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Fig. 5 | Biomarker Research

Fig. 5

From: MRI-derived radiomics assessing tumor-infiltrating macrophages enable prediction of immune-phenotype, immunotherapy response and survival in glioma

Fig. 5

Kaplan-Meier analyses of progression-free survival (PFS) and overall survival (OS) according to RIB score in patients with HGG from immunotherapy-treated cohort. a Patients with high RIB score could prolong PFS by treatment from DC vaccine. b Patients with high RIB score could prolong OS by treatment from DC vaccine. No significant survival differences of PFS (c) or OS (d) were found between patients treated by DC vaccine and placebo in subgroup with low RIB score. e Multiplexed immunostaining demonstrated one patient with high RIB score was infiltrated by abundant T cells and TAM in TIM, who could be defined as hot immune-phenotype and got an incremental survival from immunotherapy. f Few immune cells were observed in another patient with low RIB score, who got attenuated clinical benefit from DC vaccine and was classified into cold immune-phenotype

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Biomarker Research

ISSN: 2050-7771

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