Fig. 4

ScfDNA fragmentation pattern and fragmentomics in cancer vs. noncancer donors. (A) Fragment score between the cancer and noncancer groups, with each dot representing each sample. p value = 0.0059, Student’s t test, Welch’s correction (B) Area under receiver operating curve = 0.89. (C) Fragment score for every chromosomal bin for autosomal chromosomes, noncancer donors (Turquoise), and cancer donors (Peach), solid line representing mean, dashed line representing SEM. (D) Volcano plot demonstrating over 2700 chromosomal locations with significant differences in fragment scores. Multiple t test, without considering consistency of SD, false discovery rate Benjamini, Krieger and Yekutieli method, p value < 0.05, q value < 0.05. G. Top 20 significant chromosomal locations with different fragment score p values < 0.05, multiple t test, corrected FDR.