Goodacre R: Metabolic profiling: pathways in discovery. Drug Discov Today 2004, 9: 260–261. 10.1016/S1359-6446(04)03027-2
Article
PubMed
Google Scholar
Goodacre R, Vaidyanathan S, Dunn WB, Harrigan GG, Kell DB: Metabolomics by numbers: acquiring and understanding global metabolite data. Trends Biotechnol 2004, 22: 245–252. 10.1016/j.tibtech.2004.03.007
Article
CAS
PubMed
Google Scholar
Oliver SG, Winson MK, Kell DB, Baganz F: Systematic functional analysis of the yeast genome. Trends Biotechnol 1998, 16: 373–378. 10.1016/S0167-7799(98)01214-1
Article
CAS
PubMed
Google Scholar
Scarfe GB, Wright B, Clayton E, Taylor S, Wilson ID, Lindon JC, Nicholson JK: 19 F-NMR and directly coupled HPLC-NMR-MS investigations into the metabolism of 2-bromo-4-trifluoromethylaniline in rat: a urinary excretion balance study without the use of radiolabelling. Xenobiotica 1998, 28: 373–388. 10.1080/004982598239489
Article
CAS
PubMed
Google Scholar
Lindon JC, Holmes E, Nicholson JK: So what’s the deal with metabonomics? Anal Chem 2003, 75: 384A-391A.
Article
CAS
PubMed
Google Scholar
Roberts LD, Souza AL, Gerszten RE, Clish CB: Targeted metabolomics. Curr Protoc Mol Biol 2012., Chapter 30: Unit 30 32 31–24
Google Scholar
Wang C, Kong H, Guan Y, Yang J, Gu J, Yang S, Xu G: Plasma phospholipid metabolic profiling and biomarkers of type 2 diabetes mellitus based on high-performance liquid chromatography/electrospray mass spectrometry and multivariate statistical analysis. Anal Chem 2005, 77: 4108–4116. 10.1021/ac0481001
Article
CAS
PubMed
Google Scholar
Festa A, Williams K, Hanley AJ, Otvos JD, Goff DC, Wagenknecht LE, Haffner SM: Nuclear magnetic resonance lipoprotein abnormalities in prediabetic subjects in the insulin resistance atherosclerosis study. Circulation 2005, 111: 3465–3472. 10.1161/CIRCULATIONAHA.104.512079
Article
PubMed
Google Scholar
Roberts LD, Murray AJ, Menassa D, Ashmore T, Nicholls AW, Griffin JL: The contrasting roles of PPARdelta and PPARgamma in regulating the metabolic switch between oxidation and storage of fats in white adipose tissue. Genome Biol 2011,12(8):R75. 10.1186/gb-2011-12-8-r75
Article
CAS
PubMed Central
PubMed
Google Scholar
An J, Muoio DM, Shiota M, Fujimoto Y, Cline GW, Shulman GI, Koves TR, Stevens R, Millington D, Newgard CB: Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance. Nat Med 2004, 10: 268–274. 10.1038/nm995
Article
CAS
PubMed
Google Scholar
Wakelam MJ, Pettitt TR, Postle AD: Lipidomic analysis of signaling pathways. Methods Enzymol 2007, 432: 233–246.
Article
CAS
PubMed
Google Scholar
Newgard CB, An J, Bain JR, Muehlbauer MJ, Stevens RD, Lien LF, Haqq AM, Shah SH, Arlotto M, Slentz CA: A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab 2009, 9: 311–326. 10.1016/j.cmet.2009.02.002
Article
CAS
PubMed Central
PubMed
Google Scholar
Psychogios N, Hau DD, Peng J, Guo AC, Mandal R, Bouatra S, Sinelnikov I, Krishnamurthy R, Eisner R, Gautam B: The human serum metabolome. PLoS One 2011, 6: e16957. 10.1371/journal.pone.0016957
Article
CAS
PubMed Central
PubMed
Google Scholar
Atherton HJ, Bailey NJ, Zhang W, Taylor J, Major H, Shockcor J, Clarke K, Griffin JL: A combined 1H-NMR spectroscopy- and mass spectrometry-based metabolomic study of the PPAR-alpha null mutant mouse defines profound systemic changes in metabolism linked to the metabolic syndrome. Physiol Genomics 2006, 27: 178–186. 10.1152/physiolgenomics.00060.2006
Article
CAS
PubMed
Google Scholar
Sabatine MS, Liu E, Morrow DA, Heller E, McCarroll R, Wiegand R, Berriz GF, Roth FP, Gerszten RE: Metabolomic identification of novel biomarkers of myocardial ischemia. Circulation 2005, 112: 3868–3875. 10.1161/CIRCULATIONAHA.105.569137
Article
CAS
PubMed
Google Scholar
Brindle JT, Antti H, Holmes E, Tranter G, Nicholson JK, Bethell HW, Clarke S, Schofield PM, McKilligin E, Mosedale DE, Grainger DJ: Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics. Nat Med 2002, 8: 1439–1444. 10.1038/nm1202-802
Article
CAS
PubMed
Google Scholar
Brindle JT, Nicholson JK, Schofield PM, Grainger DJ, Holmes E: Application of chemometrics to 1H NMR spectroscopic data to investigate a relationship between human serum metabolic profiles and hypertension. Analyst 2003, 128: 32–36. 10.1039/b209155k
Article
CAS
PubMed
Google Scholar
Kirschenlohr HL, Griffin JL, Clarke SC, Rhydwen R, Grace AA, Schofield PM, Brindle KM, Metcalfe JC: Proton NMR analysis of plasma is a weak predictor of coronary artery disease. Nat Med 2006, 12: 705–710. 10.1038/nm1432
Article
CAS
PubMed
Google Scholar
Martinez-Pinna R, Barbas C, Blanco-Colio LM, Tunon J, Ramos-Mozo P, Lopez JA, Meilhac O, Michel JB, Egido J, Martin-Ventura JL: Proteomic and metabolomic profiles in atherothrombotic vascular disease. Curr Atheroscler Rep 2010, 12: 202–208. 10.1007/s11883-010-0102-y
Article
CAS
PubMed
Google Scholar
Teul J, Ruperez FJ, Garcia A, Vaysse J, Balayssac S, Gilard V, Malet-Martino M, Martin-Ventura JL, Blanco-Colio LM, Tunon J: Improving metabolite knowledge in stable atherosclerosis patients by association and correlation of GC-MS and 1H NMR fingerprints. J Proteome Res 2009, 8: 5580–5589. 10.1021/pr900668v
Article
CAS
PubMed
Google Scholar
Clish CB, Davidov E, Oresic M, Plasterer TN, Lavine G, Londo T, Meys M, Snell P, Stochaj W, Adourian A: Integrative biological analysis of the APOE*3-leiden transgenic mouse. OMICS 2004, 8: 3–13. 10.1089/153623104773547453
Article
CAS
PubMed
Google Scholar
Mayr M, Chung YL, Mayr U, Yin X, Ly L, Troy H, Fredericks S, Hu Y, Griffiths JR, Xu Q: Proteomic and metabolomic analyses of atherosclerotic vessels from apolipoprotein E-deficient mice reveal alterations in inflammation, oxidative stress, and energy metabolism. Arterioscler Thromb Vasc Biol 2005, 25: 2135–2142. 10.1161/01.ATV.0000183928.25844.f6
Article
CAS
PubMed
Google Scholar
Mayr U, Mayr M, Yin X, Begum S, Tarelli E, Wait R, Xu Q: Proteomic dataset of mouse aortic smooth muscle cells. Proteomics 2005, 5: 4546–4557. 10.1002/pmic.200402045
Article
CAS
PubMed
Google Scholar
Kleemann R, Verschuren L, van Erk MJ, Nikolsky Y, Cnubben NH, Verheij ER, Smilde AK, Hendriks HF, Zadelaar S, Smith GJ: Atherosclerosis and liver inflammation induced by increased dietary cholesterol intake: a combined transcriptomics and metabolomics analysis. Genome Biol 2007, 8: R200. 10.1186/gb-2007-8-9-r200
Article
PubMed Central
PubMed
CAS
Google Scholar
Leo GC, Darrow AL: NMR-based metabolomics of urine for the atherosclerotic mouse model using apolipoprotein-E deficient mice. Magn Reson Chem 2009,47(Suppl 1):S20–25.
Article
CAS
PubMed Central
PubMed
Google Scholar
Zhang F, Jia Z, Gao P, Kong H, Li X, Chen J, Yang Q, Yin P, Wang J, Lu X: Metabonomics study of atherosclerosis rats by ultra fast liquid chromatography coupled with ion trap-time of flight mass spectrometry. Talanta 2009, 79: 836–844. 10.1016/j.talanta.2009.05.010
Article
CAS
PubMed
Google Scholar
Shaham O, Wei R, Wang TJ, Ricciardi C, Lewis GD, Vasan RS, Carr SA, Thadhani R, Gerszten RE, Mootha VK: Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity. Mol Syst Biol 2008, 4: 214.
Article
PubMed Central
PubMed
CAS
Google Scholar
Lucio M, Fekete A, Weigert C, Wagele B, Zhao X, Chen J, Fritsche A, Haring HU, Schleicher ED, Xu G: Insulin sensitivity is reflected by characteristic metabolic fingerprints--a Fourier transform mass spectrometric non-targeted metabolomics approach. PLoS One 2010, 5: e13317. 10.1371/journal.pone.0013317
Article
PubMed Central
PubMed
CAS
Google Scholar
Lanza IR, Zhang S, Ward LE, Karakelides H, Raftery D, Nair KS: Quantitative metabolomics by H-NMR and LC-MS/MS confirms altered metabolic pathways in diabetes. PLoS One 2010, 5: e10538. 10.1371/journal.pone.0010538
Article
PubMed Central
PubMed
CAS
Google Scholar
Zhao X, Fritsche J, Wang J, Chen J, Rittig K, Schmitt-Kopplin P, Fritsche A, Haring HU, Schleicher ED, Xu G, Lehmann R: Metabonomic fingerprints of fasting plasma and spot urine reveal human pre-diabetic metabolic traits. Metabolomics 2010, 6: 362–374. 10.1007/s11306-010-0203-1
Article
CAS
PubMed Central
PubMed
Google Scholar
Wang TJ, Larson MG, Vasan RS, Cheng S, Rhee EP, McCabe E, Lewis GD, Fox CS, Jacques PF, Fernandez C: Metabolite profiles and the risk of developing diabetes. Nat Med 2011, 17: 448–453. 10.1038/nm.2307
Article
PubMed Central
PubMed
CAS
Google Scholar
Han LD, Xia JF, Liang QL, Wang Y, Wang YM, Hu P, Li P, Luo GA: Plasma esterified and non-esterified fatty acids metabolic profiling using gas chromatography-mass spectrometry and its application in the study of diabetic mellitus and diabetic nephropathy. Anal Chim Acta 2011, 689: 85–91. 10.1016/j.aca.2011.01.034
Article
CAS
PubMed
Google Scholar
Bonzo JA, Patterson AD, Krausz KW, Gonzalez FJ: Metabolomics identifies novel Hnf1alpha-dependent physiological pathways in vivo. Mol Endocrinol 2010, 24: 2343–2355. 10.1210/me.2010-0130
Article
CAS
PubMed Central
PubMed
Google Scholar
Li LO, Hu YF, Wang L, Mitchell M, Berger A, Coleman RA: Early hepatic insulin resistance in mice: a metabolomics analysis. Mol Endocrinol 2010, 24: 657–666. 10.1210/me.2009-0152
Article
CAS
PubMed Central
PubMed
Google Scholar
Huang Q, Yin P, Wang J, Chen J, Kong H, Lu X, Xu G: Method for liver tissue metabolic profiling study and its application in type 2 diabetic rats based on ultra performance liquid chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2011, 879: 961–967. 10.1016/j.jchromb.2011.03.009
Article
CAS
PubMed
Google Scholar
Ugarte M, Brown M, Hollywood KA, Cooper GJ, Bishop PN, Dunn WB: Metabolomic analysis of rat serum in Streptozotocin-induced diabetes and after treatment with oral triethylenetetramine (TETA). Genome Med 2012, 4: 35. 10.1186/gm334
Article
CAS
PubMed Central
PubMed
Google Scholar
Ament Z, Masoodi M, Griffin JL: Applications of metabolomics for understanding the action of peroxisome proliferator-activated receptors (PPARs) in diabetes, obesity and cancer. Genome Med 2012, 4: 32. 10.1186/gm331
Article
CAS
PubMed Central
PubMed
Google Scholar
Kim JY, Park JY, Kim OY, Ham BM, Kim HJ, Kwon DY, Jang Y, Lee JH: Metabolic profiling of plasma in overweight/obese and lean men using ultra performance liquid chromatography and Q-TOF mass spectrometry (UPLC-Q-TOF MS). J Proteome Res 2010, 9: 4368–4375. 10.1021/pr100101p
Article
CAS
PubMed
Google Scholar
Mihalik SJ, Michaliszyn SF, de las Heras J, Bacha F, Lee S, Chace DH, De Jesus VR, Vockley J, Arslanian SA: Metabolomic profiling of fatty acid and amino acid metabolism in youth with obesity and type 2 diabetes: evidence for enhanced mitochondrial oxidation. Diabetes Care 2012, 35: 605–611. 10.2337/DC11-1577
Article
CAS
PubMed Central
PubMed
Google Scholar
Adams SH: Emerging perspectives on essential amino acid metabolism in obesity and the insulin-resistant state. Adv Nutr 2012, 2: 445–456.
Article
CAS
Google Scholar
Das UN: Essential fatty acids: biochemistry, physiology and pathology. Biotechnol J 2006, 1: 420–439. 10.1002/biot.200600012
Article
CAS
PubMed
Google Scholar
Shah SH, Hauser ER, Bain JR, Muehlbauer MJ, Haynes C, Stevens RD, Wenner BR, Dowdy ZE, Granger CB, Ginsburg GS: High heritability of metabolomic profiles in families burdened with premature cardiovascular disease. Mol Syst Biol 2009, 5: 258.
Article
PubMed Central
PubMed
Google Scholar
Zhao X, Peter A, Fritsche J, Elcnerova M, Fritsche A, Haring HU, Schleicher ED, Xu G, Lehmann R: Changes of the plasma metabolome during an oral glucose tolerance test: is there more than glucose to look at? Am J Physiol Endocrinol Metab 2009, 296: E384–393.
Article
CAS
PubMed
Google Scholar
Lefebvre P, Cariou B, Lien F, Kuipers F, Staels B: Role of bile acids and bile acid receptors in metabolic regulation. Physiol Rev 2009, 89: 147–191. 10.1152/physrev.00010.2008
Article
CAS
PubMed
Google Scholar
Creager MA, Cooke JP, Mendelsohn ME, Gallagher SJ, Coleman SM, Loscalzo J, Dzau VJ: Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. J Clin Invest 1990, 86: 228–234. 10.1172/JCI114688
Article
CAS
PubMed Central
PubMed
Google Scholar
Clapp BR, Hingorani AD, Kharbanda RK, Mohamed-Ali V, Stephens JW, Vallance P, MacAllister RJ: Inflammation-induced endothelial dysfunction involves reduced nitric oxide bioavailability and increased oxidant stress. Cardiovasc Res 2004, 64: 172–178. 10.1016/j.cardiores.2004.06.020
Article
CAS
PubMed
Google Scholar
Tanner FC, Meier P, Greutert H, Champion C, Nabel EG, Luscher TF: Nitric oxide modulates expression of cell cycle regulatory proteins: a cytostatic strategy for inhibition of human vascular smooth muscle cell proliferation. Circulation 2000, 101: 1982–1989. 10.1161/01.CIR.101.16.1982
Article
CAS
PubMed
Google Scholar
Monastyrskaya E, Folarin N, Malyshev I, Green C, Andreeva L: Application of the nitric oxide donor SNAP to cardiomyocytes in culture provides protection against oxidative stress. Nitric Oxide 2002, 7: 127–131. 10.1016/S1089-8603(02)00107-6
Article
CAS
PubMed
Google Scholar
Schafer A, Wiesmann F, Neubauer S, Eigenthaler M, Bauersachs J, Channon KM: Rapid regulation of platelet activation in vivo by nitric oxide. Circulation 2004, 109: 1819–1822. 10.1161/01.CIR.0000126837.88743.DD
Article
PubMed
CAS
Google Scholar
Schachinger V, Britten MB, Zeiher AM: Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation 2000, 101: 1899–1906. 10.1161/01.CIR.101.16.1899
Article
CAS
PubMed
Google Scholar
Bugiardini R, Manfrini O, Pizzi C, Fontana F, Morgagni G: Endothelial function predicts future development of coronary artery disease: a study of women with chest pain and normal coronary angiograms. Circulation 2004, 109: 2518–2523. 10.1161/01.CIR.0000128208.22378.E3
Article
PubMed
Google Scholar
Williams IL, Chowienczyk PJ, Wheatcroft SB, Patel AG, Sherwood RA, Momin A, Shah AM, Kearney MT: Endothelial function and weight loss in obese humans. Obes Surg 2005, 15: 1055–1060. 10.1381/0960892054621134
Article
PubMed
Google Scholar
Melikian N, Kearney MT, Thomas MR, De Bruyne B, Shah AM, MacCarthy PA: A simple thermodilution technique to assess coronary endothelium-dependent microvascular function in humans: validation and comparison with coronary flow reserve. Eur Heart J 2007, 28: 2188–2194. 10.1093/eurheartj/ehm269
Article
PubMed
Google Scholar
Momin A, Melikian N, Wheatcroft SB, Grieve D, John LC, El Gamel A, Marrinan MT, Desai JB, Driver C, Sherwood R: The association between saphenous vein endothelial function, systemic inflammation, and statin therapy in patients undergoing coronary artery bypass surgery. J Thorac Cardiovasc Surg 2007, 134: 335–341. 10.1016/j.jtcvs.2006.12.064
Article
CAS
PubMed
Google Scholar
Steinberg HO, Chaker H, Leaming R, Johnson A, Brechtel G, Baron AD: Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. J Clin Invest 1996, 97: 2601–2610. 10.1172/JCI118709
Article
CAS
PubMed Central
PubMed
Google Scholar
Laine H, Yki-Jarvinen H, Kirvela O, Tolvanen T, Raitakari M, Solin O, Haaparanta M, Knuuti J, Nuutila P: Insulin resistance of glucose uptake in skeletal muscle cannot be ameliorated by enhancing endothelium-dependent blood flow in obesity. J Clin Invest 1998, 101: 1156–1162. 10.1172/JCI1065
Article
CAS
PubMed Central
PubMed
Google Scholar
Tack CJ, Ong MK, Lutterman JA, Smits P: Insulin-induced vasodilatation and endothelial function in obesity/insulin resistance. Effects of troglitazone. Diabetologia 1998, 41: 569–576. 10.1007/s001250050948
Article
CAS
PubMed
Google Scholar
Westerbacka J, Vehkavaara S, Bergholm R, Wilkinson I, Cockcroft J, Yki-Jarvinen H: Marked resistance of the ability of insulin to decrease arterial stiffness characterizes human obesity. Diabetes 1999, 48: 821–827. 10.2337/diabetes.48.4.821
Article
CAS
PubMed
Google Scholar
Williams IL, Wheatcroft SB, Shah AM, Kearney MT: Obesity, atherosclerosis and the vascular endothelium: mechanisms of reduced nitric oxide bioavailability in obese humans. Int J Obes Relat Metab Disord 2002, 26: 754–764.
Article
CAS
PubMed
Google Scholar
Noronha BT, Li JM, Wheatcroft SB, Shah AM, Kearney MT: Inducible nitric oxide synthase has divergent effects on vascular and metabolic function in obesity. Diabetes 2005, 54: 1082–1089. 10.2337/diabetes.54.4.1082
Article
CAS
PubMed
Google Scholar
Wheatcroft SB, Shah AM, Li JM, Duncan E, Noronha BT, Crossey PA, Kearney MT: Preserved glucoregulation but attenuation of the vascular actions of insulin in mice heterozygous for knockout of the insulin receptor. Diabetes 2004, 53: 2645–2652. 10.2337/diabetes.53.10.2645
Article
CAS
PubMed
Google Scholar
Duncan ER, Walker SJ, Ezzat VA, Wheatcroft SB, Li JM, Shah AM, Kearney MT: Accelerated endothelial dysfunction in mild prediabetic insulin resistance: the early role of reactive oxygen species. Am J Physiol Endocrinol Metab 2007, 293: E1311–1319. 10.1152/ajpendo.00299.2007
Article
CAS
PubMed
Google Scholar
Cai H, Harrison DG: Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 2000, 87: 840–844. 10.1161/01.RES.87.10.840
Article
CAS
PubMed
Google Scholar
Houstis N, Rosen ED, Lander ES: Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 2006, 440: 944–948. 10.1038/nature04634
Article
CAS
PubMed
Google Scholar
Bain JR, Stevens RD, Wenner BR, Ilkayeva O, Muoio DM, Newgard CB: Metabolomics applied to diabetes research: moving from information to knowledge. Diabetes 2009, 58: 2429–2443. 10.2337/db09-0580
Article
CAS
PubMed Central
PubMed
Google Scholar
Cave AC, Brewer AC, Narayanapanicker A, Ray R, Grieve DJ, Walker S, Shah AM: NADPH oxidases in cardiovascular health and disease. Antioxid Redox Signal 2006, 8: 691–728. 10.1089/ars.2006.8.691
Article
CAS
PubMed
Google Scholar
Zorov DB, Filburn CR, Klotz LO, Zweier JL, Sollott SJ: Reactive oxygen species (ROS)-induced ROS release: a new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes. J Exp Med 2000, 192: 1001–1014. 10.1084/jem.192.7.1001
Article
CAS
PubMed Central
PubMed
Google Scholar
Bernal-Mizrachi C, Gates AC, Weng S, Imamura T, Knutsen RH, DeSantis P, Coleman T, Townsend RR, Muglia LJ, Semenkovich CF: Vascular respiratory uncoupling increases blood pressure and atherosclerosis. Nature 2005, 435: 502–506. 10.1038/nature03527
Article
CAS
PubMed
Google Scholar
Silver AE, Beske SD, Christou DD, Donato AJ, Moreau KL, Eskurza I, Gates PE, Seals DR: Overweight and obese humans demonstrate increased vascular endothelial NAD(P)H oxidase-p47(phox) expression and evidence of endothelial oxidative stress. Circulation 2007, 115: 627–637. 10.1161/CIRCULATIONAHA.106.657486
Article
CAS
PubMed
Google Scholar
Steinberg HO, Baron AD: Vascular function, insulin resistance and fatty acids. Diabetologia 2002, 45: 623–634. 10.1007/s00125-002-0800-2
Article
CAS
PubMed
Google Scholar
Duncan ER, Crossey PA, Walker S, Anilkumar N, Poston L, Douglas G, Ezzat VA, Wheatcroft SB, Shah AM, Kearney MT: Effect of endothelium-specific insulin resistance on endothelial function in vivo. Diabetes 2008, 57: 3307–3314. 10.2337/db07-1111
Article
CAS
PubMed Central
PubMed
Google Scholar
Fortuno A, San Jose G, Moreno MU, Beloqui O, Diez J, Zalba G: Phagocytic NADPH oxidase overactivity underlies oxidative stress in metabolic syndrome. Diabetes 2006, 55: 209–215. 10.2337/diabetes.55.01.06.db05-0751
Article
CAS
PubMed
Google Scholar
Guzik TJ, Mussa S, Gastaldi D, Sadowski J, Ratnatunga C, Pillai R, Channon KM: Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase. Circulation 2002, 105: 1656–1662. 10.1161/01.CIR.0000012748.58444.08
Article
CAS
PubMed
Google Scholar
Dworakowski R, Walker S, Momin A, Desai J, El-Gamel A, Wendler O, Kearney MT, Shah AM: Reduced nicotinamide adenine dinucleotide phosphate oxidase-derived superoxide and vascular endothelial dysfunction in human heart failure. J Am Coll Cardiol 2008, 51: 1349–1356. 10.1016/j.jacc.2007.12.033
Article
CAS
PubMed
Google Scholar
Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y, Nakayama O, Makishima M, Matsuda M, Shimomura I: Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 2004, 114: 1752–1761.
Article
CAS
PubMed Central
PubMed
Google Scholar
Fu P, Birukov KG: Oxidized phospholipids in control of inflammation and endothelial barrier. Transl Res 2009, 153: 166–176. 10.1016/j.trsl.2008.12.005
Article
CAS
PubMed Central
PubMed
Google Scholar
Schonfeld P, Wojtczak L: Fatty acids as modulators of the cellular production of reactive oxygen species. Free Radic Biol Med 2008, 45: 231–241. 10.1016/j.freeradbiomed.2008.04.029
Article
PubMed
CAS
Google Scholar
Symons JD, McMillin SL, Riehle C, Tanner J, Palionyte M, Hillas E, Jones D, Cooksey RC, Birnbaum MJ, McClain DA: Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure. Circ Res 2009, 104: 1085–1094. 10.1161/CIRCRESAHA.108.189316
Article
CAS
PubMed Central
PubMed
Google Scholar
Karman RJ, Gupta MP, Garcia JG, Hart CM: Exogenous fatty acids modulate the functional and cytotoxic responses of cultured pulmonary artery endothelial cells to oxidant stress. J Lab Clin Med 1997, 129: 548–556. 10.1016/S0022-2143(97)90009-3
Article
CAS
PubMed
Google Scholar
Chinen I, Shimabukuro M, Yamakawa K, Higa N, Matsuzaki T, Noguchi K, Ueda S, Sakanashi M, Takasu N: Vascular lipotoxicity: endothelial dysfunction via fatty-acid-induced reactive oxygen species overproduction in obese zucker diabetic fatty rats. Endocrinology 2007, 148: 160–165.
Article
CAS
PubMed
Google Scholar
Du X, Edelstein D, Obici S, Higham N, Zou MH, Brownlee M: Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation. J Clin Invest 2006, 116: 1071–1080. 10.1172/JCI23354
Article
CAS
PubMed Central
PubMed
Google Scholar
Kim F, Tysseling KA, Rice J, Pham M, Haji L, Gallis BM, Baas AS, Paramsothy P, Giachelli CM, Corson MA, Raines EW: Free fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKKbeta. Arterioscler Thromb Vasc Biol 2005, 25: 989–994. 10.1161/01.ATV.0000160549.60980.a8
Article
CAS
PubMed
Google Scholar
Maloney E, Sweet IR, Hockenbery DM, Pham M, Rizzo NO, Tateya S, Handa P, Schwartz MW, Kim F: Activation of NF-kappaB by palmitate in endothelial cells: a key role for NADPH oxidase-derived superoxide in response to TLR4 activation. Arterioscler Thromb Vasc Biol 2009, 29: 1370–1375. 10.1161/ATVBAHA.109.188813
Article
CAS
PubMed Central
PubMed
Google Scholar
Kim F, Pham M, Luttrell I, Bannerman DD, Tupper J, Thaler J, Hawn TR, Raines EW, Schwartz MW: Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity. Circ Res 2007, 100: 1589–1596. 10.1161/CIRCRESAHA.106.142851
Article
CAS
PubMed
Google Scholar