Skip to main content

Table 2 Kinetic parameters of commonly investigated biomarkers for mTBI

From: Blood biomarkers for mild traumatic brain injury: a selective review of unresolved issues

Biomarker

Normal Plasma

Normal CSF

Half-life

Tmax

ka

ke

References

 

level (pg/ml)

level (pg/ml)

hrs

hrs

   

GFAP

60-70

2100

36

24

0.080

0.019

[9, 11, 12, 17, 65]

NF-L

6-20

400-1100

500 ??

100-300 ??

0.009

0.001

[8, 12, 67, 68]

S100B

50-60

1800

1.5†

2

0.500

0.462

[9, 11, 27, 28, 65, 69, 70]

tau

1-5

270

10

8

0.070

0.069

[8, 11, 71, 72]

UCH-L1

8-10

4500

8

8

0.090

0.086

[9, 11, 17, 22, 65, 73]

  1. Values for half-life and Tmax are mid-range of reported estimates
  2. S100B undergoes rapid redistribution to other compartments before renal elimination
  3. ??Estimates are uncertain
  4. Estimates for the absorption constant (ka) and elimination constant (ke) compartment pharmacokinetic model with first order kinetics from [74].