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  1. Content type: Research

    Asian Indians have a high incidence of type 2 diabetes, but factors associated with glycemic progression in this population are not understood. MicroRNAs are emerging as important mediators of glucose homeosta...

    Authors: Elena Flowers, Meghana Gadgil, Bradley E. Aouizerat and Alka M. Kanaya

    Citation: Biomarker Research 2015 3:22

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  2. Content type: Letter to the Editor

    The paper by Rachidi et al. suggests that antiplatelet drugs may play a role in ameliorating the clinical outcome in a large series of patients with head and neck cancer managed with either surgery or radiation. ...

    Authors: Carlo Furlan, Agostino Steffan, Jerry Polesel, Marco Trovo, Carlo Gobitti, Emanuela Vaccher, Diego Serraino, Luigi Barzan and Giovanni Franchin

    Citation: Biomarker Research 2015 3:25

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  3. Content type: Review

    The presence of chromosomal abnormalities is one of the most important criteria for leukaemia diagnosis and management. Infant leukaemia is a rare disease that affects children in their first year of life. It ...

    Authors: Sabrina Tosi, Yasser Mostafa Kamel, Temitayo Owoka, Concetta Federico, Tony H. Truong and Salvatore Saccone

    Citation: Biomarker Research 2015 3:21

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  4. Content type: Review

    Rheumatoid arthritis (RA) is a chronic inflammatory disease that preferentially affects joints, and characterized by an approximately two-fold increased risk of cardiovascular diseases compared with the genera...

    Authors: Mickael Essouma and Jean Jacques N. Noubiap

    Citation: Biomarker Research 2015 3:24

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  5. Content type: Review

    Alcoholic hepatitis (AH) is caused by acute inflammation of the liver in patients that consume excessive amounts of alcohol, usually in a background of cirrhosis. AH can range from mild to severe, life threate...

    Authors: Erik Rahimi and Jen-Jung Pan

    Citation: Biomarker Research 2015 3:20

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  6. Content type: Review

    Immune thrombocytopenia is an autoimmune disease with abnormal biomarkers. Immune thrombocytopenia pathogenesis is a complicated process in which the patient’s immune system is activated by platelet autoantige...

    Authors: Lingjia Yu, Chunmei Zhang, Liping Zhang, Yongyu Shi and Xuebin Ji

    Citation: Biomarker Research 2015 3:19

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  7. Content type: Research

    Prorenin and renin are both involved in atherosclerosis. However, the role of plasma prorenin and renin in the development and progression of coronary artery disease (CAD) is still not clear. Thus, we aimed to...

    Authors: Gakuro Yoshida, Masanori Kawasaki, Ichijiro Murata, Yuka Hayakawa, Takuma Aoyama, Nagisa Miyazaki, Yoshihisa Yamada, Kazuhiko Nishigaki, Yoshie Arai, Fumiaki Suzuki and Shinya Minatoguchi

    Citation: Biomarker Research 2015 3:18

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  8. Content type: Methodology

    Mutations of the BCR-ABL1 fusion gene represent a well established cause of resistance to tyrosine kinase inhibitors. Among the different mutations identified T315I is of particular concern since it is not effect...

    Authors: Valentina Rosso, Enrico Bracco, Roberto Pedrola, Sonia Carturan, Elisabetta Signorino, Jessica Petiti, Chiara Calabrese, Paolo Nicoli, Marco De Gobbi, Valentina Gaidano, Daniela Gallo, Stefano Ulisciani, Carmen Fava, Giovanna Rege-Cambrin, Francesco Frassoni, Giuseppe Saglio…

    Citation: Biomarker Research 2015 3:15

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  9. Content type: Case report

    A 72-year-old woman was diagnosed with uveal melanoma, peritoneal mesothelioma and a primary biliary tract adenocarcinoma. She had a strong family history of mesothelioma as well as other malignancies includin...

    Authors: Sonja Klebe, Jack Driml, Masaki Nasu, Sandra Pastorino, Amirmasoud Zangiabadi, Douglas Henderson and Michele Carbone

    Citation: Biomarker Research 2015 3:14

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  10. Content type: Case report

    Fanconi Anemia (FA) is an inherited disorder characterized by the variable presence of multiple congenital somatic abnormalities, bone marrow failure and cancer susceptibility. Medulloblastoma (MB) has been de...

    Authors: Evelina Miele, Angela Mastronuzzi, Agnese Po, Andrea Carai, Vincenzo Alfano, Annalisa Serra, Giovanna Stefania Colafati, Luisa Strocchio, Manila Antonelli, Francesca Romana Buttarelli, Massimo Zani, Sergio Ferraro, Amelia Buffone, Alessandra Vacca, Isabella Screpanti, Felice Giangaspero…

    Citation: Biomarker Research 2015 3:13

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  11. Content type: Research

    Breast cancer circulating biomarkers include carcinoembryonic antigen and carbohydrate antigen 15–3, which are used for patient follow-up. Since sensitivity and specificity are low, novel and more useful bioma...

    Authors: Alessandra Mangolini, Manuela Ferracin, Maria Vittoria Zanzi, Elena Saccenti, Sayda Omer Ebnaof, Valentina Vultaggio Poma, Juana M. Sanz, Angela Passaro, Massimo Pedriali, Antonio Frassoldati, Patrizia Querzoli, Silvia Sabbioni, Paolo Carcoforo, Alan Hollingsworth and Massimo Negrini

    Citation: Biomarker Research 2015 3:12

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  12. Content type: Case report

    Rearrangements involving ETV6 (12p13) are among the most common structural abnormalities in pediatric B-cell acute lymphoblastic leukemia (B-ALL) and involve numerous partner genes. Additionally, the t(8;14)(q11....

    Authors: Carlos A. Tirado, David Shabsovich, Yeun Kim, Peter Traum, Sheeja Pullarkat, Michael Kallen and Nagesh Rao

    Citation: Biomarker Research 2015 3:11

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    The Erratum to this article has been published in Biomarker Research 2015 3:27

  13. Content type: Case report

    Primary hepatic lymphoma (PHL) is an extremely rare disease, frequently associated with viruses such as hepatitis B virus (HBV), hepatitis C virus (HCV), and human immune deficiency virus (HIV). On the other h...

    Authors: Ai Kawahara, Junichi Tsukada, Takahiro Yamaguchi, Takefumi Katsuragi and Takehiro Higashi

    Citation: Biomarker Research 2015 3:10

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  14. Content type: Research

    Ovarian and triple-negative breast cancers with BRCA1 or BRCA2 loss are highly sensitive to treatment with PARP inhibitors and platinum-based cytotoxic agents and show an accumulation of genomic scars in the f...

    Authors: Andrea M Marquard, Aron C Eklund, Tejal Joshi, Marcin Krzystanek, Francesco Favero, Zhigang C Wang, Andrea L Richardson, Daniel P Silver, Zoltan Szallasi and Nicolai J Birkbak

    Citation: Biomarker Research 2015 3:9

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  15. Content type: Review

    Glioblastoma (GBM) is a highly angiogenic malignancy that is resistant to standard therapy; neo-formed vessels of this aggressive malignancy are thought to arise by sprouting of pre-existing brain capillaries....

    Authors: Jin-ming Mao, Jing Liu, Geng Guo, Xing-gang Mao and Chang-xin Li

    Citation: Biomarker Research 2015 3:8

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  16. Content type: Letter to the Editor

    Adiponectin has been recognized as a potent regulator of metabolism possessing anti-inflammatory and anti-atherogenic functions and inversely associated with increasing incidents of type 2 diabetes and obesity...

    Authors: Mohamed Abu-Farha, Kazem Behbehani and Naser Elkum

    Citation: Biomarker Research 2015 3:7

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  17. Content type: Short report

    The t(1;19)(q23;p13), which can result in the TCF3-PBX1 chimeric gene, is one of the most frequent translocations in B-acute lymphoblastic leukemia (B-ALL) and is observed in both adult and pediatric populations ...

    Authors: Carlos A Tirado, David Shabsovich, Lei Yeh, Sheeja T Pullarkat, Lynn Yang, Michael Kallen and Nagesh Rao

    Citation: Biomarker Research 2015 3:4

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  18. Content type: Review

    Reviewing the literature in many fields on proposed risk models reveals problems with the way many risk models are developed. Furthermore, papers reporting new risk models do not always provide sufficient info...

    Authors: Kathleen F Kerr, Allison Meisner, Heather Thiessen-Philbrook, Steven G Coca and Chirag R Parikh

    Citation: Biomarker Research 2015 3:2

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  19. Content type: Research

    Men with a negative first prostate biopsy will undergo one or more additional biopsies if they remain at high suspicion of prostate cancer. To date, there are no diagnostic tests capable of identifying patient...

    Authors: Igor Brikun, Deborah Nusskern, Daniel Gillen, Amy Lynn, Daniel Murtagh, John Feczko, William G Nelson and Diha Freije

    Citation: Biomarker Research 2014 2:25

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  20. Content type: Case report

    Paraneoplastic syndromes can precede the initial manifestation and diagnosis of cancer. Paraneoplastic syndromes are a heterogeneous group of disorders caused by mechanisms other than the local presence of tum...

    Authors: Josephine A Taverna, Hani M Babiker, Seongseok Yun, Maria C Bishop, Sarah Lau-Braunhut, Paul N Meyer and Thomas Enzler

    Citation: Biomarker Research 2014 2:23

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  21. Content type: Methodology

    Infectious agents are estimated to play a causative role in approximately 20% of cancers worldwide. Viruses, notably the Epstein-Barr virus (EBV), are associated with 10-15% of B-cell lymphomas and are found a...

    Authors: Joseph Tellez, Crystal Jaing, Jun Wang, Ralph Green and Mingyi Chen

    Citation: Biomarker Research 2014 2:24

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  22. Content type: Research

    A subset of patients with ductal carcinoma in situ (DCIS) will develop invasive breast cancer (IBC). To date, there are no effective predictive biomarkers for identifying this subset with worse prognosis whose le...

    Authors: YunQing Jiang, Indira Prabakaran, Fei Wan, Nandita Mitra, Dana K Furstenau, Rupert K Hung, Siyuan Cao, Paul J Zhang, Douglas L Fraker and Marina A Guvakova

    Citation: Biomarker Research 2014 2:22

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  23. Content type: Review

    Nephrin is a 180 KD trans-membrane protein expressed in glomerular podocytes. It was first identified in children with congenital nephrotic syndrome of the Finnish type (NPHS1). Nephrin forms an integral part ...

    Authors: Yogavijayan Kandasamy, Roger Smith, Eugenie R Lumbers and Donna Rudd

    Citation: Biomarker Research 2014 2:21

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  24. Content type: Methodology

    The skin proteome contains valuable information on skin condition, but also on how skin may evolve in time and may respond to treatments. Despite the potential of measuring regulatory-, effector- and structura...

    Authors: Kadri Orro, Olga Smirnova, Jelena Arshavskaja, Kristiina Salk, Anne Meikas, Susan Pihelgas, Reet Rumvolt, Külli Kingo, Aram Kazarjan, Toomas Neuman and Pieter Spee

    Citation: Biomarker Research 2014 2:20

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  25. Content type: Rapid communication

    Cumulating data suggest that small noncoding-RNAs such as microRNAs (miRNAs) can be utilized as potential biomarkers for the diagnosis and prognosis of a variety of diseases such as cancer, neurological disord...

    Authors: Prasun J Mishra

    Citation: Biomarker Research 2014 2:19

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  26. Content type: Research

    The isocitrate dehydrogenase (IDH1/IDH2) genes are metabolic enzymes, which are frequently mutated in acute myeloid leukemia (AML). The enzymes acquire neomorphic enzymatic activity when they mutated.

    Authors: Kerstin Willander, Ingrid Jakobsen Falk, Roza Chaireti, Esbjörn Paul, Monica Hermansson, Henrik Gréen, Kourosh Lotfi and Peter Söderkvist

    Citation: Biomarker Research 2014 2:18

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  27. Content type: Research

    Histone deacetylase inhibitor romidepsin has demonstrated durable clinical responses and tolerability in patients with relapsed/refractory peripheral and cutaneous T-cell lymphoma (PTCL, CTCL). Selection of no...

    Authors: Francine Foss, Bertrand Coiffier, Steven Horwitz, Barbara Pro, H Miles Prince, Lubomir Sokol, Matthew Greenwood, Adam Lerner, Dolores Caballero, Eugeniusz Baran, Ellen Kim, Jean Nichols, Barbara Balser, Julie Wolfson and Sean Whittaker

    Citation: Biomarker Research 2014 2:16

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  28. Content type: Research

    Three VEGF SNPs (−2578) C/A, (+405) G/C and (+936) C/T were investigated in Tunisian exudative AMD patients in order to determine their association with the disease susceptibility and their influence to intrav...

    Authors: Imen Habibi, Imen Sfar, Ahmed Chebil, Fedra Kort, Rim Bouraoui, Salwa Jendoubi-Ayed, Mouna Makhlouf, Taïeb Ben Abdallah, Leila El Matri and Yousr Gorgi

    Citation: Biomarker Research 2014 2:15

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  29. Content type: Case report

    Chronic myelogenous leukemia (CML) results from the neoplastic transformation of a hematopoietic stem cell. CML is cytogenetically characterized by the presence of the Philadelphia chromosome (Ph’). Most patie...

    Authors: Jordi Martinez-Serra, Raquel del Campo, Antonio Gutierrez, Jose Luis Antich, Magdalena Ginard, Maria A Durán, Leyre Bento, Teresa Ros, Juan C Amat, Carmen Vidal, Julio F Iglesias, Izabela Orlinska and Joan Besalduch

    Citation: Biomarker Research 2014 2:14

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  30. Content type: Short report

    Circulating microRNAs (c-miRNAs) have be identified in saliva, urine and blood, which has led to increasing interest in their development as biomarkers for diverse diseases including cancers. One of the key ad...

    Authors: Jordan L Plieskatt, Yanjun Feng, Gabriel Rinaldi, Jason P Mulvenna, Jeffrey M Bethony and Paul J Brindley

    Citation: Biomarker Research 2014 2:13

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  31. Content type: Case report

    ABVD regimen (doxorubicin, bleomycin, vinblastine and dacarbazine) remains the most commonly used front-line therapy for Hodgkin lymphoma. However, atypical and extranodal presentations present challenges to i...

    Authors: Keyur Thakar, Aileen Novero, Arundhati Das, Adriana Lisinschi, Bella Mehta, Tauseef Ahmed and Delong Liu

    Citation: Biomarker Research 2014 2:12

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  32. Content type: Research

    High nuclear expression of the RNA-binding motif protein 3 (RBM3) has previously been found to correlate with favourable clinicopathological characteristics and a prolonged survival in several cancer forms. He...

    Authors: Liv Jonsson, Charlotta Hedner, Alexander Gaber, Dejan Korkocic, Björn Nodin, Mathias Uhlén, Jakob Eberhard and Karin Jirström

    Citation: Biomarker Research 2014 2:11

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  33. Content type: Case series

    B cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma (DLBCL) and Burkitt’s lymphoma (BL) (B-UNC/BL/DLBCL) is a new category of tumors that have features resembling ...

    Authors: Michael Bellone, Ann-Leslie Zaslav, Tahmeena Ahmed, Htien L Lee, Yupo Ma and Youjun Hu

    Citation: Biomarker Research 2014 2:9

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  34. Content type: Research

    Hepatocyte growth factor (HGF) is a pleiotropic cytokine which can lead to cancer cell proliferation, migration and metastasis. In multiple myeloma (MM) patients it is an abundant component of the bone marrow....

    Authors: Christoph Rampa, Erming Tian, Thea Kristin Våtsveen, Glenn Buene, Tobias Schmidt Slørdahl, Magne Børset, Anders Waage and Anders Sundan

    Citation: Biomarker Research 2014 2:8

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  35. Content type: Case report

    Primary cutaneous follicle centre lymphoma (PCFCL) is a rare cutaneous B cell lymphoma in middle-age adults with excellent prognosis. Here we present a case of a patient with a PCFCL in the form of a giant tum...

    Authors: Yordanka Tirefort, Xuan-Cuong Pham, Yasmine Lucile Ibrahim, Thomas Pierre Lecompte, Thomas Matthes, Christa Prins, Begonia Cortes, Michael Bernimoulin, Yves Chalandon and Kaveh Samii

    Citation: Biomarker Research 2014 2:7

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  36. Content type: Research

    Nilotinib is a second-generation tyrosine kinase inhibitor that exhibits significant efficacy as first- or second-line treatment in patients with chronic myeloid leukemia (CML). We conducted a multicenter Phas...

    Authors: Naoto Takahashi, Masatomo Miura, Jun Kuroki, Kinuko Mitani, Atsushi Kitabayashi, Osamu Sasaki, Hideo Kimura, Kiyotoshi Imai, Norifumi Tsukamoto, Hideyoshi Noji, Takeshi Kondo, Mutsuhito Motegi, Yuichi Kato, Masayuki Mita, Hajime Saito, Chikashi Yoshida…

    Citation: Biomarker Research 2014 2:6

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  37. Content type: Review

    Extensive studies of the genetic aberrations related to human diseases conducted over the last two decades have identified recurrent genomic abnormalities as potential driving factors underlying a variety of c...

    Authors: Linping Hu, Kun Ru, Li Zhang, Yuting Huang, Xiaofan Zhu, Hanzhi Liu, Anders Zetterberg, Tao Cheng and Weimin Miao

    Citation: Biomarker Research 2014 2:3

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  38. Content type: Letter to the Editor

    We applied our new method, maturity-dependent fractionation of bone marrow-derived neutrophil progenitors, to a study of gene expression profiles during granulopoiesis in myelodysplastic syndromes. CD34+ cells wi...

    Authors: Huiyuan Hu, Yayoi Shikama, Tsutomu Shichishima, Kazuhiko Ikeda, Kazuko Akutsu, Tomoyuki Ono, Hideo Kimura, Kazuei Ogawa, Hideyoshi Noji, Yasuchika Takeishi and Junko Kimura

    Citation: Biomarker Research 2014 2:2

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  39. Content type: Review

    Monocytes express various receptors, which monitor and sense environmental changes. Monocytes are highly plastic and heterogeneous, and change their functional phenotype in response to environmental stimulatio...

    Authors: Jiyeon Yang, Lixiao Zhang, Caijia Yu, Xiao-Feng Yang and Hong Wang

    Citation: Biomarker Research 2014 2:1

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