Transcription factor BACH1 in cancer: roles, mechanisms, and prospects for targeted therapy

Hu, Dian; Zhang, Zerui; Luo, Xiangyuan; Li, Siwen; Jiang, Junqing; Zhang, Jiaqian; Wu, Zhangfan; Wang, Yijun; Sun, Mengyu; Chen, Xiaoping; Zhang, Bixiang; Xu, Xiao; Wang, Shuai; Xu, Shengjun; Wang, Yufei; Huang, Wenjie; Xia, Limin

doi:10.1186/s40364-024-00570-4

Biomarker Research

Table 2 The regulatory effects of BACH1 on downstream target genes

From: Transcription factor BACH1 in cancer: roles, mechanisms, and prospects for targeted therapy

Target gene	Effect	Function	Ref.
HO-1	Repression	Maintenance of heme homeostasis and regulation of oxidative stress	[4]
YAP	Promotion	Facilitates the expression of YAP by binding to its promotor, in turn promoting the transcription of ICAM1 and VCAM1	[8]
PGC-1α	Repression	Reduces the production of ROS and improves angiogenesis after hindlimb ischemia	[51]
ANGPT-1	Repression	Inhibits angiogenesis	[33, 34, 51]
FGF-2
VEGF
IL-8
Perp	Repression	Represses p53-induced cellular senescence	[35]
P21	Repression	Represses p53-induced cellular senescence	[35]
ITPR2	Repression	Decreases calcium efflux from the endoplasmic reticulum	[6]
CALM1	Repression	Activated when combined with calcium and represses the cell cycle	[6]
EWSR1	Repression	Mediates the transcriptional percent of cell cycle proteins D1a and D1b	[110]
Cebpb	Repression	Inhibits myeloid differentiation	[56]
Ebf1	Promotion	Promotes the differentiation of pro-B cells	[56]
Spic	Repression	Inhibits monocyte differentiation into red marrow and bone marrow macrophages	[59]
FIZZ1	Repression	Inhibits the differentiation of M2 macrophages	[61]
CD206
YM1
iNOS	Promotion	BACH1 deficiency in macrophages promotes NLRP3 inflammasome activation	[62]
COX-2	Repression		[62]
HK2	Promotion	Supports aerobic glycolysis	[9]
GAPDH	Promotion	Supports aerobic glycolysis	[9]
SLC16A	Repression	Reduces lactate utilization in TNBC cells to repress tumorigenesis	[73]
LDHB	Repression		[73]
FOXA1	Repression	Promotes EMT-mediated tumor metastasis by inhibiting epithelial genes	[11, 78, 80, 81]
CLDN3
CLDN4
VIM	Promotion	Promotes EMT-mediated metastasis by inhibiting mesenchymal genes
CDH2
SNAI2
IGF1R	Promotion	Promotes tumor growth and metastasis by upregulating the expression of cell motility-related genes	[12]
PTK2	Promotion		[12]
COL1A1	Promotion	Facilitates ECM remodeling to create an environment favorable to tumor metastasis	[83, 85, 86]
Fibronectin	Promotion		[83, 85, 86]
TGFBR2	Promotion	Activates the smad2/3 signaling pathway thereby promoting ECM remodeling	[87]
MMP1	Promotion	Promotes metastasis	[90,91,92]
CXCR4
OPN
FHL1
MMP9	Promotion	Promotes angiogenesis and tumor metastasis	[82, 93, 94]
CEMIP	Promotion	Promotes metastasis	[30]
CD44⁺	Promotion	Induces stemness, proliferation and invasion of lung CSCs both in vitro and in vivo	[106]
SOX2	Promotion	Maintains CSC identity and promotes self-renewal	[106]
NANOG
OCT4
PDLIM2	Repression	ROS/BACH1/PDLIM2/STAT3 signaling pathway promotes lung tumorigenesis by driving alveolar macrophages	[139]
GCLC	Repression	Reduces oxidation and promotes ferroptosis	[6, 117, 121, 122, 124]
GCLM
SLC7A11
HIF1A	Repression	Inhibits the proliferation of PDAC	[109]
VEGF	Repression
PTEN	Promotion
FTH1	Repression	Affects iron homeostasis and promotes ferroptosis via the ferritin-ferroportin pathway	[117, 121, 122]
FTL
SLC40A1
CDH1	Repression	Promotes ferroptosis by suppressing the NF2-Hippo pathway and facilitates metastasis by promoting the EMT	[126]
VEGFC	Promotion	Promotes angiogenesis and tumor progression	[7, 80, 90]
MGMT	Promotion	Competitively binds to p53 and reduces its impact on MGMT expression	[134]

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ISSN: 2050-7771

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