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  1. . At present, the prognostic prediction in advanced oral cavity squamous cell carcinoma (OCSCC) is based on the tumor-node-metastasis (TNM) staging system, and the most used imaging modality in these patients ...

    Authors: Anna Corti, Loris De Cecco, Stefano Cavalieri, Deborah Lenoci, Federico Pistore, Giuseppina Calareso, Davide Mattavelli, Pim de Graaf, C. René Leemans, Ruud H. Brakenhoff, Marco Ravanelli, Tito Poli, Lisa Licitra, Valentina Corino and Luca Mainardi
    Citation: Biomarker Research 2023 11:69
    Content type: Research Published on:

  2. Comprehensive and integrative analysis of hepatocellular carcinoma (HCC) is important. In this study, we explored Taiwanese HCCs using multi-omics analyses.

    Authors: Ya-Sian Chang, Siang-Jyun Tu, Hong-Da Chen, Chin-Chun Chung, Ming-Hon Hsu, Yu-Pao Chou, Ya-Ting Lee, Ju-Chen Yen, Long-Bin Jeng and Jan-Gowth Chang
    Citation: Biomarker Research 2023 11:68
    Content type: Research Published on:

  3. Chimeric antigen receptor (CAR) T cells and natural killer (NK) cells are genetically engineered immune cells that can detect target antigens on the surface of target cells and eliminate them following adoptiv...

    Authors: Hamed Dabiri, Pooria Safarzadeh Kozani, Mahdi Habibi Anbouhi, Mohadeseh Mirzaee Godarzee, Mohammad Hossein Haddadi, Mohsen Basiri, Vahab Ziaei, Majid Sadeghizadeh and Ensiyeh Hajizadeh Saffar
    Citation: Biomarker Research 2023 11:67
    Content type: Review Published on:

  4. Cancer exerts a multitude of effects on metabolism, including the reprogramming of cellular metabolic pathways and alterations in metabolites that facilitate inappropriate proliferation of cancer cells and ada...

    Authors: Wenxiang Wang, Zhiwei Rong, Guangxi Wang, Yan Hou, Fan Yang and Mantang Qiu
    Citation: Biomarker Research 2023 11:66
    Content type: Review Published on:

  5. The most common kind of acute leukemia in adults is acute myeloid leukemia (AML), which is often treated with induction chemotherapy regimens followed by consolidation or allogeneic hematopoietic stem cell tra...

    Authors: Ruonan Shao, Zijian Li, Honglei Xin, Suyu Jiang, Yilin Zhu, Jingan Liu, Rong Huang, Kailin Xu and Xiaofeng Shi
    Citation: Biomarker Research 2023 11:65
    Content type: Review Published on:

  6. Late diagnosis is one of the major confounders in oral squamous cell carcinoma (OSCC). Despite recent advances in molecular diagnostics, no disease-specific biomarkers are clinically available for early risk p...

    Authors: Aditi Patel, Parina Patel, Dushyant Mandlik, Kaustubh Patel, Pooja Malaviya, Kaid Johar, Krishna B.S Swamy, Shanaya Patel and Vivek Tanavde
    Citation: Biomarker Research 2023 11:64
    Content type: Research Published on:

    The Correction to this article has been published in Biomarker Research 2024 12:28

  7. The ATP-adenosine pathway has emerged as a promising target for cancer therapy, but challenges remain in achieving effective tumor control. Early research focused on blocking the adenosine generating enzyme CD...

    Authors: Yao Liu, Zhongliang Li, Xiaoguang Zhao, Jing Xiao, Jiacheng Bi, Xian-Yang Li, Guokai Chen and Ligong Lu
    Citation: Biomarker Research 2023 11:63
    Content type: Review Published on:

  8. N6-methyladenosine (m6A) is the most prevalent and well-characterized internal chemical modification in eukaryotic RNA, influencing gene expression and phenotypic changes by controlling RNA fate. Insulin-like gro...

    Authors: Tian-Yu Zhu, Lian-Lian Hong and Zhi-Qiang Ling
    Citation: Biomarker Research 2023 11:62
    Content type: Review Published on:

    The Correction to this article has been published in Biomarker Research 2023 11:72

  10. Tissue factor (TF) is a protein that plays a critical role in blood clotting, but recent research has also shown its involvement in cancer development and progression. Herein, we provide an overview of the str...

    Authors: Seyed Esmaeil Ahmadi, Ashkan Shabannezhad, Amir Kahrizi, Armin Akbar, Seyed Mehrab Safdari, Taraneh Hoseinnezhad, Mohammad Zahedi, Soroush Sadeghi, Mahsa Golizadeh Mojarrad and Majid Safa
    Citation: Biomarker Research 2023 11:60
    Content type: Review Published on:

  11. Aberrant expression of circRNAs has been proven to play a crucial role in the progression of acute myeloid leukemia (AML); however, its regulatory mechanism remains unclear. Herein, we identified a novel circR...

    Authors: Xinyu Yang, Fengjiao Han, Xiang Hu, Guosheng Li, Hanyang Wu, Can Can, Yihong Wei, Jinting Liu, Ruiqing Wang, Wenbo Jia, Chunyan ji and Daoxin Ma
    Citation: Biomarker Research 2023 11:59
    Content type: Research Published on:

  12. Chronic lymphocytic leukemia (CLL) is one of the most frequent occurring types of leukemia. It typically occurs in elderly patients and has a highly variable clinical course. At present, the molecular mechanis...

    Authors: Wenjie Zhang, Jinlan Long, Peixia Tang, Kaili Chen, Guangyao Guo, Zezhong Yu, Jie Lin, Liping Liu, Rong Zhan and Zhenshu Xu
    Citation: Biomarker Research 2023 11:58
    Content type: Research Published on:

  13. Immune checkpoint inhibitors (ICIs) have dramatically enhanced the treatment outcomes for diverse malignancies. Yet, only 15–60% of patients respond significantly. Therefore, accurate responder identification ...

    Authors: Ruixia Song, Fengsen Liu, Yu Ping, Yi Zhang and Liping Wang
    Citation: Biomarker Research 2023 11:57
    Content type: Review Published on:

  14. Inducible T cell costimulator ICOS is an emerging target in immuno-oncology. The aim of this study was to investigate the epigenetic regulation of ICOS in melanoma by DNA methylation.

    Authors: Damian J. Ralser, Emmanuelle Herr, Luka de Vos, Zsófi Kulcsár, Romina Zarbl, Niklas Klümper, Gerrit H. Gielen, Alexander Philippe Maas, Friederike Hoffmann, Jörn Dietrich, Pia Kuster, Alexander Mustea, Nicole Glodde, Glen Kristiansen, Sebastian Strieth, Jennifer Landsberg…
    Citation: Biomarker Research 2023 11:56
    Content type: Research Published on:

  17. Blood tests would be much easier to implement in the clinical diagnosis of Alzheimer’s disease (AD) as minimally invasive measurements. Multiple inspection technologies promoted AD-associated blood biomarkers’...

    Authors: Yan Wang, Ying Li, Yan Li, Tingting Li, Qi Wang, Qigeng Wang, Shuman Cao, Fangyu Li and Jianping Jia
    Citation: Biomarker Research 2023 11:53
    Content type: Research Published on:

  18. We analyzed single nucleotide polymorphisms (SNPs) in PKNOX1 (rs2839629) and in the intergenic region between PKNOX1 and CBS (rs915854) by Sanger sequencing in 88 patients with multiple myeloma treated with borte...

    Authors: Xiang Zhou, Seungbin Han, Nadine Cebulla, Larissa Haertle, Maximilian J. Steinhardt, Daniel Schirmer, Eva Runau, Leon Flamm, Calvin Terhorst, Laura Jähnel, Cornelia Vogt, Silvia Nerreter, Eva Teufel, Emilia Stanojkovska, Julia Mersi, Umair Munawar…
    Citation: Biomarker Research 2023 11:52
    Content type: Correspondence Published on:

  19. Authors: Jie Wu, Chunlei Zheng, Yizhe Wang, Zichang Yang, Ce Li, Wanxia Fang, Yue Jin, Kezuo Hou, Yang Cheng, Jianfei Qi, Xiujuan Qu, Yunpeng Liu, Xiaofang Che and Xuejun Hu
    Citation: Biomarker Research 2023 11:51
    Content type: Correction Published on:

    The original article was published in Biomarker Research 2021 9:9

  21. Chimeric antigen receptor (CAR) T cell therapy, in which a patient’s own T lymphocytes are engineered to recognize and kill cancer cells, has achieved striking success in some hematological malignancies in pre...

    Authors: Marzieh Mazinani and Fatemeh Rahbarizadeh
    Citation: Biomarker Research 2023 11:49
    Content type: Review Published on:

  23. Urinary bladder cancer (UBC) is a common malignancy of the urinary tract; however, the mechanism underlying its high recurrence and responses to immunotherapy remains unclear, making clinical outcome predictio...

    Authors: Zhen-Duo Shi, Xiao-Xiao Han, Zi-Jian Song, Yang Dong, Kun Pang, Xin-Lei Wang, Xin-Yu Liu, Hao Lu, Guang-Zhi Xu, Lin Hao, Bing-Zheng Dong, Qing Liang, Xiao-Ke Wu and Cong-Hui Han
    Citation: Biomarker Research 2023 11:47
    Content type: Research Published on:

  24. Advanced hepatic fibrosis is the main risk factor of liver-related morbidity and mortality in patients with chronic liver disease. In this study, we assessed the potential role of bone morphogenetic protein 8A...

    Authors: Patricia Marañón, Stephania C. Isaza, Carlos Ernesto Fernández-García, Esther Rey, Rocío Gallego-Durán, Rocío Montero-Vallejo, Javier Rodríguez de Cía, Javier Ampuero, Ángela M. Valverde, Manuel Romero-Gómez, Carmelo García-Monzón and Águeda González-Rodríguez
    Citation: Biomarker Research 2023 11:46
    Content type: Research Published on:

  25. Lung cancer remains the leading cause of cancer mortality worldwide. Early detection of lung cancer helps improve treatment and survival. Numerous aberrant DNA methylations have been reported in early-stage lu...

    Authors: Shuo Hu, Jinsheng Tao, Minhua Peng, Zhujia Ye, Zhiwei Chen, Haisheng Chen, Haifeng Yu, Bo Wang, Jian-Bing Fan and Bin Ni
    Citation: Biomarker Research 2023 11:45
    Content type: Research Published on:

  26. Definitive chemoradiotherapy (dCRT) is a standard treatment option for locally advanced stage inoperable esophageal squamous cell carcinoma (ESCC). Evaluating clinical outcome prior to dCRT remains challenging...

    Authors: Jinfeng Cui, Li Li, Ning Liu, Wenhong Hou, Yinjun Dong, Fengchang Yang, Shouhui Zhu, Jun Li and Shuanghu Yuan
    Citation: Biomarker Research 2023 11:44
    Content type: Research Published on:

  27. N6-methyladenosine (m6A) methylation is the most abundant chemical posttranscriptional modification of mRNA, and it is associated with the regulation of the immune response to tumors. However, the function of ...

    Authors: Lei Zhan, Jing Zhang, Jun-Hui Zhang, Xiao-Jing Liu, Bao Guo, Jia-Hua Chen, Zhen-Hai Tang, Wen-Yan Wang, Qing-Yuan Wang, Bing Wei and Yun-Xia Cao
    Citation: Biomarker Research 2023 11:43
    Content type: Correspondence Published on:

  28. N6-methyladenosine (m6A) is considered as the most common and important internal transcript modification in several diseases like type 2 diabetes, schizophrenia and especially cancer. As a main target of m6A meth...

    Authors: Jinxin Tang, Jinhui Zhang, Yu Lu, Jieyu He, Hua Wang, Binfeng Liu, Chao Tu and Zhihong Li
    Citation: Biomarker Research 2023 11:42
    Content type: Review Published on:

  29. Neoantigens generated by non-synonymous mutations of tumor genes can induce activation of neoantigen-reactive T (NRT) cells which have the ability to resist the growth of tumors expressing specific neoantigens...

    Authors: Ruichen Huang, Bi Zhao, Shi Hu, Qian Zhang, Xiaoping Su and Wei Zhang
    Citation: Biomarker Research 2023 11:41
    Content type: Review Published on:

  31. Osteoarthritis (OA) is the most prevalent age-related disease in the world. Chondrocytes undergo an age-dependent decline in their proliferation and synthetic capacity, which is the main cause of OA developmen...

    Authors: Panyang Shen, Jun Gao, Shaohan Huang, Chenan You, Haitao Wang, Pengyu Chen, Teng Yao, Tianyou Gao, Bohao Zhou, Shuying Shen, Xing Zhao and Jianjun Ma
    Citation: Biomarker Research 2023 11:39
    Content type: Research Published on:

  32. Uveal melanoma (UM) is the most common intraocular malignancy in adults, with a poor survival prognosis. To date, limited understanding of UM’s molecular mechanisms constitutes an obstacle to developing effect...

    Authors: Jingting Luo, Haowen Li, Jingying Xiu, Jingyao Zeng, Zhaoxun Feng, Hanqing Zhao, Yang Li and Wenbin Wei
    Citation: Biomarker Research 2023 11:38
    Content type: Research Published on:

  33. Androgen receptor (AR) splice variants (AR-Vs) have been discussed as a biomarker in prostate cancer (PC). However, some reports question the predictive property of AR-Vs. From a mechanistic perspective, the c...

    Authors: Neele Wüstmann, Konstantin Seitzer, Verena Humberg, Julia Vieler, Norbert Grundmann, Julie Steinestel, Dorothee Tiedje, Stefan Duensing, Laura-Maria Krabbe, Martin Bögemann, Andres Jan Schrader, Christof Bernemann and Katrin Schlack
    Citation: Biomarker Research 2023 11:37
    Content type: Research Published on:

  34. Interleukin-25 (IL-25), also known as IL-17E, is a cytokine belonging to the IL-17 family. IL-25 is abundantly expressed by Th2 cells and various kinds of epithelial cells. IL-25 is an alarm signal generated u...

    Authors: Qingfang Yuan, Na Peng, Fan Xiao, Xiaofei Shi, Bo Zhu, Ke Rui, Jie Tian and Liwei Lu
    Citation: Biomarker Research 2023 11:36
    Content type: Review Published on:

  36. The immunosuppressive tumor microenvironment (TME) supports the development of tumors and limits tumor immunotherapy, including hematological malignancies. Hematological malignancies remain a major public heal...

    Authors: Shifen Wang, Xingyun Zhao, Siwen Wu, Dawei Cui and Zhenshu Xu
    Citation: Biomarker Research 2023 11:34
    Content type: Review Published on:

  37. Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive cancer that is challenging to diagnose at an early stage. Despite recent advances in combination chemotherapy, drug resistance limits the therapeut...

    Authors: Zhipeng Li, Huaxin Zhou, Zhijia Xia, Tong Xia, Gang Du, Strohmer Dorothee Franziska, Xiaoming Li, Xiangyu Zhai and Bin Jin
    Citation: Biomarker Research 2023 11:33
    Content type: Research Published on:

    The Correction to this article has been published in Biomarker Research 2024 12:27

  38. Recent massive sequencing studies have revealed that SWI/SNF complexes are among the most frequently altered functional entities in solid tumors. However, the role of SWI/SNF in acute myeloid leukemia is poorl...

    Authors: Juan Rodrigo Patiño-Mercau, Carlos Baliñas-Gavira, Alvaro Andrades, Maria S. Benitez-Cantos, Ana Ercegovič Rot, Maria Isabel Rodriguez, Juan Carlos Álvarez-Pérez, Marta Cuadros and Pedro P. Medina
    Citation: Biomarker Research 2023 11:32
    Content type: Research Published on:

  39. Studies have not systematically compared the ability to verify performance of prognostic transcripts in paired bulk mononuclear cells versus viable CD34-expressing leukemic blasts from patients with acute myel...

    Authors: Era L. Pogosova-Agadjanyan, Xing Hua, Megan Othus, Frederick R. Appelbaum, Thomas R. Chauncey, Harry P. Erba, Matthew P. Fitzgibbon, Isaac C. Jenkins, Min Fang, Stanley C. Lee, Anna Moseley, Jasmine Naru, Jerald P. Radich, Jenny L. Smith, Brooke E. Willborg, Cheryl L. Willman…
    Citation: Biomarker Research 2023 11:31
    Content type: Research Published on:

  40. Although t (8;21) is in fact considered a good risk acute myeloid leukemia (AML), only 60% of the patients live beyond 5 years after diagnosis. Studies have shown that RNA demethylase ALKBH5 promotes leukemoge...

    Authors: Ran Li, Xiaolu Wu, Kai Xue, Dandan Feng, Jianyong Li and Junmin Li
    Citation: Biomarker Research 2023 11:30
    Content type: Research Published on:

  41. The SETD2 tumor suppressor gene encodes a histone methyltransferase that safeguards transcription fidelity and genomic integrity via trimethylation of histone H3 lysine 36 (H3K36Me3). SETD2 loss of function has b...

    Authors: Manuela Mancini, Cecilia Monaldi, Sara De Santis, Cristina Papayannidis, Michela Rondoni, Chiara Sartor, Samantha Bruno, Livio Pagano, Marianna Criscuolo, Roberta Zanotti, Massimiliano Bonifacio, Patrizia Tosi, Michel Arock, Peter Valent, Michele Cavo and Simona Soverini
    Citation: Biomarker Research 2023 11:29
    Content type: Research Published on:

  42. Immune checkpoint inhibitors (ICIs) targeting PD-1 or PD-L1 have emerged as a revolutionary treatment strategy for human cancer patients. However, as the response rate to ICI therapy varies widely among differ...

    Authors: Enkui Zhang, Chengsheng Ding, Shuchun Li, Xueliang Zhou, Batuer Aikemu, Xiaodong Fan, Jing Sun, Minhua Zheng and Xiao Yang
    Citation: Biomarker Research 2023 11:28
    Content type: Review Published on:

  43. Multiple myeloma (MM) is an incurable hematological cancer with high spatial- and temporal-heterogeneity. Invasive single-point bone marrow sampling cannot capture the tumor heterogeneity and is difficult to r...

    Authors: Shuchan Li, Enfan Zhang and Zhen Cai
    Citation: Biomarker Research 2023 11:27
    Content type: Review Published on:

  44. ADJUVANT-CTONG1104 reported a favorable survival outcome from adjuvant gefitinib treatment over chemotherapy in EGFR-mutant non-small cell lung cancer (NSCLC) patients. However, heterogeneous benefit from EGFR-TK...

    Authors: Si-Yang Maggie Liu, Cunte Chen, Yi-Kai Zhang, Wen-Zhao Zhong, Yi-Long Wu, Si-Yang Liu and Yangqiu Li
    Citation: Biomarker Research 2023 11:26
    Content type: Correspondence Published on:

  45. Activated immune cells (IC) in the tumor microenvironment (TME) are critical for anti-tumor efficacy. Greater understanding of the dynamic diversity and crosstalk between IC is needed to clarify their associat...

    Authors: Dingwei Ye, Jayesh Desai, Jingwen Shi, Si-Yang Maggie Liu, Wei Shen, Tengfei Liu, Yang Shi, Dan Wang, Liang Liang, Silu Yang, Xiaopeng Ma, Wei Jin, Pei Zhang, Ruiqi Huang, Zhirong Shen, Yun Zhang…
    Citation: Biomarker Research 2023 11:25
    Content type: Research Published on:

  46. In addition to the anti-infection response, neutrophils are linked to tumor progression through the secretion of inflammation components and neutrophil extracellular traps (NETs) formation. NET is a web-like s...

    Authors: Bingqing Shang, Honglei Cui, Ruiyang Xie, Jie Wu, Hongzhe Shi, Xingang Bi, Lin Feng and Jianzhong Shou
    Citation: Biomarker Research 2023 11:24
    Content type: Review Published on:

  49. Pyrotinib, a novel irreversible tyrosine kinase inhibitor (TKI), has demonstrated promising antitumor activity to improve the overall response rate and progression-free survival (PFS) in patients with HER2-pos...

    Authors: Xiuwen Guan, Fei Ma, Qiao Li, Shanshan Chen, Bo Lan, Ying Fan, Jiayu Wang, Yang Luo, Ruigang Cai, Pin Zhang, Qing Li and Binghe Xu
    Citation: Biomarker Research 2023 11:21
    Content type: Research Published on:

  50. Aging and diet are risks for metabolic diseases. Bile acid receptor farnesoid X receptor (FXR) knockout (KO) mice develop metabolic liver diseases that progress into cancer as they age, which is accelerated by...

    Authors: Guiyan Yang, Prasant K. Jena, Ying Hu, Lili Sheng, Shin-Yu Chen, Carolyn M. Slupsky, Ryan Davis, Clifford G. Tepper and Yu-Jui Yvonne Wan
    Citation: Biomarker Research 2023 11:20
    Content type: Research Published on:
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