Mitochondrial transfer in hematological malignancies

Biomarker Research

Table 1 Mitochondrial transfer studies in hematological malignancies

Donors	Recipients	Mechanisms of transport	Triggers	Cellular Effect	Reference
BMSCs	AML	endocytosis	Chemotherapy agents	less sensitive to chemotherapy	[131]
BMSCs	AML	TNTs	NOX2-derived ROS	Increased mitochondrial respiration and ATP production	[22]
BMSCs	AML	TNTs	OXPHOS suppression	secondary resistance to chemotherapy	[134]
BMSCs	CML	TNTs	ND	Increased survival and chemo-resistance	[143]
T-ALL	BMSCs	TNTs, ICAM-1	Chemotherapy agents	Induction of drug resistance	[146, 148]
BMSCs	ALL	TNTs	ND	Increased viability and resistance	[153]
MSCs	MM	TNTs	Cx43	increased drug resistance	[157]

ND: not defined; AML: acute myeloid leukemia; T-ALL: T cell acute lymphoblastic leukemia; ALL: acute lymphoblastic leukemia; MM: multiple myeloma; TNTs: tunneling nanotubes; BMSCs: bone marrow stromal cells; OXPHOS: oxidative phosphorylation; ROS: reactive oxygen species.

ISSN: 2050-7771