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  3. Blood tests would be much easier to implement in the clinical diagnosis of Alzheimer’s disease (AD) as minimally invasive measurements. Multiple inspection technologies promoted AD-associated blood biomarkers’...

    Authors: Yan Wang, Ying Li, Yan Li, Tingting Li, Qi Wang, Qigeng Wang, Shuman Cao, Fangyu Li and Jianping Jia
    Citation: Biomarker Research 2023 11:53
    Content type: Research Published on:

  4. We analyzed single nucleotide polymorphisms (SNPs) in PKNOX1 (rs2839629) and in the intergenic region between PKNOX1 and CBS (rs915854) by Sanger sequencing in 88 patients with multiple myeloma treated with borte...

    Authors: Xiang Zhou, Seungbin Han, Nadine Cebulla, Larissa Haertle, Maximilian J. Steinhardt, Daniel Schirmer, Eva Runau, Leon Flamm, Calvin Terhorst, Laura Jähnel, Cornelia Vogt, Silvia Nerreter, Eva Teufel, Emilia Stanojkovska, Julia Mersi, Umair Munawar…
    Citation: Biomarker Research 2023 11:52
    Content type: Correspondence Published on:

  5. Authors: Jie Wu, Chunlei Zheng, Yizhe Wang, Zichang Yang, Ce Li, Wanxia Fang, Yue Jin, Kezuo Hou, Yang Cheng, Jianfei Qi, Xiujuan Qu, Yunpeng Liu, Xiaofang Che and Xuejun Hu
    Citation: Biomarker Research 2023 11:51
    Content type: Correction Published on:

    The original article was published in Biomarker Research 2021 9:9

  7. Chimeric antigen receptor (CAR) T cell therapy, in which a patient’s own T lymphocytes are engineered to recognize and kill cancer cells, has achieved striking success in some hematological malignancies in pre...

    Authors: Marzieh Mazinani and Fatemeh Rahbarizadeh
    Citation: Biomarker Research 2023 11:49
    Content type: Review Published on:

  9. Urinary bladder cancer (UBC) is a common malignancy of the urinary tract; however, the mechanism underlying its high recurrence and responses to immunotherapy remains unclear, making clinical outcome predictio...

    Authors: Zhen-Duo Shi, Xiao-Xiao Han, Zi-Jian Song, Yang Dong, Kun Pang, Xin-Lei Wang, Xin-Yu Liu, Hao Lu, Guang-Zhi Xu, Lin Hao, Bing-Zheng Dong, Qing Liang, Xiao-Ke Wu and Cong-Hui Han
    Citation: Biomarker Research 2023 11:47
    Content type: Research Published on:

  10. Advanced hepatic fibrosis is the main risk factor of liver-related morbidity and mortality in patients with chronic liver disease. In this study, we assessed the potential role of bone morphogenetic protein 8A...

    Authors: Patricia Marañón, Stephania C. Isaza, Carlos Ernesto Fernández-García, Esther Rey, Rocío Gallego-Durán, Rocío Montero-Vallejo, Javier Rodríguez de Cía, Javier Ampuero, Ángela M. Valverde, Manuel Romero-Gómez, Carmelo García-Monzón and Águeda González-Rodríguez
    Citation: Biomarker Research 2023 11:46
    Content type: Research Published on:

  11. Lung cancer remains the leading cause of cancer mortality worldwide. Early detection of lung cancer helps improve treatment and survival. Numerous aberrant DNA methylations have been reported in early-stage lu...

    Authors: Shuo Hu, Jinsheng Tao, Minhua Peng, Zhujia Ye, Zhiwei Chen, Haisheng Chen, Haifeng Yu, Bo Wang, Jian-Bing Fan and Bin Ni
    Citation: Biomarker Research 2023 11:45
    Content type: Research Published on:

  12. Definitive chemoradiotherapy (dCRT) is a standard treatment option for locally advanced stage inoperable esophageal squamous cell carcinoma (ESCC). Evaluating clinical outcome prior to dCRT remains challenging...

    Authors: Jinfeng Cui, Li Li, Ning Liu, Wenhong Hou, Yinjun Dong, Fengchang Yang, Shouhui Zhu, Jun Li and Shuanghu Yuan
    Citation: Biomarker Research 2023 11:44
    Content type: Research Published on:

  13. N6-methyladenosine (m6A) methylation is the most abundant chemical posttranscriptional modification of mRNA, and it is associated with the regulation of the immune response to tumors. However, the function of ...

    Authors: Lei Zhan, Jing Zhang, Jun-Hui Zhang, Xiao-Jing Liu, Bao Guo, Jia-Hua Chen, Zhen-Hai Tang, Wen-Yan Wang, Qing-Yuan Wang, Bing Wei and Yun-Xia Cao
    Citation: Biomarker Research 2023 11:43
    Content type: Correspondence Published on:

  14. N6-methyladenosine (m6A) is considered as the most common and important internal transcript modification in several diseases like type 2 diabetes, schizophrenia and especially cancer. As a main target of m6A meth...

    Authors: Jinxin Tang, Jinhui Zhang, Yu Lu, Jieyu He, Hua Wang, Binfeng Liu, Chao Tu and Zhihong Li
    Citation: Biomarker Research 2023 11:42
    Content type: Review Published on:

  15. Neoantigens generated by non-synonymous mutations of tumor genes can induce activation of neoantigen-reactive T (NRT) cells which have the ability to resist the growth of tumors expressing specific neoantigens...

    Authors: Ruichen Huang, Bi Zhao, Shi Hu, Qian Zhang, Xiaoping Su and Wei Zhang
    Citation: Biomarker Research 2023 11:41
    Content type: Review Published on:

  17. Osteoarthritis (OA) is the most prevalent age-related disease in the world. Chondrocytes undergo an age-dependent decline in their proliferation and synthetic capacity, which is the main cause of OA developmen...

    Authors: Panyang Shen, Jun Gao, Shaohan Huang, Chenan You, Haitao Wang, Pengyu Chen, Teng Yao, Tianyou Gao, Bohao Zhou, Shuying Shen, Xing Zhao and Jianjun Ma
    Citation: Biomarker Research 2023 11:39
    Content type: Research Published on:

  18. Uveal melanoma (UM) is the most common intraocular malignancy in adults, with a poor survival prognosis. To date, limited understanding of UM’s molecular mechanisms constitutes an obstacle to developing effect...

    Authors: Jingting Luo, Haowen Li, Jingying Xiu, Jingyao Zeng, Zhaoxun Feng, Hanqing Zhao, Yang Li and Wenbin Wei
    Citation: Biomarker Research 2023 11:38
    Content type: Research Published on:

  19. Androgen receptor (AR) splice variants (AR-Vs) have been discussed as a biomarker in prostate cancer (PC). However, some reports question the predictive property of AR-Vs. From a mechanistic perspective, the c...

    Authors: Neele Wüstmann, Konstantin Seitzer, Verena Humberg, Julia Vieler, Norbert Grundmann, Julie Steinestel, Dorothee Tiedje, Stefan Duensing, Laura-Maria Krabbe, Martin Bögemann, Andres Jan Schrader, Christof Bernemann and Katrin Schlack
    Citation: Biomarker Research 2023 11:37
    Content type: Research Published on:

  20. Interleukin-25 (IL-25), also known as IL-17E, is a cytokine belonging to the IL-17 family. IL-25 is abundantly expressed by Th2 cells and various kinds of epithelial cells. IL-25 is an alarm signal generated u...

    Authors: Qingfang Yuan, Na Peng, Fan Xiao, Xiaofei Shi, Bo Zhu, Ke Rui, Jie Tian and Liwei Lu
    Citation: Biomarker Research 2023 11:36
    Content type: Review Published on:

  22. The immunosuppressive tumor microenvironment (TME) supports the development of tumors and limits tumor immunotherapy, including hematological malignancies. Hematological malignancies remain a major public heal...

    Authors: Shifen Wang, Xingyun Zhao, Siwen Wu, Dawei Cui and Zhenshu Xu
    Citation: Biomarker Research 2023 11:34
    Content type: Review Published on:

  23. Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive cancer that is challenging to diagnose at an early stage. Despite recent advances in combination chemotherapy, drug resistance limits the therapeut...

    Authors: Zhipeng Li, Huaxin Zhou, Zhijia Xia, Tong Xia, Gang Du, Strohmer Dorothee Franziska, Xiaoming Li, Xiangyu Zhai and Bin Jin
    Citation: Biomarker Research 2023 11:33
    Content type: Research Published on:

    The Correction to this article has been published in Biomarker Research 2024 12:27

  24. Recent massive sequencing studies have revealed that SWI/SNF complexes are among the most frequently altered functional entities in solid tumors. However, the role of SWI/SNF in acute myeloid leukemia is poorl...

    Authors: Juan Rodrigo Patiño-Mercau, Carlos Baliñas-Gavira, Alvaro Andrades, Maria S. Benitez-Cantos, Ana Ercegovič Rot, Maria Isabel Rodriguez, Juan Carlos Álvarez-Pérez, Marta Cuadros and Pedro P. Medina
    Citation: Biomarker Research 2023 11:32
    Content type: Research Published on:

  25. Studies have not systematically compared the ability to verify performance of prognostic transcripts in paired bulk mononuclear cells versus viable CD34-expressing leukemic blasts from patients with acute myel...

    Authors: Era L. Pogosova-Agadjanyan, Xing Hua, Megan Othus, Frederick R. Appelbaum, Thomas R. Chauncey, Harry P. Erba, Matthew P. Fitzgibbon, Isaac C. Jenkins, Min Fang, Stanley C. Lee, Anna Moseley, Jasmine Naru, Jerald P. Radich, Jenny L. Smith, Brooke E. Willborg, Cheryl L. Willman…
    Citation: Biomarker Research 2023 11:31
    Content type: Research Published on:

  26. Although t (8;21) is in fact considered a good risk acute myeloid leukemia (AML), only 60% of the patients live beyond 5 years after diagnosis. Studies have shown that RNA demethylase ALKBH5 promotes leukemoge...

    Authors: Ran Li, Xiaolu Wu, Kai Xue, Dandan Feng, Jianyong Li and Junmin Li
    Citation: Biomarker Research 2023 11:30
    Content type: Research Published on:

  27. The SETD2 tumor suppressor gene encodes a histone methyltransferase that safeguards transcription fidelity and genomic integrity via trimethylation of histone H3 lysine 36 (H3K36Me3). SETD2 loss of function has b...

    Authors: Manuela Mancini, Cecilia Monaldi, Sara De Santis, Cristina Papayannidis, Michela Rondoni, Chiara Sartor, Samantha Bruno, Livio Pagano, Marianna Criscuolo, Roberta Zanotti, Massimiliano Bonifacio, Patrizia Tosi, Michel Arock, Peter Valent, Michele Cavo and Simona Soverini
    Citation: Biomarker Research 2023 11:29
    Content type: Research Published on:

  28. Immune checkpoint inhibitors (ICIs) targeting PD-1 or PD-L1 have emerged as a revolutionary treatment strategy for human cancer patients. However, as the response rate to ICI therapy varies widely among differ...

    Authors: Enkui Zhang, Chengsheng Ding, Shuchun Li, Xueliang Zhou, Batuer Aikemu, Xiaodong Fan, Jing Sun, Minhua Zheng and Xiao Yang
    Citation: Biomarker Research 2023 11:28
    Content type: Review Published on:

  29. Multiple myeloma (MM) is an incurable hematological cancer with high spatial- and temporal-heterogeneity. Invasive single-point bone marrow sampling cannot capture the tumor heterogeneity and is difficult to r...

    Authors: Shuchan Li, Enfan Zhang and Zhen Cai
    Citation: Biomarker Research 2023 11:27
    Content type: Review Published on:

  30. ADJUVANT-CTONG1104 reported a favorable survival outcome from adjuvant gefitinib treatment over chemotherapy in EGFR-mutant non-small cell lung cancer (NSCLC) patients. However, heterogeneous benefit from EGFR-TK...

    Authors: Si-Yang Maggie Liu, Cunte Chen, Yi-Kai Zhang, Wen-Zhao Zhong, Yi-Long Wu, Si-Yang Liu and Yangqiu Li
    Citation: Biomarker Research 2023 11:26
    Content type: Correspondence Published on:

  31. Activated immune cells (IC) in the tumor microenvironment (TME) are critical for anti-tumor efficacy. Greater understanding of the dynamic diversity and crosstalk between IC is needed to clarify their associat...

    Authors: Dingwei Ye, Jayesh Desai, Jingwen Shi, Si-Yang Maggie Liu, Wei Shen, Tengfei Liu, Yang Shi, Dan Wang, Liang Liang, Silu Yang, Xiaopeng Ma, Wei Jin, Pei Zhang, Ruiqi Huang, Zhirong Shen, Yun Zhang…
    Citation: Biomarker Research 2023 11:25
    Content type: Research Published on:

  32. In addition to the anti-infection response, neutrophils are linked to tumor progression through the secretion of inflammation components and neutrophil extracellular traps (NETs) formation. NET is a web-like s...

    Authors: Bingqing Shang, Honglei Cui, Ruiyang Xie, Jie Wu, Hongzhe Shi, Xingang Bi, Lin Feng and Jianzhong Shou
    Citation: Biomarker Research 2023 11:24
    Content type: Review Published on:

  35. Pyrotinib, a novel irreversible tyrosine kinase inhibitor (TKI), has demonstrated promising antitumor activity to improve the overall response rate and progression-free survival (PFS) in patients with HER2-pos...

    Authors: Xiuwen Guan, Fei Ma, Qiao Li, Shanshan Chen, Bo Lan, Ying Fan, Jiayu Wang, Yang Luo, Ruigang Cai, Pin Zhang, Qing Li and Binghe Xu
    Citation: Biomarker Research 2023 11:21
    Content type: Research Published on:

  36. Aging and diet are risks for metabolic diseases. Bile acid receptor farnesoid X receptor (FXR) knockout (KO) mice develop metabolic liver diseases that progress into cancer as they age, which is accelerated by...

    Authors: Guiyan Yang, Prasant K. Jena, Ying Hu, Lili Sheng, Shin-Yu Chen, Carolyn M. Slupsky, Ryan Davis, Clifford G. Tepper and Yu-Jui Yvonne Wan
    Citation: Biomarker Research 2023 11:20
    Content type: Research Published on:

  37. It was previously believed that patients with Ph-like ALL had poorer prognosis compared with other B-ALL subgroups due to resistance to conventional chemotherapy and lack of targeted drugs. CAR-T therapy has b...

    Authors: Hai-ping Dai, Dan-qing Kong, Hong-jie Shen, Wei Cui, Qian Wang, Zheng Li, Jia Yin, Li-qing Kang, Lei Yu, De-pei Wu and Xiao-wen Tang
    Citation: Biomarker Research 2023 11:19
    Content type: Correspondence Published on:

  38. The retinal determinant gene network (RDGN), originally discovered as a critical determinator in Drosophila eye specification, has become an important regulatory network in tumorigenesis and progression, as well ...

    Authors: Shuangli Zhu, Wanling Li, Hao Zhang, Yuheng Yan, Qi Mei and Kongming Wu
    Citation: Biomarker Research 2023 11:18
    Content type: Review Published on:

  39. The Maf proteins (Mafs) belong to basic leucine zipper transcription factors and are members of the activator protein-1 (AP-1) superfamily. There are two subgroups of Mafs: large Mafs and small Mafs, which are...

    Authors: Yalan Deng, Liqing Lu, Huajun Zhang, Ying Fu, Ting Liu and Yongheng Chen
    Citation: Biomarker Research 2023 11:17
    Content type: Review Published on:

  40. The difference between clinical characteristics and outcomes between follicular lymphoma grade 1–2 (FL1-2) and FL3a defined pathologically remains unclear, resulting in uncertainty how to treat FL3a. However, ...

    Authors: Jie Zha, Qinwei Chen, Jingjing Ye, Haifeng Yu, Shuhua Yi, Zhong Zheng, Wei Xu, Zhifeng Li, Lingyan Ping, Xiaohua He, Liling Zhang, Caixia Li, Ying Xie, Feili Chen, Xiuhua Sun, Liping Su…
    Citation: Biomarker Research 2023 11:16
    Content type: Research Published on:

  42. Niemann-Pick disease, type C1 (NPC1) is an ultrarare, recessive, lethal, lysosomal disease characterized by progressive cerebellar ataxia and cognitive impairment. Although the NPC1 phenotype is heterogeneous ...

    Authors: Kiersten Campbell, Niamh X. Cawley, Rachel Luke, Katelin E. J. Scott, Nicholas Johnson, Nicole Y. Farhat, Derek Alexander, Christopher A. Wassif, Wenping Li, Stephanie M. Cologna, Elizabeth Berry-Kravis, An Dang Do, Ryan K. Dale and Forbes D. Porter
    Citation: Biomarker Research 2023 11:14
    Content type: Research Published on:

  43. Cuproptosis is a newly discovered type of cell death triggered by copper accumulation. Here we exhibited the genetic profiles of 10 cuproptosis-associated genes (CuAGs) across 21 cancer types. Only 8.0% (627/7...

    Authors: Fanqin Bu, Xiangji Li, Yu Zhao, Liyi Bai, Shutian Zhang and Li Min
    Citation: Biomarker Research 2023 11:13
    Content type: Correspondence Published on:

  44. Epithelial ovarian cancer (EOC) is a highly prevalent disease that rapidly metastasizes and has poor prognosis. Most women are in the middle or late stages when diagnosed and have low survival rates. Recently,...

    Authors: Sihui Li, Shizhen Shen, Wanzhong Ge, Yixuan Cen, Songfa Zhang, Xiaodong Cheng, Xinyu Wang, Xing Xie and Weiguo Lu
    Citation: Biomarker Research 2023 11:12
    Content type: Research Published on:

  45. BRAF mutations are the oncogenic drivers in colorectal cancer and V600 mutations (Class1), which lead to RAS-independent active monomers, are the most common mutation types. BRAF non-V600 mutants can be further ...

    Authors: Yungchang Chen, Hao Sun, Yanhong Deng, Yutong Ma, He Huang, Yang Liu, Yaru Zhang, Hongyu Zhang, Sheng Ye, Mingyan E, Hongqiang Guo, Mengmeng Wu, Chunman Wu, Xingxiang Pu, Xinggui Chen, Chaoyong Liang…
    Citation: Biomarker Research 2023 11:11
    Content type: Correspondence Published on:

  46. Cumulative preclinical and clinical evidences showed radiotherapy might augment systemic antitumoral responses to immunotherapy for metastatic non-small cell lung cancer, but the optimal timing of combination ...

    Authors: Ying Zhang, Hui-Hui Hu, Shi-Hong Zhou, Wu-Yan Xia, Yan Zhang, Jian-Ping Zhang, Xiao-Long Fu and Wen Yu
    Citation: Biomarker Research 2023 11:10
    Content type: Research Published on:

  49. Over the past decade, targeted therapy for oncogene-driven NSCLC and immune checkpoint inhibitors for non-oncogene-driven NSCLC, respectively, have greatly improved the survival and quality of life for patient...

    Authors: Luis A. Godoy, Joy Chen, Weijie Ma, Jag Lally, Kyra A. Toomey, Prabhu Rajappa, Roya Sheridan, Shirish Mahajan, Nicholas Stollenwerk, Chinh T. Phan, Danny Cheng, Robert J. Knebel and Tianhong Li
    Citation: Biomarker Research 2023 11:7
    Content type: Review Published on:
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