Table 1 Relationship between circulating ECM-associated molecules and LV dysfunction

Diastolic dysfunction

 MMP-2 per SD

1.96 (1.44–2.67)

< 0.001

1.48 (1.05–2.08)

0.024

 MMP-9 per SD

0.98 (0.79–1.23)

0.868

1.05 (0.82–1.34)

0.685

 Tenascin-C per SD

1.58 (1.04–2.41)

0.034

1.28 (0.80–2.06)

0.301

 Thrombospondin-2 per SD

1.03 (0.99–1.06)

0.172

1.02 (0.98–1.06)

0.442

LV hypertrophy

 MMP-2 per SD

1.04 (0.80–1.37)

0.769

0.85 (0.62–1.17)

0.315

 MMP-9 per SD

1.05 (0.83–1.34)

0.676

1.11 (0.84–1.45)

0.474

 Tenascin-C per SD

1.26 (0.87–1.82)

0.224

1.04 (0.69–1.58)

0.849

 Thrombospondin-2 per SD

1.00 (0.97–1.04)

0.994

0.99 (0.95–1.03)

0.563