Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D: Global cancer statistics. CA Cancer J Clin 2011,61(2):69–90.
Article
PubMed
Google Scholar
Villanueva A, Minguez B, Forner A, Reig M, Llovet JM: Hepatocellular carcinoma: novel molecular approaches for diagnosis, prognosis, and therapy. Annu Rev Med 2010, 61: 317–328.
Article
CAS
PubMed Central
PubMed
Google Scholar
Hoofnagle JH: Hepatocellular carcinoma: summary and recommendations. Gastroenterology 2004,127(5 Suppl 1):S319-S323.
Article
PubMed
Google Scholar
Yang JD, Roberts LR: Hepatocellular carcinoma: a global view. Nat Rev Gastroenterol Hepatol 2010,7(8):448–458.
Article
PubMed Central
PubMed
Google Scholar
Poon D, Anderson BO, Chen LT, Tanaka K, Lau WY, van Cutsem E, Singh H, Chow WC, Ooi LL, Chow P, Khin MW, Koo WH: Management of hepatocellular carcinoma in Asia: consensus statement from the Asian Oncology Summit 2009. Lancet Oncol 2009,10(11):1111–1118.
Article
PubMed
Google Scholar
Colli A, Fraquelli M, Casazza G, Massironi S, Colucci A, Conte D, Duca P: Accuracy of ultrasonography, spiral CT, magnetic resonance, and alpha-fetoprotein in diagnosing hepatocellular carcinoma: a systematic review: CME. Am J Gastroenterol 2006,101(3):513–523.
Article
CAS
PubMed
Google Scholar
Terentiev AA, Moldogazieva NT: Alpha-fetoprotein: a renaissance. Tumour Biol 2013,34(4):2075–2091.
Article
CAS
PubMed
Google Scholar
Song P, Tobe RG, Inagaki Y, Kokudo N, Hasegawa K, Sugawara Y, Tang W: The management of hepatocellular carcinoma around the world: a comparison of guidelines from 2001 to 2011. Liver Int 2012,32(7):1053–1063.
Article
PubMed
Google Scholar
Llovet JM, Bru C, Bruix J: Prognosis of hepatocellular carcinoma: the BCLC staging classification. Semin Liver Dis 1999,19(3):329–338.
Article
CAS
PubMed
Google Scholar
Borel F, Konstantinova P, Jansen PLM: Diagnostic and therapeutic potential of miRNA signatures in patients with hepatocellular carcinoma. J Hepatol 2012,56(6):1371–1383.
Article
CAS
PubMed
Google Scholar
Budhu A, Jia HL, Forgues M, Liu CG, Goldstein D, Lam A, Zanetti KA, Ye QH, Qin LX, Croce CM, Tang ZY, Xin WW: Identification of metastasis-related microRNAs in hepatocellular carcinoma. Hepatology 2008,47(3):897–907.
Article
CAS
PubMed
Google Scholar
Hoshida Y, Nijman SMB, Kobayashi M, Chan JA, Brunet JP, Chiang DY, Villanueva A, Newell P, Ikeda K, Hashimoto M, Watanabe G, Gabriel S, Friedman SL, Kumada H, Llovet JM, Golub TR: Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma. Cancer Res 2009,69(18):7385–7392.
Article
CAS
PubMed Central
PubMed
Google Scholar
Lee JS, Thorgeirsson SS: Genome-scale profiling of gene expression in hepatocellular carcinoma: classification, survival prediction, and identification of therapeutic targets. Gastroenterology 2004,127(SUPPL):S51-S55.
Article
CAS
PubMed
Google Scholar
Lemmer ER, Friedman SL, Llovet JM: Molecular diagnosis of chronic liver disease and hepatocellular carcinoma: the potential of gene expression profiling. Semin Liver Dis 2006,26(4):373–384.
Article
CAS
PubMed
Google Scholar
Villanueva A, Hoshida Y, Battiston C, Tovar V, Sia D, Alsinet C, Cornella H, Liberzon A, Kobayashi M, Kumada H, Thung SN, Bruix J, Newell P, April C, Fan J, Roayaie S, Mazzaferro V, Schwartz ME, Llovet JM: Combining clinical, pathology, and gene expression data to predict recurrence of hepatocellular carcinoma. Gastroenterology 2011,140(5):1501–1512. e1502
Article
CAS
PubMed Central
PubMed
Google Scholar
Minouchi K, Kaneko S, Kobayashi K: Mutation of p53 gene in regenerative nodules in cirrhotic liver. J Hepatol 2002,37(2):231–239.
Article
CAS
PubMed
Google Scholar
Bressac B, Kew M, Wands J, Ozturk M: Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa. Nature 1991,350(6317):429–431.
Article
CAS
PubMed
Google Scholar
Ishizaki Y, Ikeda S, Fujimori M, Shimizu Y, Kurihara T, Itamoto T, Kikuchi A, Okajima M, Asahara T: Immunohistochemical analysis and mutational analyses of beta-catenin, Axin family and APC genes in hepatocellular carcinomas. Int J Oncol 2004,24(5):1077–1083.
CAS
PubMed
Google Scholar
Edamoto Y, Hara A, Biernat W, Terracciano L, Cathomas G, Riehle HM, Matsuda M, Fujii H, Scoazec JY, Ohgaki H: Alterations of RB1, p53 and Wnt pathways in hepatocellular carcinomas associated with hepatitis C, hepatitis B and alcoholic liver cirrhosis. Int J Cancer 2003,106(3):334–341.
Article
CAS
PubMed
Google Scholar
Satoh S, Daigo Y, Furukawa Y, Kato T, Miwa N, Nishiwaki T, Kawasoe T, Ishiguro H, Fujita M, Tokino T, Sasaki Y, Imaoka S, Murata M, Shimano T, Yamaoka Y, Nakamura Y: AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nat Genet 2000,24(3):245–250.
Article
CAS
PubMed
Google Scholar
Taniguchi K, Roberts LR, Aderca IN, Dong X, Qian C, Murphy LM, Nagorney DM, Burgart LJ, Roche PC, Smith DI, Ross JA, Liu W: Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas. Oncogene 2002,21(31):4863–4871.
Article
CAS
PubMed
Google Scholar
Han ZG: Functional genomic studies: insights into the pathogenesis of liver cancer. Annu Rev Genom Hum G 2012, 13: 171–205.
Article
CAS
Google Scholar
Pradhan S, Bacolla A, Wells RD, Roberts RJ: Recombinant human DNA (cytosine-5) methyltransferase. I. Expression, purification, and comparison of de novo and maintenance methylation. J Biol Chem 1999,274(46):33002–33010.
Article
CAS
PubMed
Google Scholar
Feinberg AP, Vogelstein B: Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature 1983,301(5895):89–92.
Article
CAS
PubMed
Google Scholar
Tischoff I, Tannapfel A: DNA methylation in hepatocellular carcinoma. World J Gastroentero 2008,14(11):1741–1748.
Article
CAS
Google Scholar
Park IY, Sohn BH, Yu E, Suh DJ, Chung Y, Lee J, Surzycki SJ, Lee YI: Aberrant epigenetic modifications in hepatocarcinogenesis induced by hepatitis B virus X protein. Gastroenterology 2007,132(4):1476–1494.
Article
CAS
PubMed
Google Scholar
Lim JS, Park SH, Jang KL: Hepatitis C virus core protein overcomes stress-induced premature senescence by down-regulating p16 expression via DNA methylation. Cancer Lett 2012,321(2):154–161.
Article
CAS
PubMed
Google Scholar
Arora P, Kim EO, Jung JK, Jang KL: Hepatitis C virus core protein downregulates E-cadherin expression via activation of DNA methyltransferase 1 and 3b. Cancer Lett 2008,261(2):244–252.
Article
CAS
PubMed
Google Scholar
Nagai M, Nakamura A, Makino R, Mitamura K: Expression of DNA (5-cytosin)-methyltransferases (DNMTs) in hepatocellular carcinomas. Hepatol Res 2003,26(3):186–191.
Article
CAS
PubMed
Google Scholar
Park HJ, Yu E, Shim YH: DNA methyltransferase expression and DNA hypermethylation in human hepatocellular carcinoma. Cancer Lett 2006,233(2):271–278.
Article
CAS
PubMed
Google Scholar
Bibikova M, Le J, Barnes B, Saedinia-Melnyk S, Zhou L, Shen R, Gunderson KL: Genome-wide DNA methylation profiling using Infinium(R) assay. Epigenomics 2009,1(1):177–200.
Article
CAS
PubMed
Google Scholar
Touleimat N, Tost J: Complete pipeline for Infinium((R)) Human Methylation 450 K BeadChip data processing using subset quantile normalization for accurate DNA methylation estimation. Epigenomics 2012,4(3):325–341.
Article
CAS
PubMed
Google Scholar
Estécio MRH, Yan PS, Ibrahim AEK, Tellez CS, Shen L, Huang THM, Issa JPJ: High-throughput methylation profiling by MCA coupled to CpG island microarray. Genome Res 2007,17(10):1529–1536.
Article
PubMed Central
PubMed
CAS
Google Scholar
Huang TH, Perry MR, Laux DE: Methylation profiling of CpG islands in human breast cancer cells. Hum Mol Genet 1999,8(3):459–470.
Article
CAS
PubMed
Google Scholar
Mohn F, Weber M, Schubeler D, Roloff TC: Methylated DNA immunoprecipitation (MeDIP). Methods Mol Biol 2009, 507: 55–64.
Article
CAS
PubMed
Google Scholar
Gao W, Kondo Y, Shen L, Shimizu Y, Sano T, Yamao K, Natsume A, Goto Y, Ito M, Murakami H, Osada H, Zhang J, Issa JPJ, Sekido Y: Variable DNA methylation patterns associated with progression of disease in hepatocellular carcinomas. Carcinogenesis 2008,29(10):1901–1910.
Article
CAS
PubMed
Google Scholar
Lu CY, Hsieh SY, Lu YJ, Wu CS, Chen LC, Lo SJ, Wu CT, Chou MY, Huang THM, Chang YS: Aberrant DNA methylation profile and frequent methylation of KLK10 and OXGR1 genes in hepatocellular carcinoma. Genes Chromosomes Cancer 2009,48(12):1057–1068.
Article
CAS
PubMed
Google Scholar
Deng YB, Nagae G, Midorikawa Y, Yagi K, Tsutsumi S, Yamamoto S, Hasegawa K, Kokudo N, Aburatani H, Kaneda A: Identification of genes preferentially methylated in hepatitis C virus-related hepatocellular carcinoma. Cancer Sci 2010,101(6):1501–1510.
Article
CAS
PubMed
Google Scholar
Stefanska B, Huang J, Bhattacharyya B, Suderman M, Hallett M, Han ZG, Szyf M: Definition of the landscape of promoter DNA hypomethylation in liver cancer. Cancer Res 2011,71(17):5891–5903.
Article
CAS
PubMed
Google Scholar
Shitani M, Sasaki S, Akutsu N, Takagi H, Suzuki H, Nojima M, Yamamoto H, Tokino T, Hirata K, Imai K, Toyota M, Shinomura Y: Genome-wide analysis of DNA methylation identifies novel cancer-related genes in hepatocellular carcinoma. Tumor Biol 2012,33(5):1307–1317.
Article
CAS
Google Scholar
Zhang P, Wen X, Gu F, Deng X, Li J, Dong J, Jiao J, Tian Y: Methylation profiling of serum DNA from hepatocellular carcinoma patients using an Infinium Human Methylation 450 BeadChip. Hepatol Int 2013,7(3):893–900.
Article
PubMed
Google Scholar
Shen J, Wang S, Zhang YJ, Kappil M, Wu HC, Kibriya MG, Wang Q, Jasmine F, Ahsan H, Lee PH, Yu MW, Chen CJ, Santella RM: Genome-wide DNA methylation profiles in hepatocellular carcinoma. Hepatology 2012,55(6):1799–1808.
Article
CAS
PubMed Central
PubMed
Google Scholar
Hernandez-Vargas H, Lambert MP, le Calvez-Kelm F, Gouysse G, McKay-Chopin S, Tavtigian SV, Scoazec JY, Herceg Z: Hepatocellular carcinoma displays distinct DNA methylation signatures with potential as clinical predictors. PLoS One 2010,5(3):e9749.
Article
PubMed Central
PubMed
CAS
Google Scholar
Tao R, Li J, Xin J, Wu J, Guo J, Zhang L, Jiang L, Zhang W, Yang Z, Li L: Methylation profile of single hepatocytes derived from hepatitis B virus-related hepatocellular carcinoma. PLoS One 2011,6(5):e19862.
Article
CAS
PubMed Central
PubMed
Google Scholar
Song MA, Tiirikainen M, Kwee S, Okimoto G, Yu H, Wong LL: Elucidating the landscape of aberrant DNA methylation in hepatocellular carcinoma. PLoS One 2013,8(2):e55761.
Article
CAS
PubMed Central
PubMed
Google Scholar
Shen J, Wang S, Zhang YJ, Wu HC, Kibriya MG, Jasmine F, Ahsan H, Wu DPH, Siegel AB, Remotti H, Santella RM: Exploring genome-wide DNA methylation profiles altered in hepatocellular carcinoma using Infinium Human Methylation 450 BeadChips. Epigenetics 2013,8(1):34–43.
Article
CAS
PubMed Central
PubMed
Google Scholar
Hou X, Peng JX, Hao XY, Cai JP, Liang LJ, Zhai JM, Zhang KS, Lai JM, Yin XY: DNA methylation profiling identifies EYA4 gene as a prognostic molecular marker in hepatocellular carcinoma. Ann Surg Oncol 2013. in press
Google Scholar
Ammerpohl O, Pratschke J, Schafmayer C, Haake A, Faber W, von Kampen O, Brosch M, Sipos B, von Schönfels W, Balschun K, Röcken C, Arlt A, Schniewind B, Grauholm J, Kalthoff H, Neuhaus P, Stickel F, Schreiber S, Becker T, Siebert R, Hampe J: Distinct DNA methylation patterns in cirrhotic liver and hepatocellular carcinoma. Int J Cancer 2012,130(6):1319–1328.
Article
CAS
PubMed
Google Scholar
Archer KJ, Mas VR, Maluf DG, Fisher RA: High-throughput assessment of CpG site methylation for distinguishing between HCV-cirrhosis and HCV-associated hepatocellular carcinoma. Mol Genet Genomics 2010,283(4):341–349.
Article
CAS
PubMed Central
PubMed
Google Scholar
Neumann O, Kesselmeier M, Geffers R, Pellegrino R, Radlwimmer B, Hoffmann K, Ehemann V, Schemmer P, Schirmacher P, Bermejo JL, Longerich T: Methylome analysis and integrative profiling of human HCCs identify novel protumorigenic factors. Hepatology 2012,56(5):1817–1827.
Article
CAS
PubMed
Google Scholar
Matsumura S, Imoto I, Kozaki KI, Matsui T, Muramatsu T, Furuta M, Tanaka S, Sakamoto M, Arii S, Inazawa J: Integrative array-based approach identifies MZB1 as a frequently methylated putative tumor suppressor in hepatocellular carcinoma. Clin Cancer Res 2012,18(13):3541–3551.
Article
CAS
PubMed
Google Scholar
Okamura Y, Nomoto S, Hayashi M, Hishida M, Nishikawa Y, Yamada S, Fujii T, Sugimoto H, Takeda S, Kodera Y, Nakao A: Identification of the bleomycin hydrolase gene as a methylated tumor suppressor gene in hepatocellular carcinoma using a novel triple-combination array method. Cancer Lett 2011,312(2):150–157.
Article
CAS
PubMed
Google Scholar
Revill K, Wang T, Lachenmayer A, Kojima K, Harrington A, Li J, Hoshida Y, Llovet JM, Powers S: Genome-wide methylation analysis and epigenetic unmasking identify tumor suppressor genes in hepatocellular carcinoma. Gastroenterology 2013,145(6):1424–1435.
Article
CAS
PubMed Central
PubMed
Google Scholar
Yang B, Guo M, Herman JG, Clark DP: Aberrant promoter methylation profiles of tumor suppressor genes in hepatocellular carcinoma. Am J Pathol 2003,163(3):1101–1107.
Article
CAS
PubMed Central
PubMed
Google Scholar
Lee S, Lee HJ, Kim JH, Lee HS, Jang JJ, Kang GH: Aberrant CpG island hypermethylation along multistep hepatocarcinogenesis. Am J Pathol 2003,163(4):1371–1378.
Article
CAS
PubMed Central
PubMed
Google Scholar
Yu J, Zhang HY, Ma ZZ, Lu W, Wang YF, Zhu J: Methylation profiling of twenty four genes and the concordant methylation behaviours of nineteen genes that may contribute to hepatocellular carcinogenesis. Cell Res 2003,13(5):319–333.
Article
CAS
PubMed
Google Scholar
Liggett WH, Sidransky D: Role of the p16 tumor suppressor gene in cancer. J Clin Oncol 1998,16(3):1197–1206.
CAS
PubMed
Google Scholar
Esteller M, Corn PG, Baylin SB, Herman JG: A gene hypermethylation profile of human cancer. Cancer Res 2001,61(8):3225–3229.
CAS
PubMed
Google Scholar
Shim YH, Yoon GS, Choi HJ, Chung YH, Yu E: p16 Hypermethylation in the early stage of hepatitis B virus-associated hepatocarcinogenesis. Cancer Lett 2003,190(2):213–219.
Article
CAS
PubMed
Google Scholar
Su PF, Lee TC, Lin PJ, Lee PH, Jeng YM, Chen CH, Liang JD, Chiou LL, Huang GT, Lee HS: Differential DNA methylation associated with hepatitis B virus infection in hepatocellular carcinoma. Int J Cancer 2007,121(6):1257–1264.
Article
CAS
PubMed
Google Scholar
Katoh H, Shibata T, Kokubu A, Ojima H, Fukayama M, Kanai Y, Hirohashi S: Epigenetic instability and chromosomal instability in hepatocellular carcinoma. Am J Pathol 2006,168(4):1375–1384.
Article
CAS
PubMed Central
PubMed
Google Scholar
Li X, Hei AM, Sun L, Hasegawa K, Torzilli G, Minagawa M, Takayama T, Makuuchi M: p16INK4A hypermethylation is associated with hepatitis virus infection, age, and gender in hepatocellular carcinoma. Clin Cancer Res 2004,10(22):7484–7489.
Article
CAS
PubMed
Google Scholar
Jicai Z, Zongtao Y, Jun L, Haiping L, Jianmin W, Lihua H: Persistent infection of hepatitis B virus is involved in high rate of p16 methylation in hepatocellular carcinoma. Mol Carcinog 2006,45(7):530–536.
Article
PubMed
CAS
Google Scholar
Feng Q, Stern JE, Hawes SE, Lu H, Jiang M, Kiviat NB: DNA methylation changes in normal liver tissues and hepatocellular carcinoma with different viral infection. Exp Mol Pathol 2010,88(2):287–292.
Article
CAS
PubMed Central
PubMed
Google Scholar
Zhu R, Li BZ, Li H, Ling YQ, Hu XQ, Zhai WR, Zhu HG: Association of p16INK4A hypermethylation with hepatitis B virus X protein expression in the early stage of HBV-associated hepatocarcinogenesis. Pathol Int 2007,57(6):328–336.
Article
CAS
PubMed
Google Scholar
Qin Y, Liu JY, Li B, Sun ZL, Sun ZF: Association of low p16INK4a and p15INK4b mRNAs expression with their CpG islands methylation with human hepatocellular carcinogenesis. World J Gastroenterol 2004,10(9):1276–1280.
CAS
PubMed
PubMed Central
Google Scholar
Kikuchi LO, Paranagua-Vezozzo DC, Chagas AL, Mello ES, Alves VA, Farias AQ, Pietrobon R, Carrilho FJ: Nodules less than 20 mm and vascular invasion are predictors of survival in small hepatocellular carcinoma. J Clin Gastroenterol 2009,43(2):191–195.
Article
PubMed
Google Scholar
Tamura S, Kato T, Berho M, Misiakos EP, O’Brien C, Reddy KR, Nery JR, Burke GW, Schiff ER, Miller J, Tzakis AG: Impact of histological grade of hepatocellular carcinoma on the outcome of liver transplantation. Arch Surg 2001,136(1):25–30.
Article
CAS
PubMed
Google Scholar
Jonas S, Bechstein WO, Steinmuller T, Herrmann M, Radke C, Berg T, Settmacher U, Neuhaus P: Vascular invasion and histopathologic grading determine outcome after liver transplantation for hepatocellular carcinoma in cirrhosis. Hepatology 2001,33(5):1080–1086.
Article
CAS
PubMed
Google Scholar
Ko E, Kim Y, Kim SJ, Joh JW, Song S, Park CK, Park J, Kim DH: Promoter hypermethylation of the p16 gene is associated with poor prognosis in recurrent early-stage hepatocellular carcinoma. Cancer Epidemiol Biomarkers Prev 2008,17(9):2260–2267.
Article
CAS
PubMed
Google Scholar
Yoshikawa H, Matsubara K, Qian GS, Jackson P, Groopman JD, Manning JE, Harris CC, Herman JG: SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity. Nat Genet 2001,28(1):29–35.
CAS
PubMed
Google Scholar
Um TH, Kim H, Oh BK, Kim MS, Kim KS, Jung G, Park YN: Aberrant CpG island hypermethylation in dysplastic nodules and early HCC of hepatitis B virus-related human multistep hepatocarcinogenesis. J Hepatol 2011,54(5):939–947.
Article
CAS
PubMed
Google Scholar
Ko E, Kim SJ, Joh JW, Park CK, Park J, Kim DH: CpG island hypermethylation of SOCS-1 gene is inversely associated with HBV infection in hepatocellular carcinoma. Cancer Lett 2008,271(2):240–250.
Article
CAS
PubMed
Google Scholar
Zhang X, Wang J, Cheng J, Ding S, Li M, Sun S, Zhang L, Liu S, Chen X, Zhuang H, Lu F: An integrated analysis of SOCS1 down-regulation in HBV infection-related hepatocellular carcinoma. J Viral Hepat 2013. in press
Google Scholar
Chu PY, Yeh CM, Hsu NC, Chang YS, Chang JG, Yeh KT: Epigenetic alteration of the SOCS1 gene in hepatocellular carcinoma. Swiss Med Wkly 2010., 140:
Google Scholar
Nishida N, Nagasaka T, Nishimura T, Ikai I, Boland CR, Goel A: Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma. Hepatology 2008,47(3):908–918.
Article
CAS
PubMed Central
PubMed
Google Scholar
Okochi O, Hibi K, Sakai M, Inoue S, Takeda S, Kaneko T, Nakao A: Methylation-mediated silencing of SOCS-1 gene in hepatocellular carcinoma derived from cirrhosis. Clin Cancer Res 2003,9(14):5295–5298.
CAS
PubMed
Google Scholar
Freeman AJ, Dore GJ, Law MG, Thorpe M, von Overbeck J, Lloyd AR, Marinos G, Kaldor JM: Estimating progression to cirrhosis in chronic hepatitis C virus infection. Hepatology 2001,34(4 Pt 1):809–816.
Article
CAS
PubMed
Google Scholar
Laborde E: Glutathione transferases as mediators of signaling pathways involved in cell proliferation and cell death. Cell Death Differ 2010,17(9):1373–1380.
Article
CAS
PubMed
Google Scholar
Lee WH, Morton RA, Epstein JI, Brooks JD, Campbell PA, Bova GS, Hsieh WS, Isaacs WB, Nelson WG: Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis. Proc Natl Acad Sci USA 1994,91(24):11733–11737.
Article
CAS
PubMed Central
PubMed
Google Scholar
Lambert MP, Paliwal A, Vaissière T, Chemin I, Zoulim F, Tommasino M, Hainaut P, Sylla B, Scoazec JY, Tost J, Herceg Z: Aberrant DNA methylation distinguishes hepatocellular carcinoma associated with HBV and HCV infection and alcohol intake. J Hepatol 2011,54(4):705–715.
Article
CAS
PubMed
Google Scholar
Zhang YJ, Chen Y, Ahsan H, Lunn RM, Chen SY, Lee PH, Chen CJ, Santella RM: Silencing of glutathione S-transferase P1 by promoter hypermethylation and its relationship to environmental chemical carcinogens in hepatocellular carcinoma. Cancer Lett 2005,221(2):135–143.
Article
CAS
PubMed
Google Scholar
Chang HW, Chow V, Lam KY, Wei WI, WingYuen AP: Loss of E-cadherin expression resulting from promoter hypermethylation in oral tongue carcinoma and its prognostic significance. Cancer 2002,94(2):386–392.
Article
CAS
PubMed
Google Scholar
Kanazawa T, Watanabe T, Kazama S, Tada T, Koketsu S, Nagawa H: Poorly differentiated adenocarcinoma and mucinous carcinoma of the colon and rectum show higher rates of loss of heterozygosity and loss of E-cadherin expression due to methylation of promoter region. Int J Cancer 2002,102(3):225–229.
Article
CAS
PubMed
Google Scholar
Graziano F, Arduini F, Ruzzo A, Bearzi I, Humar B, More H, Silva R, Muretto P, Guilford P, Testa E, Mari D, Magnani M, Cascinu S: Prognostic analysis of E-cadherin gene promoter hypermethylation in patients with surgically resected, node-positive, diffuse gastric cancer. Clin Cancer Res 2004,10(8):2784–2789.
Article
CAS
PubMed
Google Scholar
Takeno S, Noguchi T, Fumoto S, Kimura Y, Shibata T, Kawahara K: E-cadherin expression in patients with esophageal squamos cell carcinoma: Promoter hypermethylation, Snail overexpression, and clinicopathologic implications. Am J Clin Pathol 2004,122(1):78–84.
Article
CAS
PubMed
Google Scholar
Shimamoto T, Ohyashiki JH, Ohyashiki K: Methylation of p15INK4b and E-cadherin genes is independently correlated with poor prognosis in acute myeloid leukemia. Leuk Res 2005,29(6):653–659.
Article
CAS
PubMed
Google Scholar
Caldeira JRF, Prando EC, Quevedo FC, Moraes Neto FA, Rainho CA, Rogatto SR: CDH1 promoter hypermethylation and E-cadherin protein expression in infiltrating breast cancer. BMC Cancer 2006, 6: 48.
Article
PubMed Central
PubMed
CAS
Google Scholar
Lim SO, Gu JM, Kim MS, Kim HS, Park YN, Park CK, Cho JW, Park YM, Jung G: Epigenetic changes induced by reactive oxygen species in hepatocellular carcinoma: methylation of the E-cadherin promoter. Gastroenterology 2008,135(6):2128–2140.
Article
CAS
PubMed
Google Scholar
Oh BK, Kim H, Park HJ, Shim YH, Choi J, Park C, Park YN: DNA methyltransferase expression and DNA methylation in human hepatocellular carcinoma and their clinicopathological correlation. Int J Mol Med 2007,20(1):65–73.
CAS
PubMed
Google Scholar
Ghee YK, Byung CY, Kwang CK, Jae WC, Won SP, Cheol KP: Promoter methylation of E-cadherin in hepatocellular carcinomas and dysplastic nodules. J Korean Med Sci 2005,20(2):242–247.
Article
Google Scholar
Hughes LA, Melotte V, de Schrijver J, de Maat M, Smit VT, Bovee JV, French PJ, van den Brandt PA, Schouten LJ, de Meyer T, van Criekinge W, Ahuja N, Herman JG, Weijenberg MP, van Engeland M: The CpG island methylator phenotype: what’s in a name? Cancer Res 2013,73(19):5858–5868.
Article
CAS
PubMed
Google Scholar
Noushmehr H, Weisenberger DJ, Diefes K, Phillips HS, Pujara K, Berman BP, Pan F, Pelloski CE, Sulman EP, Bhat KP, Verhaak RG, Hoadley KA, Hayes DN, Perou CM, Schmidt HK, Ding L, Wilson RK, van den Berg D, Shen H, Bengtsson H, Neuvial P, Cope LM, Buckley J, Herman JG, Baylin SB, Laird PW, Aldape K: Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell 2010,17(5):510–522.
Article
CAS
PubMed Central
PubMed
Google Scholar
Fang F, Turcan S, Rimner A, Kaufman A, Giri D, Morris LG, Shen R, Seshan V, Mo Q, Heguy A, Baylin SB, Ahuja N, Viale A, Massague J, Norton L, Vahdat LT, Moynahan ME, Chan TA: Breast cancer methylomes establish an epigenomic foundation for metastasis. Sci Transl Med 2011,3(75):75ra25.
Article
PubMed Central
PubMed
Google Scholar
Toyota M, Ahuja N, Ohe-Toyota M, Herman JG, Baylin SB, Issa JP: CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci USA 1999,96(15):8681–8686.
Article
CAS
PubMed Central
PubMed
Google Scholar
Zhang C, Li Z, Cheng Y, Jia F, Li R, Wu M, Li K, Wei L: CpG island methylator phenotype association with elevated serum α-fetoprotein level in hepatocellular carcinoma. Clin Cancer Res 2007,13(3):944–952.
Article
CAS
PubMed
Google Scholar
Zhang C, Guo X, Jiang G, Zhang L, Yang Y, Shen F, Wu M, Wei L: CpG island methylator phenotype association with upregulated telomerase activity in hepatocellular carcinoma. Int J Cancer 2008,123(5):998–1004.
Article
CAS
PubMed
Google Scholar
Cheng Y, Zhang C, Zhao J, Wang C, Xu Y, Han Z, Jiang G, Guo X, Li R, Bu X, Wu M, Wei L: Correlation of CpG island methylator phenotype with poor prognosis in hepatocellular carcinoma. Exp Mol Pathol 2010,88(1):112–117.
Article
CAS
PubMed
Google Scholar
Li B, Liu W, Wang L, Li M, Wang J, Huang L, Huang P, Yuan Y: CpG island methylator phenotype associated with tumor recurrence in tumor-node-metastasis stage I hepatocellular carcinoma. Ann Surg Oncol 2010,17(7):1917–1926.
Article
PubMed
Google Scholar
Wu LM, Zhang F, Zhou L, Yang Z, Xie HY, Zheng SS: Predictive value of CpG island methylator phenotype for tumor recurrence in hepatitis B virus-associated hepatocellular carcinoma following liver transplantation. BMC Cancer 2010, 10: 399.
Article
PubMed Central
PubMed
CAS
Google Scholar
Liu JB, Zhang YX, Zhou SH, Shi MX, Cai J, Liu Y, Chen KP, Qiang FL: CpG Island methylator phenotype in plasma is associated with hepatocellular carcinoma prognosis. World J Gastroenterol 2011,17(42):4718–4724.
Article
CAS
PubMed Central
PubMed
Google Scholar
Nishida N, Kudo M, Nagasaka T, Ikai I, Goel A: Characteristic patterns of altered DNA methylation predict emergence of human hepatocellular carcinoma. Hepatology 2012,56(3):994–1003.
Article
CAS
PubMed
Google Scholar
Wong IHN, Zhang J, Lai PBS, Lau WY, Lo YMD: Quantitative analysis of tumor-derived methylated p16INK4a sequences in plasma, serum, and blood cells of hepatocellular carcinoma patients. Clin Cancer Res 2003,9(3):1047–1052.
CAS
PubMed
Google Scholar
Lin Q, Chen LB, Tang YM, Wang J: Promoter hypermethylation of p16 gene and DAPK gene in sera from hepatocellular carcinoma (HCC) patients. Chin J Cancer Res 2005,17(4):250–254.
Article
CAS
Google Scholar
Tsutsui M, Iizuka N, Moribe T, Miura T, Kimura N, Tamatsukuri S, Ishitsuka H, Fujita Y, Hamamoto Y, Tsunedomi R, Iida M, Tokuhisa Y, Sakamoto K, Tamesa T, Sakaida I, Oka M: Methylated cyclin D2 gene circulating in the blood as a prognosis predictor of hepatocellular carcinoma. Clin Chim Acta 2010,411(7–8):516–520.
Article
CAS
PubMed
Google Scholar
Yeo W, Wong N, Wong WL, Lai PBS, Zhong S, Johnson PJ: High frequency of promoter hypermethylation of RASSF1A in tumor and plasma of patients with hepatocellular carcinoma. Liver Int 2005,25(2):266–272.
Article
CAS
PubMed
Google Scholar
Chan KCA, Lai PBS, Mok TSK, Chan HLY, Ding C, Yeung SW, Lo YMD: Quantitative analysis of circulating methylated DNA as a biomarker for hepatocellular carcinoma. Clin Chem 2008,54(9):1528–1536.
Article
CAS
PubMed
Google Scholar
Huang ZH, Hu Y, Hua D, Wu YY, Song MX, Cheng ZH: Quantitative analysis of multiple methylated genes in plasma for the diagnosis and prognosis of hepatocellular carcinoma. Exp Mol Pathol 2011,91(3):702–707.
Article
CAS
PubMed
Google Scholar
Tangkijvanich P, Hourpai N, Rattanatanyong P, Wisedopas N, Mahachai V, Mutirangura A: Serum LINE-1 hypomethylation as a potential prognostic marker for hepatocellular carcinoma. Clin Chim Acta 2007,379(1–2):127–133.
Article
CAS
PubMed
Google Scholar
Wu HC, Wang Q, Yang HI, Tsai W, Chen CJ, Santella RM: Global dna methylation levels in white blood cells as a biomarker for hepatocellular carcinoma risk: a nested case–control study. Carcinogenesis 2012,33(7):1340–1345.
Article
CAS
PubMed Central
PubMed
Google Scholar
Gao XD, Qu JH, Chang XJ, Lu YY, Bai WL, Wang H, Xu ZX, An LJ, Wang CP, Zeng Z, Yang YP: Hypomethylation of long interspersed nuclear element-1 promoter is associated with poor outcomes for curative resected hepatocellular carcinoma. Liver Int 2013. in press
Google Scholar
Nishida N, Arizumi T, Takita M, Nagai T, Kitai S, Yada N, Hagiwara S, Inoue T, Minami Y, Ueshima K, Sakurai T, Ida H, Kudo M: Quantification of tumor DNA in serum and vascular invasion of human hepatocellular carcinoma. Oncology 2013,84(SUPPL.1):82–87.
Article
CAS
PubMed
Google Scholar
Sun FK, Fan YC, Zhao J, Zhang F, Gao S, Zhao ZH, Sun Q, Wang K: Detection of TFPI2 methylation in the serum of hepatocellular carcinoma patients. Dig Dis Sci 2013,58(4):1010–1015.
Article
CAS
PubMed
Google Scholar
Zhang F, Fan YC, Mu NN, Zhao J, Sun FK, Zhao ZH, Gao S, Wang K: Exportin 4 gene expression and DNA promoter methylation status in chronic hepatitis B virus infection. J Viral Hepat 2013. in press
Google Scholar
Li F, Fan YC, Gao S, Sun FK, Yang Y, Wang K: Methylation of serum insulin-like growth factor-binding protein 7 promoter in hepatitis B virus-associated hepatocellular carcinoma. Genes Chromosomes Cancer 2014,53(1):90–97.
Article
PubMed
CAS
Google Scholar
McShane LM, Altman DG, Sauerbrei W, Taube SE, Gion M, Clark GM: REporting recommendations for tumor MARKer prognostic studies (REMARK). Nat Clin Prac Urol 2005,2(8):416–422.
Article
CAS
Google Scholar
Bossuyt PM, Reitsma JB, Bruns DE, Gatsonis CA, Glasziou PP, Irwig LM, Lijmer JG, Moher D, Rennie D, de Vet HC: Toward complete and accurate reporting of studies of diagnostic accuracy. The STARD initiative. Am J Clin Pathol 2003,119(1):18–22.
Article
PubMed
Google Scholar
Yang JD, Seol SY, Leem SH, Kim YH, Sun Z, Lee JS, Thorgeirsson SS, Chu IS, Roberts LR, Kang KJ: Genes associated with recurrence of hepatocellular carcinoma: Integrated analysis by gene expression and methylation profiling. J Korean Med Sci 2011,26(11):1428–1438.
Article
CAS
PubMed Central
PubMed
Google Scholar
Wang Y, Cheng J, Xu C, Liu S, Jiang S, Xu Q, Chen X, Zhuang H, Lu F: Quantitative methylation analysis reveals gender and age differences in p16INK4a hypermethylation in hepatitis B virus-related hepatocellular carcinoma. Liver Int 2012,32(3):420–428.
PubMed
Google Scholar
Saelee P, Chuensumran U, Wongkham S, Chariyalertsak S, Tiwawech D, Petmitr S: Hypermethylation of suppressor of cytokine signaling 1 in hepatocellular carcinoma patients. Asian Pac J Cancer Prev 2012,13(7):3489–3493.
Article
PubMed
Google Scholar
Chu HJ, Heo J, Seo SB, Kim GH, Kang DH, Song GA, Cho M, Yang US: Detection of aberrant p16INK4A methylation in sera of patients with liver cirrhosis and hepatocellular carcinoma. J Korean Med Sci 2004,19(1):83–86.
Article
CAS
PubMed Central
PubMed
Google Scholar
Wang J, Qin Y, Li B, Sun Z, Yang B: Detection of aberrant promoter methylation of GSTP1 in the tumor and serum of Chinese human primary hepatocellular carcinoma patients. Clin Biochem 2006,39(4):344–348.
Article
CAS
PubMed
Google Scholar
Tan SH, Ida H, Lau QC, Goh BC, Chieng WS, Loh M, Ito Y: Detection of promoter hypermethylation in serum samples of cancer patients by methylation-specific polymerase chain reaction for tumour suppressor genes including RUNX3. Oncol Rep 2007,18(5):1225–1230.
CAS
PubMed
Google Scholar
Zhang YJ, Wu HC, Shen J, Ahsan H, Wei YT, Yang HI, Wang LY, Chen SY, Chen CJ, Santella RM: Predicting hepatocellular carcinoma by detection of aberrant promoter methylation in serum DNA. Clin Cancer Res 2007,13(8):2378–2384.
Article
CAS
PubMed
Google Scholar
Chang H, Yi B, Li L, Zhang HY, Sun F, Dong SQ, Cao Y: Methylation of tumor associated genes in tissue and plasma samples from liver disease patients. Exp Mol Pathol 2008,85(2):96–100.
Article
CAS
PubMed
Google Scholar
Hu L, Chen G, Yu H, Qiu X: Clinicopathological significance of RASSF1A reduced expression and hypermethylation in hepatocellular carcinoma. Hepatol Int 2010,4(1):423–432.
Article
PubMed Central
PubMed
Google Scholar
Iyer P, Zekri AR, Hung CW, Schiefelbein E, Ismail K, Hablas A, Seifeldin IA, Soliman AS: Concordance of DNA methylation pattern in plasma and tumor DNA of Egyptian hepatocellular carcinoma patients. Exp Mol Pathol 2010,88(1):107–111.
Article
CAS
PubMed
PubMed Central
Google Scholar