Fig. 2
From: Critical appraisal of the piRNA-PIWI axis in cancer and cancer stem cells
Effect of PIWI proteins on stem cell characteristics in cancer. PIWIL1 and PIWIL2 are linked to expression of stem cell markers, involved in cancer stem cell renewal and growth as well as epithelial mesenchymal transition (EMT) and resistance to chemotherapy. See text for details. CDKN1B = cyclin-dependent kinase inhibitor 1B, POU5F1 (Oct-3, Oct4, Oct3/4) = octamer-binding transcription factor 4, BMI-1 = polycomb complex protein BMI-1, ALDH1 = aldehyde dehydrogenase 1 family member A1, KLF-4 = Kruppel-like factor 4