Fig. 1

Classification and mechanisms of prevalent anti-HER2-targeting medications. (PTEN: phosphatase and tensin homolog; PDK1: phosphoinositide-dependent protein kinase 1; AKT: protein kinase B; TSC1/2: tuberous sclerosis complex 1/2; GTP: guanosine triphosphate; GDP: guanosine diphosphate; mTORC: mammalian target of rapamycin; GRB2: growth factor receptor-bound protein 2; SOS: guanosine release protein; MEK: mitogen-activated extracellular signal-regulated kinase; ERK:extracellular signal-regulated kinase; PLC: phospholipase C; PKC: protein kinase C; STAT: signal transducer and activator of transcription)