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  1. Ibrutinib, an irreversible Bruton Tyrosine Kinase (BTK) inhibitor, has revolutionized Chronic Lymphocytic Leukemia (CLL) treatment, but resistances to ibrutinib have emerged, whether related or not to BTK muta...

    Authors: Sarah Cadot, Carine Valle, Marie Tosolini, Frederic Pont, Laetitia Largeaud, Camille Laurent, Jean Jacques Fournie, Loic Ysebaert and Anne Quillet-Mary
    Citation: Biomarker Research 2020 8:72
  2. Hepatocellular carcinoma (HCC) is a type of liver cancer with poor prognosis. There have been demonstrated to exist many possible mechanisms in HCC tumorigenesis, and recent investigations have provided some p...

    Authors: Mengzhen Han, Zhibin Liao, Furong Liu, Xiaoping Chen and Bixiang Zhang
    Citation: Biomarker Research 2020 8:70
  3. In recent years, there have been advancements in traditional patterns of tumor therapy with the adoption of immunotherapy. Its application with or without other combined regimens has attracted attention from c...

    Authors: Xuhong Liu and Yong Yi
    Citation: Biomarker Research 2020 8:69
  4. Esophageal cancer (ECa) is the 7th most incident cancer and the 6th leading cause of cancer-related death. Most patients are diagnosed with locally advanced or metastatic disease, enduring poor survival. Bioma...

    Authors: Sofia Salta, Catarina Macedo-Silva, Vera Miranda-Gonçalves, Nair Lopes, Davide Gigliano, Rita Guimarães, Mónica Farinha, Olga Sousa, Rui Henrique and Carmen Jerónimo
    Citation: Biomarker Research 2020 8:68
  5. Although anti-CD19 chimeric antigen receptor (CAR) T-cell therapy shows good efficacy in patients with relapsed/refractory B-cell acute lymphoblastic leukemia (r/r B-ALL), it fails to improve long-term leukemi...

    Authors: Huiwen Jiang, Yu Hu and Heng Mei
    Citation: Biomarker Research 2020 8:66
  6. Recently, novel drugs like venetoclax plus 5-azacytidine (VA) were reported to have promising efficacy in refractory acute myeloid leukemia (AML). However, there are still some cases presented with novel drugs...

    Authors: JingHan Wang, Xingnong Ye, Cuihua Fan, Jie Zhou, Shuna Luo, Jingxia Jin, Dan Chen, Yan Zheng, Cai Wu, Xiaoqiong Zhu, Jie Jin and Jian Huang
    Citation: Biomarker Research 2020 8:65
  7. Cancer-associated fibroblasts (CAFs) are the key component of tumor stromal. High heterogeneity of CAFs reflects in their origin, phenotype and function. Biological function which can be suggested by biomarker...

    Authors: Chencheng Han, Tongyan Liu and Rong Yin
    Citation: Biomarker Research 2020 8:64
  8. Excessive generation of reactive oxygen species (ROS) in the presence of a defective antioxidant system can induce cellular damage and disrupt normal physiological functions. Several studies have revealed the ...

    Authors: Natasha Mupeta Kaweme, Shu Zhou, Geoffrey Joseph Changwe and Fuling Zhou
    Citation: Biomarker Research 2020 8:63
  9. SETD2 is the only methyltransferase for H3K36me3, and our previous study has firstly demonstrated that it functioned as one tumor suppressor in hematopoiesis. Consistent with it, SETD2 mutation, which led to its ...

    Authors: Jiewen Sun, Wenjuan Yu and Xiang Zhang
    Citation: Biomarker Research 2020 8:62
  10. Non-coding RNAs are the main component of the extensive transcription results of the mammalian genome. They are not transcribed into proteins but play critical roles in regulating multiple biological processes...

    Authors: Xinyu Yang, Xiang Hu, Jinting Liu, Ruiqing Wang, Chen Zhang, Fengjiao Han, Yuhong Chen and Daoxin Ma
    Citation: Biomarker Research 2020 8:61
  11. Malignant tumor is a largely harmful disease worldwide. The cure rate of malignant tumors increases with the continuous discovery of anti-tumor drugs and the optimisation of chemotherapy options. However, drug...

    Authors: Zhe Dai, Xu-yu Gu, Shou-yan Xiang, Dan-dan Gong, Chang-feng Man and Yu Fan
    Citation: Biomarker Research 2020 8:60
  12. Chronic consumption of high sugar and high fat diet associated with liver inflammation and cognitive decline. This paper tests a hypothesis that the development and resolution of diet-induced nonalcoholic fatt...

    Authors: Prasant Kumar Jena, Lili Sheng, Michelle Nguyen, Jacopo Di Lucente, Ying Hu, Yongchun Li, Izumi Maezawa, Lee-Way Jin and Yu-Jui Yvonne Wan
    Citation: Biomarker Research 2020 8:59
  13. Ferroptosis is a recently discovered distinct type of regulated cell death caused by the accumulation of lipid-based ROS. Metabolism and expression of specific genes affect the occurrence of ferroptosis, makin...

    Authors: Zhaoqing Li, Lini Chen, Cong Chen, Yulu Zhou, Dengdi Hu, Jingjing Yang, Yongxia Chen, Wenying Zhuo, Misha Mao, Xun Zhang, Ling Xu, Linbo Wang and Jichun Zhou
    Citation: Biomarker Research 2020 8:58
  14. On-target off-tumor toxicity impedes the clinical application of chimeric antigen receptor-modified T cells (CAR-T cells) in the treatment of solid tumors. Previous reports proved that the combinatorial antige...

    Authors: Qibin Liao, Yunyu Mao, Huan He, Xiangqing Ding, Xiaoyan Zhang and Jianqing Xu
    Citation: Biomarker Research 2020 8:57
  15. Chimeric antigen receptor-modified T cells (CAR-T cells) have shown good effects in the treatment of hematologic cancers; however, they may cause on-target off-tumor toxicity because of minimal expression of t...

    Authors: Qibin Liao, Huan He, Yunyu Mao, Xiangqing Ding, Xiaoyan Zhang and Jianqing Xu
    Citation: Biomarker Research 2020 8:56
  16. To date, the association of serum macrophage migration inhibitory factor (MIF) and serum adipokines with lupus nephritis is controversial.

    Authors: Jorge Ivan Gamez-Nava, Valeria Diaz-Rizo, Edsaul Emilio Perez-Guerrero, Jose Francisco Muñoz-Valle, Ana Miriam Saldaña-Cruz, Nicte Selene Fajardo-Robledo, Heriberto Jacobo-Cuevas, Cesar Arturo Nava-Valdivia, Miriam Fabiola Alcaraz-Lopez, Xochitl Trujillo, Miguel Huerta, Ernesto German Cardona-Muñoz and Laura Gonzalez-Lopez
    Citation: Biomarker Research 2020 8:55
  17. T-cell prolymphocytic leukemia (T-PLL) is a poor prognostic disease with very limited options of efficient therapies. Most patients are refractory to chemotherapies and despite high response rates after alemtu...

    Authors: Carlos Cuesta-Mateos, Patricia Fuentes, Alexandra Schrader, Raquel Juárez-Sánchez, Javier Loscertales, Tamara Mateu-Albero, Lorena Vega-Piris, Marina Espartero-Santos, Ana Marcos-Jimenez, Blanca Andrea Sánchez-López, Yaiza Pérez-García, Dennis Jungherz, Sebastian Oberbeck, Linus Wahnschaffe, Anna Kreutzman, Emma I. Andersson…
    Citation: Biomarker Research 2020 8:54
  18. New biomarkers are urgently needed to improve personalized treatment approaches for head and neck squamous cell carcinoma (HNSCC). Global DNA hypomethylation has wide-ranging functions in multistep carcinogene...

    Authors: Kiyoshi Misawa, Satoshi Yamada, Masato Mima, Takuya Nakagawa, Tomoya Kurokawa, Atsushi Imai, Daiki Mochizuki, Daichi Shinmura, Taiki Yamada, Junya Kita, Ryuji Ishikawa, Yuki Yamaguchi, Yuki Misawa, Takeharu Kanazawa, Hideya Kawasaki and Hiroyuki Mineta
    Citation: Biomarker Research 2020 8:53
  19. Screening across a multitude of normal and malignant tissues revealed an enhanced expression of lymphocyte antigen 6 superfamily member D (LY6D) in squamous epithelium and urothelium, as well as in malignancie...

    Authors: Nina Andersson, Johan Ohlsson, Sara Wahlin, Björn Nodin, Karolina Boman, Sebastian Lundgren and Karin Jirström
    Citation: Biomarker Research 2020 8:51
  20. Ferroptosis belongs to a novel form of regulated cell death. It is characterized by iron dependence, destruction of intracellular redox balance and non-apoptosis. And cellular structure and molecules level cha...

    Authors: Sipeng Zuo, Jie Yu, Hui Pan and Linna Lu
    Citation: Biomarker Research 2020 8:50
  21. Interferon-γ (IFN-γ) plays a key role in activation of cellular immunity and subsequently, stimulation of antitumor immune-response. Based on its cytostatic, pro-apoptotic and antiproliferative functions, IFN-...

    Authors: Dragica Jorgovanovic, Mengjia Song, Liping Wang and Yi Zhang
    Citation: Biomarker Research 2020 8:49
  22. China is a highly endemic area of chronic hepatitis B (CHB). The accuracy of existed noninvasive biomarkers including TE, APRI and FIB-4 for staging fibrosis is not high enough in Chinese cohort.

    Authors: Xiao-Jie Lu, Xiao-Jun Yang, Jing-Yu Sun, Xin Zhang, Zhao-Xin Yuan and Xiu-Hui Li
    Citation: Biomarker Research 2020 8:48
  23. To establish and validate a radiomics-based model for predicting liver cirrhosis in patients with hepatitis B virus (HBV) by using non-contrast computed tomography (CT).

    Authors: Jin-Cheng Wang, Rao Fu, Xue-Wen Tao, Ying-Fan Mao, Fei Wang, Ze-Chuan Zhang, Wei-Wei Yu, Jun Chen, Jian He and Bei-Cheng Sun
    Citation: Biomarker Research 2020 8:47
  24. Clinically relevant methods are not available that prioritize and validate potential therapeutic targets for individual tumors, from the vast amount of tumor descriptive expression data.

    Authors: Wen-Hsin Liu, Paulina Mrozek-Gorska, Anna-Katharina Wirth, Tobias Herold, Larissa Schwarzkopf, Dagmar Pich, Kerstin Völse, M. Camila Melo-Narváez, Michela Carlet, Wolfgang Hammerschmidt and Irmela Jeremias
    Citation: Biomarker Research 2020 8:46
  25. The canonical and non-canonical nuclear factor-kappaB (NF-κB) signaling pathways have key roles in cancer, but studies have previously evaluated only the association of canonical transcription factors and ovar...

    Authors: Demetra H. Hufnagel, Andrew J. Wilson, Jamie Saxon, Timothy S. Blackwell, Jaclyn Watkins, Dineo Khabele, Marta A. Crispens, Fiona E. Yull and Alicia Beeghly-Fadiel
    Citation: Biomarker Research 2020 8:45
  26. Aging and average life expectancy have been increasing at a rapid rate, while there is an exponential risk to suffer from brain-related frailties and neurodegenerative diseases as the population ages. Alzheime...

    Authors: Yuan-Yuan Chen, Min-Chang Wang, Yan-Ni Wang, He-He Hu, Qing-Quan Liu, Hai-Jing Liu and Ying-Yong Zhao
    Citation: Biomarker Research 2020 8:42
  27. Long non-coding RNAs (lncRNAs) represent an important class of RNAs comprising more than 200 nucleotides, which are produced by RNA polymerase II. Although lacking an open reading framework and protein-encodin...

    Authors: Yuhang Xiao, Ta Xiao, Wei Ou, Zhining Wu, Jie Wu, Jinming Tang, Bo Tian, Yong Zhou, Min Su and Wenxiang Wang
    Citation: Biomarker Research 2020 8:41
  28. Breast cancer, a malignant tumor originating from mammary epithelial tissue, is the most common cancer among women worldwide. Challenges facing the diagnosis and treatment of breast cancer necessitate the sear...

    Authors: Yujing Zhou and Xingdang Liu
    Citation: Biomarker Research 2020 8:39
  29. Prognostic factors for the Coronavirus disease 2019 (COVID1–9) are not well established. This study aimed to summarize the available data on the association between the severity of COVID-19 and common hematolo...

    Authors: Celestin Danwang, Francky Teddy Endomba, Jan René Nkeck, Dominic Leandry Angong Wouna, Annie Robert and Jean Jacques Noubiap
    Citation: Biomarker Research 2020 8:37
  30. Mixed phenotype acute leukemia (MPAL) is a rare leukemia and is regarded as a high-risk entity with a poor prognosis. Induction therapy of an acute lymphoblastic leukemia type or hybrid regimen and hematopoiet...

    Authors: Meng-Yun Li, Zhi-Hong Lin, Ming-Ming Hu, Li-Qing Kang, Xiao-xia Wu, Qi-wei Chen, Xin Kong, Jian Zhang, Hui-Ying Qiu and De-Pei Wu
    Citation: Biomarker Research 2020 8:36
  31. PD-1/PD-L1 blockade therapy is a promising cancer treatment strategy, which has revolutionized the treatment landscape of malignancies. Over the last decade, PD-1/PD-L1 blockade therapy has been trialed in a b...

    Authors: Jin-Yu Sun, Dengke Zhang, Songquan Wu, Min Xu, Xiao Zhou, Xiao-Jie Lu and Jiansong Ji
    Citation: Biomarker Research 2020 8:35
  32. Early progression after the first-line R-CHOP treatment leads to a very dismal outcome and necessitates alternative treatment for patients with diffuse large B-cell lymphoma (DLBCL). This study aimed to develo...

    Authors: Jialin Ma, Zheng Yan, Jiuyang Zhang, Wenping Zhou, Zhihua Yao, Haiying Wang, Junfeng Chu, Shuna Yao, Shuang Zhao, Peipei Zhang, Yuanlin Xu, Qingxin Xia, Jie Ma, Bing Wei, Shujun Yang, Kangdong Liu…
    Citation: Biomarker Research 2020 8:33
  33. The term “pharmacogenetics” is used to describe the study of variability in drug response due to heredity. It is associated with “gene – drug interactions”. Later on, the term “pharmacogenomics” has been intro...

    Authors: Nelly N. Miteva-Marcheva, Hristo Y. Ivanov, Dimitar K. Dimitrov and Vili K. Stoyanova
    Citation: Biomarker Research 2020 8:32
  34. Acute myeloid leukemia (AML) is a malignant hematological neoplasm of myeloid progenitor cells. Mutations of FLT3 in its tyrosine kinase domain (FLT3-TKD) are found in ~ 8% of patients with AML, with D835Y as ...

    Authors: Yao Guo, Honghua Sun, Dengyang Zhang, Yuming Zhao, Mingxia Shi, Ming Yang, Shu Xing, Xueqi Fu, Ting Bin, Bo Lu, Shunjie Wu, Xiaojun Xu, Xuesong Xu, Yun Chen and Zhizhuang Joe Zhao
    Citation: Biomarker Research 2020 8:30
  35. The recently updated European LeukemiaNet risk stratification guidelines combine cytogenetic abnormalities and genetic mutations to provide the means to triage patients with acute myeloid leukemia for optimal ...

    Authors: Era L. Pogosova-Agadjanyan, Anna Moseley, Megan Othus, Frederick R. Appelbaum, Thomas R. Chauncey, I-Ming L. Chen, Harry P. Erba, John E. Godwin, Isaac C. Jenkins, Min Fang, Mike Huynh, Kenneth J. Kopecky, Alan F. List, Jasmine Naru, Jerald P. Radich, Emily Stevens…
    Citation: Biomarker Research 2020 8:29
  36. Beyond hemostasis, thrombosis and wound healing, it is becoming increasingly clear that platelets play an integral role in inflammatory response and immune regulation. Platelets recognize pathogenic microorgan...

    Authors: Yufei Chen, Haoxuan Zhong, Yikai Zhao, Xinping Luo and Wen Gao
    Citation: Biomarker Research 2020 8:28
  37. The early detection of tumors upon initial diagnosis or during routine surveillance is important for improving survival outcomes. Here, we investigated the feasibility and clinical significance of circulating ...

    Authors: Qiong Li, Wei Zhang, Jiali Li, Jingkang Xiong, Jia Liu, Ting Chen, Qin Wen, Yunjing Zeng, Li Gao, Lei Gao, Cheng Zhang, Peiyan Kong, Xiangui Peng, Yao Liu, Xi Zhang and Jun Rao
    Citation: Biomarker Research 2020 8:27
  38. Alterations of genes encoding subunits of the BAF/PBAF complexes are among the most frequent gene aberrations in human cancer. Such alterations have been shown to have an impact on tumor microenvironnement and...

    Authors: Kevin Courtet, Yec’han Laizet, Carlo Lucchesi, Alban Bessede and Antoine Italiano
    Citation: Biomarker Research 2020 8:26
  39. Circular RNAs (circRNAs) are covalently linked RNAs that exhibit individual strand with a closed-loop framework compared with a conserving, steady and abundant linear counterpart. In recent years, as high-thro...

    Authors: Zhouxiao Li, Ye Cheng, Fan Wu, Liangliang Wu, Hongyong Cao, Qian Wang and Weiwei Tang
    Citation: Biomarker Research 2020 8:25
  40. Defect in DNA damage response (DDR) is a common feature of cancer cells, which regulates tumor growth and therapeutic response. Recently, the approval of immune checkpoint blockade (ICB) for tumors with defect...

    Authors: Jing Zhang, David J. H. Shih and Shiaw-Yih Lin
    Citation: Biomarker Research 2020 8:23

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