Role of HOXA1-4 in the development of genetic and malignant diseases

Biomarker Research

Table 2 Role of HOXA- AS2/3 in diseases

Diseases	Expression	Regulate genes	pathways	Functions	References
HOXA-AS2
Chronic intermittent hypoxia (CIH)-induced lung inflammation	Down	miR-17-5p	miR-17-5p/tipe2	Inflammatory regulator	[138]
Diabetic nephropathy	Down	miRNA-302b-3p	miRNA-302b-3p/TIMP3	Inflammation, apoptosis	[137]
Epilepsy	Up	miR-372-3p	miR-372-3p/STAT3	Cellular damages	[141]
Parkinson's disease	Up	PRC2, PGC-1α		Neuroinflammation	[142]
Systemic lupus erythematosus	Up		ERK pathway		[143]
Vascular disorders			NF-κB signaling	Endothelium inflammation	[140]
VSMCs injury	Up	miRNA-877-3p		Proliferation, apoptosis, and migration	[139]
HOXA-AS3
Atherosclerosis	Up	miR-455-5p	miR-455-5p /p27 Kip1	Proliferation, apoptosis	[144]
Endothelium inflammation			NF-κB		[145]
Pulmonary arterial hypertension	Up	miR-675-3p	miR-675-3p/PDE5A	Proliferation, viability, and migration	[146]

ISSN: 2050-7771