Articles

Dental implant bioactive surface modifications and their effects on osseointegration: a review

The purpose of this article is to review and update the current developments of biologically active dental implant surfaces and their effect on osseointegration.

Authors: Hsiu-Wan Meng, Esther Yun Chien and Hua-Hong Chien

Application of multi-target phytotherapeutic concept in malaria drug discovery: a systems biology approach in biomarker identification

There is an urgent need for new anti-malaria drugs with broad therapeutic potential and novel mode of action, for effective treatment and to overcome emerging drug resistance. Plant-derived anti-malarials rema...

Authors: Protus Arrey Tarkang, Regina Appiah-Opong, Michael F. Ofori, Lawrence S. Ayong and Alexander K. Nyarko

Plasma microRNA biomarker detection for mild cognitive impairment using differential correlation analysis

Mild cognitive impairment (MCI) is an intermediate state between normal aging and dementia including Alzheimer’s disease. Early detection of dementia, and MCI, is a crucial issue in terms of secondary preventi...

Authors: Mitsunori Kayano, Sayuri Higaki, Jun-ichi Satoh, Kenji Matsumoto, Etsuro Matsubara, Osamu Takikawa and Shumpei Niida

Mechanically produced schistosomula as a higher-throughput tools for phenotypic pre-screening in drug sensitivity assays: current research and future trends

It is crucial to develop new antischistosomal drugs since there is no vaccine and the whole world is relying on only a single drug for the treatment of schistosomiasis. One of the obstacles to the development ...

Authors: Emmanuel Mouafo Tekwu, William Kofi Anyan, Daniel Boamah, Kofi Owusu Baffour-Awuah, Stephanie Keyetat Tekwu, Veronique Penlap Beng, Alexander Kwadwo Nyarko and Kwabena Mante Bosompem

Advance in microRNA as a potential biomarker for early detection of pancreatic cancer

Pancreatic cancer is characterized as a disease with low survival and high mortality because of no effective diagnostic and therapeutic strategies available in clinic. Conventional clinical diagnostic methods ...

Authors: Jing Huang, Jianzhou Liu, Kevin Chen-Xiao, Xuemei Zhang, W. N. Paul Lee, Vay Liang W. Go and Gary Guishan Xiao

JAK2 V617F mutation, multiple hematologic and non-hematologic processes: an association?

Population studies showed that patients with JAK2 V617F mutation had increased mortality, and increased risk of any cancer, hematologic cancer, and myeloproliferative disease.

Authors: Kenneth G. Liu, Amit Verma, Olga Derman, Noah Kornblum, Murali Janakiram, Ira Braunschweig and Ramakrishna Battini

Hypercalcemia associated with isolated bone marrow sarcoidosis in a patient with underlying monoclonal gammopathy of undetermined significance: case report and review of literature

Bone marrow sarcoidosis is extremely rare. The association between sarcoidosis and lymphoproliferative disorders has been previously speculated, although the diagnosis of sarcoidosis often precedes any hematol...

Authors: John Gubatan, Xiaohui Wang, Abner Louissaint, Anuj Mahindra and John Vanderpool

Extramedullary hematopoiesis presented as cytopenia and massive paraspinal masses leading to cord compression in a patient with hereditary persistence of fetal hemoglobin

Extramedullary hematopoeisis (EMH) can occur in various physiological and pathologic states. The spleen is the most common site of EMH.

Authors: Tasleem Katchi, Krishna Kolandaivel, Pallavi Khattar, Taliya Farooq, Humayun Islam and Delong Liu

A novel three-way rearrangement involving ETV6 (12p13) and ABL1 (9q34) with an unknown partner on 3p25 resulting in a possible ETV6-ABL1 fusion in a patient with acute myeloid leukemia: a case report and a review of the literature

Acute myeloid leukemia (AML) is commonly characterized by several chromosomal abnormalities resulting in the formation of chimeric genes that play various roles in leukemogenesis. Translocations resulting in the

Authors: Carlos A. Tirado, Ken Siangchin, David S. Shabsovich, Maryam Sharifian and Gary Schiller

Gastric mucosa-associated lymphoid tissue lymphoma and Helicobacter pylori infection: a review of current diagnosis and management

Helicobacter pylori (H. pylori)-associated gastritis is one of the most common infectious diseases in the United States, China and worldwide. Gastric mucosa-associated tissue lymphoma (MA...

Authors: Qinglong Hu, Yizhuo Zhang, Xiaoyan Zhang and Kai Fu

Pediatric chronic myeloid leukemia with inv(3)(q21q26.2) and T lymphoblastic transformation: a case report

Chronic myeloid leukemia (CML) comprises ~3 % of pediatric leukemia. Although therapy with tyrosine kinase inhibitors (TKIs) is highly effective for CML, multiple factors have been identified as predictive of ...

Authors: Margaret Lewen, Renee Gresh, Maria Queenan, Michele Paessler, Vinodh Pillai, Elizabeth Hexner, Dale Frank, Adam Bagg, Richard Aplenc, Emi Caywood and Gerald Wertheim

The effect of n-3 polyunsaturated fatty acids on incidence and severity of oxaliplatin induced peripheral neuropathy: a randomized controlled trial

Oxaliplatin induced peripheral neurotoxicity (OXIPN) is the major dose-limiting and long-lasting side effect of oxaliplatin. N-3 PUFAs have neuroprotective property via their effects on voltage-gated ion chann...

Authors: Ali Esfahani, Mohammad hossein Somi, Hormoz Ayromlou, Alireza Nikanfar, Mohammad Asghari Jafarabadi, Bina Eftekhar Sadat and Zohreh Ghoreishi

The CXCR4 antagonist plerixafor enhances the effect of rituximab in diffuse large B-cell lymphoma cell lines

Diffuse large B-cell lymphoma (DLBCL) is an aggressive disease with variable clinical outcome, accounting for at least 25-30 % of adult non-Hodgkin lymphomas. Approximately one third of DLBCL patients are not ...

Authors: Linn Reinholdt, Maria Bach Laursen, Alexander Schmitz, Julie Støve Bødker, Lasse Hjort Jakobsen, Martin Bøgsted, Hans Erik Johnsen and Karen Dybkær

Identification of functional metabolic biomarkers from lung cancer patient serum using PEP technology

Reprogrammed metabolism is a new hallmark of cancer. In many types of cancer, most of the genes in the glycolytic pathway are overexpressed, reflecting an essential shift of metabolism during cancer developmen...

Authors: Zhenyu Sun, Xiaofeng Chen, Gan. Wang, Liang Li, Guofeng Fu, Matthew Kuruc and Xing Wang

Expression of IFITM1 as a prognostic biomarker in resected gastric and esophageal adenocarcinoma

There is an increasing amount of reports on IFITM1 (interferon-inducible transmembrane protein 1) in various malignancies. The aim of this study was to examine the expression of IFITM1 and its prognostic signi...

Authors: David Borg, Charlotta Hedner, Alexander Gaber, Björn Nodin, Richard Fristedt, Karin Jirström, Jakob Eberhard and Anders Johnsson

Evaluation of Caspase-9b and PP2Acα2 as potential biomarkers for chronic lymphocytic leukemia

Disruption of alternative splicing in apoptotic factors has been associated to chronic lymphocytic leukemia among other cancers and hematological malignancies. The proapoptotic proteins Caspase-9 and PP2Acα ar...

Authors: Leticia Domínguez-Berrocal, Xiguang Zhang, Jean Marc Zini, Jesús Fominaya, Angelita Rebollo and Jerónimo Bravo

The combinatorial approach of laser-captured microdissection and reverse transcription quantitative polymerase chain reaction accurately determines HER2 status in breast cancer

HER2 expression in breast cancer correlates with increased metastatic potential, higher tumor recurrence rates and improved response to targeted therapies. Fluorescence in situ hybridization (FISH) and immunohist...

Authors: Elisabeth Hofmann, Rita Seeboeck, Nico Jacobi, Peter Obrist, Samuel Huter, Christian Klein, Kamil Oender, Christoph Wiesner, Harald Hundsberger and Andreas Eger

Treatment with rituximab and brentuximab vedotin in a patient of common variable immune deficiency-associated classic Hodgkin lymphoma

Patients with common variable immunodeficiency (CVID) have an increased risk of developing lymphoproliferative diseases, including non-Hodgkins lymphoma (Blood 116:1228–1234, 2010; Blood 119:1650–7, 2012). The...

Authors: Efren Rael, Kevin Rakszawski, Kristian Koller, Michael Bayerl, Manish Butte and Hong Zheng

SOX11 is a biomarker for cyclin D1-negative mantle cell lymphoma

Cyclin D1 (CCND1) protein overexpression and/or the t(11;14)(q13;q32) translocation are the pathognomonic hallmarks of mantle cell lymphoma (MCL). However, there have been cases that lacked both t(11;14) and c...

Authors: Roshni Narurkar, Mohammad Alkayem and Delong Liu

c-MYB is a transcriptional regulator of ESPL1/Separase in BCR-ABL-positive chronic myeloid leukemia

Genomic instability and clonal evolution are hallmarks of progressing chronic myeloid leukemia (CML). Recently, we have shown that clonal evolution and blast crisis correlate with altered expression and activi...

Authors: Wiltrud Prinzhorn, Michael Stehle, Helga Kleiner, Sabrina Ruppenthal, Martin C. Müller, Wolf-Karsten Hofmann, Alice Fabarius and Wolfgang Seifarth

A robust prognostic gene expression signature for early stage lung adenocarcinoma

Stage I lung adenocarcinoma is usually not treated with adjuvant chemotherapy; however, around half of these patients do not survive 5 years. Therefore, a reliable prognostic biomarker for early stage patients...

Authors: Marcin Krzystanek, Judit Moldvay, David Szüts, Zoltan Szallasi and Aron Charles Eklund

RECQ helicases are deregulated in hematological malignancies in association with a prognostic value

RECQ helicase family members act as guardians of the genome to assure proper DNA metabolism in response to genotoxic stress. Hematological malignancies are characterized by genomic instability that is possibly...

Authors: Elena Viziteu, Alboukadel Kassambara, Philippe Pasero, Bernard Klein and Jerome Moreaux

Ruxolitinib improves symptoms and quality of life in a patient with systemic mastocytosis

Systemic mastocytosis is a clonal myeloproliferative neoplasm associated with constitutional symptoms from mast cell mediated chemical and cytokine release. According to the literature, Ruxolitinib, a JAK1/JAK...

Authors: Abdulraheem Yacoub and Lindsey Prochaska

A panel of glycoproteins as candidate biomarkers for early diagnosis and treatment evaluation of B-cell acute lymphoblastic leukemia

Acute lymphoblastic leukemia is the most common malignant cancer in childhood. The signs and symptoms of childhood cancer are difficult to recognize, as it is not the first diagnosis to be considered for nonsp...

Authors: Marcio de Souza Cavalcante, José Camilo Torres-Romero, Marina Duarte Pinto Lobo, Frederico Bruno Mendes Batista Moreno, Leonardo Primo Bezerra, Diego Silva Lima, Jesamar Correia Matos, Renato de Azevedo Moreira and Ana Cristina de Oliveira Monteiro-Moreira

A meta-analysis of hypoxia inducible factor 1-alpha (HIF1A) gene polymorphisms: association with cancers

Hypoxia inducible factor 1-alpha (HIF1A) is a transcription factor that plays important role in regulating cascade of reactions. In this study, the effect of rs11549465 (1772 C/T) and rs11549467 (1790 G/A) pol...

Authors: Md. T Anam, Alokta Ishika, Md. B Hossain and Jesmin

A striking response of plasmablastic lymphoma of the oral cavity to bortezomib: a case report

Plasmablastic lymphoma (PBL) is a rare and aggressive subtype of non-Hodgkin diffuse large B-cell lymphoma originally with a predilection to the oral cavity of patients infected with HIV. However, PBL of extra...

Authors: Makoto Hirosawa, Hiroaki Morimoto, Ryo Shibuya, Shohei Shimajiri and Junichi Tsukada

Erratum to: A case of B-cell acute lymphoblastic leukemia in a child with Down syndrome bearing a t(2;12)(p12;p13) involving ETV6 and biallelic IGH@ rearrangements

Authors: Carlos A. Tirado, David Shabsovich, Yeun Kim, Peter Traum, Sheeja Pullarkat, Michael Kallen and Nagesh Rao

Pattern and prevelence of alloimmunization in multiply transfused patients with sickle cell disease in Nigeria

Blood transfusion is central in the prevention and treatment of certain chronic complications of sickle cell disease. It is indispensible in correcting anaemias as well as in the practice of exchange blood tra...

Authors: Umar Kangiwa, Obike Ibegbulam, Sunday Ocheni, Anazoeze Madu and Ndakosu Mohammed

Circulating micrornas associated with glycemic impairment and progression in Asian Indians

Asian Indians have a high incidence of type 2 diabetes, but factors associated with glycemic progression in this population are not understood. MicroRNAs are emerging as important mediators of glucose homeosta...

Authors: Elena Flowers, Meghana Gadgil, Bradley E. Aouizerat and Alka M. Kanaya

Lower platelet counts and antiplatelet therapy independently predict better outcomes in patients with head and neck squamous cell carcinoma: a retrospective analysis

The paper by Rachidi et al. suggests that antiplatelet drugs may play a role in ameliorating the clinical outcome in a large series of patients with head and neck cancer managed with either surgery or radiation. ...

Authors: Carlo Furlan, Agostino Steffan, Jerry Polesel, Marco Trovo, Carlo Gobitti, Emanuela Vaccher, Diego Serraino, Luigi Barzan and Giovanni Franchin

Paediatric acute myeloid leukaemia with the t(7;12)(q36;p13) rearrangement: a review of the biological and clinical management aspects

The presence of chromosomal abnormalities is one of the most important criteria for leukaemia diagnosis and management. Infant leukaemia is a rare disease that affects children in their first year of life. It ...

Authors: Sabrina Tosi, Yasser Mostafa Kamel, Temitayo Owoka, Concetta Federico, Tony H. Truong and Salvatore Saccone

Therapeutic potential of folic acid supplementation for cardiovascular disease prevention through homocysteine lowering and blockade in rheumatoid arthritis patients

Rheumatoid arthritis (RA) is a chronic inflammatory disease that preferentially affects joints, and characterized by an approximately two-fold increased risk of cardiovascular diseases compared with the genera...

Authors: Mickael Essouma and Jean Jacques N. Noubiap

Suspected anemia caused by maternal anti-Jra antibodies: a case report

Most cases of hemolytic disease of the newborn associated with anti-Jra are mild. However, rare cases of hydrops fetalis and severe anemia have been reported. We treated a neonate with anemia who was born with...

Authors: Yasufumi Endo, Shoichi Ito and Yoshiko Ogiyama

Prognostic models for alcoholic hepatitis

Alcoholic hepatitis (AH) is caused by acute inflammation of the liver in patients that consume excessive amounts of alcohol, usually in a background of cirrhosis. AH can range from mild to severe, life threate...

Authors: Erik Rahimi and Jen-Jung Pan

Biomarkers for immune thrombocytopenia

Immune thrombocytopenia is an autoimmune disease with abnormal biomarkers. Immune thrombocytopenia pathogenesis is a complicated process in which the patient’s immune system is activated by platelet autoantige...

Authors: Lingjia Yu, Chunmei Zhang, Liping Zhang, Yongyu Shi and Xuebin Ji

Higher plasma prorenin concentration plays a role in the development of coronary artery disease

Prorenin and renin are both involved in atherosclerosis. However, the role of plasma prorenin and renin in the development and progression of coronary artery disease (CAD) is still not clear. Thus, we aimed to...

Authors: Gakuro Yoshida, Masanori Kawasaki, Ichijiro Murata, Yuka Hayakawa, Takuma Aoyama, Nagisa Miyazaki, Yoshihisa Yamada, Kazuhiko Nishigaki, Yoshie Arai, Fumiaki Suzuki and Shinya Minatoguchi

Triptolide potentiates lung cancer cells to cisplatin-induced apoptosis by selectively inhibiting the NER activity

Cisplatin and many other platinum-based compounds are important anticancer drugs that are used in treating many cancer types. The development of cisplatin-resistant cancer cells, however, quickly diminishes th...

Authors: Gan Wang, Xing Wang and Xiaoxin Xu

Urinary biomarkers for early diabetic nephropathy in type 2 diabetic patients

Diabetic nephropathy (DN) is a serious complication of diabetes associated with increased risk of mortality, and cardiovascular and renal outcomes. Diagnostic markers to detect DN at early stage are important ...

Authors: Temesgen Fiseha

Detection of BCR-ABL T315I mutation by peptide nucleic acid directed PCR clamping and by peptide nucleic acid FISH

Mutations of the BCR-ABL1 fusion gene represent a well established cause of resistance to tyrosine kinase inhibitors. Among the different mutations identified T315I is of particular concern since it is not effect...

Authors: Valentina Rosso, Enrico Bracco, Roberto Pedrola, Sonia Carturan, Elisabetta Signorino, Jessica Petiti, Chiara Calabrese, Paolo Nicoli, Marco De Gobbi, Valentina Gaidano, Daniela Gallo, Stefano Ulisciani, Carmen Fava, Giovanna Rege-Cambrin, Francesco Frassoni, Giuseppe Saglio…

BAP1 hereditary cancer predisposition syndrome: a case report and review of literature

A 72-year-old woman was diagnosed with uveal melanoma, peritoneal mesothelioma and a primary biliary tract adenocarcinoma. She had a strong family history of mesothelioma as well as other malignancies includin...

Authors: Sonja Klebe, Jack Driml, Masaki Nasu, Sandra Pastorino, Amirmasoud Zangiabadi, Douglas Henderson and Michele Carbone

Characterization of medulloblastoma in Fanconi Anemia: a novel mutation in the BRCA2 gene and SHH molecular subgroup

Fanconi Anemia (FA) is an inherited disorder characterized by the variable presence of multiple congenital somatic abnormalities, bone marrow failure and cancer susceptibility. Medulloblastoma (MB) has been de...

Authors: Evelina Miele, Angela Mastronuzzi, Agnese Po, Andrea Carai, Vincenzo Alfano, Annalisa Serra, Giovanna Stefania Colafati, Luisa Strocchio, Manila Antonelli, Francesca Romana Buttarelli, Massimo Zani, Sergio Ferraro, Amelia Buffone, Alessandra Vacca, Isabella Screpanti, Felice Giangaspero…

Diagnostic and prognostic microRNAs in the serum of breast cancer patients measured by droplet digital PCR

Breast cancer circulating biomarkers include carcinoembryonic antigen and carbohydrate antigen 15–3, which are used for patient follow-up. Since sensitivity and specificity are low, novel and more useful bioma...

Authors: Alessandra Mangolini, Manuela Ferracin, Maria Vittoria Zanzi, Elena Saccenti, Sayda Omer Ebnaof, Valentina Vultaggio Poma, Juana M. Sanz, Angela Passaro, Massimo Pedriali, Antonio Frassoldati, Patrizia Querzoli, Silvia Sabbioni, Paolo Carcoforo, Alan Hollingsworth and Massimo Negrini

A case of B-cell acute lymphoblastic leukemia in a child with Down syndrome bearing a t(2;12)(p12;p13) involving ETV6 and biallelic IGH@ rearrangements

Rearrangements involving ETV6 (12p13) are among the most common structural abnormalities in pediatric B-cell acute lymphoblastic leukemia (B-ALL) and involve numerous partner genes. Additionally, the t(8;14)(q11....

Authors: Carlos A. Tirado, David Shabsovich, Yeun Kim, Peter Traum, Sheeja Pullarkat, Michael Kallen and Nagesh Rao

Reversible methotrexate-associated lymphoma of the liver in rheumatoid arthritis: a unique case of primary hepatic lymphoma

Primary hepatic lymphoma (PHL) is an extremely rare disease, frequently associated with viruses such as hepatitis B virus (HBV), hepatitis C virus (HCV), and human immune deficiency virus (HIV). On the other h...

Authors: Ai Kawahara, Junichi Tsukada, Takahiro Yamaguchi, Takefumi Katsuragi and Takehiro Higashi

Pan-cancer analysis of genomic scar signatures associated with homologous recombination deficiency suggests novel indications for existing cancer drugs

Ovarian and triple-negative breast cancers with BRCA1 or BRCA2 loss are highly sensitive to treatment with PARP inhibitors and platinum-based cytotoxic agents and show an accumulation of genomic scars in the f...

Authors: Andrea M Marquard, Aron C Eklund, Tejal Joshi, Marcin Krzystanek, Francesco Favero, Zhigang C Wang, Andrea L Richardson, Daniel P Silver, Zoltan Szallasi and Nicolai J Birkbak

Glioblastoma vasculogenic mimicry: signaling pathways progression and potential anti-angiogenesis targets

Glioblastoma (GBM) is a highly angiogenic malignancy that is resistant to standard therapy; neo-formed vessels of this aggressive malignancy are thought to arise by sprouting of pre-existing brain capillaries....

Authors: Jin-ming Mao, Jing Liu, Geng Guo, Xing-gang Mao and Chang-xin Li

High adiponectin levels in lean Arab women compared to Asian women

Adiponectin has been recognized as a potent regulator of metabolism possessing anti-inflammatory and anti-atherogenic functions and inversely associated with increasing incidents of type 2 diabetes and obesity...

Authors: Mohamed Abu-Farha, Kazem Behbehani and Naser Elkum

A genome wide association study on Newfoundland colorectal cancer patients’ survival outcomes

In this study we performed genome-wide association studies to identify candidate SNPs that may predict the risk of disease outcome in colorectal cancer.

Authors: Wei Xu, Jingxiong Xu, Konstantin Shestopaloff, Elizabeth Dicks, Jane Green, Patrick Parfrey, Roger Green and Sevtap Savas

Update on the treatment of metastatic clear cell and non-clear cell renal cell carcinoma

The advent of new knowledge surrounding the molecular pathology of renal-cell carcinoma (RCC) has culminated in a number of emerging targeted therapies. In just the last year, several new studies have been abl...

Authors: Kevin Y Xu and Shenhong Wu

A (1;19) translocation involving TCF3-PBX1 fusion within the context of a hyperdiploid karyotype in adult B-ALL: a case report and review of the literature

The t(1;19)(q23;p13), which can result in the TCF3-PBX1 chimeric gene, is one of the most frequent translocations in B-acute lymphoblastic leukemia (B-ALL) and is observed in both adult and pediatric populations ...

Authors: Carlos A Tirado, David Shabsovich, Lei Yeh, Sheeja T Pullarkat, Lynn Yang, Michael Kallen and Nagesh Rao