Figure 3

The 3D protein-backbone structure of the β5 subunit of proteasome. The 3D model of protein-backbone structure of the β5 subunit of proteasome (PSMB5) consults the yeast proteasomal crystal structure in complex with bortezomib [22]; the bovine proteasomal crystal structure [23]; models made by Franke et al [19],. de Wilt et al [21]. and Suzuki et al [24]. Mutation sites are depicted in red. P1, substrate side chain 1; S1, specificity binding pocket 1.