Fig. 7

RUNX1 promotes angiogenesis in CRC by regulating the crosstalk between tumor cells and TAMs. Summary diagram showing a complex interaction in the crosstalk of CRC cells and TAMs. RUNX1 derived from CRC cells recruits macrophages and induces the M2 polarization phenotype. The latter contributes to tumor angiogenesis in vivo and in vitro and migration and invasion of CRC cells via PDGF-BB, so as to form a positive feedback loop to promote the progression of CRC