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  1. It was previously believed that patients with Ph-like ALL had poorer prognosis compared with other B-ALL subgroups due to resistance to conventional chemotherapy and lack of targeted drugs. CAR-T therapy has b...

    Authors: Hai-ping Dai, Dan-qing Kong, Hong-jie Shen, Wei Cui, Qian Wang, Zheng Li, Jia Yin, Li-qing Kang, Lei Yu, De-pei Wu and Xiao-wen Tang
    Citation: Biomarker Research 2023 11:19
    Content type: Correspondence Published on:

  2. The retinal determinant gene network (RDGN), originally discovered as a critical determinator in Drosophila eye specification, has become an important regulatory network in tumorigenesis and progression, as well ...

    Authors: Shuangli Zhu, Wanling Li, Hao Zhang, Yuheng Yan, Qi Mei and Kongming Wu
    Citation: Biomarker Research 2023 11:18
    Content type: Review Published on:

  3. The Maf proteins (Mafs) belong to basic leucine zipper transcription factors and are members of the activator protein-1 (AP-1) superfamily. There are two subgroups of Mafs: large Mafs and small Mafs, which are...

    Authors: Yalan Deng, Liqing Lu, Huajun Zhang, Ying Fu, Ting Liu and Yongheng Chen
    Citation: Biomarker Research 2023 11:17
    Content type: Review Published on:

  4. The difference between clinical characteristics and outcomes between follicular lymphoma grade 1–2 (FL1-2) and FL3a defined pathologically remains unclear, resulting in uncertainty how to treat FL3a. However, ...

    Authors: Jie Zha, Qinwei Chen, Jingjing Ye, Haifeng Yu, Shuhua Yi, Zhong Zheng, Wei Xu, Zhifeng Li, Lingyan Ping, Xiaohua He, Liling Zhang, Caixia Li, Ying Xie, Feili Chen, Xiuhua Sun, Liping Su…
    Citation: Biomarker Research 2023 11:16
    Content type: Research Published on:

  6. Niemann-Pick disease, type C1 (NPC1) is an ultrarare, recessive, lethal, lysosomal disease characterized by progressive cerebellar ataxia and cognitive impairment. Although the NPC1 phenotype is heterogeneous ...

    Authors: Kiersten Campbell, Niamh X. Cawley, Rachel Luke, Katelin E. J. Scott, Nicholas Johnson, Nicole Y. Farhat, Derek Alexander, Christopher A. Wassif, Wenping Li, Stephanie M. Cologna, Elizabeth Berry-Kravis, An Dang Do, Ryan K. Dale and Forbes D. Porter
    Citation: Biomarker Research 2023 11:14
    Content type: Research Published on:

  7. Cuproptosis is a newly discovered type of cell death triggered by copper accumulation. Here we exhibited the genetic profiles of 10 cuproptosis-associated genes (CuAGs) across 21 cancer types. Only 8.0% (627/7...

    Authors: Fanqin Bu, Xiangji Li, Yu Zhao, Liyi Bai, Shutian Zhang and Li Min
    Citation: Biomarker Research 2023 11:13
    Content type: Correspondence Published on:

  8. Epithelial ovarian cancer (EOC) is a highly prevalent disease that rapidly metastasizes and has poor prognosis. Most women are in the middle or late stages when diagnosed and have low survival rates. Recently,...

    Authors: Sihui Li, Shizhen Shen, Wanzhong Ge, Yixuan Cen, Songfa Zhang, Xiaodong Cheng, Xinyu Wang, Xing Xie and Weiguo Lu
    Citation: Biomarker Research 2023 11:12
    Content type: Research Published on:

  9. BRAF mutations are the oncogenic drivers in colorectal cancer and V600 mutations (Class1), which lead to RAS-independent active monomers, are the most common mutation types. BRAF non-V600 mutants can be further ...

    Authors: Yungchang Chen, Hao Sun, Yanhong Deng, Yutong Ma, He Huang, Yang Liu, Yaru Zhang, Hongyu Zhang, Sheng Ye, Mingyan E, Hongqiang Guo, Mengmeng Wu, Chunman Wu, Xingxiang Pu, Xinggui Chen, Chaoyong Liang…
    Citation: Biomarker Research 2023 11:11
    Content type: Correspondence Published on:

  10. Cumulative preclinical and clinical evidences showed radiotherapy might augment systemic antitumoral responses to immunotherapy for metastatic non-small cell lung cancer, but the optimal timing of combination ...

    Authors: Ying Zhang, Hui-Hui Hu, Shi-Hong Zhou, Wu-Yan Xia, Yan Zhang, Jian-Ping Zhang, Xiao-Long Fu and Wen Yu
    Citation: Biomarker Research 2023 11:10
    Content type: Research Published on:

  13. Over the past decade, targeted therapy for oncogene-driven NSCLC and immune checkpoint inhibitors for non-oncogene-driven NSCLC, respectively, have greatly improved the survival and quality of life for patient...

    Authors: Luis A. Godoy, Joy Chen, Weijie Ma, Jag Lally, Kyra A. Toomey, Prabhu Rajappa, Roya Sheridan, Shirish Mahajan, Nicholas Stollenwerk, Chinh T. Phan, Danny Cheng, Robert J. Knebel and Tianhong Li
    Citation: Biomarker Research 2023 11:7
    Content type: Review Published on:

  15. YTHDF1 is a well-characterized m6A reader protein that is essential for protein translation, stem cell self-renewal, and embryonic development. YTHDF1 regulates target gene expression by diverse molecular mech...

    Authors: Wenjun Ren, Yixiao Yuan, Yongwu Li, Luciano Mutti, Jun Peng and Xiulin Jiang
    Citation: Biomarker Research 2023 11:5
    Content type: Review Published on:

  16. To assess the association between plasma procalcitonin concentration at hospital admission and the risk of 50-day in-hospital mortality among patients with community-acquired bloodstream infections.

    Authors: Abderrahim Oussalah, Jonas Callet, Anne-Elisabeth Manteaux, Nathalie Thilly, Nicolas Jay, Jean-Louis Guéant and Alain Lozniewski
    Citation: Biomarker Research 2023 11:4
    Content type: Research Published on:

  17. Osteosarcoma (OSA) is the most prevalent type of bone cancer with a high rate of metastasis. Circular RNAs (CircRNAs) play an essential role in multiple aspects of tumour biology. This study aimed to elucidate...

    Authors: Jianye Tan, Bingsheng Yang, Haobo Zhong, Mengliang Luo, Zexin Su, Chao Xie, Meiling Shi, Chunhan Sun and Lijun Lin
    Citation: Biomarker Research 2023 11:3
    Content type: Research Published on:

  18. Head and neck cancer is a malignant tumour with a high mortality rate characterized by late diagnosis, high recurrence and metastasis rates, and poor prognosis. Head and neck squamous cell carcinoma (HNSCC) is...

    Authors: Yuting Xue, Xuejiao Jiang, Junrong Wang, Yuxuan Zong, Zhennan Yuan, Susheng Miao and Xionghui Mao
    Citation: Biomarker Research 2023 11:2
    Content type: Review Published on:

  19. Metastasis is a significant factor that affects the survival of patients with non-small cell lung cancer (NSCLC). Nevertheless, the molecular regulatory mechanism underlying the metastasis is currently not ful...

    Authors: Qing Zhu, Yixuan Zhang, Mo Li, Ying Zhang, Huan Zhang, Jiayi Chen, Zhaoyang Liu, Peng Yuan, Zhaogang Yang and Xiaobing Wang
    Citation: Biomarker Research 2023 11:1
    Content type: Research Published on:

  20. The strongest risk factor of neurodegenerative diseases (NDDs) is aging. Spontaneous asparaginyl deamidation leading to formation of isoaspartate (isoAsp) has been correlated with protein aggregation in NDDs.

    Authors: Jijing Wang, Ya-Ru Zhang, Xue-Ning Shen, Jinming Han, Mei Cui, Lan Tan, Qiang Dong, Roman A. Zubarev and Jin-Tai Yu
    Citation: Biomarker Research 2022 10:91
    Content type: Research Published on:

  22. Toll-like receptors (TLRs) are a large family of proteins that are expressed in immune cells and various tumor cells. TLR7/8 are located in the intracellular endosomes, participate in tumor immune surveillance...

    Authors: Hao Sun, Yingmei Li, Peng Zhang, Haizhou Xing, Song Zhao, Yongping Song, Dingming Wan and Jifeng Yu
    Citation: Biomarker Research 2022 10:89
    Content type: Review Published on:

    The Correction to this article has been published in Biomarker Research 2022 10:90

  23. Rates of endometrial cancer (EC) are increasing. For a definitive diagnosis, women undergo various time-consuming and painful medical procedures, such as endometrial biopsy with or without hysteroscopy, and di...

    Authors: Paweł Łaniewski, Haiyan Cui, Nichole D. Mahnert, Jamal Mourad, Matthew P. Borst, Lyndsay Willmott, Dana M. Chase, Denise J. Roe and Melissa M. Herbst-Kralovetz
    Citation: Biomarker Research 2022 10:88
    Content type: Research Published on:

  24. HCC is a major health concern worldwide. PKC gamma, a member of the conventional PKC subclass, is involved in many cancer types, but the protein has received little attention in the context of single nucleotid...

    Authors: Fizzah Abid, Talha Iqbal, Khushbukhat Khan, Yasmin Badshah, Janeen H Trembley, Naeem Mahmood Ashraf, Maria Shabbir, Tayyaba Afsar, Ali Almajwal and Suhail Razak
    Citation: Biomarker Research 2022 10:87
    Content type: Research Published on:

  25. Chimeric antigen receptor T (CAR-T) cell therapy has significantly improved the life expectancy for patients with refractory or relapse B cell lymphoma. As for B cell acute lymphoblastic leukemia (B-ALL), alt...

    Authors: Yue Liu, Lingna An, Ruihao Huang, Jingkang Xiong, Haoyu Yang, Xiaoqi Wang and Xi Zhang
    Citation: Biomarker Research 2022 10:86
    Content type: Review Published on:

  27. Children with birth defects (BD) are more likely to develop cancer and the increased risk of cancer persists into adulthood. Prior population-based assessments have demonstrated that even non-chromosomal BDs a...

    Authors: Yichuan Liu, Hui-Qi Qu, Xiao Chang, Frank D Mentch, Haijun Qiu, Kenny Nguyen, Xiang Wang, Amir Hossein Saeidian, Deborah Watson, Joseph Glessner and Hakon Hakonarson
    Citation: Biomarker Research 2022 10:84
    Content type: Research Published on:

  28. Fluid protein biomarkers are important tools in clinical research and health care to support diagnosis and to monitor patients. Especially within the field of dementia, novel biomarkers could address the curre...

    Authors: Katharina Waury, Eline A. J. Willemse, Eugeen Vanmechelen, Henrik Zetterberg, Charlotte E. Teunissen and Sanne Abeln
    Citation: Biomarker Research 2022 10:83
    Content type: Review Published on:

  29. Shugoshin-like protein 2 (SGOL2) is a centromeric protein that ensures the correct and orderly process of mitosis by protecting and maintaining centripetal adhesions during meiosis and mitosis. Here, we examin...

    Authors: Qingqing Hu, Qiuhong Liu, Yalei Zhao, Lingjian Zhang and Lanjuan Li
    Citation: Biomarker Research 2022 10:82
    Content type: Research Published on:

  30. Esophageal adenocarcinoma is a lethal disease. For locally advanced patients, neoadjuvant chemoradiotherapy followed by surgery is the standard of care. Risk stratification relies heavily on clinicopathologic ...

    Authors: Hirsch Matani, Divya Sahu, Michael Paskewicz, Anastasia Gorbunova, Ashten N. Omstead, Rodney Wegner, Gene G. Finley, Blair A. Jobe, Ronan J. Kelly, Ali H. Zaidi and Ajay Goel
    Citation: Biomarker Research 2022 10:81
    Content type: Research Published on:

  31. BRCAness is a characteristic feature of homologous recombination deficiency (HRD) mimicking BRCA gene mutation in breast cancer. We hypothesized that a measure to quantify BRCAness that causes synthetic lethal...

    Authors: Masanori Oshi, Shipra Gandhi, Rongrong Wu, Mariko Asaoka, Li Yan, Akimitsu Yamada, Shinya Yamamoto, Kazutaka Narui, Takashi Chishima, Takashi Ishikawa, Itaru Endo and Kazuaki Takabe
    Citation: Biomarker Research 2022 10:80
    Content type: Research Published on:

  32. A few critically short telomeres trigger genomic instability regardless of average telomere length (TL). Recently, the telomere shortest length assay (TeSLA) was developed to detect critically short telomeres ...

    Authors: Dong-Yeop Shin, Kyu Min Lim, Hee Sue Park, Sunghoon Kwon, Sung-Soo Yoon and Dong-Soon Lee
    Citation: Biomarker Research 2022 10:79
    Content type: Correspondence Published on:

  34. Esophageal carcinoma is the highly lethal cancer in the world, predominantly in some areas of East Asia. We previously reported that overexpression of cytoskeleton regulator Wiskott-Aldrich syndrome protein an...

    Authors: Mengxing Guo, Jingyao Lian, Yaqing Liu, Bo Dong, Qianyi He, Qitai Zhao, Hongyan Zhang, Yu Qi, Yi Zhang and Lan Huang
    Citation: Biomarker Research 2022 10:77
    Content type: Research Published on:

  35. There is a growing body of evidence to support tears as a non-traditional biological fluid in clinical laboratory testing. In addition to the simplicity of tear fluid processing, the ability to access key canc...

    Authors: Anna Daily, Prashanth Ravishankar, Wanyi Wang, Ryan Krone, Steve Harms and V. Suzanne Klimberg
    Citation: Biomarker Research 2022 10:76
    Content type: Research Published on:

  36. Chronic lymphocytic leukemia (CLL) is a heterogeneous B-cell malignancy that lacks specific biomarkers and drug targets. Competing endogenous RNAs (ceRNAs) play vital roles in oncogenesis and tumor progression...

    Authors: Xin Zhang, Yang Han, Xinting Hu, Hua Wang, Zheng Tian, Ya Zhang and Xin Wang
    Citation: Biomarker Research 2022 10:75
    Content type: Research Published on:

  38. Gastrointestinal cancers (GICs) occupy more than 30% of the cancer-related incidence and mortality around the world. Despite advances in the treatment strategies, the long-term overall survival has not been im...

    Authors: Ya-ya Yu, Yan-juan Zhu, Zhen-zhen Xiao, Ya-dong Chen, Xue-song Chang, Yi-hong Liu, Qing Tang and Hai-bo Zhang
    Citation: Biomarker Research 2022 10:73
    Content type: Review Published on:

  39. MicroRNAs (miRNAs) are a class of small non-coding RNAs ranging from 17 to 25 nt in length. miR-637 is down-regulated in most cancers and up-regulated only in clear cell renal cell carcinoma (ccRCC). miR-637 c...

    Authors: Jinze Shen, Chenhao Liang, Xinming Su, Qurui Wang, Yufei Ke, Jie Fang, Dayong Zhang and Shiwei Duan
    Citation: Biomarker Research 2022 10:72
    Content type: Review Published on:

  40. Recently, the global incidence of gastric/gastroesophageal junction (G/GEJ) cancer has remained high. China is also a large country with a high gastric cancer (GC) incidence rate, where the cases of GC account...

    Authors: Weiling Li, Xiaoling Zhang, Yunyi Du, Ying Zhang, Jing Lu, Wenqing Hu and Jun Zhao
    Citation: Biomarker Research 2022 10:71
    Content type: Review Published on:

  42. Interferon-α2b (IFN-α2b) is a highly active cytokine that belongs to the interferon-α (IFN-α) family. IFN-α2b has beneficial antiviral, antitumour, antiparasitic and immunomodulatory activities. Direct and ind...

    Authors: Fei Xiong, Qi Wang, Guan-hua Wu, Wen-zheng Liu, Bing Wang and Yong-jun Chen
    Citation: Biomarker Research 2022 10:69
    Content type: Review Published on:

  43. Neuroblastoma (NBL) is the most common extra-cranial solid tumour in childhood, with prognosis ranging from spontaneous remission to high risk for rapid and fatal progression. Despite existing therapy approach...

    Authors: Ying Huang, Jieyi Ma, Cuiyun Yang, Paijia Wei, Minghui Yang, Hui Han, Hua Dong Chen, Tianfang Yue, Shu Xiao, Xuanyu Chen, Zuoqing Li, Yanlai Tang, Jiesi Luo, Shuibin Lin and Libin Huang
    Citation: Biomarker Research 2022 10:68
    Content type: Research Published on:

  44. Gastric cancer is characterized by high morbidity and mortality worldwide. Early-stage gastric cancer is mainly treated with surgery, while for advanced gastric cancer, the current treatment options remain ins...

    Authors: Hongzhen Cai, Man Li, Ruiyi Deng, Mopei Wang and Yanyan Shi
    Citation: Biomarker Research 2022 10:67
    Content type: Review Published on:

  46. Hepatocellular carcinoma (HCC) is a type of cancer that affects the liver and has a high mortality rate. Long non-coding RNAs (lncRNAs) dysregulation can contribute to cancer occurrence and progression, althou...

    Authors: Chen Su, Weijian Wang, Jie Mo, Furong Liu, Hongwei Zhang, Yachong Liu, Xiaoping Chen, Zhibin Liao, Bixiang Zhang and Peng Zhu
    Citation: Biomarker Research 2022 10:65
    Content type: Research Published on:

  50. Esophageal squamous cell carcinoma (ESCC) represents a major malignancy with poor clinical outcomes. Long noncoding RNAs (lncRNAs) are known to regulate the development and progression of multiple cancers. How...

    Authors: Yuhang Xiao, Jinming Tang, Desong Yang, Baihua Zhang, Jie Wu, Zhining Wu, Qianjin Liao, Hui Wang, Wenxiang Wang and Min Su
    Citation: Biomarker Research 2022 10:60
    Content type: Research Published on:
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