MRI-derived radiomics assessing tumor-infiltrating macrophages enable prediction of immune-phenotype, immunotherapy response and survival in glioma

Table 1 Characteristics of HGG patients in three independent cohorts

Characteristics	TCGA microarray cohort (N=145) Median (range, %)	Immune-phenotype cohort (N=203) Median (range, %)	Immunotherapy-treated cohort (N=31) ^a Median (range, %)
Age	60(14-86)	56(37-77)	51(22-71)
>40	131(90.3%)	175(86.2%)	22(71.0%)
≤40	14(9.7%)	28(13.8%)	9(29.0%)
Gender
Male	92(63.4%)	113(55.7%)	17(54.8%)
Female	53(36.6%)	90(44.3%)	14(45.2%)
Tumor location	NA
Frontal	/	83(40.9%)	16(51.6%)
Non-frontal	/	120(59.1%)	15(48.4%)
IDH1 mutation		NA
Yes	3(2.1%)	19(9.4%)	1(3.2%)
No	116(80.0%)	132(65.0%)	30(96.8%)
NA	26(17.9%)	52(25.6%)	/
TERT promoter mutation		NA
Yes	10(6.9%)	/	14(45.2%)
No	1(0.7%)	/	17(54.8%)
NA	134(92.4%)	/	/

^aPatients information was extracted from a randomized controlled prospective clinical trial (NCT01567202) whose MRI images are available. Clinicopathological characteristics can be also found in our previous paper²²

ISSN: 2050-7771