Table 1 Characteristics of human PIWI proteins
From: Critical appraisal of the piRNA-PIWI axis in cancer and cancer stem cells
| Â | PIWIL1 | PIWIL2 | PIWIL3 | PIWIL4 |
|---|---|---|---|---|
Other names | HIWI | HILI | HIWI3 | HIWI2 |
Gene location | 12q24.33 | 8p21.3 | 22q11.23 | 11q21 |
Number of exons | 26 | 25 | 23 | 20 |
Protein isoforms (transcript variants) | Isoform 1 (tv1) Isoform 2 (tv2) | Isoform 1 (tv1 and tv2) Isoform 2 (tv3) | Isoform 1 (tv1) Isoform 2 (tv2) | Isoform 1 (tv1) |
Number of amino acids | 861 (isoform 1) | 973 (isoform 1) | 882 (isoform 1) | 852 (isoform 1) |
Molecular weight (kDa) | 98.6 (isoform 1) | 109.8 (isoform 1) | 101.1 (isoform 1) | 96.6 (isoform 1) |
Isoelectric point | 9.258 (isoform 1) | 8.781 (isoform 1) | 9.328 (isoform 1) | 8.669 (isoform 1) |