Fig. 4

The combination of IN10018 and crizotinib effectively suppressed the proliferation of TNBC cells. A Colony formation and quantitative analysis of MDA-MB-231 cells. B, C Quantitative analysis of colony formation of MDA-MB-231 cells. D Colony formation of Hs578T cells. E, F Quantitative analysis of colony formation of Hs578T cells. G, H EdU staining results of MDA-MB-231 and Hs578T cells. I, J Quantitative analysis of EdU-positive cells. K, L Cell cycle analysis of MDA-MB-231 and Hs578T cells. M, N Quantitative analysis of cell cycle distribution. O, P Western blotting assessment of cell cycle-related proteins in MDA-MB-231 cells and Hs578T cells. Data are represented as mean ± SEM. Significant levels: ns = not significant (P > 0.05), * P < 0.05, ** P < 0.01, and *** P < 0.001. Ctrl: Control