Fig. 7

Comparative proteomic analysis of Huh7 and BCLC-3 cells. A Venn diagram showing exclusiveness and commonness of proteins identified in proteomes of Huh7^mock, Huh7^hMT3, and BCLC-3^WT cells. The red number highlights exclusive proteins shared between BCLC-3^WT and Huh7^hMT3. B Venn diagrams showing overlap of proteins commonly expressed (n = 52) in HCC cells with intrinsic (BCLC-3^WT) and induced (Huh7^hMT3) resistance to sorafenib. C Protein expression-based heatmap of 52 proteins deregulated in Huh7^hMT3 cells compared to Huh7^mock and BCLC-3^WT. D Proposed mechanism of interaction and co-regulation of proteins that have been found deregulated in Huh7^hMT3 and BCLC-3^WT