Table 4 Area under the receiver operator curve (AUROC) for diagnosis of concussion per biomarker
From: Blood biomarkers for mild traumatic brain injury: a selective review of unresolved issues
Marker | Study | Year | Study Size | Sampling | AUROC∗ |
|---|---|---|---|---|---|
Lead Author | (N) | Time (hrs)†| |||
GFAP | Gill [71] | 2018 | 277 | 0-48 | 0.93 |
Papa [17] | 2019 | 452 | 0-4 | 0.76 | |
Giza [83] | 2021 | 167 | 0-6 | 0.75 | |
Lewis [103] | 2017 | 188 | 0-6 | 0.70 | |
McCrea [31] | 2020 | 206 | 0-6 | 0.68 | |
Posti [81] | 2017 | 44 | 0-24 | 0.63 | |
Asken [79] | 2018 | 29 | 0-4 | 0.63 | |
McDonald [68] | 2021 | 28 | 2 days | 0.60 | |
Meier [80] | 2017 | 32 | 0-6 | 0.53 | |
NF-L | McDonald [68] | 2021 | 20‡ | 6 days | 0.85 |
Gill [71] | 2018 | 277 | 0-48 | 0.77 | |
Giza [83] | 2021 | 167 | 0-6 | 0.73 | |
McCrea [31] | 2020 | 206 | 0-6 | 0.56 | |
Wallace [104] | 2018 | 12 | 6 days | NS | |
S100B | Asken [79] | 2018 | 29 | 0-4 | 0.75 |
Meier [80] | 2017 | 32 | 0-6 | 0.72 | |
Lewis [103] | 2017 | 188 | 0-6 | 0.69 | |
Shahim [85] | 2014 | 35 | 0-1 | 0.67 | |
Rogatzi [86] | 2021 | 8 | 0-1 | 0.48 | |
tau-T | Shahim [85] | 2014 | 35 | 0-1 | 0.86 |
Asken [79] | 2018 | 27 | 0-4 | 0.74 | |
McDonald [68] | 2021 | 20‡ | 13 days | 0.72 | |
Gill [71] | 2018 | 277 | 0-48 | 0.68 | |
McCrea [31] | 2020 | 206 | 0-6 | 0.55 | |
Giza [83] | 2021 | 167 | 0-6 | 0.50 | |
Wallace [104] | 2018 | 11 | 6 days | NS | |
Wallace [104] | 2019 | 11 | 14 days | NS | |
UCH-L1 | Meier [80] | 2017 | 32 | 0-6 | 0.74 |
Giza [83] | 2021 | 167 | 0-6 | 0.73 | |
McCrea [31] | 2020 | 206 | 0-6 | 0.66 | |
Lewis [103] | 2017 | 188 | 0-6 | 0.65 | |
Papa [17] | 2019 | 452 | 0-4 | 0.65 | |
Asken [79] | 2018 | 26 | 0-4 | 0.62 | |
McDonald [68] | 2021 | 20‡ | 2 days | 0.61 | |
Posti [81] | 2017 | 44 | 0-24 | 0.52 |