MiRNAs as potential therapeutic targets and biomarkers for non-traumatic intracerebral hemorrhage

Biomarker Research

Table 1 Results of studies on cerebrovascular microRNAs (miRNAs)

Neurovascular unit	MiRNA	Targets	Important find	References
OPCs	MiR-3074-3p	Cav-1	Great clinical value in ischemic demyelination. Ameliorates OPCs clustering and promotes oligodendrogenesis	[4]
Microglia	MiR-195	CX3CL1/CX3CR1 signaling pathway	Regulates of microglia M1 polarization	[5]
OPCs	MiR-23a-5p	Olig3	Promotes white matter remodeling and repair in stroke and demyelinating diseases	[6]
ECs	MiR‐140‐5p	VEGFA	Promotes proliferation, migration, and tube formation	[7]
ECs	Mir‐126‐3p and miR‐126‐5p	IL‐1β, TNF‐α, VCAM‐1, E‐selectin	Maintenances of BBB integrity	[8]
ECs	MiR‐107	Dicer‐1	Promotes angiogenesis	[9,10,11]
	MiR‐24‐1‐5p	HIF‐1α
	MiR‐191	NF‐kβ
VSMCs	MiR-552	ATF4 and SKI	Critical role in the proliferation and migration	[12]
VSMCs	MiR-137	Calcineurin/NFATC3 signaling pathway	Modulates the dedifferentiation and proliferation	[13]
Pericytes	Let-7d	bFGF	Induces of pericyte differentiation	[14]
Astrocytes	MiR-182-5p	IL-1β, IL-6 and TNF-α	Inhibits neuroinflammation and improves brain injury after ischemic stroke	[15]
Neurons	MiR‐106b‐5p	Mcl‐1/Bcl‐2 signaling pathway	Inhibits of apoptosis and oxidative stress	[16]
Neurons	MiR‐149‐5p	P53/caspase‐3 signaling pathway	Regulates of cell survival and apoptosis	[17]
Neurons and astrocytes	MiR‐19a‐3p	ADIPOR2	Modulates of glucose metabolism and neuronal apoptosis	[18]

Abbreviations: EC Endothelial cells, VSMCs Vascular smooth muscle cells, OPCs Oligodendrocyte precursor cells, BBB Blood–brain barrier, Cav-1 Caveolin-1, CX3CL1 Chemokine (C-X3-C motif) ligand 1, CX3CR1 CX3C motif chemokine receptor 1, Olig3 Oligodendrocyte transcription factor 3, VEGFA Vascular endothelial growth factor A, IL‐1β Interleukin 1β, TNF‐α Tumor necrosis factor-alpha, VCAM‐1 Vascular cell adhesion molecule 1, HIF‐1α Hypoxia-induced factor-1alpha, NF‐kβ Nuclear factor kappa β, ATF4, Activating transcription factor 4, SKI Proto-oncogene bFGF Basic fibroblast growth factor, NFATC3 Nuclear factor of activated T-cells, IL-6 Interleukin 6, Mcl‐1 Myeloid leukemia 1, Bcl‐2 B-cell lymphoma 2, P53 Tumor protein p53, ADIPOR2 Polyclonal antibody to adiponectin receptor 2

ISSN: 2050-7771