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Fig. 2 | Biomarker Research

Fig. 2

From: Circulating cell-free DNA (cfDNA) in patients with medullary thyroid carcinoma is characterized by specific fragmentation and methylation changes with diagnostic value

Fig. 2

Evaluation of MGMT_623CG methylation. (A) MGMT_623CG methylation percentage in MTC patients and healthy donors (HD) plasma samples. The methylation rate was calculated by using the bisulfite converted Human Methylated DNA and human unmethylated DNA as positive and negative controls, respectively. Unpaired t-test * p < 0.05. (B) ROC curve of MGMT_623CG methylation percentage in a cohort of 9 MTC patients and 7 healthy donors subjects (AUC = 0.8750; p-value = 0.0201). Black line = sensitivity, red line = identity. (C) MGMT_623CG methylation percentage in MTC patients before (T0) and three months after the surgical resection (T1)

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Biomarker Research

ISSN: 2050-7771

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