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Table 4 CIMP studies in HCC

From: DNA methylation: potential biomarker in Hepatocellular Carcinoma

Genes used to define CIMP HCC patients (n) Clinicopathological correlation Validation method Publication Year
ER, c-MYC, p14, p15, p16, p53, RB1, RASSF1A, WT1 50 AFP level MSP Zhang et al. [96] 2007
E2F1, p15, p16, p21, p27, p300, p53, RB, WT1 120 Metastasis MSP Zhang et al. [97] 2008
CDH1, p14, p15, p16, p21, RB1, RASSF1A, SYK, TIMP3, WT1 60 Metastasis, tumor stage MSP Cheng et al. [98] 2010
CDH1, DAPK, GSTP1, p16, SOCS1, SYK, XAF1 65 AFP, RFS, tumor numbers MSP Wu et al. [100] 2010
GSTP1, MGMT, OPCML, p14, p15, p16, p73, RARβ, SOCS1 115 OS, RFS MSP Li et al. [99] 2010
APC, CDH1, DKK, DLC1, RUNX3, SFRP1, WIF1 108 AFP level, DFS, Gender, HBV status, tumor stage MSP Liu et al. [101] 2011
APC, GSTP1, HIC1, p16, PRDM2, RASSF1A, RUNX3, SOCS1 177 DFS Methylight Nishida et al. [102] 2012
  1. AFP, Alpha fetoprotein; DFS, Disease free survival; HBV, Hepatitis B virus; MSP, Methylation-specific PCR; OS, Overall survival; RFS, Recurrence free survival.