Role of HOXA1-4 in the development of genetic and malignant diseases

Wang, Lumin; Sun, Haifeng; Cao, Li; Wang, Jinhai

doi:10.1186/s40364-024-00569-x

Biomarker Research

Table 1 HOXA1-4 genes were regulated by ncRNA in cancers

From: Role of HOXA1-4 in the development of genetic and malignant diseases

ncRNA	Tumor	HOXAs	Direct/Indirect	HOXA up/low expression	Function	References
miRNAs
miR-10a-5p	OC	HOXA1	Direct	Up	Viability, colony formation, migration ability, invasiveness	[67]
miR-10b	CC	HOXA1	Direct	Up	Proliferation, invasion	[68]
miR-10b	ccRCC	HOXA3	Direct	Up	Invasion, migration	[69]
miR-100	NSCLC	HOXA1	Direct	Up	Invasion, migration	[70]
miR-100	NPC	HOXA1	Direct	Up	Proliferation	[71]
miR-202-3p	HCC	HOXA1	Indirect	Up	Viability, migration, invasion	[64]
miR-218	HCC	HOXA1	Direct	Up	Proliferation	[62]
miR-218	MDS	HOXA1	Direct	Up	Proliferation, colony formation, and apoptosis	[72]
miR‑338‑3p	T‑LBL	HOXA3	Direct	Up	Malignancy	[73]
miR‑577	NSCLC	HOXA1	Direct	Up	Proliferation, invasion	[74]
miR-99a	HCC	HOXA1	Direct	Up	Invasion, migration	[63]
miR-99a	OC	HOXA1	Direct	Up	Proliferation,invasion	[75]
lncRNAs
DLX6‐AS1	TC	HOXA1	Direct as a sponge of miR‐193b‐3p	Up	Autophagy, apoptosis	[76]
HOTAIR	SCLC	HOXA1	Indirect By H3K27me3	N/A DNA methylation	Multidrug resistance	[77]
HOTAIRM1	GBM	HOXA1	Demethylation of histone H3K9 and H3K27	Up	Proliferation, migration, invasion	[78]
HOTAIRM1	EC	HOXA1	N/A	Up	Proliferation, migration, invasion	[79]
HOXA-AS2	HB	HOXA3	Form RNA‐RNA dimers and increase the stability of HOXA3	Up	Proliferation, migration, invasion	[65]
HOXA-AS3	NSCLC	HOXA3	Direct	Down	EMT, cisplatin resistance	[80]
LINC00152	CC	HOXA1	Direct as a sponge of miR-216b-5p	Up	Proliferation	[81]
LINC00689	GC	HOXA3	Direct as a sponge of miR-338-3p	Up	Cell growth, EMT	[82]
LINC00958	LUAD	HOXA1	N/A	Up	Proliferation, migration	[83]
SNHG1	BC	HOXA1	Direct as a sponge of miR-193a-5p	Up	Proliferation, migration	[84]
ZFPM2-AS1	RB	HOXA1	Direct as a sponge of miR‐515	Up	Growth, metastasis	[85]
circRNAs
circ_0058063	Esophageal cancer	HOXA1	Direct as a sponge of miR-377-3p	Up	Proliferation, migration, invasion,	[86]
circ_0074032	PCa	HOXA1	Direct as a sponge of miR-198	Up	Proliferation, migration, invasion	[87]
circ_0008945	BC	HOXA3	Direct as a sponge of miR-338-3p	Up	Proliferation, migration, invasion	[88]
circEIF4G2	CC	HOXA1	Direct as a sponge of miR‑218	Up	proliferation, migration, invasion	[89]
circRASSF2	BC	HOXA1	Direct as a sponge of miR-1205	Up	Proliferation, migration	[90]
circWHSC1	HCC	HOXA1	Direct as a sponge of miR-142-3p	Up	Proliferation, migration	[66]

BC Breast cancer, CC Cervical cancer, ccRCC Clear cell renal cell carcinoma, EC Endometrial cancer, GBM Glioblastoma multiforme, GC Gastric cancer, HB Hepatoblastoma, HCC Hepatocellular carcinoma, lncRNA Long non-coding RNA, LUAD Lung adenocarcinoma, MDS myelodysplastic neoplasm, miRNA microRNAs, ncRNA non-coding RNAs, NPC Nasopharyngeal carcinoma, NSCLC Non‑small cell lung cancer, OC Ovarian cancer, PCa Prostate cancer, RB Retinoblastoma, SCLC Small cell lung cancer, TC Thyroid carcinoma, T‑LBL T‑cell lymphoblastic lymphoma

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ISSN: 2050-7771

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