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Table 3 Commonly studied methylation markers in HCC

From: DNA methylation: potential biomarker in Hepatocellular Carcinoma

Gene HCC patients (n) Clinicopathological correlation Validation method Publication Year
p16 28 Tumor stage MSP Yu et al. [56] 2003
  18 Tumor stage MSP Shim et al. [59] 2003
  20 Tumor differentiation MSP Qin et al. [66] 2004
  50 Age, gender, virus infection (HBV/HCV) MSP Li et al. [62] 2004
  44 HBV infection MSP Jicai et al. [63] 2006
  60 Age, tumor stage, vascular invasion, virus infection (HBV/HCV) MSP Katoh et al. [61] 2006
  58 Tumor stage MSP Su et al. [60] 2007
  23 HBV infection (HBx) MSP Zhu et al. [65] 2007
  265 Disease free survival MSP Ko et al. [70] 2008
  118 Gender Methylscreen Wang et al. [119] 2012
SOCS1 50 Liver cirrhosis MSP Okochi et al. [77] 2003
  51 HCV infection MSP Yang et al. [54] 2003
  284 Age, tumor size, virus infection (HBV/HCV) MSP Ko et al. [73] 2008
  77 HCV infection COBRA Nishida et al. [76] 2008
  46 Liver cirrhosis, tumor size MSP Chu et al. [75] 2010
  46 Tumor stage MethyLight Um et al. [72] 2011
  29 Chemotherapy treatment MSP Saelee et al. [120] 2012
  116 Age and gender Methylscreen Zhang et al. [74] 2013
GSTP1 60 Overall survival MSP Lee et al. [55] 2003
  83 Alcohol consumption, gender MSP Zhang et al. [82] 2005
  60 Gender, viral infection (HBV/HCV) MSP Katoh et al. [61] 2006
  58 HBV infection, tumor stage MSP Su et al. [60] 2007
  77 HCV infection COBRA Nishida et al. [76] 2008
  166 HBV infection Pyrosequencing Lambert et al. [81] 2011
CDH1 60 Overall survival MSP Lee et al. [55] 2003
  32 Vascular invasion, recurrence MSP Ghee [91] 2005
  1. COBRA, Combined Bisulfite Restriction Analysis; HBV, Hepatitis B virus; HCV, Hepatitis C virus; HBx, Hepatitis B virus X protein; MSP, Methylation-specific PCR.