Table 3 The effects of upstream regulators on BACH1.

SNHG5/miR-299

Upregulation

Upregulates BACH1, thereby regulating the levels of glucometabolic enzymes, glucose consumption and lactate secretion, facilitating proliferation

[66]

USP47

Stabilization

Inhibits the ubiquitination of BACH1

[67]

UBR7/Keap1/Nrf2

Downregulation

Induces the transcription of Keap1, thereby upregulating the Nrf2/BACH1/HK2 pathway

[68]

RCC2

Stabilization

Stabilizes BACH1 at the C terminal

[69]

Circ-0087862/ miR-142-3p

Upregulation

Promotes cellular proliferation, tumor invasion and migration

[113]

Circ-0000337/ miR-4458

[112]

SNHG8/ miR-1270

[115]

CXCR3-B/p38 MAPK&ERK-1/2

Stabilization

Increases the nuclear localization of BACH1

[133]

TBK1

Upregulation

Increases ferroptosis, thereby promoting metastasis

[78]

IGF/ IGFR/ERK1/2/EST1

Upregulation

Promotes tumor growth and metastasis by upregulating the expression of cell motility-related genes

[12]

RKIP/let-7

Downregulation

Inhibits metastasis

[97, 100, 101]

Myc/HOXB8

Upregulation

Activates transcription of BACH1 and enhances tumor invasion

[101]

p53^R175H

Upregulation

Exerts a bidirectional effect on BACH1 in transcriptional regulation

[30]

miR-148a

Downregulation

Suppresses the maturation and homeostasis of B lymphocytes

[56, 57]