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  1. Well-differentiated neuroendocrine tumors (NET) most frequently arise from the gastrointestinal tract (GI), pancreas, and lung. Patients often present as metastasis with an unknown primary, and the clinical ma...

    Authors: Michelle X. Yang, Ryan F. Coates, Abiy Ambaye, Valerie Cortright, Jeannette M. Mitchell, Alexa M. Buskey, Richard Zubarik, James G. Liu, Steven Ades and Maura M. Barry

    Citation: Biomarker Research 2018 6:15

    Content type: Research

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  2. Inhaled allergen challenges are often used to evaluate novel asthma treatments in early phase clinical trials. Current novel therapeutic targets in asthma include phosphoinositide 3-kinases (PI3K) delta and ga...

    Authors: Thomas Southworth, Sarah Mason, Alan Bell, Isabel Ramis, Marta Calbet, Anna Domenech, Neus Prats, Montserrat Miralpeix and Dave Singh

    Citation: Biomarker Research 2018 6:14

    Content type: Research

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  3. GATA2 deficiency presents with a spectrum of phenotypes including increased susceptibility to viral and bacterial infections, multi-lineage cytopenias, aplastic anemia, leukemic transformation and lymphedema. ...

    Authors: Allen Sanyi, David L. Jaye, Cecilia B. Rosand, Amanda Box, Chandrakasan Shanmuganathan and Edmund K. Waller

    Citation: Biomarker Research 2018 6:13

    Content type: Case report

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  4. Biomarkers promise biomolecular explanations as well as reliable diagnostics, stratification, and treatment strategies that have the potential to help mitigate the effects of disorders. While no reliable bioma...

    Authors: Daniel P. Howsmon, James B. Adams, Uwe Kruger, Elizabeth Geis, Eva Gehn and Juergen Hahn

    Citation: Biomarker Research 2018 6:12

    Content type: Short report

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  5. Yin Yang 1 (YY1) is a transcription factor that plays an important role during all stages of B cell differentiation. Several studies reported upregulation of YY1 in B cell derived lymphoma, indicating that it ...

    Authors: Jéssica Arribas Arranz, Dalia Nilufar Winter, Hans Günter Drexler and Sonja Eberth

    Citation: Biomarker Research 2018 6:11

    Content type: Research

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  6. Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase and a catalytic component of PRC2, catalyzes tri-methylation of histone H3 at Lys 27 (H3K27me3) to regulate gene expression through epigenetic ma...

    Authors: Lu Gan, Yanan Yang, Qian Li, Yi Feng, Tianshu Liu and Weijian Guo

    Citation: Biomarker Research 2018 6:10

    Content type: Review

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  7. The original article [1] contains an error in Fig. 3 whereby the trend lines denoting Low & High E-cadherin were mistakenly labelled the opposite way around.

    Authors: W. Goto, S. Kashiwagi, Y. Asano, K. Takada, K. Takahashi, T. Hatano, T. Takashima, S. Tomita, H. Motomura, M. Ohsawa, K. Hirakawa and M. Ohira

    Citation: Biomarker Research 2018 6:9

    Content type: Correction

    Published on:

    The original article was published in Biomarker Research 2017 5:19

  8. Sphingosine kinase (SphK) 2 has been implicated in the development of a range of cancers and inhibitors of this enzyme are currently in clinical trial. We have previously demonstrated a role for SphK2 in the d...

    Authors: Vicki Xie, Daochen Tong, Craig T. Wallington-Beddoe, Ken F. Bradstock and Linda J. Bendall

    Citation: Biomarker Research 2018 6:6

    Content type: Research

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  9. Alzheimer’s disease (AD) is a most common dementia in elderly people. Since AD symptoms resemble those of other neurodegenerative diseases, including idiopathic normal pressure hydrocephalus (iNPH), it is diff...

    Authors: Yuki Nagata, Akiyoshi Hirayama, Satsuki Ikeda, Aoi Shirahata, Futaba Shoji, Midori Maruyama, Mitsunori Kayano, Masahiko Bundo, Kotaro Hattori, Sumiko Yoshida, Yu-ichi Goto, Katsuya Urakami, Tomoyoshi Soga, Kouichi Ozaki and Shumpei Niida

    Citation: Biomarker Research 2018 6:5

    Content type: Research

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  10. Acute kidney injury (AKI) is a frequent complication of cardiac surgery. We sought prognostic combinations of postoperative biomarkers measured within 6 h of surgery, potentially in combination with cardiopulm...

    Authors: Allison Meisner, Kathleen F. Kerr, Heather Thiessen-Philbrook, Francis Perry Wilson, Amit X. Garg, Michael G. Shlipak, Peter Kavsak, Richard P. Whitlock, Steven G. Coca and Chirag R. Parikh

    Citation: Biomarker Research 2018 6:3

    Content type: Research

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  11. Platelets support cancer growth and spread making platelet proteins candidates in the search for biomarkers.

    Authors: Marta Lomnytska, Rui Pinto, Susanne Becker, Ulla Engström, Sonja Gustafsson, Christina Björklund, Markus Templin, Jan Bergstrand, Lei Xu, Jerker Widengren, Elisabeth Epstein, Bo Franzén and Gert Auer

    Citation: Biomarker Research 2018 6:2

    Content type: Research

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  12. Diagnosis of malaria in pregnancy is problematic due to the low sensitivity of conventional diagnostic tests (rapid diagnostic test and microscopy), which is exacerbated due to low peripheral parasite densitie...

    Authors: E. Ruizendaal, H. D. F. H. Schallig, J. Bradley, M. Traore-Coulibaly, P. Lompo, U. d’Alessandro, S. Scott, F. Njie, S. H. Zango, O. Sawadogo, M. D. de Jong, H. Tinto and P. F. Mens

    Citation: Biomarker Research 2017 5:34

    Content type: Research

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  13. Selective kinase and immune checkpoint inhibitors, and their combinations, have significantly improved the survival of patients with advanced metastatic melanoma. Not all patients will respond to treatment how...

    Authors: Su Yin Lim, Jenny H. Lee, Sarah J. Welsh, Seong Beom Ahn, Edmond Breen, Alamgir Khan, Matteo S. Carlino, Alexander M. Menzies, Richard F. Kefford, Richard A. Scolyer, Georgina V. Long and Helen Rizos

    Citation: Biomarker Research 2017 5:32

    Content type: Research

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  14. Quantitative proteomics allows for the discovery and functional investigation of blood-based pre-diagnostic biomarkers for early cancer detection. However, a major limitation of proteomic investigations in bio...

    Authors: Christine Y. Yeh, Ravali Adusumilli, Majlinda Kullolli, Parag Mallick, Esther M. John and Sharon J. Pitteri

    Citation: Biomarker Research 2017 5:30

    Content type: Research

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  15. Monomeric laminin-γ2 in urine is a potential biomarker for bladder cancer. However, the current detection system uses an antibody that cannot discriminate between monomeric laminin-γ2 and the heterotrimeric γ2...

    Authors: Masatoshi Nakagawa, Takashi Karashima, Masayuki Kamada, Eisaku Yoshida, Toru Yoshimura, Masanori Nojima, Keiji Inoue, Taro Shuin, Motoharu Seiki and Naohiko Koshikawa

    Citation: Biomarker Research 2017 5:29

    Content type: Research

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  16. Because soluble (or secreted) amyloid precursor protein-β (sAPPβ) and -α (sAPPα) possibly reflect pathological features of Alzheimer’s disease (AD), they are potential biomarker candidates for dementia disorde...

    Authors: Wataru Araki, Kotaro Hattori, Kazutomi Kanemaru, Yuma Yokoi, Yoshie Omachi, Harumasa Takano, Masuhiro Sakata, Sumiko Yoshida, Tadashi Tsukamoto, Miho Murata, Yuko Saito, Hiroshi Kunugi, Yu-ichi Goto, Utako Nagaoka, Masahiro Nagao, Takashi Komori…

    Citation: Biomarker Research 2017 5:28

    Content type: Research

    Published on:

  17. The pattern of serotonin transporter clustering on the plasma membrane of lymphocytes extracted from human whole blood samples has been identified as a putative biomarker of therapeutic efficacy in major depre...

    Authors: Raquel Romay-Tallon, Tania Rivera-Baltanas, Josh Allen, Jose M. Olivares, Lisa E. Kalynchuk and Hector J. Caruncho

    Citation: Biomarker Research 2017 5:27

    Content type: Methodology

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  18. The purpose of this study was to investigate the potential of cerebrospinal fluid miRNAs as diagnostic biomarkers of acute ischemic stroke using three different profiling techniques in order to identify and by...

    Authors: Sofie Sølvsten Sørensen, Ann-Britt Nygaard, Anting Liu Carlsen, Niels H. H. Heegaard, Mads Bak and Thomas Christensen

    Citation: Biomarker Research 2017 5:24

    Content type: Research

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  19. Because the prevalence of antibiotic resistance markedly increases with time worldwide, anti-H. pylori treatment is continuing to be a great challenge forsphysicians in clinical practice. The Real-world Practice ...

    Authors: Chih-Chieh Huang, Kuo-Wang Tsai, Tzung-Jiun Tsai and Ping-I Hsu

    Citation: Biomarker Research 2017 5:23

    Content type: Review

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  20. Chimeric antigen receptor redirected T cells (CAR-T cells) have achieved inspiring outcomes in patients with B cell malignancies, and are now being investigated in other hematologic malignancies and solid tumo...

    Authors: Cheng Zhang, Jun Liu, Jiang F. Zhong and Xi Zhang

    Citation: Biomarker Research 2017 5:22

    Content type: Review

    Published on:

  21. Breast cancer, the most commonly diagnosed cancer among women and leading cause of cancer-related deaths worldwide, exhibits aggressive behavior in indigenous African women evidenced by high histologic grade t...

    Authors: Benjamin Arko-Boham, Justice Tanihu Lomotey, Emmanuel Nomo Tetteh, Emmanuel Ayitey Tagoe, Nii Ayite Aryee, Ewurama Ampadu Owusu, Isaac Okai, Richard Michael Blay and Joe-Nat Clegg-Lamptey

    Citation: Biomarker Research 2017 5:21

    Content type: Research

    Published on:

  22. Analysis of databases from the human genome project (HGP), the 1000 Genomes Project (1KGP), and The Cancer Genome Atlas (TCGA) revealed bacterial DNA integration into the human somatic genome, particularly in ...

    Authors: Saveen Sidhoo, Jesusa L. Rosales and Ki-Young Lee

    Citation: Biomarker Research 2017 5:20

    Content type: Letter to the Editor

    Published on:

  23. Circulating tumor cells (CTCs) are linked to metastatic relapse and are regarded as a prognostic marker for human cancer. High expression of plakoglobin, a cell adhesion protein, within the primary tumor is po...

    Authors: Wataru Goto, Shinichiro Kashiwagi, Yuka Asano, Koji Takada, Katsuyuki Takahashi, Takaharu Hatano, Tsutomu Takashima, Shuhei Tomita, Hisashi Motomura, Masahiko Ohsawa, Kosei Hirakawa and Masaichi Ohira

    Citation: Biomarker Research 2017 5:19

    Content type: Research

    Published on:

    The Correction to this article has been published in Biomarker Research 2018 6:9

  24. Alternate BRAF splicing is the most common mechanism of acquired resistance to BRAF inhibitor treatment in melanoma. Recently, alternate BRAF exon 4–8 splicing was shown to involve an intronic mutation, locate...

    Authors: Gulietta M. Pupo, Suzanah C. Boyd, Carina Fung, Matteo S. Carlino, Alexander M. Menzies, Bernadette Pedersen, Peter Johansson, Nicholas K. Hayward, Richard F. Kefford, Richard A. Scolyer, Georgina V. Long and Helen Rizos

    Citation: Biomarker Research 2017 5:17

    Content type: Short report

    Published on:

  25. Babesiosis is endemic in selected areas in North America. Babesia infection is commonly associated with anemia, thrombocytopenia, hyponatremia and elevated liver enzymes. Autoimmune hemolytic anemia (AIHA) is ...

    Authors: Roshni Narurkar, Aleksandra Mamorska-Dyga, John C. Nelson and Delong Liu

    Citation: Biomarker Research 2017 5:14

    Content type: Case report

    Published on:

  26. Low albumin levels and low lymphocyte counts are intra hospital conditions that exert a negative influence on prognosis, healing and length of hospitalization. The study aimed to analyze the correlation betwee...

    Authors: Antonio E. Pontiroli, Lara Loreggian, Marco P. L. Rovati, Elena De Patto, Laura Folini, Federico Raveglia, Matilde De Simone, Alessandro Baisi and Ugo Cioffi

    Citation: Biomarker Research 2017 5:13

    Content type: Case series

    Published on:

  27. Cancer is a genetic disease; its development and metastasis depend on the function of many proteins. Human serum contains thousands of proteins; it is a window for the homeostasis of individual’s health. Many ...

    Authors: David L. Wang, Chuanguang Xiao, Guofeng Fu, Xing Wang and Liang Li

    Citation: Biomarker Research 2017 5:11

    Content type: Research

    Published on:

  28. Urothelial bladder cancer (UBC) is a disease that often is discovered when the tumour is non-muscle invasive, i.e. in Ta or T1 stage. Some patients will progress into muscle-invasive disease, a potentially dea...

    Authors: Karolina Boman, Gustav Andersson, Christoffer Wennersten, Björn Nodin, Göran Ahlgren and Karin Jirström

    Citation: Biomarker Research 2017 5:10

    Content type: Research

    Published on:

  29. Environmental Enteropathy (EE) is a subclinical condition caused by constant fecal-oral contamination and resulting in blunting of intestinal villi and intestinal inflammation. Of primary interest in the clini...

    Authors: Miao Lu, Jianhui Zhou, Caitlin Naylor, Beth D. Kirkpatrick, Rashidul Haque, William A. Petri Jr and Jennie Z. Ma

    Citation: Biomarker Research 2017 5:9

    Content type: Research

    Published on:

  30. The aim of this study was to validate previously described diagnostic and prognostic microRNA expression profiles in tissue samples from patients with pancreatic cancer and other periampullary cancers.

    Authors: Dan Calatayud, Christian Dehlendorff, Mogens K. Boisen, Jane Preuss Hasselby, Nicolai Aagaard Schultz, Jens Werner, Heike Immervoll, Anders Molven, Carsten Palnæs Hansen and Julia S. Johansen

    Citation: Biomarker Research 2017 5:8

    Content type: Research

    Published on:

  31. Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin lymphoma. Rhabdomyosarcoma, the most common soft tissue sarcoma of childhood. makes up less than 1% of solid malignancies in adults ...

    Authors: M. D. Mathias, M. V. Ortiz, H. Magnan, S. R. Ambati, E. K. Slotkin, A. J. Chou, M. F. Walsh, K. Offit, C. Moskowitz, A. Kentsis and L. H. Wexler

    Citation: Biomarker Research 2017 5:7

    Content type: Case Report

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  32. CD20 negative B cell non-Hodgkin lymphoma (NHL) is rare and accounts for approximately 1-2% of B cell lymphomas. CD20- negative NHL is frequently associated with extranodal involvement, atypical morphology, ag...

    Authors: Tasleem Katchi and Delong Liu

    Citation: Biomarker Research 2017 5:5

    Content type: Review

    Published on:

  33. Synovial sarcoma (SS) is an aggressive soft tissue sarcoma (STS) that typically occurs in the extremities near a joint. Metastatic disease is common and usually occurs in the lungs and lymph nodes. Surgical ma...

    Authors: Rosalia de Necochea-Campion, Lee M. Zuckerman, Hamid R. Mirshahidi, Shahrzad Khosrowpour, Chien-Shing Chen and Saied Mirshahidi

    Citation: Biomarker Research 2017 5:4

    Content type: Review

    Published on:

  34. Essential molecular pathways such as the MAPK pathway, NO system, or the influence of PIK3CA as an oncogene are known to regulate fundamental signalling networks. However, few knowledge about their role in the...

    Authors: Steffen Koerdt, Nadine Tanner, Niklas Rommel, Nils H. Rohleder, Gesche Frohwitter, Oliver Ristow, Klaus-Dietrich Wolff and Marco R. Kesting

    Citation: Biomarker Research 2017 5:3

    Content type: Research

    Published on:

  35. DNA methylation plays an important role in gene expression, chromatin stability, and genetic imprinting. In mammals, DNA methylation patterns are written and regulated by DNA methyltransferases (DNMTs), includ...

    Authors: Wu Zhang and Jie Xu

    Citation: Biomarker Research 2017 5:1

    Content type: Review

    Published on:

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