate the potential of cerebrospinal fluid miRNAs as diagnostic biomarkers of acute ischemic stroke using three different profiling techniques in order to identify and by...

    Authors: Sofie Sølvsten Sørensen, Ann-Britt Nygaard, Anting Liu Carlsen, Niels H. H. Heegaard, Mads Bak and Thomas Christensen

    Citation: Biomarker Research 2017 5:24

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  6. Content type: Review

    Because the prevalence of antibiotic resistance markedly increases with time worldwide, anti-H. pylori treatment is continuing to be a great challenge forsphysicians in clinical practice. The Real-world Practice ...

    Authors: Chih-Chieh Huang, Kuo-Wang Tsai, Tzung-Jiun Tsai and Ping-I Hsu

    Citation: Biomarker Research 2017 5:23

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  7. Content type: Review

    Chimeric antigen receptor redirected T cells (CAR-T cells) have achieved inspiring outcomes in patients with B cell malignancies, and are now being investigated in other hematologic malignancies and solid tumo...

    Authors: Cheng Zhang, Jun Liu, Jiang F. Zhong and Xi Zhang

    Citation: Biomarker Research 2017 5:22

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  8. Content type: Research

    Breast cancer, the most commonly diagnosed cancer among women and leading cause of cancer-related deaths worldwide, exhibits aggressive behavior in indigenous African women evidenced by high histologic grade t...

    Authors: Benjamin Arko-Boham, Justice Tanihu Lomotey, Emmanuel Nomo Tetteh, Emmanuel Ayitey Tagoe, Nii Ayite Aryee, Ewurama Ampadu Owusu, Isaac Okai, Richard Michael Blay and Joe-Nat Clegg-Lamptey

    Citation: Biomarker Research 2017 5:21

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  9. Content type: Letter to the Editor

    Analysis of databases from the human genome project (HGP), the 1000 Genomes Project (1KGP), and The Cancer Genome Atlas (TCGA) revealed bacterial DNA integration into the human somatic genome, particularly in ...

    Authors: Saveen Sidhoo, Jesusa L. Rosales and Ki-Young Lee

    Citation: Biomarker Research 2017 5:20

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  10. Content type: Research

    Circulating tumor cells (CTCs) are linked to metastatic relapse and are regarded as a prognostic marker for human cancer. High expression of plakoglobin, a cell adhesion protein, within the primary tumor is po...

    Authors: Wataru Goto, Shinichiro Kashiwagi, Yuka Asano, Koji Takada, Katsuyuki Takahashi, Takaharu Hatano, Tsutomu Takashima, Shuhei Tomita, Hisashi Motomura, Masahiko Ohsawa, Kosei Hirakawa and Masaichi Ohira

    Citation: Biomarker Research 2017 5:19

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    The Correction to this article has been published in Biomarker Research 2018 6:9

  11. Content type: Short report

    Alternate BRAF splicing is the most common mechanism of acquired resistance to BRAF inhibitor treatment in melanoma. Recently, alternate BRAF exon 4–8 splicing was shown to involve an intronic mutation, locate...

    Authors: Gulietta M. Pupo, Suzanah C. Boyd, Carina Fung, Matteo S. Carlino, Alexander M. Menzies, Bernadette Pedersen, Peter Johansson, Nicholas K. Hayward, Richard F. Kefford, Richard A. Scolyer, Georgina V. Long and Helen Rizos

    Citation: Biomarker Research 2017 5:17

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  12. Content type: Case report

    Babesiosis is endemic in selected areas in North America. Babesia infection is commonly associated with anemia, thrombocytopenia, hyponatremia and elevated liver enzymes. Autoimmune hemolytic anemia (AIHA) is ...

    Authors: Roshni Narurkar, Aleksandra Mamorska-Dyga, John C. Nelson and Delong Liu

    Citation: Biomarker Research 2017 5:14

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  13. Content type: Case series

    Low albumin levels and low lymphocyte counts are intra hospital conditions that exert a negative influence on prognosis, healing and length of hospitalization. The study aimed to analyze the correlation betwee...

    Authors: Antonio E. Pontiroli, Lara Loreggian, Marco P. L. Rovati, Elena De Patto, Laura Folini, Federico Raveglia, Matilde De Simone, Alessandro Baisi and Ugo Cioffi

    Citation: Biomarker Research 2017 5:13

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  14. Content type: Research

    Cancer is a genetic disease; its development and metastasis depend on the function of many proteins. Human serum contains thousands of proteins; it is a window for the homeostasis of individual’s health. Many ...

    Authors: David L. Wang, Chuanguang Xiao, Guofeng Fu, Xing Wang and Liang Li

    Citation: Biomarker Research 2017 5:11

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  15. Content type: Research

    Urothelial bladder cancer (UBC) is a disease that often is discovered when the tumour is non-muscle invasive, i.e. in Ta or T1 stage. Some patients will progress into muscle-invasive disease, a potentially dea...

    Authors: Karolina Boman, Gustav Andersson, Christoffer Wennersten, Björn Nodin, Göran Ahlgren and Karin Jirström

    Citation: Biomarker Research 2017 5:10

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  16. Content type: Research

    Environmental Enteropathy (EE) is a subclinical condition caused by constant fecal-oral contamination and resulting in blunting of intestinal villi and intestinal inflammation. Of primary interest in the clini...

    Authors: Miao Lu, Jianhui Zhou, Caitlin Naylor, Beth D. Kirkpatrick, Rashidul Haque, William A. Petri Jr and Jennie Z. Ma

    Citation: Biomarker Research 2017 5:9

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  17. Content type: Research

    The aim of this study was to validate previously described diagnostic and prognostic microRNA expression profiles in tissue samples from patients with pancreatic cancer and other periampullary cancers.

    Authors: Dan Calatayud, Christian Dehlendorff, Mogens K. Boisen, Jane Preuss Hasselby, Nicolai Aagaard Schultz, Jens Werner, Heike Immervoll, Anders Molven, Carsten Palnæs Hansen and Julia S. Johansen

    Citation: Biomarker Research 2017 5:8

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  18. Content type: Case Report

    Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin lymphoma. Rhabdomyosarcoma, the most common soft tissue sarcoma of childhood. makes up less than 1% of solid malignancies in adults ...

    Authors: M. D. Mathias, M. V. Ortiz, H. Magnan, S. R. Ambati, E. K. Slotkin, A. J. Chou, M. F. Walsh, K. Offit, C. Moskowitz, A. Kentsis and L. H. Wexler

    Citation: Biomarker Research 2017 5:7

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  19. Content type: Review

    CD20 negative B cell non-Hodgkin lymphoma (NHL) is rare and accounts for approximately 1-2% of B cell lymphomas. CD20- negative NHL is frequently associated with extranodal involvement, atypical morphology, ag...

    Authors: Tasleem Katchi and Delong Liu

    Citation: Biomarker Research 2017 5:5

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  20. Content type: Review

    Synovial sarcoma (SS) is an aggressive soft tissue sarcoma (STS) that typically occurs in the extremities near a joint. Metastatic disease is common and usually occurs in the lungs and lymph nodes. Surgical ma...

    Authors: Rosalia de Necochea-Campion, Lee M. Zuckerman, Hamid R. Mirshahidi, Shahrzad Khosrowpour, Chien-Shing Chen and Saied Mirshahidi

    Citation: Biomarker Research 2017 5:4

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  21. Content type: Research

    Essential molecular pathways such as the MAPK pathway, NO system, or the influence of PIK3CA as an oncogene are known to regulate fundamental signalling networks. However, few knowledge about their role in the...

    Authors: Steffen Koerdt, Nadine Tanner, Niklas Rommel, Nils H. Rohleder, Gesche Frohwitter, Oliver Ristow, Klaus-Dietrich Wolff and Marco R. Kesting

    Citation: Biomarker Research 2017 5:3

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  22. Content type: Review

    DNA methylation plays an important role in gene expression, chromatin stability, and genetic imprinting. In mammals, DNA methylation patterns are written and regulated by DNA methyltransferases (DNMTs), includ...

    Authors: Wu Zhang and Jie Xu

    Citation: Biomarker Research 2017 5:1

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  23. Content type: Methodology

    Glucocorticoids (GCs) remain the first line treatment for almost all non-infectious inflammatory diseases, ranging from acute asthma to rheumatoid arthritis. However, across all conditions, patients have a var...

    Authors: Emily L. Williams, Madeleine L. Stimpson, Peter L. Collins, Doyo G. Enki, Ashish Sinha, Richard W. Lee and Ashwin D. Dhanda

    Citation: Biomarker Research 2016 4:26

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  24. Content type: Review

    There is an urgent need for new anti-malaria drugs with broad therapeutic potential and novel mode of action, for effective treatment and to overcome emerging drug resistance. Plant-derived anti-malarials rema...

    Authors: Protus Arrey Tarkang, Regina Appiah-Opong, Michael F. Ofori, Lawrence S. Ayong and Alexander K. Nyarko

    Citation: Biomarker Research 2016 4:25

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  25. Content type: Methodology

    Mild cognitive impairment (MCI) is an intermediate state between normal aging and dementia including Alzheimer’s disease. Early detection of dementia, and MCI, is a crucial issue in terms of secondary preventi...

    Authors: Mitsunori Kayano, Sayuri Higaki, Jun-ichi Satoh, Kenji Matsumoto, Etsuro Matsubara, Osamu Takikawa and Shumpei Niida

    Citation: Biomarker Research 2016 4:22

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  26. Content type: Review

    It is crucial to develop new antischistosomal drugs since there is no vaccine and the whole world is relying on only a single drug for the treatment of schistosomiasis. One of the obstacles to the development ...

    Authors: Emmanuel Mouafo Tekwu, William Kofi Anyan, Daniel Boamah, Kofi Owusu Baffour-Awuah, Stephanie Keyetat Tekwu, Veronique Penlap Beng, Alexander Kwadwo Nyarko and Kwabena Mante Bosompem

    Citation: Biomarker Research 2016 4:21

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  27. Content type: Review

    Pancreatic cancer is characterized as a disease with low survival and high mortality because of no effective diagnostic and therapeutic strategies available in clinic. Conventional clinical diagnostic methods ...

    Authors: Jing Huang, Jianzhou Liu, Kevin Chen-Xiao, Xuemei Zhang, W. N. Paul Lee, Vay Liang W. Go and Gary Guishan Xiao

    Citation: Biomarker Research 2016 4:20

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  28. Content type: Case report

    Population studies showed that patients with JAK2 V617F mutation had increased mortality, and increased risk of any cancer, hematologic cancer, and myeloproliferative disease.

    Authors: Kenneth G. Liu, Amit Verma, Olga Derman, Noah Kornblum, Murali Janakiram, Ira Braunschweig and Ramakrishna Battini

    Citation: Biomarker Research 2016 4:19

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  29. Content type: Case report

    Bone marrow sarcoidosis is extremely rare. The association between sarcoidosis and lymphoproliferative disorders has been previously speculated, although the diagnosis of sarcoidosis often precedes any hematol...

    Authors: John Gubatan, Xiaohui Wang, Abner Louissaint, Anuj Mahindra and John Vanderpool

    Citation: Biomarker Research 2016 4:18

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  30. Content type: Case report

    Extramedullary hematopoeisis (EMH) can occur in various physiological and pathologic states. The spleen is the most common site of EMH.

    Authors: Tasleem Katchi, Krishna Kolandaivel, Pallavi Khattar, Taliya Farooq, Humayun Islam and Delong Liu

    Citation: Biomarker Research 2016 4:17

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  31. Content type: Short report

    Acute myeloid leukemia (AML) is commonly characterized by several chromosomal abnormalities resulting in the formation of chimeric genes that play various roles in leukemogenesis. Translocations resulting in the

    Authors: Carlos A. Tirado, Ken Siangchin, David S. Shabsovich, Maryam Sharifian and Gary Schiller

    Citation: Biomarker Research 2016 4:16

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  32. Content type: Case report

    Chronic myeloid leukemia (CML) comprises ~3 % of pediatric leukemia. Although therapy with tyrosine kinase inhibitors (TKIs) is highly effective for CML, multiple factors have been identified as predictive of ...

    Authors: Margaret Lewen, Renee Gresh, Maria Queenan, Michele Paessler, Vinodh Pillai, Elizabeth Hexner, Dale Frank, Adam Bagg, Richard Aplenc, Emi Caywood and Gerald Wertheim

    Citation: Biomarker Research 2016 4:14

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  33. Content type: Research

    Oxaliplatin induced peripheral neurotoxicity (OXIPN) is the major dose-limiting and long-lasting side effect of oxaliplatin. N-3 PUFAs have neuroprotective property via their effects on voltage-gated ion chann...

    Authors: Ali Esfahani, Mohammad hossein Somi, Hormoz Ayromlou, Alireza Nikanfar, Mohammad Asghari Jafarabadi, Bina Eftekhar Sadat and Zohreh Ghoreishi

    Citation: Biomarker Research 2016 4:13

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  34. Content type: Research

    Diffuse large B-cell lymphoma (DLBCL) is an aggressive disease with variable clinical outcome, accounting for at least 25-30 % of adult non-Hodgkin lymphomas. Approximately one third of DLBCL patients are not ...

    Authors: Linn Reinholdt, Maria Bach Laursen, Alexander Schmitz, Julie Støve Bødker, Lasse Hjort Jakobsen, Martin Bøgsted, Hans Erik Johnsen and Karen Dybkær

    Citation: Biomarker Research 2016 4:12

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  35. Content type: Research

    Reprogrammed metabolism is a new hallmark of cancer. In many types of cancer, most of the genes in the glycolytic pathway are overexpressed, reflecting an essential shift of metabolism during cancer developmen...

    Authors: Zhenyu Sun, Xiaofeng Chen, Gan. Wang, Liang Li, Guofeng Fu, Matthew Kuruc and Xing Wang

    Citation: Biomarker Research 2016 4:11

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  36. Content type: Research

    There is an increasing amount of reports on IFITM1 (interferon-inducible transmembrane protein 1) in various malignancies. The aim of this study was to examine the expression of IFITM1 and its prognostic signi...

    Authors: David Borg, Charlotta Hedner, Alexander Gaber, Björn Nodin, Richard Fristedt, Karin Jirström, Jakob Eberhard and Anders Johnsson

    Citation: Biomarker Research 2016 4:10

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  37. Content type: Short report

    Disruption of alternative splicing in apoptotic factors has been associated to chronic lymphocytic leukemia among other cancers and hematological malignancies. The proapoptotic proteins Caspase-9 and PP2Acα ar...

    Authors: Leticia Domínguez-Berrocal, Xiguang Zhang, Jean Marc Zini, Jesús Fominaya, Angelita Rebollo and Jerónimo Bravo

    Citation: Biomarker Research 2016 4:9

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  38. Content type: Research

    HER2 expression in breast cancer correlates with increased metastatic potential, higher tumor recurrence rates and improved response to targeted therapies. Fluorescence in situ hybridization (FISH) and immunohist...

    Authors: Elisabeth Hofmann, Rita Seeboeck, Nico Jacobi, Peter Obrist, Samuel Huter, Christian Klein, Kamil Oender, Christoph Wiesner, Harald Hundsberger and Andreas Eger

    Citation: Biomarker Research 2016 4:8

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  39. Content type: Case report

    Patients with common variable immunodeficiency (CVID) have an increased risk of developing lymphoproliferative diseases, including non-Hodgkins lymphoma (Blood 116:1228–1234, 2010; Blood 119:1650–7, 2012). The...

    Authors: Efren Rael, Kevin Rakszawski, Kristian Koller, Michael Bayerl, Manish Butte and Hong Zheng

    Citation: Biomarker Research 2016 4:7

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