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Table 2 Completed CD19 CAR-T clinical trials for B-cell non-Hodgkin lymphoma

From: Advances in chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma

NCT Number Phase Status Locations Clinical outcomes
NCT01593696 Phase I Completed National Institutes of Health Clinical Center, 9000 RockvillePike, Bethesda, Maryland, United States The CR rate was 59.6% (31/52). The occurrence rate of serious adverse events and high grade CRS were 26.9% (14/52) and 9.6% (5/52).
NCT02132624 Phase I / IIa Completed Uppsala University Hospital, Dept of Oncology, Uppsala,Sweden Six of the 15 patients had complete responses (4/11 lymphoma and 2/4 ALL). Three patients developed severe CRS in 15 patients and 2 patients developed high grade ICANS.
NCT02030834 Phase IIa Completed Abramson Cancer Center of the University of Pennsylvania,Philadelphia, Pennsylvania, United States The objective response rate was 64% (18/28). Occurrence rate of serious CRS and ICANS were 18% (5/28) and 11% (3/28)
NCT01626495 Phase I /IIa Completed CHOP-http://www.chop.edu/service/oncology/pediatric-cancer-research/cart-19-trial.html, Philadelphia, Pennsylvania, UnitedStates The CR rate was 25.8% (16/62) and CRi (complete remission with incomplete blood count recovery) rate was 61.3% (38/62).
  1. Abbreviations: CR complete response, CRS cytokine release syndrome, ICANS immune effector cell-associated neurotoxicity syndrome, CRi complete remission with incomplete blood count recovery, ALL acute lymphoblastic leukemia