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Correction: Vitamin D activates FBP1 to block the Warburg effect and modulate blast metabolism in acute myeloid leukemia

The Original Article was published on 02 April 2022

Correction: Biomarker Res 10, 1-5 (2022)

https://doi.org/10.1186/s40364-022-00367-3

The original article [1] contained a typographical error in Fig 1F as well as some revision highlights in the supplementary material. These errors have since been corrected.

Fig. 1
figure 1

1,25 vitamin D induced FBP1 expression and reduced lactate production. A Pie distribution of RNA-seq FPKM-based gene expression in MV4–11 cells; B The FBP1 expression (FPKM) increased sharply from the low rank in non-treated (NO-TX) group to the high rank in 80 nM 1,25VD3-treated groups in different experimental groups of MV4–11, MOLM-14 cells, MV4–11-MIDO-R and MOLM-14-MIDO-R cells (MV4–11 or MOLM-14 resistant to midostaurin). MIDO: midostaurin (80 nM); C1–3 40x Images from Immunocytochemistry (ICC) to compare FBP1 protein before or after 1,25VD3 treatment; ICC control: 2nd antibody was applied without the primary antibody; D Representative FC plots showing the co-expression of FBP1 and VDR in 1,25VD3-treated MV4–11 cells; The Supplementary Figure 2 showing the FC plot of FITC-isotype control; E MV4–11 cells were treated with 80 nM 1,25VD3 for 48 h, then harvested and analyzed by RT-qPCR for expression of human FBP1 (Fold Change); F Treated MV4–11 cells were analyzed by WB for protein expression of human FBP1; G Treated MV4–11 cells were analyzed by Lactate Assay; Cumulative data of the concentration of intracellular lactate; Where applicable, data are means ± SEM and were analyzed by student “t” test. *p < 0.05, ***p < 0.005, n = 5

Reference

  1. Xu Y, et al. Vitamin D activates FBP1 to block the Warburg effect and modulate blast metabolism in acute myeloid leukemia. Biomarker Res. 2022;10:16. https://doi.org/10.1186/s40364-022-00367-3.

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40364_2022_379_MOESM1_ESM.docx

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Xu, Y., Hino, C., Baylink, D.J. et al. Correction: Vitamin D activates FBP1 to block the Warburg effect and modulate blast metabolism in acute myeloid leukemia. Biomark Res 10, 33 (2022). https://doi.org/10.1186/s40364-022-00379-z

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  • DOI: https://doi.org/10.1186/s40364-022-00379-z