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  1. Content type: Review

    Nephrin is a 180 KD trans-membrane protein expressed in glomerular podocytes. It was first identified in children with congenital nephrotic syndrome of the Finnish type (NPHS1). Nephrin forms an integral part ...

    Authors: Yogavijayan Kandasamy, Roger Smith, Eugenie R Lumbers and Donna Rudd

    Citation: Biomarker Research 2014 2:21

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  2. Content type: Methodology

    The skin proteome contains valuable information on skin condition, but also on how skin may evolve in time and may respond to treatments. Despite the potential of measuring regulatory-, effector- and structura...

    Authors: Kadri Orro, Olga Smirnova, Jelena Arshavskaja, Kristiina Salk, Anne Meikas, Susan Pihelgas, Reet Rumvolt, Külli Kingo, Aram Kazarjan, Toomas Neuman and Pieter Spee

    Citation: Biomarker Research 2014 2:20

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  3. Content type: Rapid communication

    Cumulating data suggest that small noncoding-RNAs such as microRNAs (miRNAs) can be utilized as potential biomarkers for the diagnosis and prognosis of a variety of diseases such as cancer, neurological disord...

    Authors: Prasun J Mishra

    Citation: Biomarker Research 2014 2:19

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  4. Content type: Research

    The isocitrate dehydrogenase (IDH1/IDH2) genes are metabolic enzymes, which are frequently mutated in acute myeloid leukemia (AML). The enzymes acquire neomorphic enzymatic activity when they mutated.

    Authors: Kerstin Willander, Ingrid Jakobsen Falk, Roza Chaireti, Esbjörn Paul, Monica Hermansson, Henrik Gréen, Kourosh Lotfi and Peter Söderkvist

    Citation: Biomarker Research 2014 2:18

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  5. Content type: Research

    Histone deacetylase inhibitor romidepsin has demonstrated durable clinical responses and tolerability in patients with relapsed/refractory peripheral and cutaneous T-cell lymphoma (PTCL, CTCL). Selection of no...

    Authors: Francine Foss, Bertrand Coiffier, Steven Horwitz, Barbara Pro, H Miles Prince, Lubomir Sokol, Matthew Greenwood, Adam Lerner, Dolores Caballero, Eugeniusz Baran, Ellen Kim, Jean Nichols, Barbara Balser, Julie Wolfson and Sean Whittaker

    Citation: Biomarker Research 2014 2:16

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  6. Content type: Research

    Three VEGF SNPs (−2578) C/A, (+405) G/C and (+936) C/T were investigated in Tunisian exudative AMD patients in order to determine their association with the disease susceptibility and their influence to intrav...

    Authors: Imen Habibi, Imen Sfar, Ahmed Chebil, Fedra Kort, Rim Bouraoui, Salwa Jendoubi-Ayed, Mouna Makhlouf, Taïeb Ben Abdallah, Leila El Matri and Yousr Gorgi

    Citation: Biomarker Research 2014 2:15

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  7. Content type: Case report

    Chronic myelogenous leukemia (CML) results from the neoplastic transformation of a hematopoietic stem cell. CML is cytogenetically characterized by the presence of the Philadelphia chromosome (Ph’). Most patie...

    Authors: Jordi Martinez-Serra, Raquel del Campo, Antonio Gutierrez, Jose Luis Antich, Magdalena Ginard, Maria A Durán, Leyre Bento, Teresa Ros, Juan C Amat, Carmen Vidal, Julio F Iglesias, Izabela Orlinska and Joan Besalduch

    Citation: Biomarker Research 2014 2:14

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  8. Content type: Short report

    Circulating microRNAs (c-miRNAs) have be identified in saliva, urine and blood, which has led to increasing interest in their development as biomarkers for diverse diseases including cancers. One of the key ad...

    Authors: Jordan L Plieskatt, Yanjun Feng, Gabriel Rinaldi, Jason P Mulvenna, Jeffrey M Bethony and Paul J Brindley

    Citation: Biomarker Research 2014 2:13

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  9. Content type: Case report

    ABVD regimen (doxorubicin, bleomycin, vinblastine and dacarbazine) remains the most commonly used front-line therapy for Hodgkin lymphoma. However, atypical and extranodal presentations present challenges to i...

    Authors: Keyur Thakar, Aileen Novero, Arundhati Das, Adriana Lisinschi, Bella Mehta, Tauseef Ahmed and Delong Liu

    Citation: Biomarker Research 2014 2:12

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  10. Content type: Research

    High nuclear expression of the RNA-binding motif protein 3 (RBM3) has previously been found to correlate with favourable clinicopathological characteristics and a prolonged survival in several cancer forms. He...

    Authors: Liv Jonsson, Charlotta Hedner, Alexander Gaber, Dejan Korkocic, Björn Nodin, Mathias Uhlén, Jakob Eberhard and Karin Jirström

    Citation: Biomarker Research 2014 2:11

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  11. Content type: Case series

    B cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma (DLBCL) and Burkitt’s lymphoma (BL) (B-UNC/BL/DLBCL) is a new category of tumors that have features resembling ...

    Authors: Michael Bellone, Ann-Leslie Zaslav, Tahmeena Ahmed, Htien L Lee, Yupo Ma and Youjun Hu

    Citation: Biomarker Research 2014 2:9

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  12. Content type: Research

    Hepatocyte growth factor (HGF) is a pleiotropic cytokine which can lead to cancer cell proliferation, migration and metastasis. In multiple myeloma (MM) patients it is an abundant component of the bone marrow....

    Authors: Christoph Rampa, Erming Tian, Thea Kristin Våtsveen, Glenn Buene, Tobias Schmidt Slørdahl, Magne Børset, Anders Waage and Anders Sundan

    Citation: Biomarker Research 2014 2:8

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  13. Content type: Case report

    Primary cutaneous follicle centre lymphoma (PCFCL) is a rare cutaneous B cell lymphoma in middle-age adults with excellent prognosis. Here we present a case of a patient with a PCFCL in the form of a giant tum...

    Authors: Yordanka Tirefort, Xuan-Cuong Pham, Yasmine Lucile Ibrahim, Thomas Pierre Lecompte, Thomas Matthes, Christa Prins, Begonia Cortes, Michael Bernimoulin, Yves Chalandon and Kaveh Samii

    Citation: Biomarker Research 2014 2:7

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  14. Content type: Research

    Nilotinib is a second-generation tyrosine kinase inhibitor that exhibits significant efficacy as first- or second-line treatment in patients with chronic myeloid leukemia (CML). We conducted a multicenter Phas...

    Authors: Naoto Takahashi, Masatomo Miura, Jun Kuroki, Kinuko Mitani, Atsushi Kitabayashi, Osamu Sasaki, Hideo Kimura, Kiyotoshi Imai, Norifumi Tsukamoto, Hideyoshi Noji, Takeshi Kondo, Mutsuhito Motegi, Yuichi Kato, Masayuki Mita, Hajime Saito, Chikashi Yoshida…

    Citation: Biomarker Research 2014 2:6

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  15. Content type: Review

    Extensive studies of the genetic aberrations related to human diseases conducted over the last two decades have identified recurrent genomic abnormalities as potential driving factors underlying a variety of c...

    Authors: Linping Hu, Kun Ru, Li Zhang, Yuting Huang, Xiaofan Zhu, Hanzhi Liu, Anders Zetterberg, Tao Cheng and Weimin Miao

    Citation: Biomarker Research 2014 2:3

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  16. Content type: Letter to the Editor

    We applied our new method, maturity-dependent fractionation of bone marrow-derived neutrophil progenitors, to a study of gene expression profiles during granulopoiesis in myelodysplastic syndromes. CD34+ cells wi...

    Authors: Huiyuan Hu, Yayoi Shikama, Tsutomu Shichishima, Kazuhiko Ikeda, Kazuko Akutsu, Tomoyuki Ono, Hideo Kimura, Kazuei Ogawa, Hideyoshi Noji, Yasuchika Takeishi and Junko Kimura

    Citation: Biomarker Research 2014 2:2

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  17. Content type: Review

    Monocytes express various receptors, which monitor and sense environmental changes. Monocytes are highly plastic and heterogeneous, and change their functional phenotype in response to environmental stimulatio...

    Authors: Jiyeon Yang, Lixiao Zhang, Caijia Yu, Xiao-Feng Yang and Hong Wang

    Citation: Biomarker Research 2014 2:1

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  18. Content type: Research

    Natural killer cells comprise the body’s first line of defense against virus-infected cells. As is true of all lymphocytes, natural killer cell malignancies can develop, however natural killer cell leukemias c...

    Authors: Jon Crosbie, Marc Magnussen, Ryan Dornbier, Alexandra Iannone and Timothy A Steele

    Citation: Biomarker Research 2013 1:33

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  19. Content type: Review

    Although palliative chemotherapy has been shown to prolong survival and improve quality of life, the survival of advanced gastric cancer (AGC) patients remains poor. With the advent of targeted therapy, many m...

    Authors: Miao-zhen Qiu and Rui-hua Xu

    Citation: Biomarker Research 2013 1:32

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  20. Content type: Short report

    B-cell acute lymphoblastic leukemia (B-ALL) is the most common malignancy in pediatric patients and the leading cause of cancer-related death in children and young adults. Translocations of 9p24 involving JAK2 (9...

    Authors: Carlos A Tirado, David Shabsovich, Matthew DeNicola, Dinesh Rao, Lynn Yang, Rolando Garcia and Nagesh Rao

    Citation: Biomarker Research 2013 1:31

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  21. Content type: Research

    Glioblastoma Multiforme (GBM) is the most common primary malignant tumor of the central nervous system. Standard of care includes maximal resection followed by chemoradiotherapy. Tumors need adequate perfusion...

    Authors: Andra V Krauze, Minhee Won, Christian Graves, Ben W Corn, Thierry M Muanza, Steven P Howard, Arul Mahadevan, Christopher J Schultz, Michael L Haas, Minesh P Mehta and Kevin A Camphausen

    Citation: Biomarker Research 2013 1:29

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  22. Content type: Short report

    Huntington Disease (HD) is a progressive neurological disorder, with pathological manifestations in brain areas and in periphery caused by the ubiquitous expression of mutant Huntingtin protein. Transcriptiona...

    Authors: Daniela Diamanti, Elisa Mori, Danny Incarnato, Federico Malusa, Costanza Fondelli, Letizia Magnoni and Giuseppe Pollio

    Citation: Biomarker Research 2013 1:28

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  23. Content type: Review

    A higher concentration of high density lipoprotein cholesterol (HDL-C) in ex-smokers than smokers has consistently been observed. Better evidence of quitting effects comes from within-subject changes. We exten...

    Authors: Barbara A Forey, John S Fry, Peter N Lee, Alison J Thornton and Katharine J Coombs

    Citation: Biomarker Research 2013 1:26

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  24. Content type: Review

    Carbohydrate antigen 125 (CA-125), traditionally a tumor marker for screening, diagnosis, and monitoring in ovarian malignancy, had recently been shown increasing evidence and more extensively recognized/explo...

    Authors: Chung-Lieh Hung, Ta-Chuan Hung, Yau-Hui Lai, Chi-Sheng Lu, Yih-Jer Wu and Hung-I Yeh

    Citation: Biomarker Research 2013 1:25

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  25. Content type: Research

    The Cancer Testis Antigens (CTAs) are a group of genes that are highly expressed in the normal testis and several types of cancer. Due to their restricted expression in normal adult tissues, CTAs have been att...

    Authors: John J Kim, Krithika Rajagopalan, Basil Hussain, Brenten H Williams, Prakash Kulkarni and Steven M Mooney

    Citation: Biomarker Research 2013 1:22

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  26. Content type: Research

    Toll-like receptor 4 (TLR4) and its co-receptor CD14 play a major role in innate immunity by recognizing PAMPs and signal the activation of adaptive responses. These receptors can recognize endogenous ligands ...

    Authors: Tarak Dhaouadi, Imen Sfar, Youssra Haouami, Leila Abdelmoula, Sami Turki, Lamia Ben Hassine, Rafik Zouari, Adel Khedher, Narjess Khalfallah, Taieb Ben Abdallah and Yousr Gorgi

    Citation: Biomarker Research 2013 1:20

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  27. Content type: Research

    Accumulated data from previous studies appear to suggest a link between the overexpression of a 35 kDa fragment of serum inter-alpha-trypsin inhibitor H4 (ITIH4) with cancers that are associated with up-regula...

    Authors: Emida Mohamed, Jaime Jacqueline Jayapalan, Puteri Shafinaz Abdul-Rahman, Siti Zawiah Omar and Onn Haji Hashim

    Citation: Biomarker Research 2013 1:19

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  28. Content type: Short report

    Nipple aspirate fluid (NAF) contains large amounts of protein thought to reflect the microenvironment of the breast, and is of interest in breast cancer prevention research. The correlation between specific NA...

    Authors: Jessica A Miller, Patricia A Thompson, Iman A Hakim, Ana Maria Lopez, Cynthia A Thomson, Chiu-Hsieh Hsu and H-H Sherry Chow

    Citation: Biomarker Research 2013 1:18

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  29. Content type: Review

    Insulin resistance associated with type 2 diabetes mellitus (T2DM), obesity, and atherosclerosis is a global health problem. A portfolio of abnormalities of metabolic and vascular homeostasis accompanies T2DM ...

    Authors: Fuyong Du, Anthony Virtue, Hong Wang and Xiao-Feng Yang

    Citation: Biomarker Research 2013 1:17

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  30. Content type: Research

    Colorectal cancer remains one of the leading causes of death from cancer in industrialized countries. Integrins are a family of heterodimeric glycoproteins involved in bidirectional cell signaling and particip...

    Authors: Salah Boudjadi, Julie C Carrier and Jean-François Beaulieu

    Citation: Biomarker Research 2013 1:16

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  31. Content type: Short report

    The cyclin-dependent kinase inhibitor p27Kip1 functions during normal cerebellar development and has demonstrated tumor suppressor functions in mouse models of medulloblastoma. Because P27 loss is associated with...

    Authors: Beryl A Hatton, David W Ellison, Amar Gajjar, Marcel Kool, Matthew Fero and James M Olson

    Citation: Biomarker Research 2013 1:14

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  32. Content type: Research

    Endometrial cancer (EC) is the leading malignant tumor occurring in the female genital tract and some subtypes are highly invasive and metastatic. miRNAs are small non-coding RNAs that have a broad impact on c...

    Authors: Haiyan Zhai, Mihriban Karaayvaz, Peixin Dong, Noriaki Sakuragi and Jingfang Ju

    Citation: Biomarker Research 2013 1:12

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  33. Content type: Research

    IK is a nuclear protein containing a unique domain named RED due to the presence of a repetitive arginine (R), aspartic (E), and glutamic acid (D) sequence. To date, the function of this protein remains largel...

    Authors: Liyan Hu, Feikun Yang, Xianan Liu, Dazhong Xu and Wei Dai

    Citation: Biomarker Research 2013 1:11

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  34. Content type: Review

    Diabetic kidney disease is the leading cause of end-stage renal disease in developed and developing countries. Microalbuminuria is the gold standard for detection and prediction of diabetic kidney disease and ...

    Authors: Cheng Wang, CuiCui Li, WenYu Gong and Tanqi Lou

    Citation: Biomarker Research 2013 1:9

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  35. Content type: Research

    Metabolic alteration is one of the hallmarks of carcinogenesis. We aimed to identify certain metabolic biomarkers for the early detection of pancreatic cancer (PC) using the transgenic PTEN-null mouse model. P...

    Authors: He N Xu, Shoko Nioka and Lin Z Li

    Citation: Biomarker Research 2013 1:6

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