Table 2 Overview of circulating microRNAs (miRNAs) in patient’s biological fluids with cerebrovascular diseases. Note: studies examining non-traumatic intracerebral hemorrhage (ICH) were not included
From: MiRNAs as potential therapeutic targets and biomarkers for non-traumatic intracerebral hemorrhage
Disease | MiRNA | Regulation | Biological fluid | Important finding | References |
|---|---|---|---|---|---|
AIS | MiR-451a | Down | Serum | Diagnostic significance. Significantly associated with poor clinical outcomes of stroke, as defined by the modified Rankin scores | [28] |
AIS | EV-derived miR-19a-3p, miR-186-5p and let-7f | Up | Plasma | Diagnostic significance. Combining circulating miRNAs might be beneficial for early diagnosis of ischemic events | [29] |
AIS | Exosomal miR-223 | Up | Serum | Diagnostic significance. Associated with acute ischemic stroke occurrence, stroke severity, and short-term outcomes | [30] |
AIS and TIA | MiR-195-5p and miR-451 | Up and down | Serum | At admission were significantly upregulated and significantly decreased over time at 24 h and 48 h, and it is associated with decreased HIF-α levels and increased VEGF serum levels | [31] |
aSAH | Exosomal miR-369-3p, miR-193b-3p, and miR-486-3p | Up | Plasma | Diagnostic significance. Significantly associated with poor clinical outcomes of aSAH, as defined by the WFNS grade, Hunt–Hess grade, and Fisher score | [32] |
aSAH | MiR-132 and miR-324 | Up | Plasma | Diagnostic significance. Correlation with DCI | [33] |
aSAH and UIA | MiR-126 | Up | Plasma | Potential non-invasive biomarker in UIAs detection and prevention aneurysms with a high risk of rupture | [34] |
aSAH and UIA | MiR-183-5p and let7b-5p | Down | Plasma | Potential non-invasive biomarkers in UIAs detection and prevention aneurysms with a high risk of rupture | [35] |
MiR-200a-3p | Up | ||||
BAVM | MiR-7-5p, miR-199a-5p and miR-200b-3p | Up | Whole blood | Diagnostic significance | [36] |