Fig. 3

Neddylation plays a crucial role in the regulation of the NF-κB pathway and EGFR pathway, affecting several immune cells. In the NF-κB pathway, IκB inhibition and subsequent proteasomal degradation occur via IKK complex activation. The SCF complex, whose function is enhanced by neddylation, is instrumental in IκB ubiquitination. In the EGFR pathway, neddylation helps regulate the function of Tregs, dendritic cells, M2 macrophages, and CD8 + T cells. NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells; IκB, inhibitor of κB; IKK, IκB kinase; TLRs, Toll-like receptors; c-Rel, proto-oncogene c-Rel; SCF, Skp1-Cul1-F-box protein; Skp1, S-phase kinase-associated protein 1; Rbx1, ring-box 1; ROC1, regulator of Cullins 1; NEDD8, neural precursor cell expressed developmentally downregulated protein 8; UBE2M, ubiquitin-conjugating enzyme E2 M; c-CBL, casitas B-lineage lymphoma; Tregs, regulatory T cells. Created with BioRender.com