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  1. Content type: Case report

    Extramedullary hematopoeisis (EMH) can occur in various physiological and pathologic states. The spleen is the most common site of EMH.

    Authors: Tasleem Katchi, Krishna Kolandaivel, Pallavi Khattar, Taliya Farooq, Humayun Islam and Delong Liu

    Citation: Biomarker Research 2016 4:17

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  2. Content type: Short report

    Acute myeloid leukemia (AML) is commonly characterized by several chromosomal abnormalities resulting in the formation of chimeric genes that play various roles in leukemogenesis. Translocations resulting in the

    Authors: Carlos A. Tirado, Ken Siangchin, David S. Shabsovich, Maryam Sharifian and Gary Schiller

    Citation: Biomarker Research 2016 4:16

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  3. Content type: Case report

    Chronic myeloid leukemia (CML) comprises ~3 % of pediatric leukemia. Although therapy with tyrosine kinase inhibitors (TKIs) is highly effective for CML, multiple factors have been identified as predictive of ...

    Authors: Margaret Lewen, Renee Gresh, Maria Queenan, Michele Paessler, Vinodh Pillai, Elizabeth Hexner, Dale Frank, Adam Bagg, Richard Aplenc, Emi Caywood and Gerald Wertheim

    Citation: Biomarker Research 2016 4:14

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  4. Content type: Research

    Oxaliplatin induced peripheral neurotoxicity (OXIPN) is the major dose-limiting and long-lasting side effect of oxaliplatin. N-3 PUFAs have neuroprotective property via their effects on voltage-gated ion chann...

    Authors: Ali Esfahani, Mohammad hossein Somi, Hormoz Ayromlou, Alireza Nikanfar, Mohammad Asghari Jafarabadi, Bina Eftekhar Sadat and Zohreh Ghoreishi

    Citation: Biomarker Research 2016 4:13

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  5. Content type: Research

    Diffuse large B-cell lymphoma (DLBCL) is an aggressive disease with variable clinical outcome, accounting for at least 25-30 % of adult non-Hodgkin lymphomas. Approximately one third of DLBCL patients are not ...

    Authors: Linn Reinholdt, Maria Bach Laursen, Alexander Schmitz, Julie Støve Bødker, Lasse Hjort Jakobsen, Martin Bøgsted, Hans Erik Johnsen and Karen Dybkær

    Citation: Biomarker Research 2016 4:12

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  6. Content type: Research

    Reprogrammed metabolism is a new hallmark of cancer. In many types of cancer, most of the genes in the glycolytic pathway are overexpressed, reflecting an essential shift of metabolism during cancer developmen...

    Authors: Zhenyu Sun, Xiaofeng Chen, Gan. Wang, Liang Li, Guofeng Fu, Matthew Kuruc and Xing Wang

    Citation: Biomarker Research 2016 4:11

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  7. Content type: Research

    There is an increasing amount of reports on IFITM1 (interferon-inducible transmembrane protein 1) in various malignancies. The aim of this study was to examine the expression of IFITM1 and its prognostic signi...

    Authors: David Borg, Charlotta Hedner, Alexander Gaber, Björn Nodin, Richard Fristedt, Karin Jirström, Jakob Eberhard and Anders Johnsson

    Citation: Biomarker Research 2016 4:10

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  8. Content type: Short report

    Disruption of alternative splicing in apoptotic factors has been associated to chronic lymphocytic leukemia among other cancers and hematological malignancies. The proapoptotic proteins Caspase-9 and PP2Acα ar...

    Authors: Leticia Domínguez-Berrocal, Xiguang Zhang, Jean Marc Zini, Jesús Fominaya, Angelita Rebollo and Jerónimo Bravo

    Citation: Biomarker Research 2016 4:9

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  9. Content type: Research

    HER2 expression in breast cancer correlates with increased metastatic potential, higher tumor recurrence rates and improved response to targeted therapies. Fluorescence in situ hybridization (FISH) and immunohist...

    Authors: Elisabeth Hofmann, Rita Seeboeck, Nico Jacobi, Peter Obrist, Samuel Huter, Christian Klein, Kamil Oender, Christoph Wiesner, Harald Hundsberger and Andreas Eger

    Citation: Biomarker Research 2016 4:8

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  10. Content type: Case report

    Patients with common variable immunodeficiency (CVID) have an increased risk of developing lymphoproliferative diseases, including non-Hodgkins lymphoma (Blood 116:1228–1234, 2010; Blood 119:1650–7, 2012). The...

    Authors: Efren Rael, Kevin Rakszawski, Kristian Koller, Michael Bayerl, Manish Butte and Hong Zheng

    Citation: Biomarker Research 2016 4:7

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  11. Content type: Research

    Genomic instability and clonal evolution are hallmarks of progressing chronic myeloid leukemia (CML). Recently, we have shown that clonal evolution and blast crisis correlate with altered expression and activi...

    Authors: Wiltrud Prinzhorn, Michael Stehle, Helga Kleiner, Sabrina Ruppenthal, Martin C. Müller, Wolf-Karsten Hofmann, Alice Fabarius and Wolfgang Seifarth

    Citation: Biomarker Research 2016 4:5

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  12. Content type: Research

    Stage I lung adenocarcinoma is usually not treated with adjuvant chemotherapy; however, around half of these patients do not survive 5 years. Therefore, a reliable prognostic biomarker for early stage patients...

    Authors: Marcin Krzystanek, Judit Moldvay, David Szüts, Zoltan Szallasi and Aron Charles Eklund

    Citation: Biomarker Research 2016 4:4

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  13. Content type: Research

    RECQ helicase family members act as guardians of the genome to assure proper DNA metabolism in response to genotoxic stress. Hematological malignancies are characterized by genomic instability that is possibly...

    Authors: Elena Viziteu, Alboukadel Kassambara, Philippe Pasero, Bernard Klein and Jerome Moreaux

    Citation: Biomarker Research 2016 4:3

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  14. Content type: Research

    Acute lymphoblastic leukemia is the most common malignant cancer in childhood. The signs and symptoms of childhood cancer are difficult to recognize, as it is not the first diagnosis to be considered for nonsp...

    Authors: Marcio de Souza Cavalcante, José Camilo Torres-Romero, Marina Duarte Pinto Lobo, Frederico Bruno Mendes Batista Moreno, Leonardo Primo Bezerra, Diego Silva Lima, Jesamar Correia Matos, Renato de Azevedo Moreira and Ana Cristina de Oliveira Monteiro-Moreira

    Citation: Biomarker Research 2016 4:1

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  15. Content type: Case report

    Plasmablastic lymphoma (PBL) is a rare and aggressive subtype of non-Hodgkin diffuse large B-cell lymphoma originally with a predilection to the oral cavity of patients infected with HIV. However, PBL of extra...

    Authors: Makoto Hirosawa, Hiroaki Morimoto, Ryo Shibuya, Shohei Shimajiri and Junichi Tsukada

    Citation: Biomarker Research 2015 3:28

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  16. Content type: Research

    Blood transfusion is central in the prevention and treatment of certain chronic complications of sickle cell disease. It is indispensible in correcting anaemias as well as in the practice of exchange blood tra...

    Authors: Umar Kangiwa, Obike Ibegbulam, Sunday Ocheni, Anazoeze Madu and Ndakosu Mohammed

    Citation: Biomarker Research 2015 3:26

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  17. Content type: Research

    Asian Indians have a high incidence of type 2 diabetes, but factors associated with glycemic progression in this population are not understood. MicroRNAs are emerging as important mediators of glucose homeosta...

    Authors: Elena Flowers, Meghana Gadgil, Bradley E. Aouizerat and Alka M. Kanaya

    Citation: Biomarker Research 2015 3:22

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  18. Content type: Letter to the Editor

    The paper by Rachidi et al. suggests that antiplatelet drugs may play a role in ameliorating the clinical outcome in a large series of patients with head and neck cancer managed with either surgery or radiation. ...

    Authors: Carlo Furlan, Agostino Steffan, Jerry Polesel, Marco Trovo, Carlo Gobitti, Emanuela Vaccher, Diego Serraino, Luigi Barzan and Giovanni Franchin

    Citation: Biomarker Research 2015 3:25

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  19. Content type: Review

    The presence of chromosomal abnormalities is one of the most important criteria for leukaemia diagnosis and management. Infant leukaemia is a rare disease that affects children in their first year of life. It ...

    Authors: Sabrina Tosi, Yasser Mostafa Kamel, Temitayo Owoka, Concetta Federico, Tony H. Truong and Salvatore Saccone

    Citation: Biomarker Research 2015 3:21

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  20. Content type: Review

    Rheumatoid arthritis (RA) is a chronic inflammatory disease that preferentially affects joints, and characterized by an approximately two-fold increased risk of cardiovascular diseases compared with the genera...

    Authors: Mickael Essouma and Jean Jacques N. Noubiap

    Citation: Biomarker Research 2015 3:24

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  21. Content type: Review

    Alcoholic hepatitis (AH) is caused by acute inflammation of the liver in patients that consume excessive amounts of alcohol, usually in a background of cirrhosis. AH can range from mild to severe, life threate...

    Authors: Erik Rahimi and Jen-Jung Pan

    Citation: Biomarker Research 2015 3:20

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  22. Content type: Review

    Immune thrombocytopenia is an autoimmune disease with abnormal biomarkers. Immune thrombocytopenia pathogenesis is a complicated process in which the patient’s immune system is activated by platelet autoantige...

    Authors: Lingjia Yu, Chunmei Zhang, Liping Zhang, Yongyu Shi and Xuebin Ji

    Citation: Biomarker Research 2015 3:19

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  23. Content type: Research

    Prorenin and renin are both involved in atherosclerosis. However, the role of plasma prorenin and renin in the development and progression of coronary artery disease (CAD) is still not clear. Thus, we aimed to...

    Authors: Gakuro Yoshida, Masanori Kawasaki, Ichijiro Murata, Yuka Hayakawa, Takuma Aoyama, Nagisa Miyazaki, Yoshihisa Yamada, Kazuhiko Nishigaki, Yoshie Arai, Fumiaki Suzuki and Shinya Minatoguchi

    Citation: Biomarker Research 2015 3:18

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  24. Content type: Methodology

    Mutations of the BCR-ABL1 fusion gene represent a well established cause of resistance to tyrosine kinase inhibitors. Among the different mutations identified T315I is of particular concern since it is not effect...

    Authors: Valentina Rosso, Enrico Bracco, Roberto Pedrola, Sonia Carturan, Elisabetta Signorino, Jessica Petiti, Chiara Calabrese, Paolo Nicoli, Marco De Gobbi, Valentina Gaidano, Daniela Gallo, Stefano Ulisciani, Carmen Fava, Giovanna Rege-Cambrin, Francesco Frassoni, Giuseppe Saglio…

    Citation: Biomarker Research 2015 3:15

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  25. Content type: Case report

    A 72-year-old woman was diagnosed with uveal melanoma, peritoneal mesothelioma and a primary biliary tract adenocarcinoma. She had a strong family history of mesothelioma as well as other malignancies includin...

    Authors: Sonja Klebe, Jack Driml, Masaki Nasu, Sandra Pastorino, Amirmasoud Zangiabadi, Douglas Henderson and Michele Carbone

    Citation: Biomarker Research 2015 3:14

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  26. Content type: Case report

    Fanconi Anemia (FA) is an inherited disorder characterized by the variable presence of multiple congenital somatic abnormalities, bone marrow failure and cancer susceptibility. Medulloblastoma (MB) has been de...

    Authors: Evelina Miele, Angela Mastronuzzi, Agnese Po, Andrea Carai, Vincenzo Alfano, Annalisa Serra, Giovanna Stefania Colafati, Luisa Strocchio, Manila Antonelli, Francesca Romana Buttarelli, Massimo Zani, Sergio Ferraro, Amelia Buffone, Alessandra Vacca, Isabella Screpanti, Felice Giangaspero…

    Citation: Biomarker Research 2015 3:13

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  27. Content type: Research

    Breast cancer circulating biomarkers include carcinoembryonic antigen and carbohydrate antigen 15–3, which are used for patient follow-up. Since sensitivity and specificity are low, novel and more useful bioma...

    Authors: Alessandra Mangolini, Manuela Ferracin, Maria Vittoria Zanzi, Elena Saccenti, Sayda Omer Ebnaof, Valentina Vultaggio Poma, Juana M. Sanz, Angela Passaro, Massimo Pedriali, Antonio Frassoldati, Patrizia Querzoli, Silvia Sabbioni, Paolo Carcoforo, Alan Hollingsworth and Massimo Negrini

    Citation: Biomarker Research 2015 3:12

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  28. Content type: Case report

    Rearrangements involving ETV6 (12p13) are among the most common structural abnormalities in pediatric B-cell acute lymphoblastic leukemia (B-ALL) and involve numerous partner genes. Additionally, the t(8;14)(q11....

    Authors: Carlos A. Tirado, David Shabsovich, Yeun Kim, Peter Traum, Sheeja Pullarkat, Michael Kallen and Nagesh Rao

    Citation: Biomarker Research 2015 3:11

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    The Erratum to this article has been published in Biomarker Research 2015 3:27

  29. Content type: Case report

    Primary hepatic lymphoma (PHL) is an extremely rare disease, frequently associated with viruses such as hepatitis B virus (HBV), hepatitis C virus (HCV), and human immune deficiency virus (HIV). On the other h...

    Authors: Ai Kawahara, Junichi Tsukada, Takahiro Yamaguchi, Takefumi Katsuragi and Takehiro Higashi

    Citation: Biomarker Research 2015 3:10

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  30. Content type: Research

    Ovarian and triple-negative breast cancers with BRCA1 or BRCA2 loss are highly sensitive to treatment with PARP inhibitors and platinum-based cytotoxic agents and show an accumulation of genomic scars in the f...

    Authors: Andrea M Marquard, Aron C Eklund, Tejal Joshi, Marcin Krzystanek, Francesco Favero, Zhigang C Wang, Andrea L Richardson, Daniel P Silver, Zoltan Szallasi and Nicolai J Birkbak

    Citation: Biomarker Research 2015 3:9

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  31. Content type: Review

    Glioblastoma (GBM) is a highly angiogenic malignancy that is resistant to standard therapy; neo-formed vessels of this aggressive malignancy are thought to arise by sprouting of pre-existing brain capillaries....

    Authors: Jin-ming Mao, Jing Liu, Geng Guo, Xing-gang Mao and Chang-xin Li

    Citation: Biomarker Research 2015 3:8

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  32. Content type: Letter to the Editor

    Adiponectin has been recognized as a potent regulator of metabolism possessing anti-inflammatory and anti-atherogenic functions and inversely associated with increasing incidents of type 2 diabetes and obesity...

    Authors: Mohamed Abu-Farha, Kazem Behbehani and Naser Elkum

    Citation: Biomarker Research 2015 3:7

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  33. Content type: Short report

    The t(1;19)(q23;p13), which can result in the TCF3-PBX1 chimeric gene, is one of the most frequent translocations in B-acute lymphoblastic leukemia (B-ALL) and is observed in both adult and pediatric populations ...

    Authors: Carlos A Tirado, David Shabsovich, Lei Yeh, Sheeja T Pullarkat, Lynn Yang, Michael Kallen and Nagesh Rao

    Citation: Biomarker Research 2015 3:4

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  34. Content type: Review

    Reviewing the literature in many fields on proposed risk models reveals problems with the way many risk models are developed. Furthermore, papers reporting new risk models do not always provide sufficient info...

    Authors: Kathleen F Kerr, Allison Meisner, Heather Thiessen-Philbrook, Steven G Coca and Chirag R Parikh

    Citation: Biomarker Research 2015 3:2

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  35. Content type: Research

    Men with a negative first prostate biopsy will undergo one or more additional biopsies if they remain at high suspicion of prostate cancer. To date, there are no diagnostic tests capable of identifying patient...

    Authors: Igor Brikun, Deborah Nusskern, Daniel Gillen, Amy Lynn, Daniel Murtagh, John Feczko, William G Nelson and Diha Freije

    Citation: Biomarker Research 2014 2:25

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  36. Content type: Methodology

    Infectious agents are estimated to play a causative role in approximately 20% of cancers worldwide. Viruses, notably the Epstein-Barr virus (EBV), are associated with 10-15% of B-cell lymphomas and are found a...

    Authors: Joseph Tellez, Crystal Jaing, Jun Wang, Ralph Green and Mingyi Chen

    Citation: Biomarker Research 2014 2:24

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  37. Content type: Case report

    Paraneoplastic syndromes can precede the initial manifestation and diagnosis of cancer. Paraneoplastic syndromes are a heterogeneous group of disorders caused by mechanisms other than the local presence of tum...

    Authors: Josephine A Taverna, Hani M Babiker, Seongseok Yun, Maria C Bishop, Sarah Lau-Braunhut, Paul N Meyer and Thomas Enzler

    Citation: Biomarker Research 2014 2:23

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  38. Content type: Research

    A subset of patients with ductal carcinoma in situ (DCIS) will develop invasive breast cancer (IBC). To date, there are no effective predictive biomarkers for identifying this subset with worse prognosis whose le...

    Authors: YunQing Jiang, Indira Prabakaran, Fei Wan, Nandita Mitra, Dana K Furstenau, Rupert K Hung, Siyuan Cao, Paul J Zhang, Douglas L Fraker and Marina A Guvakova

    Citation: Biomarker Research 2014 2:22

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