Voges D, Zwickl P, Baumeister W: The 26S proteasome: a molecular machine designed for controlled proteolysis. Ann Rev Biochem 1999, 68: 1015–1068. 10.1146/annurev.biochem.68.1.1015
Article
CAS
PubMed
Google Scholar
Daniel KG, Kuhn DJ, Kazi A, Dou QP: Anti-angiogenic and anti-tumor properties of proteasome inhibitors. Curr Cancer Drug Targets 2005, 5: 529–541. 10.2174/156800905774574075
Article
CAS
PubMed
Google Scholar
Kisselev AF, Akopian TN, Castillo V, Goldberg AL: Proteasome active sites allosterically regulate each other, suggesting a cyclical bite-chew mechanism for protein breakdown. Mol Cell 1999, 4: 395–402. 10.1016/S1097-2765(00)80341-X
Article
CAS
PubMed
Google Scholar
Rajkumar SV, Richardson PG, Hideshima T, Anderson KC: Proteasome inhibition as a novel therapeutic target in human cancer. J Clin Oncol 2005, 23: 630–639.
Article
CAS
PubMed
Google Scholar
Rivett AJ: The multicatalytic proteinase. Multiple proteolytic activities. J Biol Chem 1989, 264: 12215–12219.
CAS
PubMed
Google Scholar
Löwe J, Stock D, Jap B, Zwickl P, Baumeister W, Huber R: Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 A resolution. Science 1995, 268: 533–539. 10.1126/science.7725097
Article
PubMed
Google Scholar
Chen P, Hochstrasser M: Autocatalytic subunit processing couples active site formation in the 20S proteasome to completion of assembly. Cell 1996, 86: 961–972. 10.1016/S0092-8674(00)80171-3
Article
CAS
PubMed
Google Scholar
Murata S, Yashiroda H, Tanaka K: Molecular mechanisms of proteasome assembly. Nat Rev Mol Cell Biol 2009, 10: 104–115. 10.1038/nrm2630
Article
CAS
PubMed
Google Scholar
Hideshima T, Richardson P, Chauhan D, Palombella VJ, Elliott PJ, Adams J, Anderson KC: The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res 2001, 61: 3071–3076.
CAS
PubMed
Google Scholar
Adams J: The development of proteasome inhibitors as anticancer drugs. Cancer Cell 2004, 5: 417–421. 10.1016/S1535-6108(04)00120-5
Article
CAS
PubMed
Google Scholar
Wang M, Fayad L, Wagner-Bartak N, Zhang L, Hagemeister F, Neelapu SS, Samaniego F, McLaughlin P, Fanale M, Younes A, Cabanillas F, Fowler N, Newberry KJ, Sun L, Young KH, Champlin R, Kwak L, Feng L, Badillo M, Bejarano M, Hartig K, Chen W, Chen Y, Byrne C, Bell N, Zeldis J, Romaguera J: A phase 2 study of bortezomib in relapsed, refractory myeloma. N Engl J Med 2003, 348: 2609–2617. 10.1056/NEJMoa030288
Article
Google Scholar
Richardson PG, Sonneveld P, Schuster MW, Irwin D, Stadtmauer EA, Facon T, Harousseau JL, Ben-Yehuda D, Lonial S, Goldschmidt H, Reece D, San-Miguel JF, Bladé J, Boccadoro M, Cavenagh J, Dalton WS, Boral AL, Esseltine DL, Porter JB, Schenkein D, Anderson KC, Assessment of Proteasome Inhibition for Extending Remissions (APEX) Investigators: Bortezomib or high-dose dexamethazone for relapsed multiple myeloma. N Engl J Med 2005, 352: 2487–2498. 10.1056/NEJMoa043445
Article
CAS
PubMed
Google Scholar
Goy A, Younes A, McLaughlin P: Phase II study of proteasome inhibitor bortezomib in relapsed or refractory B-cell non-Hodgkin’s lymphoma. J Clin Oncol 2005, 23: 667–675. 10.1200/JCO.2005.03.108
Article
CAS
PubMed
Google Scholar
Goy A, Younes A, McLaughlin P, Pro B, Romaguera JE, Hagemeister F, Fayad L, Dang NH, Samaniego F, Wang M, Broglio K, Samuels B, Gilles F, Sarris AH, Hart S, Trehu E, Schenkein D, Cabanillas F, Rodriguez AM: Phase I study of bortezomib in refractory or relapsed acute leukemias. Clin Cancer Res 2004, 10: 3371–3376. 10.1158/1078-0432.CCR-03-0508
Article
Google Scholar
Horton TM, Gannavarapu A, Blaney SM, D’Argenio DZ, Plon SE, Berg SL: Bortezomib interactions with chemotherapy agents in acute leukemia in vitro. Cancer Chemother Pharmacol 2006, 58: 13–23. 10.1007/s00280-005-0135-z
Article
CAS
PubMed
Google Scholar
Lü S, Yang J, Song X, Gong S, Zhou H, Guo L, Song N, Bao X, Chen P, Wang J: Point mutation of the PSMB5 gene is an important mechanism of bortezomib resistance in bortezomib-selected variants of Jurkat T cell lymphoblastic lymphoma/leukemia line. J Pharmacol Exp Ther 2008, 326: 423–431. 10.1124/jpet.108.138131
Article
PubMed
CAS
Google Scholar
Lü S, Yang J, Chen Z, Gong S, Zhou H, Xu X, Wang J: Different mutants of PSMB5 confer varying bortezomib resistance in T lymphoblastic lymphoma/leukemia cells derived from the Jurkat cell line. Exp Hematol 2009, 37: 831–837. 10.1016/j.exphem.2009.04.001
Article
PubMed
CAS
Google Scholar
Oerlemans R, Franke NE, Assaraf YG, Cloos J, van Zantwijk I, Berkers CR, Scheffer GL, Debipersad K, Vojtekova K, Lemos C, van der Heijden JW, Ylstra B, Peters GJ, Kaspers GL, Dijkmans BA, Scheper RJ, Jansen G: Molecular basis of bortezomib resistance: proteasome subunit beta 5 (PSMB5) gene mutation and overexpression of PSMB5 protein. Blood 2008, 112: 2489–2499. 10.1182/blood-2007-08-104950
Article
CAS
PubMed
Google Scholar
Franke NE, Niewerth D, Assaraf YG, van Meerloo J, Vojtekova K, van Zantwijk CH, Zweegman S, Chan ET, Kirk CJ, Geerke DP, Schimmer AD, Kaspers GJ, Jansen G, Cloos J: Impaired bortezomib binding to mutant b5 subunit of the proteasome is the underlying basis for bortezomib resistance in leukemia cells. Leukemia 2012, 26: 757–768. 10.1038/leu.2011.256
Article
CAS
PubMed
Google Scholar
Ri M, Iida S, Nakashima T, Miyazaki H, Mori F, Ito A, Inagaki A, Kusumoto S, Ishida T, Komatsu H, Shiotsu Y, Ueda R: Bortezomib-resistant myeloma cell lines: a role for mutated PSMB5 in preventing the accumulation of unfolded proteins and fatal ER stress. Leukemia 2010, 24: 1506–1512. 10.1038/leu.2010.137
Article
CAS
PubMed
Google Scholar
de Wilt LH, Jansen G, Assaraf YG, van Meerloo J, Cloos J, Schimmer AD, Chan ET, Kirk CJ, Peters GJ, Kruyt FA: Proteasome-based mechanisms of intrinsic and acquired bortezomib resistance in non-small cell lung cancer. Biochem Pharmacol 2012, 83: 207–217. 10.1016/j.bcp.2011.10.009
Article
CAS
PubMed
Google Scholar
Groll M, Berkers CR, Ploegh HL, Ovaa H: Crystal structure of the boronic acidbased proteasome inhibitor bortezomib in complex with the yeast 20S proteasome. Structure 2006, 14: 451–456. 10.1016/j.str.2005.11.019
Article
CAS
PubMed
Google Scholar
Unno M, Mizushima T, Morimoto Y, Tomisugi Y, Tanaka K, Yasuoka N, Tsukihara T: The structure of the mammalian 20S proteasome at 2.75 A˚ resolution. Structure 2002, 10: 609–618. 10.1016/S0969-2126(02)00748-7
Article
CAS
PubMed
Google Scholar
Suzuki E, Demo S, Deu E, Keats J, Arastu-Kapur S, Bergsagel PL, Bennett MK, Kirk CJ: Molecular mechanisms of bortezomib resistant adenocarcinoma cells. PLoS One 2011, 6: e27996. 10.1371/journal.pone.0027996
Article
CAS
PubMed Central
PubMed
Google Scholar
Wang L, Kumar S, Fridley BL, Kalari KR, Moon I, Pelleymounter LL, Hildebrandt MA, Batzler A, Eckloff BW, Wieben ED, Greipp PR: Proteasome beta subunit pharmacogenomics gene resequencing and functional genomics. Clin Cancer Res 2008, 14: 3503–3513. 10.1158/1078-0432.CCR-07-5150
Article
CAS
PubMed Central
PubMed
Google Scholar
Kale AJ, McGlinchey RP, Lechner A, Moore BS: Bacterial self-resistance to the natural proteasome inhibitor salinosporamide A. ACS Chem Biol 2011, 6: 1257–1264. 10.1021/cb2002544
Article
CAS
PubMed Central
PubMed
Google Scholar
Politou M, Karadimitris A, Terpos E, Kotsianidis I, Apperley JF, Rahemtulla A: No evidence of mutations of the PSMB5 (beta-5 subunit of proteasome) in a case of myeloma with clinical resistance to bortezomib. Leuk Res 2006, 30: 240–241. 10.1016/j.leukres.2005.06.014
Article
CAS
PubMed
Google Scholar
Lü S, Yang J, Huang C, Cheng H, Wang J: Up regulated expression of the PSMB5 gene may contribute to drug resistance in patient with multiple myeloma when treated with bortezomib-based regimen. Exp Hematol 2011, 39: 1117–1118. 10.1016/j.exphem.2011.09.003
Article
CAS
Google Scholar
Lü S, Chen Z, Yang J, Chen L, Gong S, Zhou H, Guo L, Wang J: Overexpression of the PSMB5 Gene contributes to bortezomib resistance in T lymphoblastic lymphoma/leukemia cells derived from Jurkat line. Exp Hematol 2008, 36: 1278–1284. 10.1016/j.exphem.2008.04.013
Article
PubMed
CAS
Google Scholar
Balsas P, Galán-Malo P, Marzo I, Naval J: Bortezomib resistance in a myeloma cell line is associated to PSMβ5 overexpression and polyploidy. Leuk Res 2012, 36: 212–218. 10.1016/j.leukres.2011.09.011
Article
CAS
PubMed
Google Scholar
Yang YM, Lee S, Nam CW, Ha JH, Jayaraman M, Dhanasekaran DN, Lee CH, Kwak MK, Kim SG: Ga12/13 inhibition enhances the anticancer effect of bortezomib through PSMB5 Downregulation. Carcinogenesis 2010, 31: 1230–1237. 10.1093/carcin/bgq097
Article
CAS
PubMed
Google Scholar
Kraus M, Rückrich T, Reich M, Gogel J, Beck A, Kammer W, Berkers CR, Burg D, Overkleeft H, Ovaa H, Driessen C: Activity patterns of proteasome subunits reflect bortezomib sensitivity of hematologic malignancies and are variable in primary human leukemia cells. Leukemia 2007, 21: 84–92. 10.1038/sj.leu.2404414
Article
CAS
PubMed
Google Scholar
Vij R, Siegel DS, Jagannath S, Jakubowiak AJ, Stewart AK, McDonagh K, Bahlis N, Belch A, Kunkel LA, Wear S, Wong AF, Wang M: An open-label, single-arm, phase 2 study of single-agent carfilzomib in patients with relapsed and/or refractory multiple myeloma who have been previously treated with bortezomib. Br J Haematol 2012, 158: 739–748. 10.1111/j.1365-2141.2012.09232.x
Article
CAS
PubMed
Google Scholar
Xu GW, Ali M, Wood TE, Wong D, Maclean N, Wang X, Gronda M, Skrtic M, Li X, Hurren R, Mao X, Venkatesan M, Beheshti Zavareh R, Ketela T, Reed JC, Rose D, Moffat J, Batey RA, Dhe-Paganon S, Schimmer AD: The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma. Blood 2010, 115: 2251–2259. 10.1182/blood-2009-07-231191
Article
CAS
PubMed Central
PubMed
Google Scholar
Chauhan D, Tian Z, Nicholson B, Kumar KG, Zhou B, Carrasco R, McDermott JL, Leach CA, Fulcinniti M, Kodrasov MP, Weinstock J, Kingsbury WD, Hideshima T, Shah PK, Minvielle S, Altun M, Kessler BM, Orlowski R, Richardson P, Munshi N, Anderson KC: A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance. Cancer Cell 2012, 22: 345–358. 10.1016/j.ccr.2012.08.007
Article
CAS
PubMed Central
PubMed
Google Scholar
Kale AJ, Moore BS: Molecular Mechanisms of Acquired Proteasome Inhibitor. Resistance. J Med Chem 2012. Epub ahead of print
Google Scholar
Shringarpure R, Catley L, Bhole D, Burger R, Podar K, Tai YT, Kessler B, Galardy P, Ploegh H, Tassone P, Hideshima T, Mitsiades C, Munshi NC, Chauhan D, Anderson KC: Gene expression analysis of B-lymphoma cells resistant and sensitive to bortezomib. Br J Haematol 2006, 134: 145–156. 10.1111/j.1365-2141.2006.06132.x
Article
CAS
PubMed
Google Scholar
Chauhan D, Li G, Shringarpure R, Podar K, Ohtake Y, Hideshima T, Anderson KC: Blockade of Hsp27 overcomes Bortezomib/proteasome inhibitor PS-341 resistance in lymphoma cells. Cancer Res 2003, 63: 6174–6177.
CAS
PubMed
Google Scholar
McConkey DJ, Zhu K: Mechanisms of proteasome inhibitor action and resistance in cancer. Drug Resist Updat 2008, 11: 164–179. 10.1016/j.drup.2008.08.002
Article
CAS
PubMed
Google Scholar
Zhou L, Hou J, Fu W, Wang D, Yuan Z, Jiang H: Arsenic trioxide and 2-methoxyestradiol reduce beta-catenin accumulation after proteasome inhibition and enhance the sensitivity of myeloma cells to Bortezomib. Leuk Res 2008, 32: 1674–1683. 10.1016/j.leukres.2008.03.039
Article
CAS
PubMed
Google Scholar
Siegel DS: Relapsed/Refractory multiple myeloma: defining refractory disease and identifying strategies to overcome resistance. Semin Hematol 2012,49(Suppl 1):S3-S15.
Article
PubMed
Google Scholar
Wang X, Li C, Ju S, Wang X, Li C, Ju S, Wang Y, Wang H, Zhong R: Myeloma cell adhesion to bone marrow stromal cells confers drug resistance by microRNA-21 up-regulation. Leuk Lymphoma 2011, 52: 1991–1998. 10.3109/10428194.2011.591004
Article
CAS
PubMed
Google Scholar
Zang MR, Li F, An G, Xie ZQ, Li CH, Yu Z, Xu Y, Qiu LG, Hao M: Regulation of miRNA-15a/-16 expression on the drug resistance of myeloma cells. Zhonghua Yi Xue Za Zhi 2012, 92: 1100–1103.
PubMed
Google Scholar
Chng WJ, Gualberto A, Fonseca R: IGF-1R is overexpressed in poor-prognostic subtypes of multiple myeloma. Leukemia 2006, 20: 174–176. 10.1038/sj.leu.2403997
Article
CAS
PubMed
Google Scholar
Tucci A, Bonadonna S, Cattaneo C, Ungari M, Giustina A, Guiseppe R: Transformation of a MGUS to overt multiple myeloma: the possible role of a pituitary macroadenoma secreting high levels of insulin-like growth factor 1 (IGF-1). Leuk Lymphoma 2003, 44: 543–545. 10.1080/1042819021000037895
Article
CAS
PubMed
Google Scholar
Bataille R, Robillard N, Avet-Loiseau H, Harousseau JL, Moreau P: CD221 (IGF-1R) is aberrantly expressed in multiple myeloma, in relation to disease severity. Haematologica 2005, 90: 706–707.
CAS
PubMed
Google Scholar
Kuhn DJ, Berkova Z, Jones RJ, Woessner R, Bjorklund CC, Ma W, Davis RE, Lin P, Wang H, Madden TL, Wei C, Baladandayuthapani V, Wang M, Thomas SK, Shah JJ, Weber DM, Orlowski RZ: Targeting the insulin-like growth factor-1 receptor to overcome bortezomib resistance in pre-clinical models of multiple myeloma. Blood 2012, 120: 3260–3270. 10.1182/blood-2011-10-386789
Article
CAS
PubMed Central
PubMed
Google Scholar
Que W, Chen J, Chuang M, Jiang D: Knockdown of c-Met enhances sensitivity to bortezomib in human multiple myeloma U266 cells via inhibiting Akt/mTOR activity. APMIS 2012, 120: 195–203. 10.1111/j.1600-0463.2011.02836.x
Article
CAS
PubMed
Google Scholar
Kim A, Park S, Lee JE, Jang WS, Lee SJ, Kang HJ, Lee SS: The dual PI3K and mTOR inhibitor NVP-BEZ235 exhibits anti-proliferative activity and overcomes bortezomib resistance in mantle cell lymphoma cells. Leuk Res 2012, 36: 912–920. 10.1016/j.leukres.2012.02.010
Article
CAS
PubMed
Google Scholar
Yeom SY, Lee SJ, Kim WS, Park C: Rad knockdown induces mitochondrial apoptosis in bortezomib resistant leukemia and lymphoma cells. Leuk Res 2012, 36: 1172–1178. 10.1016/j.leukres.2012.05.004
Article
CAS
PubMed
Google Scholar
Gu JL, Li J, Zhou ZH, Liu JR, Huang BH, Zheng D, Su C: Differentiation induction enhances bortezomib efficacy and overcomes drug resistance in multiple myeloma. Biochem Biophys Res Commun 2012, 420: 644–650. 10.1016/j.bbrc.2012.03.056
Article
CAS
PubMed
Google Scholar
Jung HJ, Chen Z, Fayad L, Wang M, Romaguera J, Kwak LW, McCarty N: Bortezomib-resistant nuclear factor κB expression in stem-like cells in mantle cell lymphoma. Exp Hematol 2012, 40: 107–118.e2. 10.1016/j.exphem.2011.10.004
Article
CAS
PubMed Central
PubMed
Google Scholar
Lü S, Chen Z, Yang J, Chen L, Zhou H, Xu X, Li J, Han F, Wang J: The effects of proteasome inhibitor bortezomib on a P-gp positive leukemia cell line 562/A02. Int J Lab Hematol 2010, 32: e123-e131. 10.1111/j.1751-553X.2009.01145.x
Article
PubMed
Google Scholar
Verbrugge SE, Assaraf YG, Dijkmans BA, Scheffer GL, Al M, den Uyl D, Oerlemans R, Chan ET, Kirk CJ, Peters GJ, van der Heijden JW, de Gruijl TD, Scheper RJ, Jansen G: Inactivating PSMB5 mutations and P-glycoprotein (multidrug resistance-associated protein/ATP-binding cassette B1) mediate resistance to proteasome inhibitors: ex vivo efficacy of (immuno)proteasome inhibitors in mononuclear blood cells from patients with rheumatoid arthritis. J Pharmacol Exp Ther 2012, 341: 174–182. 10.1124/jpet.111.187542
Article
CAS
PubMed
Google Scholar
Minderman H, Zhou Y, O’Loughlin KL, Baer MR: Bortezomib activity and in vitro interactions with anthracyclines and cytarabine in acute myeloid leukemia cells are independent of multidrug resistance mechanisms and p53 status. Cancer Chemother Pharmacol 2007, 60: 245–255. 10.1007/s00280-006-0367-6
Article
CAS
PubMed
Google Scholar
Rumpold H, Salvador C, Wolf AM, Tilg H, Gastl G, Wolf D: Knockdown of PgP resensitizes leukemic cells to proteasome inhibitors. Biochem Biophys Res Commun 2007, 361: 549–554. 10.1016/j.bbrc.2007.07.049
Article
CAS
PubMed
Google Scholar