Fig. 1
From: Phenotypic and metabolomic characteristics of mouse models of metabolic associated steatohepatitis
Phenotypic characteristics of mouse models of diet-induced MASH. A Nutrients and energy source in the three experimental diets. B Experimental design for establishing mouse models of MASLD/MASH. Mice were fed various diets for 16 and 32 weeks and then euthanized; liver specimens and blood samples were collected for analysis. C Changes in the body weight of mice after 32 weeks of feeding. D Livers of mice receiving different diets fed for 16 and 32 weeks. E Liver weight/body weight ratio of mice fed different diets for 16 weeks (left) and 32 weeks (right). Statistical significance: *p < 0.05, **p < 0.01, and ***p < 0.001. NC: normal chow; HFD: high-fat diet; WD: Western diet; HFC: high-fat, high-cholesterol diet; MASH, metabolic dysfunction-associated steatohepatitis; ppm: parts per million