Role of HOXA1-4 in the development of genetic and malignant diseases

Biomarker Research

Table 4 Role of HOXA- AS3 in tumor regulation

Cancers	Expression	Regulate genes	pathways	Functions	References
BCa	Up	miR-455-5p	miR-455-5p/Notch1	Viability, proliferation, apoptosis, and chemoresistance	[185]
CC	Up	miR-29a-3p		Proliferation, migration, and invasion	[183]
CRC	Up	miR-4319	miR-4319/SPNS2	Proliferation, apoptosis	[186]
EOC	Up			Proliferation, metastasis	[179]
GBM	Up	miR-455-5p	miR-455-5p/USP3	Proliferation, invasion	[187]
GC	Up	miR-29a-3p	miR-29a-3p/LTβR/NF-κB	Proliferation, metastasis, and invasion	[188]
HCC	Up	miR-455-5p	miR-455-5p/PD-L1	Proliferation, apoptosis, metastasis, and invasion	[181]
HCC	Up	miR-29c	miR-29c/BMP1 MEK/ERK	Proliferation, metastasis, and EMT	[182]
NSCLC	Up	HOXA3		Cisplatin resistance	[80]
OSCC	Up	miR-218-5p	miR-218-5p/COL1A1/LPCAT1	Proliferation	[189]
Osteosarcoma	Up	miR-1286	miR-1286/TEAD1	Proliferation, migration, and invasion	[184]
PC	Up	miR-29c	miR-29c/CDK6	Proliferation	[180]

BCa bladder cancer, CC Cervical cancer, CRC colorectal cancer, EOC Epithelial ovarian cancer, GBM Glioblastoma multiforme, GC Gastric cancer, HCC Hepatocellular carcinoma, OSCC oral squamous cell carcinoma, PC Pancreatic cancer, NSCLC Non‑small cell lung cancer

ISSN: 2050-7771