Role of HOXA1-4 in the development of genetic and malignant diseases

Wang, Lumin; Sun, Haifeng; Cao, Li; Wang, Jinhai

doi:10.1186/s40364-024-00569-x

Biomarker Research

Table 3 Role of HOXA- AS2 in tumor regulation

From: Role of HOXA1-4 in the development of genetic and malignant diseases

Cancers	Expression	Regulate genes	pathways	Functions	References
AML	Up	LATS2	Combine with EZH2	Proliferation, differentiation of AML cells	[154]
BC	Up	miR-520c-3p	miR-520c-3p/TGFBR2/RELA	Proliferation, metastasis	[169]
BC	Up	miR-106a	miR-106a/SCN3A		[170]
BCa	Up	miR-125b	miR-125b/Smad2	Migration, invasion and stemness	[177]
CC	Up	Notch intracellular domain (NICD)	Notch	Proliferation, migration	[158]
CC	Up	miR-509-3p	miR-509-3p/BTN3A1	Proliferation, migration and invasion	[171]
CRC	Up	P21, KLF2	Combine with EZH2 and LSD1	Proliferation, apoptosis	[150]
GBC	Up			Proliferation, EMT, migration and invasion	[156]
GBM	Up	miR-2116-3p	miR-2116-3p/SERPINA3	Viability, proliferation, migration, and invasion	[162]
GBM	Up	miR-885-5p	miR-885-5p/RBBP4	Proliferation, apoptosis	[163]
GBM	Up	miR-302-3p	miR-302-3p/IGF1	Temozolomide Resistance	[164]
GC	Up			Associated with clinicopathological features	[148]
GC	Up	P21, PLK3, and DDIT3	Combine with EZH2	Proliferation, apoptosis	[149]
Glioma	Up	RND3	Combine with EZH2	Proliferation, apoptosis, and invasion	[155]
Glioma	Up	miR-373	miR-373/EGFR	Viability, migration, invasion, and VM formation	[160]
Glioma	Up	miR-302a	miR-302a/KDM2A/JAG1	Proliferation, immune tolerance	[161]
GSCs	Up	E2F8, E2F1, ATF3, STAT1		Proliferation	[157]
HCC	Up			Proliferation	[147]
NPC	Up	miR-519	miR-519/HIF-1α/PD-L1	Proliferation, migration, and invasion	[174]
NSCLC	Up	IGF-2		Migration, invasion	[159]
NSCLC	Up	miR-216a-5p		Proliferation, migration, and invasion	[176]
OSCC	Up	EZH2		Proliferation, migration, and invasion	[153]
OSCC	Up	miR-567	miR-567/CDK8	Proliferation	[167]
OSCC	Up	miR-520c-3p	miR-520c-3p/SNX5	Proliferation, migration, and invasion	[168]
Osteosarcoma	Up	miR-124-3p	miR-124-3p/E2F3	Proliferation, migration, and invasion	[175]
Papillary thyroid cancer	Up	miR-15a-5p	miR-15a-5p/HOXA3	Proliferation, apoptosis, migration, and invasion	[172]
PC	Up		Combine with EZH2 and LSD1	Proliferation, apoptosis	[152]
PCa	Up	miR-885-5p	miR-885-5p/KDM5B	Proliferation, apoptosis, and migration	[165]
PCa	Up	miR-509-3p	miR-509-3p/PBX3	Proliferation, migration, invasion, and EMT	[166]
Type I endometrial carcinoma	Up	miR-302c-3p	miR-302c-3p/ZFX	Proliferation, invasion	[173]
Thoracic aortic aneurysm	Up	miR-520d-3p	miR-520d-3p/KIAA1522/IGF2BP3	Proliferation, apoptosis	[178]

AML Acute myeloid leukemia, BC Breast cancer, BCa bladder cancer, CC Cervical cancer, CRC colorectal cancer, EOC Epithelial ovarian cancer, GBC Gallbladder carcinoma, GBM Glioblastoma multiforme, GC Gastric cancer, GSCs Glioma stem cells, HCC Hepatocellular carcinoma, NPC Nasopharyngeal carcinoma, NSCLC Non‑small cell lung cancer, OSCC oral squamous cell carcinoma, PC Pancreatic cancer, PCa Prostate cancer

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ISSN: 2050-7771

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