Transcription factor BACH1 in cancer: roles, mechanisms, and prospects for targeted therapy

Biomarker Research

Table 1 The oncogenic roles of BACH1 in different types of cancer

Cancer type	Expression	Effects	Ref.
Breast cancer	High expression in the TIMER 2.0 and CPTAC databases	Promotes mitochondrial metabolism, aerobic glycolysis, lactate metabolism, metastasis, and apoptosis	[10, 66, 73, 76, 82, 91, 92]
Lung cancer	High expression in lung stem cells	Promotes glycolysis, metastasis, and tumorigenesis	[9, 22, 67, 106]
Hepatocellular carcinoma	High expression	Promotes glycolysis, growth and metastasis	[12, 68]
Glioma	High expression in TIMER 2.0	Promotes glycolysis, progression, invasion and metastasis	[69, 83, 87]
Pancreatic adenocarcinoma	Low expression	Promotes metastasis and proliferation	[78, 109]
Ovarian cancer	High expression	Promotes metastasis and angiogenesis	[7, 81]
Colorectal cancer	High expression	Promotes invasion, metastasis, and angiogenesis	[28, 29, 90, 101, 113, 160]
Esophageal squamous cancer	High expression in TIMER 2.0 and significantly higher in metastatic tumor tissues	Promotes metastasis, proliferation, and angiogenesis	[76, 80, 115]
Osteosarcoma	-	Promotes progression and migration	[112]
Skin cancer	High expression	Promotes invasion and metastasis	[28, 29]

ISSN: 2050-7771