Table 1 Oncogenic role of ZFPs in HCC
ZFPs | Aliases | Role | Target genes | Mechanism in HCC | Ref |
|---|---|---|---|---|---|
ZNF384 | NMP4、CAGH1 | Oncogene | Cyclin D1 | Promotes proliferation | [102] |
ZNF263 | ZSCAN44、FPM315 | Oncogene | Beclin1、LC3 | Promotes proliferation, chemotherapy resistance and inhibits apoptosis | [103] |
ZNF703 | NLZ1、ZPO1 | Oncogene | CLDN4 | Induces EMT progress | [104] |
ZNF687 | PDB6 | Oncogene | BMI1、OCT4、Nanog | Enhances invasion and chemoresistance | [7] |
ZNF143 | SBF、STAF | Oncogene | MDIG | Promotes proliferation and tumor growth | [101] |
ZNF191 | ZNF24、ZSCAN3 | Oncogene | CTNNB1 | Activates Wnt signaling pathway | [105] |
ZNF503 | Nlz2、NOLZ1 | Oncogene | GATA3 | Promotes migration, invasion and EMT progress | [106] |
ZFX | ZNF926 | Oncogene | Nanog、SOX-2 | Enhances proliferation, drug resistance, and the ability of self-renewal | [107] |
Gli1 | PPD1、PAPA8 | Oncogene | MMP-2、MMP-9 | Promotes migration and invasion | [8] |
Caveolin-1 | Induces EMT and promotes the motility and invasion | [9] | |||
Twist | Induces EMT progress | [10] | |||