Fig. 1

Comparison of T-cell receptor beta-chain (TCRβ) repertoire between IgAN, non-IgAN, and healthy group. A Flow diagram of sample collection and TCR sequencing (TCR-seq) analysis. B The Shannon index shown in IgAN (red), non-IgAN (green), and healthy (blue) subjects. Differences in the repertoire diversity index were calculated by the Kruskal–Wallis test (among three groups) and the Wilcoxon rank sum test (between any two of groups). C Mean CDR3 length of TCRβ repertoire shown in IgAN (red), non-IgAN (green), and healthy (blue) subjects. Differences in means CDR3 length were examined by the Kruskal–Wallis test (among three groups) and the Wilcoxon rank sum test (between any two of groups). D Gene usages of TRBV5-4, TRBV6-4, TRBV12-1, TRBV16, and TRBV21-1 shown in IgAN (red), non-IgAN (green), and healthy (blue) subjects. Differences in gene usage were calculated by the Wilcoxon rank sum test. P-value < 0.05 was considered statistically significant and is denoted by “*”