Table 4 Summary of the reported relationships between single nucleotide polymorphisms located in the BTLA gene and cancer risk

Fu et al. [119]

BC

Chinese

rs9288952

rs2931761

rs2633562

rs2705535

rs1844089

Genotype distributions of rs1844089, rs2705535 and rs9288952 differed between BC patients and HC;

rs1844089 CT genotype increased BC risk by 1.3 times, CC genotype decreased BC risk 1.3 times;

rs2705535 CT genotype increased BC risk by 1.5 times, CC genotype decreased BC risk 1.5 times;

rs9288952 GG genotype lowered BC risk 1.7 times;

Haplotype GTTTT (rs9288952, rs2931761, rs2633562, rs2705535, rs1844089) was associated with 3 times increased BC risk and haplotype GTCTC was more frequent in patients with lymph node invasion;

Zhao et al. [120]

BC

Chinese

rs1982809

rs1982809 AA genotype was associated with 1.95 times higher BC risk after adjustment of BMI, age, and menopausal status compared to GG genotype;

rs1982809 was associated with the ER status, Ki-67 status, TNM stage and tumor size of BC;

Karabon et al. [118]

CLL

Caucasian

rs2705511

rs1982809

rs9288952

rs76844316

rs16859633

rs9288953

rs2705535

rs1844089

rs2705565

rs2633580

rs1982809 G allele (AG + GG genotypes) was associated with 1.5 times higher CLL risk;

rs2705511 C allele (AC + CC genotypes) was associated with 1.5 times higher CLL risk;

rs9288953 TT genotype was associated with 2 times higher CLL risk and the CT genotype with 25% higher risk of CLL;

Haplotypes distribution differed significantly between CLL patients and controls;

Haplotype CGATCGCC (rs2705511, rs1982809, rs9288952, rs9288953, rs2705535, rs1844089, rs2705565, rs2633580) increased CLL risk and haplotype AAACCGCC decreased the risk of CLL;

rs1982809 G allele (AG + GG genotype) was associated with lower BTLA mRNA expression level in T-cells compared to AA genotype in CLL patients

Khadhraoui et al. [121]

lung cancer

Tunisian

rs1982809

rs9288952

rs9288953

rs1982809 G allele (AG + GG genotypes) was associated with 1.5 times higher NSCLC risk;

rs1982809 was associated with T4 tumor size, lymph node invasion and adenocarcinoma subtype;

Haplotypes were differently distributed in patients than in controls;

Andrzejczak et al. [122]

NSCLC

Caucasian

rs2705511

rs1982809

rs9288952

rs9288953

rs1844089

rs11921669

rs2633582

rs1982809 G allele (AG + GG genotypes) was associated with 1.3 times higher NSCLC risk;

rs9288953 genotype distribution differed between female patients and female controls and rs9288953 T allele (CT + TT genotypes) was associated with 2.2 times higher NSCLC risk in females;

rs1982809 genotypes distribution differed between non-smokers and controls, and rs1982809 A allele (AA + AG genotypes) decreases susceptibility to NSCLC by 3 times;

rs1982809 G and rs2705511 C alleles correlated with the more advanced stages of NSCLC;

Haplotype distribution differed significantly between never-smokers and controls;

rs1982809 and rs270551 significantly modified patient survival (OS);

Wang et al. [123]

NSCLC

Chinese

rs1982809

rs16859629

rs2171513

rs3112270

rs3112270 G allele (GG + AG genotype) decreased NSCLC risk;

rs1982809 GA and AA + GA genotypes were associated with NSCLC risk;

rs2171513 AA and rs16859629 CC genotypes increased squamous cell carcinoma (SCC) risk;

Haplotype TAGG (rs16859629, rs1982809, rs2171513, rs3112270) reduced NSCLC risk compared to TGGA;

Ge et al. [116]

CRC

RCa

Chinese

rs3087243

rs231775

rs231777

rs1844089

rs2705535

rs10204525

rs2227982

rs9288953

rs7421861

rs6710479

rs2705535 TT genotype was associated with 2 times higher CRC risk compared to the CC genotype;

rs9288953 TT genotype decreased RCa risk by 1.4 times;

Tang et al. [124]

EGJA

Chinese

rs16859629

rs1982809

rs2171513

rs3112270

No association was found between BTLA SNPs and EGJA risk in the overall analysis;

Haplotype TAAG (rs16859629, rs1982809, rs2171513, rs3112270) increased EGJA risk by 3 times;

rs1982809 AA genotype was associated with 2 times higher EGJA risk in heavy-smokers;

Cao et al. [125]

ESCC

Chinese

rs2171513

rs3112270

rs1982809

rs16859629

No association was found between BTLA SNPs and ESCC risk in the overall analysis;

rs3112270 CT genotype reduced ESCC risk in male patients by 1.2 times;

rs3112270 CC genotype increased ESCC risk in BMI ≥ 24 kg/m2 patients’ group by 2 times;

rs2171513 AG genotype, when compared to AA genotype, reduced ESCC risk by 1.6 times in the ever-drinking patients;

Partyka et al. [126]

RCC

Caucasian

rs1844089

rs2705535

rs9288953

rs9288952

rs16859633

rs1982809 G allele (AG + GG genotypes) was associated with 1.4 times higher RCC risk;

Overrepresentation of rs2705511 C allele carriers (dominant model) in RCC patients;

Haplotype CGATCG (rs2705511, rs1982809, rs9288952, rs9288953, rs2705535, rs1844089) increased RCC risk by 46%;

rs1982809 GG genotype was associated with 2.75 times higher risk of High Grade ccRCC;

Genotype distribution of rs2705535 in High Grade ccRCC significantly differed compared to controls;

rs9288953 TT genotype tended to be more frequent in High Grade ccRCC than in controls