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  1. Chronic inflammatory demyelinating polyneuropathy (CIDP) is characterised by significant clinical heterogeneity and as such reliable biomarkers are required to measure disease activity and assess treatment res...

    Authors: Anthony Khoo, Joseph Frasca and David Schultz
    Citation: Biomarker Research 2019 7:3
    Content type: Review Published on:

  2. Factors regulating transcription of pluripotency genes in congenital nevo-melanocytes are not known. Nevo-melanocytes belong somewhere in-between the ends of a spectrum where the normal epidermal melanocyte re...

    Authors: Dipanjan Basu, Cláudia M. Salgado, Janki R. Patel, Joie Zabec, Ryan M. Hoehl, Bruce Bauer and Miguel Reyes-Múgica
    Citation: Biomarker Research 2019 7:2
    Content type: Letter to the Editor Published on:

  3. There is a great unmet clinical need to identify patients with thin primary cutaneous melanomas (T1, Breslow thickness ≤ 1 mm) who have a high risk for tumour recurrence and death from melanoma. Kin of IRRE-li...

    Authors: Sebastian Lundgren, Helena Fagerström-Vahman, Cheng Zhang, Liv Ben-Dror, Adil Mardinoglu, Mathias Uhlen, Björn Nodin and Karin Jirström
    Citation: Biomarker Research 2019 7:1
    Content type: Letter to the Editor Published on:

  4. Altered mitochondrial function and large-scale changes to DNA methylation patterns in the nuclear genome are both hallmarks of colorectal cancer (CRC). Mitochondria have multiple copies of a 16 kb circular gen...

    Authors: M. J. Morris, L. B. Hesson, R. C. Poulos, R. L. Ward, J. W. H. Wong and N. A. Youngson
    Citation: Biomarker Research 2018 6:37
    Content type: Research Published on:

  5. In patients with myelodysplastic syndrome (MDS), bone marrow cells have an increased predisposition to apoptosis, yet MDS cells outcompete normal bone marrow (BM)-- suggesting that factors regulating growth po...

    Authors: Christine V. Ichim, Dzana D. Dervovic, Lap Shu Alan Chan, Claire J. Robertson, Alden Chesney, Marciano D. Reis and Richard A. Wells
    Citation: Biomarker Research 2018 6:36
    Content type: Research Published on:

  6. OPCML hypermethylation is considered a promising cancer biomarker. We examined methylation levels in the first exon of OPCML in two patient cohorts within the esophageal adenocarcinoma and gastric adenocarcinoma ...

    Authors: Natalia Castaño-Rodríguez, Georgia L. Popple, Gloria Liliana Porras-Hurtado, José Luis Cardona-Deazza, Juan José Montoya-Martinez, Antonio Javier Cadavid-Velez, Héctor William Toro-Hidalgo, Alba Ruth Cobo-Alvarado, Ofelia del Socorro Hincapié-Rincón, Stephen M. Riordan and Nadeem O. Kaakoush
    Citation: Biomarker Research 2018 6:35
    Content type: Short report Published on:

  7. Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase that is of great interest in human cancer. It has been shown to have a dual nature, as it can act as a gene repressor or activator. Studies hav...

    Authors: Rosemarie Tremblay-LeMay, Nasrin Rastgoo, Maryam Pourabdollah and Hong Chang
    Citation: Biomarker Research 2018 6:34
    Content type: Review Published on:

  8. A feature of myeloproliferative neoplasia is transforming to more aggressive and malignant myeloid neoplasia, including acute myeloid leukemia. Different pathogenesis mechanisms participate in transformation, ...

    Authors: Marte Karen Brattås, Kyrre Lilleeng, Randi Hovland, Ingvild Jenssen Lægreid, Marta Vorland, Friedemann Leh, Øystein Bruserud, Bjørn Tore Gjertsen and Håkon Reikvam
    Citation: Biomarker Research 2018 6:33
    Content type: Case report Published on:

  10. We aim to characterize the heterogeneous circulating tumour cells (CTCs) in peripheral blood, independently of physical or immunological purification, by using patient-derived xenografts (PDXs) models. CTC stu...

    Authors: Chiara Agnoletto, Linda Minotti, Laura Brulle-Soumare, Lorenzo Pasquali, Marco Galasso, Fabio Corrà, Federica Baldassari, Jean-Gabriel Judde, Stefano Cairo and Stefano Volinia
    Citation: Biomarker Research 2018 6:31
    Content type: Research Published on:

  11. In most women with ovarian cancer, the diagnosis occurs after dissemination of tumor cells beyond ovaries. Several molecular perturbations occur ahead of tumor initiation including loss of lamin A/C. Our hypot...

    Authors: Callinice D Capo-chichi, Kathy Q Cai and Xiang-Xi Xu
    Citation: Biomarker Research 2018 6:30
    Content type: Research Published on:

  12. Recurrent gene mutations have been described with varying frequencies in myelodysplasia (MDS) /myeloproliferative neoplasm (MPN) overlap syndromes (MMOS). Recent work has placed significant focus on understand...

    Authors: Amandeep Aujla, Katherine Linder, Chaitanya Iragavarapu, Michael Karass and Delong Liu
    Citation: Biomarker Research 2018 6:29
    Content type: Review Published on:

  13. Metabolic syndrome is a cluster of abnormalities that increases the risk for type 2 diabetes and atherosclerosis. Plasma and serum water T2 from benchtop nuclear magnetic resonance relaxometry are early, global a...

    Authors: Vipulkumar Patel, Alok K. Dwivedi, Sneha Deodhar, Ina Mishra and David P. Cistola
    Citation: Biomarker Research 2018 6:28
    Content type: Research Published on:

  14. For children and young adults with T-lineage acute lymphoblastic leukemia (T-ALL), event free survival following relapse is < 10%. We recently showed that rearrangements of the mixed lineage leukemia gene (KMT2A-...

    Authors: Huining Kang, Nitesh D. Sharma, Christian K. Nickl, Meenakshi Devidas, Mignon L. Loh, Stephen P. Hunger, Kimberly P. Dunsmore, Stuart S. Winter and Ksenia Matlawska-Wasowska
    Citation: Biomarker Research 2018 6:27
    Content type: Rapid communication Published on:

  16. Diagnosing pancreatic ductal adenocarcinoma (PDAC) in the setting of metastasis with an unknown primary remains very challenging due to the lack of specific biomarkers. HNF-1B has been characterized as an impo...

    Authors: Michelle X. Yang, Ryan F. Coates, Abiy Ambaye, Juli-Anne Gardner, Richard Zubarick, Yuan Gao, Joan Skelly, James G. Liu and Mari Mino-Kenudson
    Citation: Biomarker Research 2018 6:25
    Content type: Research Published on:

  17. The prognosis of adult T-cell leukemia-lymphoma (ATL) remains very poor, and there is an urgent clinical need to investigate novel therapies for ATL. The expression of phosphatidylinositol 3-kinase-δ (PI3k-δ) ...

    Authors: Hiroo Katsuya, Lucy B. M. Cook, Aileen G. Rowan, Yorifumi Satou, Graham P. Taylor and Charles R. M. Bangham
    Citation: Biomarker Research 2018 6:24
    Content type: Letter to the Editor Published on:

  18. Carcinogenesis is a multistep process which involves interplay between the tumour cells and the matrix proteins. This occurs by adherence between the tumour cells and proteins in the extracellular matrix. VHL ...

    Authors: Sandeep Kondisetty, Krishnakumar N. Menon and Ginil Kumar Pooleri
    Citation: Biomarker Research 2018 6:23
    Content type: Research Published on:

  19. For glioblastoma (GBM) treatments to be effective in vivo, understanding the effects of the tumor microenvironment is imperative. In traditional cell culture conditions, glucose concentrations do not model phy...

    Authors: Kiera Walker, Nathaniel H. Boyd, Joshua C. Anderson, Christopher D. Willey and Anita B. Hjelmeland
    Citation: Biomarker Research 2018 6:22
    Content type: Research Published on:

  20. Chemerin is a recently discovered adipokine shown to be involved in both inflammatory and metabolic processes. Here, we demonstrate that chemerin serum levels are elevated in patients with multiple myeloma and...

    Authors: Marita Westhrin, Siv Helen Moen, Ida Bruun Kristensen, Glenn Buene, Anne Kærsgaard Mylin, Ingemar Turesson, Niels Abildgaard, Anders Waage and Therese Standal
    Citation: Biomarker Research 2018 6:21
    Content type: Letter to the Editor Published on:

  21. Metronomic therapy has been gaining importance in the neoadjuvant setting of breast cancer treatment. Its clinical benefits may involve antiangiogenic machinery. Cancer cells induce angiogenesis to support tum...

    Authors: Roberto J. Arai, Vanessa Petry, Paulo M. Hoff and Max S. Mano
    Citation: Biomarker Research 2018 6:20
    Content type: Short report Published on:

  22. Colorectal cancer has significant impact on individuals and healthcare systems. Many genes have been identified to influence its pathogenesis. However, the genetic basis of mucinous tumor histology, an aggress...

    Authors: Michelle E. Penney, Patrick S. Parfrey, Sevtap Savas and Yildiz E. Yilmaz
    Citation: Biomarker Research 2018 6:17
    Content type: Research Published on:

  23. Calretinin is the most widespread positive marker for the immunohistochemical identification of malignant mesothelioma (MM) and was proposed to serve as a blood-based biomarker. Functionally, evidence has accu...

    Authors: Walter Blum, Thomas Henzi, Hugues-Etienne Châtel-Soulet, Laszlo Pecze, Janine Wörthmüller Rodriguez, Bart Vrugt and Beat Schwaller
    Citation: Biomarker Research 2018 6:19
    Content type: Short report Published on:

  24. Despite tremendous research efforts focused on diagnosis and treatment, pancreatic ductal adenocarcinoma remains the third leading cause of cancer-related death in the United States, with a 5-year overall surv...

    Authors: Shixiang Guo, Andrew Fesler, Huaizhi Wang and Jingfang Ju
    Citation: Biomarker Research 2018 6:18
    Content type: Review Published on:

  25. Germline mutations in the RUNX1 transcription factor give rise to a rare autosomal dominant genetic condition classified under the entity: Familial Platelet Disorders with predisposition to Acute Myeloid Leukaemi...

    Authors: Isaac KS Ng, Joanne Lee, Christopher Ng, Bustamin Kosmo, Lily Chiu, Elaine Seah, Michelle Meng Huang Mok, Karen Tan, Motomi Osato, Wee-Joo Chng, Benedict Yan and Lip Kun Tan
    Citation: Biomarker Research 2018 6:16
    Content type: Case report Published on:

  26. Well-differentiated neuroendocrine tumors (NET) most frequently arise from the gastrointestinal tract (GI), pancreas, and lung. Patients often present as metastasis with an unknown primary, and the clinical ma...

    Authors: Michelle X. Yang, Ryan F. Coates, Abiy Ambaye, Valerie Cortright, Jeannette M. Mitchell, Alexa M. Buskey, Richard Zubarik, James G. Liu, Steven Ades and Maura M. Barry
    Citation: Biomarker Research 2018 6:15
    Content type: Research Published on:

  27. Inhaled allergen challenges are often used to evaluate novel asthma treatments in early phase clinical trials. Current novel therapeutic targets in asthma include phosphoinositide 3-kinases (PI3K) delta and ga...

    Authors: Thomas Southworth, Sarah Mason, Alan Bell, Isabel Ramis, Marta Calbet, Anna Domenech, Neus Prats, Montserrat Miralpeix and Dave Singh
    Citation: Biomarker Research 2018 6:14
    Content type: Research Published on:

  28. GATA2 deficiency presents with a spectrum of phenotypes including increased susceptibility to viral and bacterial infections, multi-lineage cytopenias, aplastic anemia, leukemic transformation and lymphedema. ...

    Authors: Allen Sanyi, David L. Jaye, Cecilia B. Rosand, Amanda Box, Chandrakasan Shanmuganathan and Edmund K. Waller
    Citation: Biomarker Research 2018 6:13
    Content type: Case report Published on:

  29. Biomarkers promise biomolecular explanations as well as reliable diagnostics, stratification, and treatment strategies that have the potential to help mitigate the effects of disorders. While no reliable bioma...

    Authors: Daniel P. Howsmon, James B. Adams, Uwe Kruger, Elizabeth Geis, Eva Gehn and Juergen Hahn
    Citation: Biomarker Research 2018 6:12
    Content type: Short report Published on:

  30. Yin Yang 1 (YY1) is a transcription factor that plays an important role during all stages of B cell differentiation. Several studies reported upregulation of YY1 in B cell derived lymphoma, indicating that it ...

    Authors: Jéssica Arribas Arranz, Dalia Nilufar Winter, Hans Günter Drexler and Sonja Eberth
    Citation: Biomarker Research 2018 6:11
    Content type: Research Published on:

  31. Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase and a catalytic component of PRC2, catalyzes tri-methylation of histone H3 at Lys 27 (H3K27me3) to regulate gene expression through epigenetic ma...

    Authors: Lu Gan, Yanan Yang, Qian Li, Yi Feng, Tianshu Liu and Weijian Guo
    Citation: Biomarker Research 2018 6:10
    Content type: Review Published on:

  32. The original article [1] contains an error in Fig. 3 whereby the trend lines denoting Low & High E-cadherin were mistakenly labelled the opposite way around.

    Authors: W. Goto, S. Kashiwagi, Y. Asano, K. Takada, K. Takahashi, T. Hatano, T. Takashima, S. Tomita, H. Motomura, M. Ohsawa, K. Hirakawa and M. Ohira
    Citation: Biomarker Research 2018 6:9
    Content type: Correction Published on:

    The original article was published in Biomarker Research 2017 5:19

  35. Sphingosine kinase (SphK) 2 has been implicated in the development of a range of cancers and inhibitors of this enzyme are currently in clinical trial. We have previously demonstrated a role for SphK2 in the d...

    Authors: Vicki Xie, Daochen Tong, Craig T. Wallington-Beddoe, Ken F. Bradstock and Linda J. Bendall
    Citation: Biomarker Research 2018 6:6
    Content type: Research Published on:

  36. Alzheimer’s disease (AD) is a most common dementia in elderly people. Since AD symptoms resemble those of other neurodegenerative diseases, including idiopathic normal pressure hydrocephalus (iNPH), it is diff...

    Authors: Yuki Nagata, Akiyoshi Hirayama, Satsuki Ikeda, Aoi Shirahata, Futaba Shoji, Midori Maruyama, Mitsunori Kayano, Masahiko Bundo, Kotaro Hattori, Sumiko Yoshida, Yu-ichi Goto, Katsuya Urakami, Tomoyoshi Soga, Kouichi Ozaki and Shumpei Niida
    Citation: Biomarker Research 2018 6:5
    Content type: Research Published on:

  38. Acute kidney injury (AKI) is a frequent complication of cardiac surgery. We sought prognostic combinations of postoperative biomarkers measured within 6 h of surgery, potentially in combination with cardiopulm...

    Authors: Allison Meisner, Kathleen F. Kerr, Heather Thiessen-Philbrook, Francis Perry Wilson, Amit X. Garg, Michael G. Shlipak, Peter Kavsak, Richard P. Whitlock, Steven G. Coca and Chirag R. Parikh
    Citation: Biomarker Research 2018 6:3
    Content type: Research Published on:

  39. Platelets support cancer growth and spread making platelet proteins candidates in the search for biomarkers.

    Authors: Marta Lomnytska, Rui Pinto, Susanne Becker, Ulla Engström, Sonja Gustafsson, Christina Björklund, Markus Templin, Jan Bergstrand, Lei Xu, Jerker Widengren, Elisabeth Epstein, Bo Franzén and Gert Auer
    Citation: Biomarker Research 2018 6:2
    Content type: Research Published on:

  41. Diagnosis of malaria in pregnancy is problematic due to the low sensitivity of conventional diagnostic tests (rapid diagnostic test and microscopy), which is exacerbated due to low peripheral parasite densitie...

    Authors: E. Ruizendaal, H. D. F. H. Schallig, J. Bradley, M. Traore-Coulibaly, P. Lompo, U. d’Alessandro, S. Scott, F. Njie, S. H. Zango, O. Sawadogo, M. D. de Jong, H. Tinto and P. F. Mens
    Citation: Biomarker Research 2017 5:34
    Content type: Research Published on:

  43. Selective kinase and immune checkpoint inhibitors, and their combinations, have significantly improved the survival of patients with advanced metastatic melanoma. Not all patients will respond to treatment how...

    Authors: Su Yin Lim, Jenny H. Lee, Sarah J. Welsh, Seong Beom Ahn, Edmond Breen, Alamgir Khan, Matteo S. Carlino, Alexander M. Menzies, Richard F. Kefford, Richard A. Scolyer, Georgina V. Long and Helen Rizos
    Citation: Biomarker Research 2017 5:32
    Content type: Research Published on:

  45. Quantitative proteomics allows for the discovery and functional investigation of blood-based pre-diagnostic biomarkers for early cancer detection. However, a major limitation of proteomic investigations in bio...

    Authors: Christine Y. Yeh, Ravali Adusumilli, Majlinda Kullolli, Parag Mallick, Esther M. John and Sharon J. Pitteri
    Citation: Biomarker Research 2017 5:30
    Content type: Research Published on:

  46. Monomeric laminin-γ2 in urine is a potential biomarker for bladder cancer. However, the current detection system uses an antibody that cannot discriminate between monomeric laminin-γ2 and the heterotrimeric γ2...

    Authors: Masatoshi Nakagawa, Takashi Karashima, Masayuki Kamada, Eisaku Yoshida, Toru Yoshimura, Masanori Nojima, Keiji Inoue, Taro Shuin, Motoharu Seiki and Naohiko Koshikawa
    Citation: Biomarker Research 2017 5:29
    Content type: Research Published on:

  47. Because soluble (or secreted) amyloid precursor protein-β (sAPPβ) and -α (sAPPα) possibly reflect pathological features of Alzheimer’s disease (AD), they are potential biomarker candidates for dementia disorde...

    Authors: Wataru Araki, Kotaro Hattori, Kazutomi Kanemaru, Yuma Yokoi, Yoshie Omachi, Harumasa Takano, Masuhiro Sakata, Sumiko Yoshida, Tadashi Tsukamoto, Miho Murata, Yuko Saito, Hiroshi Kunugi, Yu-ichi Goto, Utako Nagaoka, Masahiro Nagao, Takashi Komori…
    Citation: Biomarker Research 2017 5:28
    Content type: Research Published on:

  48. The pattern of serotonin transporter clustering on the plasma membrane of lymphocytes extracted from human whole blood samples has been identified as a putative biomarker of therapeutic efficacy in major depre...

    Authors: Raquel Romay-Tallon, Tania Rivera-Baltanas, Josh Allen, Jose M. Olivares, Lisa E. Kalynchuk and Hector J. Caruncho
    Citation: Biomarker Research 2017 5:27
    Content type: Methodology Published on:
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