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  1. Fanconi Anemia (FA) is an inherited disorder characterized by the variable presence of multiple congenital somatic abnormalities, bone marrow failure and cancer susceptibility. Medulloblastoma (MB) has been de...

    Authors: Evelina Miele, Angela Mastronuzzi, Agnese Po, Andrea Carai, Vincenzo Alfano, Annalisa Serra, Giovanna Stefania Colafati, Luisa Strocchio, Manila Antonelli, Francesca Romana Buttarelli, Massimo Zani, Sergio Ferraro, Amelia Buffone, Alessandra Vacca, Isabella Screpanti, Felice Giangaspero…

    Citation: Biomarker Research 2015 3:13

    Content type: Case report

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  2. Rearrangements involving ETV6 (12p13) are among the most common structural abnormalities in pediatric B-cell acute lymphoblastic leukemia (B-ALL) and involve numerous partner genes. Additionally, the t(8;14)(q11....

    Authors: Carlos A. Tirado, David Shabsovich, Yeun Kim, Peter Traum, Sheeja Pullarkat, Michael Kallen and Nagesh Rao

    Citation: Biomarker Research 2015 3:11

    Content type: Case report

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    The Erratum to this article has been published in Biomarker Research 2015 3:27

  3. Primary hepatic lymphoma (PHL) is an extremely rare disease, frequently associated with viruses such as hepatitis B virus (HBV), hepatitis C virus (HCV), and human immune deficiency virus (HIV). On the other h...

    Authors: Ai Kawahara, Junichi Tsukada, Takahiro Yamaguchi, Takefumi Katsuragi and Takehiro Higashi

    Citation: Biomarker Research 2015 3:10

    Content type: Case report

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  4. Ovarian and triple-negative breast cancers with BRCA1 or BRCA2 loss are highly sensitive to treatment with PARP inhibitors and platinum-based cytotoxic agents and show an accumulation of genomic scars in the f...

    Authors: Andrea M Marquard, Aron C Eklund, Tejal Joshi, Marcin Krzystanek, Francesco Favero, Zhigang C Wang, Andrea L Richardson, Daniel P Silver, Zoltan Szallasi and Nicolai J Birkbak

    Citation: Biomarker Research 2015 3:9

    Content type: Research

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  5. Glioblastoma (GBM) is a highly angiogenic malignancy that is resistant to standard therapy; neo-formed vessels of this aggressive malignancy are thought to arise by sprouting of pre-existing brain capillaries....

    Authors: Jin-ming Mao, Jing Liu, Geng Guo, Xing-gang Mao and Chang-xin Li

    Citation: Biomarker Research 2015 3:8

    Content type: Review

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  6. Adiponectin has been recognized as a potent regulator of metabolism possessing anti-inflammatory and anti-atherogenic functions and inversely associated with increasing incidents of type 2 diabetes and obesity...

    Authors: Mohamed Abu-Farha, Kazem Behbehani and Naser Elkum

    Citation: Biomarker Research 2015 3:7

    Content type: Letter to the Editor

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  9. The t(1;19)(q23;p13), which can result in the TCF3-PBX1 chimeric gene, is one of the most frequent translocations in B-acute lymphoblastic leukemia (B-ALL) and is observed in both adult and pediatric populations ...

    Authors: Carlos A Tirado, David Shabsovich, Lei Yeh, Sheeja T Pullarkat, Lynn Yang, Michael Kallen and Nagesh Rao

    Citation: Biomarker Research 2015 3:4

    Content type: Short report

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  11. Reviewing the literature in many fields on proposed risk models reveals problems with the way many risk models are developed. Furthermore, papers reporting new risk models do not always provide sufficient info...

    Authors: Kathleen F Kerr, Allison Meisner, Heather Thiessen-Philbrook, Steven G Coca and Chirag R Parikh

    Citation: Biomarker Research 2015 3:2

    Content type: Review

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  13. Men with a negative first prostate biopsy will undergo one or more additional biopsies if they remain at high suspicion of prostate cancer. To date, there are no diagnostic tests capable of identifying patient...

    Authors: Igor Brikun, Deborah Nusskern, Daniel Gillen, Amy Lynn, Daniel Murtagh, John Feczko, William G Nelson and Diha Freije

    Citation: Biomarker Research 2014 2:25

    Content type: Research

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  14. Infectious agents are estimated to play a causative role in approximately 20% of cancers worldwide. Viruses, notably the Epstein-Barr virus (EBV), are associated with 10-15% of B-cell lymphomas and are found a...

    Authors: Joseph Tellez, Crystal Jaing, Jun Wang, Ralph Green and Mingyi Chen

    Citation: Biomarker Research 2014 2:24

    Content type: Methodology

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  15. Paraneoplastic syndromes can precede the initial manifestation and diagnosis of cancer. Paraneoplastic syndromes are a heterogeneous group of disorders caused by mechanisms other than the local presence of tum...

    Authors: Josephine A Taverna, Hani M Babiker, Seongseok Yun, Maria C Bishop, Sarah Lau-Braunhut, Paul N Meyer and Thomas Enzler

    Citation: Biomarker Research 2014 2:23

    Content type: Case report

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  16. A subset of patients with ductal carcinoma in situ (DCIS) will develop invasive breast cancer (IBC). To date, there are no effective predictive biomarkers for identifying this subset with worse prognosis whose le...

    Authors: YunQing Jiang, Indira Prabakaran, Fei Wan, Nandita Mitra, Dana K Furstenau, Rupert K Hung, Siyuan Cao, Paul J Zhang, Douglas L Fraker and Marina A Guvakova

    Citation: Biomarker Research 2014 2:22

    Content type: Research

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  17. Nephrin is a 180 KD trans-membrane protein expressed in glomerular podocytes. It was first identified in children with congenital nephrotic syndrome of the Finnish type (NPHS1). Nephrin forms an integral part ...

    Authors: Yogavijayan Kandasamy, Roger Smith, Eugenie R Lumbers and Donna Rudd

    Citation: Biomarker Research 2014 2:21

    Content type: Review

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  18. The skin proteome contains valuable information on skin condition, but also on how skin may evolve in time and may respond to treatments. Despite the potential of measuring regulatory-, effector- and structura...

    Authors: Kadri Orro, Olga Smirnova, Jelena Arshavskaja, Kristiina Salk, Anne Meikas, Susan Pihelgas, Reet Rumvolt, Külli Kingo, Aram Kazarjan, Toomas Neuman and Pieter Spee

    Citation: Biomarker Research 2014 2:20

    Content type: Methodology

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  19. Cumulating data suggest that small noncoding-RNAs such as microRNAs (miRNAs) can be utilized as potential biomarkers for the diagnosis and prognosis of a variety of diseases such as cancer, neurological disord...

    Authors: Prasun J Mishra

    Citation: Biomarker Research 2014 2:19

    Content type: Rapid communication

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  20. The isocitrate dehydrogenase (IDH1/IDH2) genes are metabolic enzymes, which are frequently mutated in acute myeloid leukemia (AML). The enzymes acquire neomorphic enzymatic activity when they mutated.

    Authors: Kerstin Willander, Ingrid Jakobsen Falk, Roza Chaireti, Esbjörn Paul, Monica Hermansson, Henrik Gréen, Kourosh Lotfi and Peter Söderkvist

    Citation: Biomarker Research 2014 2:18

    Content type: Research

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  22. Histone deacetylase inhibitor romidepsin has demonstrated durable clinical responses and tolerability in patients with relapsed/refractory peripheral and cutaneous T-cell lymphoma (PTCL, CTCL). Selection of no...

    Authors: Francine Foss, Bertrand Coiffier, Steven Horwitz, Barbara Pro, H Miles Prince, Lubomir Sokol, Matthew Greenwood, Adam Lerner, Dolores Caballero, Eugeniusz Baran, Ellen Kim, Jean Nichols, Barbara Balser, Julie Wolfson and Sean Whittaker

    Citation: Biomarker Research 2014 2:16

    Content type: Research

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  23. Three VEGF SNPs (−2578) C/A, (+405) G/C and (+936) C/T were investigated in Tunisian exudative AMD patients in order to determine their association with the disease susceptibility and their influence to intrav...

    Authors: Imen Habibi, Imen Sfar, Ahmed Chebil, Fedra Kort, Rim Bouraoui, Salwa Jendoubi-Ayed, Mouna Makhlouf, Taïeb Ben Abdallah, Leila El Matri and Yousr Gorgi

    Citation: Biomarker Research 2014 2:15

    Content type: Research

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  24. Chronic myelogenous leukemia (CML) results from the neoplastic transformation of a hematopoietic stem cell. CML is cytogenetically characterized by the presence of the Philadelphia chromosome (Ph’). Most patie...

    Authors: Jordi Martinez-Serra, Raquel del Campo, Antonio Gutierrez, Jose Luis Antich, Magdalena Ginard, Maria A Durán, Leyre Bento, Teresa Ros, Juan C Amat, Carmen Vidal, Julio F Iglesias, Izabela Orlinska and Joan Besalduch

    Citation: Biomarker Research 2014 2:14

    Content type: Case report

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  25. Circulating microRNAs (c-miRNAs) have be identified in saliva, urine and blood, which has led to increasing interest in their development as biomarkers for diverse diseases including cancers. One of the key ad...

    Authors: Jordan L Plieskatt, Yanjun Feng, Gabriel Rinaldi, Jason P Mulvenna, Jeffrey M Bethony and Paul J Brindley

    Citation: Biomarker Research 2014 2:13

    Content type: Short report

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  26. ABVD regimen (doxorubicin, bleomycin, vinblastine and dacarbazine) remains the most commonly used front-line therapy for Hodgkin lymphoma. However, atypical and extranodal presentations present challenges to i...

    Authors: Keyur Thakar, Aileen Novero, Arundhati Das, Adriana Lisinschi, Bella Mehta, Tauseef Ahmed and Delong Liu

    Citation: Biomarker Research 2014 2:12

    Content type: Case report

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  27. High nuclear expression of the RNA-binding motif protein 3 (RBM3) has previously been found to correlate with favourable clinicopathological characteristics and a prolonged survival in several cancer forms. He...

    Authors: Liv Jonsson, Charlotta Hedner, Alexander Gaber, Dejan Korkocic, Björn Nodin, Mathias Uhlén, Jakob Eberhard and Karin Jirström

    Citation: Biomarker Research 2014 2:11

    Content type: Research

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  29. B cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma (DLBCL) and Burkitt’s lymphoma (BL) (B-UNC/BL/DLBCL) is a new category of tumors that have features resembling ...

    Authors: Michael Bellone, Ann-Leslie Zaslav, Tahmeena Ahmed, Htien L Lee, Yupo Ma and Youjun Hu

    Citation: Biomarker Research 2014 2:9

    Content type: Case series

    Published on:

  30. Hepatocyte growth factor (HGF) is a pleiotropic cytokine which can lead to cancer cell proliferation, migration and metastasis. In multiple myeloma (MM) patients it is an abundant component of the bone marrow....

    Authors: Christoph Rampa, Erming Tian, Thea Kristin Våtsveen, Glenn Buene, Tobias Schmidt Slørdahl, Magne Børset, Anders Waage and Anders Sundan

    Citation: Biomarker Research 2014 2:8

    Content type: Research

    Published on:

  31. Primary cutaneous follicle centre lymphoma (PCFCL) is a rare cutaneous B cell lymphoma in middle-age adults with excellent prognosis. Here we present a case of a patient with a PCFCL in the form of a giant tum...

    Authors: Yordanka Tirefort, Xuan-Cuong Pham, Yasmine Lucile Ibrahim, Thomas Pierre Lecompte, Thomas Matthes, Christa Prins, Begonia Cortes, Michael Bernimoulin, Yves Chalandon and Kaveh Samii

    Citation: Biomarker Research 2014 2:7

    Content type: Case report

    Published on:

  32. Nilotinib is a second-generation tyrosine kinase inhibitor that exhibits significant efficacy as first- or second-line treatment in patients with chronic myeloid leukemia (CML). We conducted a multicenter Phas...

    Authors: Naoto Takahashi, Masatomo Miura, Jun Kuroki, Kinuko Mitani, Atsushi Kitabayashi, Osamu Sasaki, Hideo Kimura, Kiyotoshi Imai, Norifumi Tsukamoto, Hideyoshi Noji, Takeshi Kondo, Mutsuhito Motegi, Yuichi Kato, Masayuki Mita, Hajime Saito, Chikashi Yoshida…

    Citation: Biomarker Research 2014 2:6

    Content type: Research

    Published on:

  35. Extensive studies of the genetic aberrations related to human diseases conducted over the last two decades have identified recurrent genomic abnormalities as potential driving factors underlying a variety of c...

    Authors: Linping Hu, Kun Ru, Li Zhang, Yuting Huang, Xiaofan Zhu, Hanzhi Liu, Anders Zetterberg, Tao Cheng and Weimin Miao

    Citation: Biomarker Research 2014 2:3

    Content type: Review

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  36. We applied our new method, maturity-dependent fractionation of bone marrow-derived neutrophil progenitors, to a study of gene expression profiles during granulopoiesis in myelodysplastic syndromes. CD34+ cells wi...

    Authors: Huiyuan Hu, Yayoi Shikama, Tsutomu Shichishima, Kazuhiko Ikeda, Kazuko Akutsu, Tomoyuki Ono, Hideo Kimura, Kazuei Ogawa, Hideyoshi Noji, Yasuchika Takeishi and Junko Kimura

    Citation: Biomarker Research 2014 2:2

    Content type: Letter to the Editor

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  37. Monocytes express various receptors, which monitor and sense environmental changes. Monocytes are highly plastic and heterogeneous, and change their functional phenotype in response to environmental stimulatio...

    Authors: Jiyeon Yang, Lixiao Zhang, Caijia Yu, Xiao-Feng Yang and Hong Wang

    Citation: Biomarker Research 2014 2:1

    Content type: Review

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  38. Natural killer cells comprise the body’s first line of defense against virus-infected cells. As is true of all lymphocytes, natural killer cell malignancies can develop, however natural killer cell leukemias c...

    Authors: Jon Crosbie, Marc Magnussen, Ryan Dornbier, Alexandra Iannone and Timothy A Steele

    Citation: Biomarker Research 2013 1:33

    Content type: Research

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  39. Although palliative chemotherapy has been shown to prolong survival and improve quality of life, the survival of advanced gastric cancer (AGC) patients remains poor. With the advent of targeted therapy, many m...

    Authors: Miao-zhen Qiu and Rui-hua Xu

    Citation: Biomarker Research 2013 1:32

    Content type: Review

    Published on:

  40. B-cell acute lymphoblastic leukemia (B-ALL) is the most common malignancy in pediatric patients and the leading cause of cancer-related death in children and young adults. Translocations of 9p24 involving JAK2 (9...

    Authors: Carlos A Tirado, David Shabsovich, Matthew DeNicola, Dinesh Rao, Lynn Yang, Rolando Garcia and Nagesh Rao

    Citation: Biomarker Research 2013 1:31

    Content type: Short report

    Published on:

  42. Glioblastoma Multiforme (GBM) is the most common primary malignant tumor of the central nervous system. Standard of care includes maximal resection followed by chemoradiotherapy. Tumors need adequate perfusion...

    Authors: Andra V Krauze, Minhee Won, Christian Graves, Ben W Corn, Thierry M Muanza, Steven P Howard, Arul Mahadevan, Christopher J Schultz, Michael L Haas, Minesh P Mehta and Kevin A Camphausen

    Citation: Biomarker Research 2013 1:29

    Content type: Research

    Published on:

  43. Huntington Disease (HD) is a progressive neurological disorder, with pathological manifestations in brain areas and in periphery caused by the ubiquitous expression of mutant Huntingtin protein. Transcriptiona...

    Authors: Daniela Diamanti, Elisa Mori, Danny Incarnato, Federico Malusa, Costanza Fondelli, Letizia Magnoni and Giuseppe Pollio

    Citation: Biomarker Research 2013 1:28

    Content type: Short report

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  45. A higher concentration of high density lipoprotein cholesterol (HDL-C) in ex-smokers than smokers has consistently been observed. Better evidence of quitting effects comes from within-subject changes. We exten...

    Authors: Barbara A Forey, John S Fry, Peter N Lee, Alison J Thornton and Katharine J Coombs

    Citation: Biomarker Research 2013 1:26

    Content type: Review

    Published on:

  46. Carbohydrate antigen 125 (CA-125), traditionally a tumor marker for screening, diagnosis, and monitoring in ovarian malignancy, had recently been shown increasing evidence and more extensively recognized/explo...

    Authors: Chung-Lieh Hung, Ta-Chuan Hung, Yau-Hui Lai, Chi-Sheng Lu, Yih-Jer Wu and Hung-I Yeh

    Citation: Biomarker Research 2013 1:25

    Content type: Review

    Published on:

  49. The Cancer Testis Antigens (CTAs) are a group of genes that are highly expressed in the normal testis and several types of cancer. Due to their restricted expression in normal adult tissues, CTAs have been att...

    Authors: John J Kim, Krithika Rajagopalan, Basil Hussain, Brenten H Williams, Prakash Kulkarni and Steven M Mooney

    Citation: Biomarker Research 2013 1:22

    Content type: Research

    Published on:

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