Figure 2From: The resistance mechanisms of proteasome inhibitor bortezomib Interaction model of bortezomib with active site of β5 subunit of proteasome. Ala49, Ala50, Thr21 cited at the specific pocket of β5 subunit of proteasome (PSMB5). Ala49, Ala50, Thr21 participate in the tight hydrogen-bonding network, when bortezomib (in blue) interacts with the active site of PSMB5.Back to article page