Table 2 CeRNA networks regulated MICA in cancers
Cancer type | Competing endogenous RNAs | Cancer tissues/cells status | Sponge miRNAs | Cancer tissues/cells status | Competitor mRNAs | Cancer tissues/cells status | CeRNA Network | CeRNA Role | Functions | References |
|---|---|---|---|---|---|---|---|---|---|---|
Colon cancer | BCL11B | Downregulated | miR-17, miR-93, miR-20a, miR-20b, miR-106a, miR-106b | Upregulated | MICA | Downregulated | BCL11B/ miR-17, miR-93, miR-20a, miR-20b, miR-106a, miR-106b/MICA | Tumour suppressorgene | MiRNAs negatively regulate MICA and BCL11B. MICA-NKG2D pathway mediates the immune response to the killing effect of NK cells in tumourigenesis. | [75] |
Triple-negative breast cancer | LncRNA HEIH | Upregulated | miR-939-5p | Downregulated | NOSs/NO/MICA | Downregulated/Downregulated/Upregulated | LncRNA HEIH/miR-939-5p/NOSs/NO/MICA | Oncogene | Silencing of lncRNA HEIH causes a significant down-regulation of NOSs, NO production, cellular viability, migration ability and increases the expression of MICA in TNBC cells. | [78] |
Hepatocelluar carcinoma | LINC01149[C] | Upregulated | miR-128-3p | Downregulated | MICA | Upregulated | LINC01149[C]/miR-128-3p/MICA | Oncogene | LINC01149 genotypes are associated with sMICA level in HCC patients and the C allele contributed to higher sMICA level and increase risk of hepatocelllular carcinoma in persistent HBV infection and HCC. | [18] |
Pancreatic cancer | Circ_0000977 | Upregulated | miR-153 | Downregulated | HIF1A/ADAM10 | Upregulated/Upregulated | Circ_0000977/miR-153/HIF1A/ADAM10/MICA | Oncogene | Circ_0000977 could inhibit the expression of miR-153 and reverse the downregulation of HIF1A and ADAM10 mediated by miR-153, circ_0000977 upregulates ADAM10 to shedding of mMICA transforming to sMICA; hyporesponsiveness in NK cells. | [85] |
Neuroblastoma | MALAT1 | Upregulated | miR-92a | Downregulated | ADAM10 | Upregulated | MALAT1/miR-92a/ADAM10/MICA | Oncogene | MALAT1 shedding of mMICA transforming to sMICA contributes to the formation of a suppressive immune microenvironment and promoting immune escape. | [88] |
Cervical cancer | LINC00240 | Upregulated | miR-124-3p | Downregulated | STAT3/MICA | Upregulated/Downregulated | LINC00240/miR124-3p/STAT3/MICA | Oncogene | LINC00240 significantly downregulates miR-124-3p, and decreases MICA mRNA and protein expression and reduced the cytotoxic activity of NKT cells through regulation of STAT3 promoted cervical cancer progression in vitro and vivo. | [91] |