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  2. Extensive studies of the genetic aberrations related to human diseases conducted over the last two decades have identified recurrent genomic abnormalities as potential driving factors underlying a variety of c...

    Authors: Linping Hu, Kun Ru, Li Zhang, Yuting Huang, Xiaofan Zhu, Hanzhi Liu, Anders Zetterberg, Tao Cheng and Weimin Miao
    Citation: Biomarker Research 2014 2:3
    Content type: Review Published on:

  3. We applied our new method, maturity-dependent fractionation of bone marrow-derived neutrophil progenitors, to a study of gene expression profiles during granulopoiesis in myelodysplastic syndromes. CD34+ cells wi...

    Authors: Huiyuan Hu, Yayoi Shikama, Tsutomu Shichishima, Kazuhiko Ikeda, Kazuko Akutsu, Tomoyuki Ono, Hideo Kimura, Kazuei Ogawa, Hideyoshi Noji, Yasuchika Takeishi and Junko Kimura
    Citation: Biomarker Research 2014 2:2
    Content type: Letter to the Editor Published on:

  4. Monocytes express various receptors, which monitor and sense environmental changes. Monocytes are highly plastic and heterogeneous, and change their functional phenotype in response to environmental stimulatio...

    Authors: Jiyeon Yang, Lixiao Zhang, Caijia Yu, Xiao-Feng Yang and Hong Wang
    Citation: Biomarker Research 2014 2:1
    Content type: Review Published on:

  5. Natural killer cells comprise the body’s first line of defense against virus-infected cells. As is true of all lymphocytes, natural killer cell malignancies can develop, however natural killer cell leukemias c...

    Authors: Jon Crosbie, Marc Magnussen, Ryan Dornbier, Alexandra Iannone and Timothy A Steele
    Citation: Biomarker Research 2013 1:33
    Content type: Research Published on:

  6. Although palliative chemotherapy has been shown to prolong survival and improve quality of life, the survival of advanced gastric cancer (AGC) patients remains poor. With the advent of targeted therapy, many m...

    Authors: Miao-zhen Qiu and Rui-hua Xu
    Citation: Biomarker Research 2013 1:32
    Content type: Review Published on:

  7. B-cell acute lymphoblastic leukemia (B-ALL) is the most common malignancy in pediatric patients and the leading cause of cancer-related death in children and young adults. Translocations of 9p24 involving JAK2 (9...

    Authors: Carlos A Tirado, David Shabsovich, Matthew DeNicola, Dinesh Rao, Lynn Yang, Rolando Garcia and Nagesh Rao
    Citation: Biomarker Research 2013 1:31
    Content type: Short report Published on:

  9. Glioblastoma Multiforme (GBM) is the most common primary malignant tumor of the central nervous system. Standard of care includes maximal resection followed by chemoradiotherapy. Tumors need adequate perfusion...

    Authors: Andra V Krauze, Minhee Won, Christian Graves, Ben W Corn, Thierry M Muanza, Steven P Howard, Arul Mahadevan, Christopher J Schultz, Michael L Haas, Minesh P Mehta and Kevin A Camphausen
    Citation: Biomarker Research 2013 1:29
    Content type: Research Published on:

  10. Huntington Disease (HD) is a progressive neurological disorder, with pathological manifestations in brain areas and in periphery caused by the ubiquitous expression of mutant Huntingtin protein. Transcriptiona...

    Authors: Daniela Diamanti, Elisa Mori, Danny Incarnato, Federico Malusa, Costanza Fondelli, Letizia Magnoni and Giuseppe Pollio
    Citation: Biomarker Research 2013 1:28
    Content type: Short report Published on:

  12. A higher concentration of high density lipoprotein cholesterol (HDL-C) in ex-smokers than smokers has consistently been observed. Better evidence of quitting effects comes from within-subject changes. We exten...

    Authors: Barbara A Forey, John S Fry, Peter N Lee, Alison J Thornton and Katharine J Coombs
    Citation: Biomarker Research 2013 1:26
    Content type: Review Published on:

  13. Carbohydrate antigen 125 (CA-125), traditionally a tumor marker for screening, diagnosis, and monitoring in ovarian malignancy, had recently been shown increasing evidence and more extensively recognized/explo...

    Authors: Chung-Lieh Hung, Ta-Chuan Hung, Yau-Hui Lai, Chi-Sheng Lu, Yih-Jer Wu and Hung-I Yeh
    Citation: Biomarker Research 2013 1:25
    Content type: Review Published on:

  16. The Cancer Testis Antigens (CTAs) are a group of genes that are highly expressed in the normal testis and several types of cancer. Due to their restricted expression in normal adult tissues, CTAs have been att...

    Authors: John J Kim, Krithika Rajagopalan, Basil Hussain, Brenten H Williams, Prakash Kulkarni and Steven M Mooney
    Citation: Biomarker Research 2013 1:22
    Content type: Research Published on:

  18. Toll-like receptor 4 (TLR4) and its co-receptor CD14 play a major role in innate immunity by recognizing PAMPs and signal the activation of adaptive responses. These receptors can recognize endogenous ligands ...

    Authors: Tarak Dhaouadi, Imen Sfar, Youssra Haouami, Leila Abdelmoula, Sami Turki, Lamia Ben Hassine, Rafik Zouari, Adel Khedher, Narjess Khalfallah, Taieb Ben Abdallah and Yousr Gorgi
    Citation: Biomarker Research 2013 1:20
    Content type: Research Published on:

  19. Accumulated data from previous studies appear to suggest a link between the overexpression of a 35 kDa fragment of serum inter-alpha-trypsin inhibitor H4 (ITIH4) with cancers that are associated with up-regula...

    Authors: Emida Mohamed, Jaime Jacqueline Jayapalan, Puteri Shafinaz Abdul-Rahman, Siti Zawiah Omar and Onn Haji Hashim
    Citation: Biomarker Research 2013 1:19
    Content type: Research Published on:

  20. Nipple aspirate fluid (NAF) contains large amounts of protein thought to reflect the microenvironment of the breast, and is of interest in breast cancer prevention research. The correlation between specific NA...

    Authors: Jessica A Miller, Patricia A Thompson, Iman A Hakim, Ana Maria Lopez, Cynthia A Thomson, Chiu-Hsieh Hsu and H-H Sherry Chow
    Citation: Biomarker Research 2013 1:18
    Content type: Short report Published on:

  21. Insulin resistance associated with type 2 diabetes mellitus (T2DM), obesity, and atherosclerosis is a global health problem. A portfolio of abnormalities of metabolic and vascular homeostasis accompanies T2DM ...

    Authors: Fuyong Du, Anthony Virtue, Hong Wang and Xiao-Feng Yang
    Citation: Biomarker Research 2013 1:17
    Content type: Review Published on:

  22. Colorectal cancer remains one of the leading causes of death from cancer in industrialized countries. Integrins are a family of heterodimeric glycoproteins involved in bidirectional cell signaling and particip...

    Authors: Salah Boudjadi, Julie C Carrier and Jean-François Beaulieu
    Citation: Biomarker Research 2013 1:16
    Content type: Research Published on:

  24. The cyclin-dependent kinase inhibitor p27Kip1 functions during normal cerebellar development and has demonstrated tumor suppressor functions in mouse models of medulloblastoma. Because P27 loss is associated with...

    Authors: Beryl A Hatton, David W Ellison, Amar Gajjar, Marcel Kool, Matthew Fero and James M Olson
    Citation: Biomarker Research 2013 1:14
    Content type: Short report Published on:

  26. Endometrial cancer (EC) is the leading malignant tumor occurring in the female genital tract and some subtypes are highly invasive and metastatic. miRNAs are small non-coding RNAs that have a broad impact on c...

    Authors: Haiyan Zhai, Mihriban Karaayvaz, Peixin Dong, Noriaki Sakuragi and Jingfang Ju
    Citation: Biomarker Research 2013 1:12
    Content type: Research Published on:

  27. IK is a nuclear protein containing a unique domain named RED due to the presence of a repetitive arginine (R), aspartic (E), and glutamic acid (D) sequence. To date, the function of this protein remains largel...

    Authors: Liyan Hu, Feikun Yang, Xianan Liu, Dazhong Xu and Wei Dai
    Citation: Biomarker Research 2013 1:11
    Content type: Research Published on:

  29. Diabetic kidney disease is the leading cause of end-stage renal disease in developed and developing countries. Microalbuminuria is the gold standard for detection and prediction of diabetic kidney disease and ...

    Authors: Cheng Wang, CuiCui Li, WenYu Gong and Tanqi Lou
    Citation: Biomarker Research 2013 1:9
    Content type: Review Published on:

  32. Metabolic alteration is one of the hallmarks of carcinogenesis. We aimed to identify certain metabolic biomarkers for the early detection of pancreatic cancer (PC) using the transgenic PTEN-null mouse model. P...

    Authors: He N Xu, Shoko Nioka and Lin Z Li
    Citation: Biomarker Research 2013 1:6
    Content type: Research Published on:

  34. Despite several decades of intensive effort to improve the imaging techniques for lung cancer diagnosis and treatment, primary lung cancer is still the number one cause of cancer death in the United States and...

    Authors: Dong Xiang, Bicheng Zhang, Donald Doll, Kui Shen, Goetz Kloecker and Carl Freter
    Citation: Biomarker Research 2013 1:4
    Content type: Review Published on:
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